M Zeier

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. ncbi request reprint No regression of renal AL amyloid in monoclonal gammopathy after successful autologous blood stem cell transplantation and significant clinical improvement
    Martin Zeier
    Department of Medicine Nephrology, University of Heidelberg, Bergheimerstrasse 56a, D 69115 Heidelberg, Germany
    Nephrol Dial Transplant 18:2644-7. 2003
  2. ncbi request reprint Risk of mortality in patients with end-stage renal disease: the role of malnutrition and possible therapeutic implications
    M Zeier
    Department of Medicine, Division of Nephrology, University of Heidelberg, Germany
    Horm Res 58:30-4. 2002
  3. ncbi request reprint The effect of donor gender on graft survival
    Martin Zeier
    Department of Internal Medicine Nephrology, University of Heidelberg, Heidelberg, Germany
    J Am Soc Nephrol 13:2570-6. 2002
  4. ncbi request reprint Malignancy after renal transplantation
    Martin Zeier
    Department of Internal Medicine, Ruperto Carola University, Heidelberg, Germany
    Am J Kidney Dis 39:E5. 2002
  5. doi request reprint Influence of test technique on sensitization status of patients on the kidney transplant waiting list
    P Gombos
    Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
    Am J Transplant 13:2075-82. 2013
  6. doi request reprint Recent developments in desensitization of crossmatch-positive kidney transplant recipients
    C Morath
    Department of Nephrology, University of Heidelberg, Germany
    Transplant Proc 44:1648-51. 2012
  7. doi request reprint Simultaneous pancreas-kidney transplantation in type 1 diabetes
    C Morath
    Department of Nephrology, University of Heidelberg, Heidelberg, Germany
    Clin Transplant 23:115-20. 2009
  8. ncbi request reprint Hypertension after renal transplantation
    V Schwenger
    Department Internal Medicine, University of Heidelberg, Bergheimer Str. 56a, D-69115 Heidelberg, Germany
    Curr Hypertens Rep 3:434-9. 2001
  9. doi request reprint [Combined liver-kidney and kidney after liver transplantation: indications and experiences from a nephrological perspective at a single center]
    J Seckinger
    Klinik fur Innere Medizin I, Sektion Nephrologie, Medizinische Universitatsklinik Heidelberg, Heidelberg, Germany
    Dtsch Med Wochenschr 135:1973-8. 2010
  10. doi request reprint Angiotensin-converting enzyme inhibitors and angiotensin II type 1 receptor blockers after renal transplantation
    C Morath
    Department of Nephrology, University of Heidelberg, Heidelberg, Germany
    Clin Transplant 23:33-6. 2009

Collaborators

Detail Information

Publications139 found, 100 shown here

  1. ncbi request reprint No regression of renal AL amyloid in monoclonal gammopathy after successful autologous blood stem cell transplantation and significant clinical improvement
    Martin Zeier
    Department of Medicine Nephrology, University of Heidelberg, Bergheimerstrasse 56a, D 69115 Heidelberg, Germany
    Nephrol Dial Transplant 18:2644-7. 2003
    ..High-dose chemotherapy followed by autologous blood stem cell transplantation induces remission of plasma cell dyscrasia in patients with AL amyloidosis. The impact of this treatment on the glomerular amyloid mass is still unknown...
  2. ncbi request reprint Risk of mortality in patients with end-stage renal disease: the role of malnutrition and possible therapeutic implications
    M Zeier
    Department of Medicine, Division of Nephrology, University of Heidelberg, Germany
    Horm Res 58:30-4. 2002
    ..Further studies are required to measure the impact of for example growth hormone supplementation on mortality rate and quality of life in malnourished patients on chronic dialysis...
  3. ncbi request reprint The effect of donor gender on graft survival
    Martin Zeier
    Department of Internal Medicine Nephrology, University of Heidelberg, Heidelberg, Germany
    J Am Soc Nephrol 13:2570-6. 2002
    ..Therefore, in addition to potential "nephron underdosing," further pathomechanisms must play a role, possibly differences in immunogenicity according to donor gender...
  4. ncbi request reprint Malignancy after renal transplantation
    Martin Zeier
    Department of Internal Medicine, Ruperto Carola University, Heidelberg, Germany
    Am J Kidney Dis 39:E5. 2002
    ..In addition to specific oncological treatment, managing a malignancy after renal transplantation should include modification of immunosuppression...
  5. doi request reprint Influence of test technique on sensitization status of patients on the kidney transplant waiting list
    P Gombos
    Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
    Am J Transplant 13:2075-82. 2013
    ..False SAB reactions can be unveiled by testing with additional antibody assays. Denial of donor kidneys to recipients based on HLA-antibody specificities detected exclusively in the SAB assay is not advisable...
  6. doi request reprint Recent developments in desensitization of crossmatch-positive kidney transplant recipients
    C Morath
    Department of Nephrology, University of Heidelberg, Germany
    Transplant Proc 44:1648-51. 2012
    ..Finally, integrated algorithms that combine different measures are acknowledged...
  7. doi request reprint Simultaneous pancreas-kidney transplantation in type 1 diabetes
    C Morath
    Department of Nephrology, University of Heidelberg, Heidelberg, Germany
    Clin Transplant 23:115-20. 2009
    ..We give a short overview on SPK transplantation, with a focus on the effects of this procedure on diabetic complications as well as patient and kidney graft survival...
  8. ncbi request reprint Hypertension after renal transplantation
    V Schwenger
    Department Internal Medicine, University of Heidelberg, Bergheimer Str. 56a, D-69115 Heidelberg, Germany
    Curr Hypertens Rep 3:434-9. 2001
    ....
  9. doi request reprint [Combined liver-kidney and kidney after liver transplantation: indications and experiences from a nephrological perspective at a single center]
    J Seckinger
    Klinik fur Innere Medizin I, Sektion Nephrologie, Medizinische Universitatsklinik Heidelberg, Heidelberg, Germany
    Dtsch Med Wochenschr 135:1973-8. 2010
    ..In CLKT, there appears to be a certain immunological protection for the kidney transplant by the liver transplant...
  10. doi request reprint Angiotensin-converting enzyme inhibitors and angiotensin II type 1 receptor blockers after renal transplantation
    C Morath
    Department of Nephrology, University of Heidelberg, Heidelberg, Germany
    Clin Transplant 23:33-6. 2009
    ..In addition, we review their influence on morphologic and biochemical markers as well as on renal function, graft and patient survival after renal transplantation...
  11. doi request reprint A single center experience of combined liver kidney transplantation
    A Mehrabi
    Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany
    Clin Transplant 23:102-14. 2009
    ..Providing a model to reliably determine the need for CLKTx seems necessary. Such a model can be shaped based upon new and precise markers of renal function, and modification of MELD system...
  12. ncbi request reprint Henoch-Schönlein purpura in adults is not uncommon in elderly patients with an adverse prognosis
    M Schaier
    Department of Nephrology, University of Heidelberg, Heidelberg, Germany
    Clin Nephrol 76:49-56. 2011
    ..Henoch-Schönlein purpura (HSP) is a fairly common disease in children and adolescents. There are only limited data available for adults...
  13. ncbi request reprint Comprehensive immunohistological analysis of the endothelin system in human kidney grafts
    Kathrin Frank
    Department of Pathology, University of Heidelberg, Germany
    Nephrol Dial Transplant 21:1365-72. 2006
    ..It was the purpose of the present study to analyse by immunohistology the expression of ET-1 as well as of the two ET receptors (ET-RA and ET-RB) in the different cells and compartments of kidney grafts and control kidneys...
  14. ncbi request reprint Hypertension after renal transplantation
    V Schwenger
    Department Internal Medicine, University of Heidelberg, Germany
    Ann Transplant 6:25-30. 2001
    ....
  15. ncbi request reprint Monitoring immunosuppression with measures of NFAT decreases cancer incidence
    Thomas Giese
    Department of Immunology, University of Heidelberg, Im Neuenheimer Feld 305, Heidelberg 69120, Germany
    Clin Immunol 132:305-11. 2009
    ..Thus patients could maintain a stable allograft function. This represents a breakthrough in transplantation medicine and advances our attempts to individualize treatment in transplanted patients...
  16. ncbi request reprint Wound complications following kidney and liver transplantation
    A Mehrabi
    Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany
    Clin Transplant 20:97-110. 2006
    ..Surgical risk factors can be prevented by applying precise surgical techniques. Therapeutic modalities must focus on the most efficient and cost-effective medications and/or interventions to facilitate and improve wound healing...
  17. ncbi request reprint Four cases of sirolimus-associated interstitial pneumonitis: identification of risk factors
    C Morath
    Department of Nephrology, University of Heidelberg, Heidelberg, Germany
    Transplant Proc 39:99-102. 2007
    ..With careful monitoring (or even exclusion from therapy) of patients at risk for the development of disease, we have had no case of sirolimus-associated interstitial pneumonitis since September 2004...
  18. ncbi request reprint Optimal blood pressure control versus additional immunosuppressive therapy in idiopathic membranous nephropathy - a retrospective analysis
    R Dikow
    Department of Nephrology, University Hospital of Heidelberg, Heidelberg, Germany
    Clin Nephrol 72:366-72. 2009
    ....
  19. ncbi request reprint Blood pressure after renal transplantation
    M Zeier
    Department Internal Medicine, Ruperto Carola University, Heidelberg, Germany
    Ann Transplant 6:21-4. 2001
    ..There is recent documentation of a specific antiproteinuric effect of ACE inhibitors on proteinuria which is of interest since proteinuria is an independent predictor of longterm graft outcome...
  20. doi request reprint RAGE expression in the human peritoneal membrane
    Lars P Kihm
    Department of Nephrology, University of Heidelberg, Im Neuenheimer Feld 162, 69120 Heidelberg, Germany
    Nephrol Dial Transplant 23:3302-6. 2008
    ..This study investigates the in vivo expression of RAGE in the peritoneal membrane of uraemic human patients...
  21. doi request reprint Uremia aggravates left ventricular remodeling after myocardial infarction
    Ralf Dikow
    Department of Nephrology, University of Heidelberg, Heidelberg, Germany
    Am J Nephrol 32:13-22. 2010
    ..Renal failure is a well-established cardiovascular risk factor. We hypothesized that uremia negatively affects post-myocardial infarction (MI) remodeling and left ventricular (LV) function and examined the pathohistological correlations...
  22. ncbi request reprint The success of assisted reproduction technologies in relation to composition of the total regulatory T cell (Treg) pool and different Treg subsets
    V Schlossberger
    Department of Obstetrics and Gynecology, University of Heidelberg, Voss Strasse 9, 69115 Heidelberg, Germany
    Hum Reprod 28:3062-73. 2013
    ..Are there differences in composition of the total regulatory T cell (Treg) pool and distinct Treg subsets (naïve CD45RA(+)-Tregs, HLA-DR(-)- and HLA-DR(+)-memory Tregs) between successfully and non-successfully IVF/ICSI-treated women?..
  23. doi request reprint Superiority of AbCross enzyme-linked immunosorbent assay cross-match over the B-cell complement-dependent lymphocytotoxicity cross-match
    P Gombos
    Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
    Transplant Proc 45:1383-5. 2013
    ..The AbCross enzyme-linked immunosorbent assay (ELISA) cross-match is a recently introduced solid phase cross-match technique with several technical advantages over the currently available Antibody Monitoring System ELISA cross-match...
  24. ncbi request reprint Immunosuppressive standards in simultaneous kidney-pancreas transplantation
    B M Schmied
    Department of Surgery, University of Heidelberg, Heidelberg, Germany
    Clin Transplant 20:44-50. 2006
    ..In this article, we summarize the current status of immunosuppressive regimens in simultaneous pancreas and kidney transplantation...
  25. doi request reprint The role of an interdisciplinary transplant team on living donation kidney transplantation program
    H Fonouni
    Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany
    Transplant Proc 42:137-40. 2010
    ....
  26. ncbi request reprint Cardiac biomarkers and survival in haemodialysis patients
    C Sommerer
    University Hospital of Heidelberg, Heidelberg, Germany
    Eur J Clin Invest 37:350-6. 2007
    ..In a longitudinal observation, we evaluated the association of cTNT and NT-proBNP on cardiovascular morbidity and mortality in haemodialysis patients with and without fluid overload...
  27. ncbi request reprint The role and value of sirolimus administration in kidney and liver transplantation
    A Mehrabi
    Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany
    Clin Transplant 20:30-43. 2006
    ..It could improve the quality of life, graft and patient survival rate, and achieve excellent outcomes with few adverse effects when wisely used in combination with other immunosuppressants...
  28. doi request reprint In renal transplants with delayed graft function chemokines and chemokine receptor expression predict long-term allograft function
    Ralf Dikow
    Department of Nephrology, University of Heidelberg, INF Heidelberg, Germany
    Transplantation 90:771-6. 2010
    ..We studied the role of chemokines in kidney allografts with delayed graft function and the subsequent long-term outcome of renal function and fibrosis...
  29. ncbi request reprint The long-term consequences of living-related or unrelated kidney donation
    Claudia Sommerer
    Department of Medicine, Division of Nephrology, University of Heidelberg, Germany
    Nephrol Dial Transplant 19:iv45-7. 2004
    ..After age adjustment, no increase of blood pressure is noted. The benefit of living kidney transplantation is superceding the potential risks. After careful work-up of the donor short- and long-term risks are minimal...
  30. ncbi request reprint Individualized monitoring of nuclear factor of activated T cells-regulated gene expression in FK506-treated kidney transplant recipients
    Claudia Sommerer
    Department of Medicine, Division of Nephrology, University of Heidelberg, Heidelberg, Germany
    Transplantation 89:1417-23. 2010
    ....
  31. doi request reprint Successful deceased-donor kidney transplantation in crossmatch-positive patients with peritransplant plasma exchange and Rituximab
    Jörg H M Beimler
    Department of Medicine, Division of Nephrology, University of Heidelberg, Heidelberg, Germany
    Transplantation 87:668-71. 2009
    ..Both patients showed good graft outcome at 27 and 21 months after transplantation with serum creatinine values of 1.60 and 1.25 mg/dL, respectively...
  32. ncbi request reprint Comparison of the laparoscopic versus open live donor nephrectomy: an overview of surgical complications and outcome
    H Fonouni
    Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany
    Langenbecks Arch Surg 399:543-51. 2014
    ..The development of a minimally invasive surgery, laparoscopic live donor nephrectomy (LDN), was based on this concept...
  33. doi request reprint Borderline rejection after renal transplantation--to treat or not to treat
    J Beimler
    Department of Medicine, Division of Nephrology, University of Heidelberg, 69120 Heidelberg, Germany
    Clin Transplant 23:19-25. 2009
    ....
  34. ncbi request reprint Color Doppler indices of renal allografts depend on vascular stiffness of the transplant recipients
    V Schwenger
    Division of Nephrology, University Medical Hospital, Heidelberg, Germany
    Am J Transplant 6:2721-4. 2006
    ..For a more correct interpretation of the RI values in renal allografts parameters of vascular stiffness such as IMT, PP or PWV should be included...
  35. doi request reprint Rosiglitazone reduces angiotensin II and advanced glycation end product-dependent sustained nuclear factor-kappaB activation in cultured human proximal tubular epithelial cells
    M Morcos
    Department of Internal Medicine 1 Endocrinology, Metabolism and Clinical Chemistry, University of Heidelberg, Germany
    Horm Metab Res 40:752-9. 2008
    ..Most importantly, rosiglitazone effects on NFkappaB activation were maximal at later time points, indicating that rosiglitazone treatment confers long lasting renoprotective effects...
  36. doi request reprint Activity of nuclear factor of activated T cells is independent of the number of peripheral lymphocytes in FTY720-treated patients
    C Sommerer
    Department of Nephrology, University of Heidelberg, Heidelberg, Germany
    Transplant Proc 40:1416-8. 2008
    ....
  37. ncbi request reprint Immunosuppression after kidney transplantation
    L P Kihm
    Department of Nephrology, University Hospital, Heidelberg, Germany
    Minerva Urol Nefrol 63:45-57. 2011
    ..With the development of a broad armamentarium of new immunosuppressive agents with different mechanisms of action, the minimization or avoidance of corticosteroids and calcineurin inhibitors became feasible...
  38. doi request reprint Cytomegalovirus infection of the major duodenal papilla in a renal allograft recipient with severe biliary obstruction and acalculous cholecystitis
    C Riediger
    Department of Hepatology, University of Heidelberg, Heidelberg, Germany
    Transpl Infect Dis 15:E129-33. 2013
    ..Diagnosis of the CMV-related disease was established only in tissue samples, whereas standard serologic tests had failed...
  39. pmc High-risk human papillomavirus in non-melanoma skin lesions from renal allograft recipients and immunocompetent patients
    M Reuschenbach
    Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Im Neuenheimer Feld 220, Heidelberg 69120, Germany
    Br J Cancer 104:1334-41. 2011
    ..Data on prevalence are inconclusive, but are essential to estimate the relevance of HR-HPV, particularly with regard to prophylactic HPV vaccines for skin cancer prevention...
  40. doi request reprint Kidney transplantation for high-risk sensitized patients - the "Heidelberg algorithm"
    C Morath
    Department of Nephrology, University of Heidelberg, Heidelberg, Germany
    Transplant Proc 43:801-4. 2011
    ..Graft and patient survival rates did not differ from those in nonsensitized recipients. Antibody-mediated rejection episodes were <10% and infectious complications infrequent...
  41. doi request reprint [Living-donor kidney transplantation]
    A Mehrabi
    Klinik fUr Allgemein, Viszeral und Transplantationschirurgie, Chirurgische Universitatsklinik Heidelberg, Deutschland
    Chirurg 81:794, 796-800, 802-3. 2010
    ..Finally, the risks of living donation KTx will be discussed based on the reported experiences of other centers...
  42. ncbi request reprint Treatment of life-threatening multiresistant staphylococcal and enterococcal infections in patients with end-stage renal failure with quinupristin/dalfopristin: preliminary report
    V Schwenger
    Dept of Internal Medicine, University Hospital Heidelberg, Bergheimer Str 56a, D 69115 Heidelberg, Germany
    Infection 30:257-61. 2002
    ..Life-threatening infections with multiresistant gram-positive bacteria are increasing. Treatment with quinupristin/dalfopristin (Q-D) has turned out to be effective against such resistant pathogens...
  43. ncbi request reprint [Renal replacement therapy in the intensive care unit]
    C Morath
    Nierenzentrum Heidelberg, Medizinische Universitatsklinik Heidelberg, Im Neuenheimer Feld 162, 69120 Heidelberg
    Anaesthesist 55:901-13; quiz 914. 2006
    ..Furthermore, we discuss timing of the initiation of renal replacement therapy, patient outcome with different renal replacement therapies and the adequate dialysis dose to be delivered...
  44. doi request reprint [Increase in the number of cases of epidemic nephropathy in Germany. Virological and ecological aspects]
    E Krautkramer
    Nephrologie, Universitatsklinikum Heidelberg, Im Neuenheimer Feld 162, 69120 Heidelberg
    Dtsch Med Wochenschr 133:476-8. 2008
    ..In Germany the number of cases of EN has increased in the past few years and huge rise in the incidence of the infection, more than 1600 cases, occurred in 2007...
  45. ncbi request reprint Cardiac biomarkers are influenced by dialysis characteristics
    C Sommerer
    Department of Nephrology, University Department of Cardiology, University Hospital of Heidelberg, Germany
    Clin Nephrol 68:392-400. 2007
    ..The high percentage and magnitude of these increased molecules is associated with cardiovascular morbidity and mortality in hemodialysis patients. This study investigates the impact of the dialysis procedure itself on cardiac biomarkers...
  46. ncbi request reprint Review of the antiproliferative properties of mycophenolate mofetil in non-immune cells
    C Morath
    Department of Nephrology, University of Heidelberg, Germany
    Int J Clin Pharmacol Ther 41:465-9. 2003
    ..Taken together, there is a growing body of evidence pointing to therapeutic applications of MMF other than immunosuppression, in particular the prevention of fibrosis...
  47. ncbi request reprint [Diabetic nephropathy]
    M Morcos
    Abteilung für Innere Medizin 1, Endokrinologie, Stoffwechsel und Klinische Chemie, Medizinische Universitätsklinik Heidelberg und Sektion Nephrologie, Medizinische Universitatsklinik Heidelberg
    Dtsch Med Wochenschr 132:1039-42. 2007
  48. ncbi request reprint [Incidence and clinical characteristics of renal insufficiency in diabetic patients]
    V Schwenger
    Medizinische Universitatsklinik Heidelberg
    Dtsch Med Wochenschr 126:1322-6. 2001
    ..Very different figures for incidence and prevalence have been reported. There is a strong suspicion that the epidemiological dimension of the problem has been underestimated in many of the statistics...
  49. ncbi request reprint Thymoglobulin and ischemia reperfusion injury in kidney and liver transplantation
    A Mehrabi
    Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg
    Nephrol Dial Transplant 22:viii54-viii60. 2007
    ..No single optimal immunosuppressive regimen has given consistent results in decreasing the graft damage following IRI; however, TG usage in KTx and LTx appears to have some benefits in reducing IRI...
  50. ncbi request reprint [Integrated skills laboratory concept for undergraduate training in internal medicine]
    C Nikendei
    Abteilung für Allgemeine Klinische und Psychosomatische Medizin, Medizinische Universitatsklinik Heidelberg
    Dtsch Med Wochenschr 130:1133-8. 2005
    ..We report here on the implementation and evaluation of an obligatory, tutor-guided, and integrated skills laboratory concept in the field of internal medicine...
  51. pmc Hantavirus causing hemorrhagic fever with renal syndrome enters from the apical surface and requires decay-accelerating factor (DAF/CD55)
    Ellen Krautkrämer
    Department of Nephrology, University of Heidelberg, Im Neuenheimer Feld 162, D 69120 Heidelberg, Germany
    J Virol 82:4257-64. 2008
    ..These results demonstrate that the Old World hantaviruses Hantaan and Puumala enter polarized target cells from the apical site and that DAF is a critical cofactor for infection...
  52. doi request reprint The patient with C-ANCA/PR3-ANCA-positive crescentic pauci-immune glomerulonephritis and recurrence of nephritic sediment
    Martin Andrassy
    Department of Internal Medicine, University Hospital, Heidelberg, Germany
    Nephrol Dial Transplant 23:2084-7. 2008
  53. doi request reprint Ciclosporin A tapering monitored by NFAT-regulated gene expression: a new concept of individual immunosuppression
    Claudia Sommerer
    Department of Nephrology, University Hospital, University of Heidelberg, Heidelberg, Germany
    Transplantation 85:15-21. 2008
    ..Pharmacodynamic monitoring of the relative reduction of T-cell-specific gene expression in renal transplant recipients treated with cyclosporine A (CsA) was applied in this study...
  54. ncbi request reprint Donor preconditioning with taurine protects kidney grafts from injury after experimental transplantation
    Xiaohai Guan
    Department of General Surgery, Ruprecht Karls University, Heidelberg, Germany
    J Surg Res 146:127-34. 2008
    ..Taurine has been shown to protect liver grafts from ischemia/reperfusion injury after Tx. Thus, this study was designed to evaluate its effect on kidney grafts after transplantation...
  55. doi request reprint Effect of paricalcitol and calcitriol on aortic wall remodeling in uninephrectomized ApoE knockout mice
    Luis E Becker
    Division of Nephrology, Ruperto Carola University, Heidelberg, Germany
    Am J Physiol Renal Physiol 300:F772-82. 2011
    ..While at the dose employed paricalcitol significantly reduced TGF-β expression in plaques, calcitriol in contrast caused significant vascular calcification and elevated expression of related proteins (BMP2, RANKL, and Runx2)...
  56. pmc Benfotiamine protects against peritoneal and kidney damage in peritoneal dialysis
    Lars P Kihm
    Department of Nephrology, University of Heidelberg, Im Neuenheimer Feld 162, 69120 Heidelberg, Germany
    J Am Soc Nephrol 22:914-26. 2011
    ..Taken together, these data suggest that benfotiamine protects the peritoneal membrane and remnant kidney in a rat model of peritoneal dialysis and uremia...
  57. doi request reprint AEB071--a promising immunosuppressive agent
    Claudia Sommerer
    Department of Nephrology, University Hospital, Heidelberg, Baden Wuerttemberg, Germany
    Clin Transplant 23:15-8. 2009
    ..AEB071 inhibits early T-cell activation via a calcineurin inhibitor independent pathway and is currently investigated as a therapeutic agent to prevent allograft rejection after renal transplantation...
  58. doi request reprint Decreasing plasma soluble IL-1 receptor antagonist and increasing monocyte activation early post-transplant may be involved in pathogenesis of delayed graft function in renal transplant recipients
    Mahmoud Sadeghi
    Department of Transplantation Immunology, University of Heidelberg, D 69120 Heidelberg, Germany
    Clin Transplant 24:415-23. 2010
    ..Blocking of monocyte activity after renal transplantation may be considered a potential approach for improving graft outcome...
  59. doi request reprint Association of pretransplant soluble glycoprotein 130 (sgp130) plasma levels and posttransplant acute tubular necrosis in renal transplant recipients
    Mahmoud Sadeghi
    Department of Transplantation Immunology, University of Heidelberg, D 69120 Heidelberg, Germany
    Transplantation 88:266-71. 2009
    ..Previously, we reported that high pretransplant sIL-6R plasma levels are associated with posttransplant acute tubular necrosis (ATN). In this study, we examined associations of pretransplant plasma levels of sgp130 with ATN...
  60. doi request reprint Role of FTY720 on M1 and M2 macrophages, lymphocytes, and chemokines in 5/6 nephrectomized rats
    Matthias Schaier
    Dept of Nephrology, Univ of Heidelberg, Im Neuenheimer Feld 162, 69120 Heidelberg, Germany
    Am J Physiol Renal Physiol 297:F769-80. 2009
    ..FTY720 significantly reduced key mediators of renal inflammation and fibrosis. FTY720 also decreased immunoregulation of M2 macrophages, which are beneficial for tissue remodeling and repair...
  61. doi request reprint Urinary proinflammatory cytokine response in renal transplant recipients with polyomavirus BK viruria
    Mahmoud Sadeghi
    Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
    Transplantation 88:1109-16. 2009
    ..BKV-associated nephropathy develops in approximately 5% to 8% of renal transplant recipients, and its prognosis is poor. The relationship between urine cytokines and BK viruria in kidney recipients has not been defined...
  62. doi request reprint Effect of insulin and glucose infusion on myocardial infarction size in uraemic rats
    Ralf Dikow
    Department of Nephrology, University Hospital of Heidelberg, Heidelberg, Germany
    Basic Res Cardiol 104:571-9. 2009
    ..Further analysis did not reveal a down regulation in GLUT 4 and IRS-1/IRS-2...
  63. doi request reprint Acute phase reaction to gadolinium-DTPA in dialysis patients
    Henning Steen
    Division of Cardiology, Department of Internal Medicine, University of Heidelberg, Heidelberg, Germany
    Nephrol Dial Transplant 24:1274-7. 2009
    ..In an observational series, we found a remarkable frequency of peracute reactions after administration of Gd-DTPA used for cardiovascular evaluation before renal transplantation...
  64. doi request reprint Mutations in the BC-loop of the BKV VP1 region do not influence viral load in renal transplant patients
    Ellen Krautkrämer
    Department of Nephrology, University of Heidelberg, Heidelberg, Germany
    J Med Virol 81:75-81. 2009
    ..These in vivo results demonstrate that high replication rates which serve as a predictive marker for BKVAN are not caused by altered receptor binding or affinity via mutated BC-loops...
  65. doi request reprint Effects of donor pretreatment with dopamine on graft function after kidney transplantation: a randomized controlled trial
    Peter Schnuelle
    University Medical Centre Mannheim, 5th Department of Medicine, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    JAMA 302:1067-75. 2009
    ..Kidney graft function after transplantation can be improved through pharmacological donor pretreatment to limit organ injury from cold preservation...
  66. doi request reprint Chronic low-dose isotretinoin treatment limits renal damage in subtotally nephrectomized rats
    Christian Morath
    Department of Nephrology, University of Heidelberg, Im Neuenheimer Feld 162, 69120, Heidelberg, Germany
    J Mol Med (Berl) 87:53-64. 2009
    ..We conclude that LD isotretinoin attenuates progressive renal damage, whereas HD isotretinoin cumulates and aggravates renal damage independent of blood pressure reduction...
  67. ncbi request reprint Cyclosporin A toxicity of the renal allograft--a late complication and potentially reversible
    Claudia Sommerer
    Department Medicine Nephrology, University of Heidelberg, Bergheimerstrasse 56a, D 69115 Heidelberg, Germany
    Nephron 92:339-45. 2002
    ..Reduction of CsA improves renal function, reduces graft resistive index and systolic blood pressure...
  68. doi request reprint Dysregulated cytokine responses during cytomegalovirus infection in renal transplant recipients
    Mahmoud Sadeghi
    Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
    Transplantation 86:275-85. 2008
    ..The aim of this study was to examine whether there are differences in plasma cytokine levels pretransplant, before and during CMV replication in renal transplant recipients...
  69. ncbi request reprint Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis
    Berend Isermann
    Department of Medicine I and Clinical Chemistry, University of Heidelberg, INF 410, 69120 Heidelberg, Germany
    Nat Med 13:1349-58. 2007
    ..Conversely, maintaining high APC levels during long-term diabetes protects against diabetic nephropathy...
  70. ncbi request reprint Molecular mechanisms of the antiangiogenic and antitumor effects of mycophenolic acid
    Sophie Domhan
    Department of Radiation Oncology, German Cancer Research Center, Heidelberg, Germany
    Mol Cancer Ther 7:1656-68. 2008
    ..Together, these data provide a molecular basis for the antiangiogenic and antifibrotic effects of MPA, which warrants further clinical investigations...
  71. pmc Metabolic control improves long-term renal allograft and patient survival in type 1 diabetes
    Christian Morath
    Department of Nephrology, University of Heidelberg, Im Neuenheimer Feld 162, 69120 Heidelberg, Germany
    J Am Soc Nephrol 19:1557-63. 2008
    ..55; P = 0.005). In summary, the early survival advantage of LDK over SPK is lost during long-term follow-up, probably as a result of improved glycemic control in SPK recipients...
  72. ncbi request reprint Unusual spindle cell squamous carcinoma in a renal transplant patient
    Hjalmar Kurzen
    Department of Dermatology, University of Heidelberg, Heidelberg, Germany
    Acta Derm Venereol 84:61-4. 2004
    ....
  73. ncbi request reprint Pharmacodynamic cyclosporine A-monitoring: relation of gene expression in lymphocytes to cyclosporine blood levels in cardiac allograft recipients
    Mathias H Konstandin
    Department of Cardiology, Internal Medicine, Ruprecht Karls University, Heidelberg, Germany
    Transpl Int 20:1036-43. 2007
    ..It correlates better with the incidence of infections than measurement of CsA concentrations and might help in avoiding over-immunosuppression...
  74. doi request reprint Calcineurin inhibitor sparing regimens using m-target of rapamycin inhibitors: an opportunity to improve cardiovascular risk following kidney transplantation?
    Martin Zeier
    Department of Nephrology, University of Heidelberg, Heidelberg, Germany
    Transpl Int 24:30-42. 2011
    ..In conclusion, use of m-TORs has the potential to lessen the toll of cardiovascular disease following kidney transplantation - an opportunity that merits further exploration...
  75. ncbi request reprint A generalized seizure in a renal allograft recipient
    Sophie Domhan
    Department of Nephrology, University Hospital Heidelberg, Heidelberg, Germany
    Nephrol Dial Transplant 20:834-6. 2005
  76. ncbi request reprint No improvement of patient or graft survival in transplant recipients treated with angiotensin-converting enzyme inhibitors or angiotensin II type 1 receptor blockers: a collaborative transplant study report
    Gerhard Opelz
    Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
    J Am Soc Nephrol 17:3257-62. 2006
    ..It is concluded that recommendations for a widespread use of ACEI/ARB treatment in transplant recipients are unwarranted...
  77. ncbi request reprint ABO-incompatible transplantation--a safe way to perform renal transplantation?
    Jorg Beimler
    Nierenzentrum Heidelberg, Department of Nephrology, University of Heidelberg, Im Neuenheimer Feld 162, 69120 Heidelberg, Germany
    Nephrol Dial Transplant 22:25-7. 2007
  78. doi request reprint Proton pump inhibitors interfere with the immunosuppressive potency of mycophenolate mofetil
    Matthias Schaier
    Department of Nephrology, University of Heidelberg, Heidelberg, Germany
    Rheumatology (Oxford) 49:2061-7. 2010
    ..Since PPIs are widely used, it is useful to clarify whether the total drug amount of MMF is available in patients undergoing PPI treatment...
  79. ncbi request reprint Color doppler ultrasonography in the diagnostic evaluation of renal allografts
    Vedat Schwenger
    Department of Nephrology, Heidelberg University Hospital, Heidelberg, Germany
    Nephron Clin Pract 104:c107-12. 2006
    ..The timely diagnosis of vascular damage prior to a rise in S-creatinine offers the possibility of early therapeutic intervention and thus at least the potential for the improvement of allograft survival...
  80. doi request reprint An integrative approach for the transplantation of high-risk sensitized patients
    Christian Morath
    Department of Nephrology, University of Heidelberg, Heidelberg, Germany
    Transplantation 90:645-53. 2010
    ..Sensitized patients have a lower chance of receiving a crossmatch-negative kidney and, if transplanted, are at risk of antibody-mediated allograft rejection...
  81. ncbi request reprint Pulmonary cavernae in Wegener's granulomatosis
    Vedat Schwenger
    Division of Nephrology, University Hospital Heidelberg, Heidelberg, Germany
    Nephrol Dial Transplant 21:818. 2006
  82. ncbi request reprint Late referral--a major cause of poor outcome in the very elderly dialysis patient
    Vedat Schwenger
    Department of Internal Medicine, Ruperto Carola University, Heidelberg, Germany
    Nephrol Dial Transplant 21:962-7. 2006
    ..There is little documentation whether late referral is more frequent in the very elderly (> or =75 years) as compared with non-elderly patients and whether it contributes, at least in part, to their particularly poor outcome...
  83. ncbi request reprint Damage to the peritoneal membrane by glucose degradation products is mediated by the receptor for advanced glycation end-products
    Vedat Schwenger
    Department of Medicine Division of Nephrology, University of Heidelberg, Im Neuenheimer Feld 162, 69120 Heidelberg, Germany
    J Am Soc Nephrol 17:199-207. 2006
    ..Peritoneal damage by GDP in PDF is dependent at least in part on AGE-RAGE interaction...
  84. ncbi request reprint The ongoing need for innovation in transplant medicine and surgery
    Thomas W Kraus
    Department of Surgery, Ruprecht Karls University Heidelberg, Germany
    Transplantation 80:S95-6. 2005
  85. ncbi request reprint Impact of intraoperative parathyroid hormone levels on surgical results in patients with renal hyperparathyroidism
    Theresia Weber
    Department of Surgery, University of Heidelberg, Im Neuenheimer Feld 110, Heidelberg 69120, Germany
    World J Surg 29:1176-9. 2005
    ..0432). Intraoperative PTH measurement with a decrease in intraoperative PTH of at least 90% is highly predictive of successful parathyroidectomy and normalization of postoperative calcium and PTH levels...
  86. ncbi request reprint Indications for high-dose chemotherapy with autologous stem cell support in patients with systemic amyloid light chain amyloidosis
    Stefan O Schonland
    Department of Internal Medicine V Hematology, Oncology and Rheumatology, University of Heidelberg, Heidelberg, Germany
    Transplantation 80:S160-3. 2005
    ..Here we review recent results of ASCT, eligibility criteria for HDM and report our own treatment results in 41 patients...
  87. ncbi request reprint Living-donor kidney transplantation: risks of the donor--benefits of the recipient
    Jurgen Weitz
    Department of Surgery, University of Heidelberg, Heidelberg, Germany
    Clin Transplant 20:13-6. 2006
    ..With donor safety being constantly monitored, it seems to be justified to further pursue living-donor kidney transplantation programs...
  88. ncbi request reprint Antifibrotic actions of mycophenolic acid
    Christian Morath
    Department of Nephrology, University of Heidelberg, Heidelberg, Germany
    Clin Transplant 20:25-9. 2006
    ..MMF is well tolerated and has proven to be a relatively safe drug. Taken together, there is a growing body of evidence pointing to therapeutic applications of MMF other than immunosuppression, in particular the prevention of fibrosis...
  89. ncbi request reprint Evidence for IFN-gamma up- and IL-4 downregulation late post-transplant in patients with good kidney graft outcome
    Mahmoud Sadeghi
    Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
    Clin Transplant 21:449-59. 2007
    ..These data suggest that increased plasma IFN-gamma and decreased plasma IL-4 late post-transplant might be involved in the induction of mechanisms that facilitate good long-term graft outcome...
  90. ncbi request reprint An oral load of the early glycation compound lactuloselysine fails to accumulate in the serum of uraemic patients
    Vedat Schwenger
    Department of Nephrology, University of Heidelberg, Bergheimerstr 56a, 69115 Heidelberg, Germany
    Nephrol Dial Transplant 21:383-8. 2006
    ..It has been hypothesized that in renal failure, exogenous glycation compounds from food accumulate and play a major pathogenetic role when renal excretion is impaired...
  91. ncbi request reprint Procalcitonin as marker of infection in patients with Goodpasture's syndrome is misleading
    Christian Morath
    Department of Nephrology, University of Heidelberg, Im Neuenheimer Feld 162, 69120 Heidelberg, Germany
    Nephrol Dial Transplant 22:2701-4. 2007
    ..e. in vasculitis. To investigate the value of PCT in Goodpasture's syndrome, we reviewed the charts of patients with Goodpasture's syndrome who were treated from 1996 to 2006...
  92. ncbi request reprint Increased infarct size in uremic rats: reduced ischemia tolerance?
    Ralf Dikow
    University Hospital of Heidelberg, Bergheimerstrasse 561, 69115 Heidelberg, Germany
    J Am Soc Nephrol 15:1530-6. 2004
    ..The findings could explain the high rate of death from MI in patients with impaired renal function...
  93. ncbi request reprint Malignancy in renal transplantation
    Christian Morath
    Department of Nephrology, University of Heidelberg, Bergheimerstrasse 56a, 69115 Heidelberg, Germany
    J Am Soc Nephrol 15:1582-8. 2004
  94. doi request reprint Approaches towards individualized immune intervention
    Thomas Giese
    Department of Immunology, University of Heidelberg, Heidelberg, Germany
    Dig Dis 28:45-50. 2010
    ....
  95. ncbi request reprint Transmission of malignancy with solid organ transplants
    Christian Morath
    Department of Nephrology, University of Heidelberg, Heidelberg, Germany
    Transplantation 80:S164-6. 2005
    ..Finally, suggestions are made for screening regimens for living as well as cadaveric donors to minimize the risk of inadvertent tumor transmission...
  96. ncbi request reprint Pharmacodynamic monitoring of cyclosporine a in renal allograft recipients shows a quantitative relationship between immunosuppression and the occurrence of recurrent infections and malignancies
    Claudia Sommerer
    Department of Nephrology, University of Heidelberg, Heidelberg, Germany
    Transplantation 82:1280-5. 2006
    ..Several pharmacodynamic measures of CsA effects have been proposed, but have not become clinical routine yet. Besides the lack of practicability, the biological relevance of these assays has not been determined so far...
  97. ncbi request reprint New concepts to individualize calcineurin inhibitor therapy in renal allograft recipients
    Claudia Sommerer
    Department of Nephrology, University Hospital, INF 162, Heidelberg, Germany
    Saudi J Kidney Dis Transpl 21:1030-7. 2010
    ..Several approaches have been undertaken to measure immunosuppression by calcineurin inhibitors. In this manuscript, general and specific immune monitoring strategies of calcineurin inhibitors and their clinical benefits are discussed...
  98. ncbi request reprint Real-time contrast-enhanced sonography in renal transplant recipients
    Vedat Schwenger
    Department of Nephrology, Medical University of Heidelberg, Heidelberg, Germany
    Clin Transplant 20:51-4. 2006
    ..CES does not provide only quantitative information on microvascular perfusion of the renal allografts but also represents improved diagnostic significance compared with CDUS for the detection of chronic allograft nephropathy...
  99. ncbi request reprint Compelling drug indications in diabetic and nondiabetic nephropathy
    Eberhard Ritz
    Department of Internal Medicine, Ruperto Carola University, Bergheimerstrasse 58, D69115 Heidelberg, Germany
    Curr Hypertens Rep 6:293-9. 2004
    ....
  100. ncbi request reprint High-dose melphalan with autologous stem cell transplantation after VAD induction chemotherapy for treatment of amyloid light chain amyloidosis: a single centre prospective phase II study
    Jolanta B Perz
    Department of Haematology Oncology, Clinic of Internal Medicine, University of Heidelberg, 69120 Heidelberg, Germany
    Br J Haematol 127:543-51. 2004
    ..We could not show an additional benefit of VAD induction in terms of increasing haematological response rate; however the 13% mortality rate after HDM and ASCT in our series was lower than the previous report...
  101. ncbi request reprint Acquired Glanzmann's thrombasthenia variant and immune thrombocytopenia in a renal transplant recipient receiving tacrolimus
    Christian Morath
    Department of Nephrology, University Hospital, Universitiy of Heidelberg, Germany
    Thromb Haemost 94:879-80. 2005