Research Topics
Genomes and Genes | Emre F YekebasSummaryAffiliation: University of Hamburg Country: Germany Publications
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Publications
Impact of different modalities of continuous venovenous hemofiltration on sepsis-induced alterations in experimental pancreatitisEmre F Yekebas
Department of Surgery, University Hospital Eppendorf, Hamburg, Germany
Kidney Int 62:1806-18. 2002..The impact of different treatment intensities of CVVH on immunologic and systemic alterations in experimental pancreatitis was evaluated...
En bloc vascular resection for locally advanced pancreatic malignancies infiltrating major blood vessels: perioperative outcome and long-term survival in 136 patientsEmre F Yekebas
Department of General, Visceral and Thoracic Surgery, University Medical Centre Hamburg Eppendorf, University of Hamburg, Hamburg, Germany
Ann Surg 247:300-9. 2008..To assess in-hospital complication rates and survival duration after en bloc vascular resection (VR) for infiltration of pancreatic malignancies in major vessels...
Postpancreatectomy hemorrhage: diagnosis and treatment: an analysis in 1669 consecutive pancreatic resectionsEmre F Yekebas
Department of General, Visceral and Thoracic Surgery, University Medical Centre Hamburg Eppendorf, University of Hamburg, Hamburg, Germany
Ann Surg 246:269-80. 2007..To analyze clinical courses and outcome of postpancreatectomy hemorrhage (PPH) after major pancreatic surgery...- Strong impact of micrometastatic tumor cell load in patients with esophageal carcinomaAlexandra M Koenig
Department of General, Visceral and Thoracic Surgery, University Medical Centre of Hamburg Eppendorf, Germany
Ann Surg Oncol 16:454-62. 2009..To assess the role of immunohistochemically detectable nodal microinvolvement of patients with "curatively" resected esophageal carcinoma... - Clinical value of loss of heterozygosity in serum microsatellite DNA of patients with gastrointestinal stromal tumorsPaulus G Schurr
Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg Eppendorf, Martinistrasse 52, Hamburg
J Clin Gastroenterol 43:27-35. 2009..To study the role of loss of heterozygosity (LOH) in serum microsatellite DNA of patients with gastrointestinal stromal tumors (GIST)... - Prognostic implications of netrin-1 expression and its receptors in patients with adenocarcinoma of the pancreasBjörn Christian Link
Department of General, Visceral and Thoracic Surgery, University Medical Center of Hamburg Eppendorf, Martinistr 52, 20246, Hamburg, Germany
Ann Surg Oncol 14:2591-9. 2007..To assess the interaction between the expression of netrin-1 or of its receptors to the prognosis of ductal adenocarcinoma of the pancreas... - Subset of esophageal adenocarcinoma expresses adhesion molecule l1 in contrast to squamous cell carcinomaTamina Rawnaq
Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
Anticancer Res 29:1195-9. 2009..The aim of the current study was to determine L1 expression in esophageal cancer and to evaluate whether L1 could serve as a potential marker and therapeutic target for this tumor type... - L1 is associated with micrometastatic spread and poor outcome in colorectal cancerJussuf T Kaifi
Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Mod Pathol 20:1183-90. 2007..It may have a role in early metastatic spread, as L1 is associated with micrometastases to both the lymph nodes and bone marrow. Thus, L1 should be explored further as a target for adjuvant therapy for micrometastatic disease... - Nodal microinvolvement in patients with carcinoma of the papilla of vater receiving no adjuvant chemotherapyDean Bogoevski
University Clinic Eppendorf, Hamburg, Germany
J Gastrointest Surg 12:1830-7; discussion 1837-8. 2008..To assess the prognostic significance of nodal microinvolvement in patients with carcinoma of the papilla of Vater... - Short tandem repeat polymorphism in exon 4 of esophageal cancer-related gene 2 detected in genomic DNA is a prognostic marker for esophageal cancerJussuf T Kaifi
Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
Am J Surg 194:380-4. 2007..Short tandem repeat (STR) polymorphisms in exon 4 of the esophageal cancer-related gene 2 (ECRG2) are a risk marker for esophageal carcinoma. The aim of the present study was to correlate these STRs with clinical outcome... - Lymphatic spread and microinvolvement in adenocarcinoma of the esophago-gastric junctionPaulus G Schurr
Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
J Surg Oncol 94:307-15. 2006..CONCLUSIONS: Lymphatic microinvolvement shows a high incidence in curatively resected EGJ cancer. Spread to mediastinal lymph nodes seems to necessitate lymphadenectomy of the thoracic cavity in either type... - Insulin-like growth factor-1 receptor as a novel prognostic marker and its implication as a cotarget in the treatment of human adenocarcinoma of the esophagusTatyana Kalinina
Department of General, Visceral and Thoracic Surgery, University Medical Center, Hamburg Eppendorf, Hamburg, Germany
Int J Cancer 127:1931-40. 2010..IGF-1R expression can be used as a novel prognostic marker for adenocarcinomas of the esophagus. Cotreatment with IGF-1R and HER2 antibodies might become a valuable and effective treatment option in esophageal adenocarcinoma... - Heme oxygenase-1 germ line GTn promoter polymorphism is an independent prognosticator of tumor recurrence and survival in pancreatic cancerYogesh K Vashist
Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg Eppendorf, Hamburg, Germany
J Surg Oncol 104:305-11. 2011..We evaluated the prognostic value of the basal transcription controlling germ line GTn repeat polymorphism (GTn) in the promoter region of the HO-1 gene in PC... - Is it time for a new TNM classification in esophageal carcinoma?Dean Bogoevski
Department of General, Visceral and Thoracic Surgery, University of Hamburg, Hamburg, Germany
Ann Surg 247:633-41. 2008..To investigate the importance of lymph node yield (LNY) and the ratio of afflicted lymph nodes in esophageal carcinoma patients... - Establishment and characterization of a new human pancreatic adenocarcinoma cell line with high metastatic potential to the lungTatyana Kalinina
Department of General, Visceral and Thoracic Surgery, University Hospital Hamburg, Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
BMC Cancer 10:295. 2010..Therefore new models are urgently needed to investigate this deadly disease. As a part of this process we have established and characterized a new human pancreatic cancer cell line... - Extended central pancreatic resection as an alternative for extended left or extended right resection for appropriate pancreatic neoplasmsGuellue Cataldegirmen
Department of General, Viszeral and Thoracic Surgery, University Medical Center Hamburg Eppendorf, University of Hamburg, Hamburg, Germany
Surgery 147:331-8. 2010.... - Effectiveness of radical en-bloc-esophagectomy compared to transhiatal esophagectomy in squamous cell cancer of the esophagus is influenced by nodal micrometastasesEmre F Yekebas
Department of General, Visceral and Thoracic Surgery at the University Medical Center Hamburg-Eppendorf, University of Hamburg, Hamburg, Germany
J Surg Oncol 93:541-9. 2006..333). CONCLUSION: TTE results in improved outcome in the absence of lymph node micrometastases. Poor survival in patients with lymphatic micro-dissemination indicates systemic disease and the need for adjuvant treatment... - Heme oxygenase-1 promoter polymorphism is a predictor of disease relapse in pancreatic neuroendocrine tumorsYogesh K Vashist
Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg Eppendorf, Hamburg, Germany
J Surg Res 166:e121-7. 2011..The aim of the present study was to evaluate the potential prognostic role of the promoter GTn repeat polymorphism (GTn) of the heme oxygenase-1 gene in PNET... - Short tandem repeat polymorphisms of exon 4 in Kazal-type gene ECRG2 in pancreatic carcinoma and chronic pancreatitisJussuf T Kaifi
Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg Eppendorf Martinistrasse 52, 20246 Hamburg, Germany
Anticancer Res 27:69-73. 2007..Kazal-type genes are associated with cancer and pancreatic disease. The aim of the present study was to examine whether ECRG2 STR polymorphisms are associated with pancreatic carcinoma and chronic pancreatitis... - Aggressive surgery improves long-term survival in neuroendocrine pancreatic tumors: an institutional experiencePaulus G Schurr
Department of General, Visceral and Thoracic Surgery, University Medical Center of Hamburg Eppendorf, University of Hamburg, Hamburg, Germany
Ann Surg 245:273-81. 2007..To evaluate surgical strategies for neuroendocrine pancreatic tumors (NEPT) in the light of the new WHO classification from 2004 and to draw conclusions for future surgical concepts... - Midkine as a prognostic marker for gastrointestinal stromal tumorsJussuf T Kaifi
Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
J Cancer Res Clin Oncol 133:431-5. 2007..The outcome of patients with gastrointestinal stromal tumors (GISTs) is correlated with tumor size and mitotic count. The aim of this study was to determine MK expression in GISTs... - The GNAS1 T393C single nucleotide polymorphism predicts the natural postoperative course of complete resected esophageal cancerYogesh Kumar Vashist
Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg Eppendorf, Germany
Cell Oncol (Dordr) 34:281-8. 2011..The aim of this study was to evaluate the potential prognostic value of T393C-SNP in complete resected only surgically treated esophageal cancer (EC)... - Disseminated tumor cells in bone marrow and the natural course of resected esophageal cancerYogesh K Vashist
Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg Eppendorf, Martinistrasse, Hamburg, Germany
Ann Surg 255:1105-12. 2012..To assess the impact of disseminated tumor cells (DTC) in bone marrow on recurrence and survival in complete resected esophageal cancer (EC)... - Epoetin alfa improves survival after chemoradiation for stage III esophageal cancer: final results of a prospective observational studyDirk Rades
Department of Radiation Oncology, University Hospital, Hamburg, Germany
Int J Radiat Oncol Biol Phys 65:459-65. 2006..18% at 2 years, p = 0.09). CONCLUSIONS: The findings suggest that epoetin alfa when used to maintain the hemoglobin levels at 12 to 14 g/dL can improve OS and LC of Stage III esophageal cancer patients... - Absence of L1 in pancreatic masses distinguishes adenocarcinomas from poorly differentiated neuroendocrine carcinomasJussuf T Kaifi
Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg Eppendorf, 20246 Hamburg, Germany
Anticancer Res 26:1167-70. 2006..The aim of this study was to determine the expression of L1 in pancreatic adenocarcinomas to evaluate whether L1 might differentiate between pancreatic carcinomas of neuroendocrine and ductal origin... - Frequent homogeneous HER-2 amplification in primary and metastatic adenocarcinoma of the esophagusUta Reichelt
Department of Pathology, University Medical Center Hamburg Eppendorf, University of Hamburg, Hamburg, Germany
Mod Pathol 20:120-9. 2007..The strong concordance of the HER-2 status in primary and metastatic cancers argues for a possible response of metastases from patients with HER-2-positive primary tumors to Herceptin... - Thy-1 as a potential novel diagnostic marker for gastrointestinal stromal tumorsDespoina Oikonomou
Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
J Cancer Res Clin Oncol 133:951-5. 2007..Thy-1, a cell-surface glycoprotein, is a marker for several types of stem cells and particularly for neuronal precursor cells. The aim of this study was to determine Thy-1 expression in GISTs... - Glasgow Prognostic Score is a predictor of perioperative and long-term outcome in patients with only surgically treated esophageal cancerYogesh K Vashist
Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Ann Surg Oncol 18:1130-8. 2011..The purpose of the study was to evaluate the potential prognostic role of GPS in a homogeneous population of esophageal cancer (EC) patients undergoing only resection... - Long-term follow-up in small duct chronic pancreatitis: A plea for extended drainage by "V-shaped excision" of the anterior aspect of the pancreasEmre F Yekebas
Department of General, Visceral and Thoracic Surgery, University Medical Centre Hamburg-Eppendorf, University of Hamburg, Hamburg, Germany
Ann Surg 244:940-6; discussion 946-8. 2006..The deterioration of exocrine and endocrine pancreatic functions is comparable with that observed during the natural course of the disease... - For which type of chronic pancreatitis is the "Hamburg procedure" indicated?Asad Kutup
Department of General, Visceral and Thoracic Surgery, University Medical Centre Hamburg Eppendorf, University of Hamburg, Martinistrasse 52, 20246, Hamburg, Germany
J Hepatobiliary Pancreat Sci 17:758-62. 2010..In contrast, in patients with so-called "small duct pancreatitis" (SDP) with a PDD < 3 mm, extended resectional procedures are suggested including, as an "ultima ratio", even total pancreatectomy... - Chronic pancreatitis complicated by cavernous transformation of the portal vein: contraindication to surgery?Maximilian Bockhorn
Department of General, Visceral, and Thoracic Surgery, University Medical Center Hamburg Eppendorf, Germany
Surgery 149:321-8. 2011..The purpose of this study was to address the question of whether a noninterventional approach regarding surgery is justified... - Crossing the Rubicon: when pancreatic resection with curative intent ends in an R2 status. Impact of "desmoplastic pseudo-pancreatitis" and anatomical site of irresectabilityMaximilian Bockhorn
Department of General, Visceral and Thoracic Surgery, University Medical Centre Hamburg Eppendorf, University of Hamburg, Hamburg, Germany
Ann Surg Oncol 16:1212-21. 2009..To analyze the impact of pancreatitis-mimicking, concomitant alterations on intraoperative assessment of curative resectability, the anatomical site of irresectability, and outcome after nonintentional R2 resection in pancreatic cancer... - Perivascular epitheloid cell tumour (PEComa) of the retroperitoneum - a rare tumor with uncertain malignant behaviour: a case reportAlexandra M Koenig
Department of General, Visceral and Thoracic Surgery, University Medical Centre of Hamburg Eppendorf, Martinistrasse 52, Hamburg, Germany
J Med Case Reports 3:62. 2009..Perivascular epitheloid cell tumours are rare mesenchymal neoplasms characterized by a proliferation of perivascular cells with an epitheloid phenotype and expression of myomelanocytic markers... - L1 is a potential marker for poorly-differentiated pancreatic neuroendocrine carcinomaJussuf T Kaifi
Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
World J Gastroenterol 12:94-8. 2006..To determine the expression of L1 in pancreatic neuroendocrine tumor and to correlate it with WHO classification of this tumor... - Management of the difficult duodenal stump in penetrating duodenal ulcer disease: a comparative analysis of duodenojejunostomy with "classical" stump closure (Nissen-Bsteh)Yogesh K Vashist
Department of Surgery, University Hospital Hamburg Eppendorf, Martinistrasse52, 20246, Hamburg, Germany
Langenbecks Arch Surg 397:1243-9. 2012.... - Haeme oxygenase-1 promoter polymorphism is an independent prognostic marker of gastrointestinal stromal tumourYogesh K Vashist
Department of General, Visceral and Thoracic Surgery, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
Histopathology 54:303-8. 2009..The aim was to investigate the role of HMOX-1 promoter polymorphism in GIST patients... - Allelic loss of Hox11L1 gene locus predicts outcome of gastrointestinal stromal tumorsJussuf T Kaifi
Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg Eppendorf, D 20246 Hamburg, Germany
Oncol Rep 16:915-9. 2006..05 by log-rank test; median follow-up time 37 months). LOH of Hox11L1 gene locus is a useful parameter for prognosis of GIST. The data propose that Hox11L1 has a role in tumorigenesis in GISTs... - Genomic profiles associated with early micrometastasis in lung cancer: relevance of 4q deletionMichaela Wrage
Institute of Tumor Biology and Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Clin Cancer Res 15:1566-74. 2009..It is still unclear whether the shedding of DTC from the primary tumor is a random process or a selective release driven by a specific genomic pattern... - Association of rare SPINK1 gene mutation with another base substitution in chronic pancreatitis patientsViacheslav N Kalinin
Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg Eppendorf, Martinistrasse 52, Hamburg 20246, Germany
World J Gastroenterol 12:5352-6. 2006..To verify and expand the known spectrum of serine protease inhibitor Kazal type 1 (SPINK1) gene mutations in chronic pancreatitis... - Mode of spread in the early phase of lymphatic metastasis in pancreatic ductal adenocarcinoma: prognostic significance of nodal microinvolvementDean Bogoevski
Department of General, Visceral and Thoracic Surgery, University Medical Centre of Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
Ann Surg 240:993-1000; discussion 1000-1. 2004..This could be a helpful tool in proper selection of patients for adjuvant chemotherapy... - Surgery for advanced and metastatic pancreatic cancer--current state and perspectivesOliver Mann
Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Germany
Anticancer Res 26:681-6. 2006..This question should be answered in a multicenter randomized trial, otherwise the palliative Whipple's operation should still be considered experimental, since it is not likely to significantly prolong survival... - Extrahepatic portal hypertension in chronic pancreatitis: an old problem revisitedJakob R Izbicki
Department of General Surgery, University Hospital Eppendorf, University of Hamburg, Germany
Ann Surg 236:82-9. 2002..To evaluate the impact of concomitant nonhepatic portal hypertension in chronic pancreatitis on immediate and long-term outcome after major pancreatic surgery... - Percutaneous transhepatic cholangiodrainage as rescue therapy for symptomatic biliary leakage without biliary tract dilation after major surgeryBjörn Christian Link
Department of General, Visceral and Thoracic Surgery, University Medical Center of Hamburg Eppendorf, Martinistr 52, 20246 Hamburg, Germany
J Gastrointest Surg 11:166-70. 2007..Depending on the experience with the interventional procedure, percutaneous transhepatic cholangiodrainage should be considered as an alternative for treatment of symptomatic biliary leakage instead of immediate reoperation... - Quo vadis STARR? A prospective long-term follow-up of stapled transanal rectal resection for obstructed defecation syndromeOliver Zehler
Department of General, Visceral and Thoracic Surgery, University Medical Centre Hamburg Eppendorf, University of Hamburg, Martinistrasse 52, 20246, Hamburg, Germany
J Gastrointest Surg 14:1349-54. 2010..Several studies have reported short-term outcome after STARR, but long-term results are still missing. The objective of this study was to evaluate long-term clinical outcome after STARR with a follow-up of 5 years... - L1 (CD171) is highly expressed in gastrointestinal stromal tumorsJussuf T Kaifi
Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Mod Pathol 19:399-406. 2006..The trend towards a reduced survival of L1-positive patients in this study has to be further evaluated in future trials with higher patient numbers... - Epoetin-alpha during radiotherapy for stage III esophageal carcinomaDirk Rades
Department of Radiation Oncology, University Hospital Hamburg Eppendorf, Hamburg, Germany
Cancer 103:2274-9. 2005.... - Chronic pancreatitis: modern surgical managementKai Bachmann
Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg Eppendorf, Martinistrase 52, 20246 Hamburg, Germany
Langenbecks Arch Surg 396:139-49. 2011..It has the benefit of combining the highest safety with the highest efficiency. Additionally, the extent of the operation can be adapted to the morphology of the individual patient...