Malgorzata Wygrecka

Summary

Affiliation: University of Giessen
Country: Germany

Publications

  1. doi request reprint Protease-activated receptors (PAR)-1 and -3 drive epithelial-mesenchymal transition of alveolar epithelial cells - potential role in lung fibrosis
    Malgorzata Wygrecka
    Department of Biochemistry, University of Giessen Lung Center, Friedrichstrasse 24, Giessen, Germany
    Thromb Haemost 110:295-307. 2013
  2. doi request reprint Mast cells and fibroblasts work in concert to aggravate pulmonary fibrosis: role of transmembrane SCF and the PAR-2/PKC-α/Raf-1/p44/42 signaling pathway
    Malgorzata Wygrecka
    Department of Biochemistry, Justus Liebig University Giessen, Universities Giessen, Giessen, Germany
    Am J Pathol 182:2094-108. 2013
  3. doi request reprint TGF-β1 induces tissue factor expression in human lung fibroblasts in a PI3K/JNK/Akt-dependent and AP-1-dependent manner
    Malgorzata Wygrecka
    Department of Biochemistry, Faculty of Medicine, University of Giessen Lung Center, Friedrichstrasse 24, 35392 Giessen, Germany
    Am J Respir Cell Mol Biol 47:614-27. 2012
  4. doi request reprint PAR-2 inhibition reverses experimental pulmonary hypertension
    Grazyna Kwapiszewska
    Department of Internal Medicine, University of Giessen Lung Centre, Germany
    Circ Res 110:1179-91. 2012
  5. doi request reprint Role of protease-activated receptor-2 in idiopathic pulmonary fibrosis
    Malgorzata Wygrecka
    Department of Biochemistry, Faculty of Medicine, University of Giessen Lung Center, Friedrichstrasse 24, 35392 Giessen, Germany
    Am J Respir Crit Care Med 183:1703-14. 2011
  6. doi request reprint Current view on alveolar coagulation and fibrinolysis in acute inflammatory and chronic interstitial lung diseases
    Malgorzata Wygrecka
    Department of Biochemistry, Faculty of Medicine, University of Giessen Lung Center, Friedrichstrasse 24, 35392 Giessen, Germany
    Thromb Haemost 99:494-501. 2008
  7. ncbi request reprint Plasminogen activator inhibitor-1 is an inhibitor of factor VII-activating protease in patients with acute respiratory distress syndrome
    Malgorzata Wygrecka
    Department of Biochemistry, Faculty of Medicine, Justus Liebig University Giessen, Giessen, Germany
    J Biol Chem 282:21671-82. 2007
  8. pmc Raised protein levels and altered cellular expression of factor VII activating protease (FSAP) in the lungs of patients with acute respiratory distress syndrome (ARDS)
    Malgorzata Wygrecka
    Department of Biochemistry, Faculty of Medicine, University of Giessen Lung Center, Friedrichstrasse 24, 35392 Giessen, Germany
    Thorax 62:880-8. 2007
  9. doi request reprint Enolase-1 promotes plasminogen-mediated recruitment of monocytes to the acutely inflamed lung
    Malgorzata Wygrecka
    Department of Biochemistry, Faculty of Medicine, University of Giessen Lung Center, Giessen, Germany
    Blood 113:5588-98. 2009
  10. pmc Transforming growth factor-β1 induces expression of human coagulation factor XII via Smad3 and JNK signaling pathways in human lung fibroblasts
    Ewa Jablonska
    Department of Biochemistry, Faculty of Medicine, Justus Liebig University, 35392 Giessen, Germany
    J Biol Chem 285:11638-51. 2010

Collaborators

Detail Information

Publications29

  1. doi request reprint Protease-activated receptors (PAR)-1 and -3 drive epithelial-mesenchymal transition of alveolar epithelial cells - potential role in lung fibrosis
    Malgorzata Wygrecka
    Department of Biochemistry, University of Giessen Lung Center, Friedrichstrasse 24, Giessen, Germany
    Thromb Haemost 110:295-307. 2013
    ....
  2. doi request reprint Mast cells and fibroblasts work in concert to aggravate pulmonary fibrosis: role of transmembrane SCF and the PAR-2/PKC-α/Raf-1/p44/42 signaling pathway
    Malgorzata Wygrecka
    Department of Biochemistry, Justus Liebig University Giessen, Universities Giessen, Giessen, Germany
    Am J Pathol 182:2094-108. 2013
    ..Thus, fibroblasts and MCs appear to work in concert to perpetuate fibrotic processes and so contribute to lung fibrosis progression...
  3. doi request reprint TGF-β1 induces tissue factor expression in human lung fibroblasts in a PI3K/JNK/Akt-dependent and AP-1-dependent manner
    Malgorzata Wygrecka
    Department of Biochemistry, Faculty of Medicine, University of Giessen Lung Center, Friedrichstrasse 24, 35392 Giessen, Germany
    Am J Respir Cell Mol Biol 47:614-27. 2012
    ....
  4. doi request reprint PAR-2 inhibition reverses experimental pulmonary hypertension
    Grazyna Kwapiszewska
    Department of Internal Medicine, University of Giessen Lung Centre, Germany
    Circ Res 110:1179-91. 2012
    ..Accumulating evidence suggests that mast cell mediators play a role in the pathogenesis of PH...
  5. doi request reprint Role of protease-activated receptor-2 in idiopathic pulmonary fibrosis
    Malgorzata Wygrecka
    Department of Biochemistry, Faculty of Medicine, University of Giessen Lung Center, Friedrichstrasse 24, 35392 Giessen, Germany
    Am J Respir Crit Care Med 183:1703-14. 2011
    ..Activation of the coagulation cascade has been demonstrated in pulmonary fibrosis. In addition to its procoagulant function, various coagulation proteases exhibit cellular effects that may also contribute to fibrotic processes in the lung...
  6. doi request reprint Current view on alveolar coagulation and fibrinolysis in acute inflammatory and chronic interstitial lung diseases
    Malgorzata Wygrecka
    Department of Biochemistry, Faculty of Medicine, University of Giessen Lung Center, Friedrichstrasse 24, 35392 Giessen, Germany
    Thromb Haemost 99:494-501. 2008
    ..In the current article, the role of the alveolar coagulation and fibrinolysis systems in acute inflammatory and chronic interstitial lung diseases is discussed with regard to pathomechanisms and modalities of intervention...
  7. ncbi request reprint Plasminogen activator inhibitor-1 is an inhibitor of factor VII-activating protease in patients with acute respiratory distress syndrome
    Malgorzata Wygrecka
    Department of Biochemistry, Faculty of Medicine, Justus Liebig University Giessen, Giessen, Germany
    J Biol Chem 282:21671-82. 2007
    ....
  8. pmc Raised protein levels and altered cellular expression of factor VII activating protease (FSAP) in the lungs of patients with acute respiratory distress syndrome (ARDS)
    Malgorzata Wygrecka
    Department of Biochemistry, Faculty of Medicine, University of Giessen Lung Center, Friedrichstrasse 24, 35392 Giessen, Germany
    Thorax 62:880-8. 2007
    ..Factor VII activating protease (FSAP) is a recently described serine protease in plasma and tissues known to be involved in haemostasis, cell proliferation and migration...
  9. doi request reprint Enolase-1 promotes plasminogen-mediated recruitment of monocytes to the acutely inflamed lung
    Malgorzata Wygrecka
    Department of Biochemistry, Faculty of Medicine, University of Giessen Lung Center, Giessen, Germany
    Blood 113:5588-98. 2009
    ..These data suggest an important mechanism of inflammatory cell invasion mediated by increased cell-surface expression of ENO-1...
  10. pmc Transforming growth factor-β1 induces expression of human coagulation factor XII via Smad3 and JNK signaling pathways in human lung fibroblasts
    Ewa Jablonska
    Department of Biochemistry, Faculty of Medicine, Justus Liebig University, 35392 Giessen, Germany
    J Biol Chem 285:11638-51. 2010
    ..Our results show that JNK/Smad3 pathway plays a critical role in TGF-beta1-induced FXII expression in human lung fibroblasts and implicate its possible involvement in pathological conditions characterized by elevated TGF-beta1 levels...
  11. pmc Time-dependent changes in pulmonary surfactant function and composition in acute respiratory distress syndrome due to pneumonia or aspiration
    Reinhold Schmidt
    University of Giessen Lung Center, Medical Clinic II, Giessen, Germany
    Respir Res 8:55. 2007
    ..We therefore examined the time-course of surfactant changes in 15 patients with direct ARDS (pneumonia, aspiration) over the first 8 days after onset of mechanical ventilation...
  12. doi request reprint Comparative proteomic analysis of lung tissue from patients with idiopathic pulmonary fibrosis (IPF) and lung transplant donor lungs
    Martina Korfei
    University of Giessen Lung Center, Department of Internal Medicine II, Klinikstrasse 36, Justus Liebig University Giessen, Germany
    J Proteome Res 10:2185-205. 2011
    ..In summary, our results indicate that IPF is characterized by epithelial cell injury, apoptosis, and aberrant epithelial proliferation...
  13. doi request reprint Shedding of low-density lipoprotein receptor–related protein-1 in acute respiratory distress syndrome
    Malgorzata Wygrecka
    Department of Biochemistry, University of Giessen Lung Center, Giessen, Germany
    Am J Respir Crit Care Med 184:438-48. 2011
    ..The ectodomain of LRP-1 can be shed from the cell surface, releasing a soluble form of this receptor (sLRP-1), which antagonizes ligand endocytosis by cellular LRP-1...
  14. doi request reprint BDNF/TrkB signaling augments smooth muscle cell proliferation in pulmonary hypertension
    Grazyna Kwapiszewska
    Department of Internal Medicine II, Universities of Giessen and Marburg Lung Center UGMLC, Justus Liebig University, Giessen, Germany
    Am J Pathol 181:2018-29. 2012
    ..Consequently, we have identified the BDNF-TrkB-ERK1/2 pathway as a proproliferative signaling pathway for PASMC in PH. Interference with this pathway may thus serve as an attractive reverse remodeling approach...
  15. doi request reprint Fhl-1, a new key protein in pulmonary hypertension
    Grazyna Kwapiszewska
    Med Klinik II, University of Giessen Lung Center, Klinik Strasse 36, 35392 Giessen, Germany
    Circulation 118:1183-94. 2008
    ..We hypothesized that underlying key factors can be identified at the onset of the disease. Thus, we screened for alterations to protein expression in lung tissue at the onset of PH in a mouse model of hypoxia-induced PH...
  16. doi request reprint Safety and tolerability of inhaled heparin in idiopathic pulmonary fibrosis
    Philipp Markart
    Department of Internal Medicine, Faculty of Medicine, Justus Liebig University, Giessen, Germany
    J Aerosol Med Pulm Drug Deliv 23:161-72. 2010
    ..In this study, we first examined the pharmacokinetics of inhaled heparin in healthy subjects. Second, we investigated the safety and tolerability of heparin inhalation in IPF patients...
  17. ncbi request reprint Recombinant production of a hybrid plasminogen activator composed of surfactant protein B and low-molecular-weight urokinase
    Clemens Ruppert
    Department of Internal Medicine, University of Giessen Lung Center, Giessen, Germany
    Thromb Haemost 100:1185-92. 2008
    ..We conclude that recombinant production of a fusion protein consisting of mature SP-B and uPA is feasible, when the SP-B moiety is fused to the C-terminus of urokinase...
  18. ncbi request reprint Hyperoxia modulates TGF-beta/BMP signaling in a mouse model of bronchopulmonary dysplasia
    Miguel A Alejandre-Alcázar
    Department of Internal Medicine, University of Giessen Lung Center, Justus Liebig University, Giessen, Germany
    Am J Physiol Lung Cell Mol Physiol 292:L537-49. 2007
    ..The amenability of these pathways to genetic and pharmacological manipulation may provide alternative avenues for the management of BPD...
  19. doi request reprint Alveolar oxidative stress is associated with elevated levels of nonenzymatic low-molecular-weight antioxidants in patients with different forms of chronic fibrosing interstitial lung diseases
    Philipp Markart
    Department of Internal Medicine, Faculty of Medicine, University of Giessen Lung Center, Giessen, Germany
    Antioxid Redox Signal 11:227-40. 2009
    ..This increase may be part of an adaptive response to oxidative stress. However, a leakage from the blood may also contribute to our findings...
  20. ncbi request reprint Mast cell chymase: an indispensable instrument in the pathological symphony of idiopathic pulmonary fibrosis?
    Djuro Kosanovic
    Universities of Giessen and Marburg Lung Center UGMLC, German Center for Lung Research, Giessen, Germany
    Histol Histopathol 28:691-9. 2013
    ..Moreover, the findings from animal model studies will be discussed to highlight the chymase inhibitors as a promising strategy for the treatment of pulmonary fibrosis...
  21. doi request reprint TGF-β directs trafficking of the epithelial sodium channel ENaC which has implications for ion and fluid transport in acute lung injury
    Dorothea M Peters
    Department of Internal Medicine, Department of Biochemistry, Justus Liebig University, Universities of Giessen and Marburg Lung Center, German Center for Lung Research, 35392 Giessen, Germany
    Proc Natl Acad Sci U S A 111:E374-83. 2014
    ....
  22. ncbi request reprint Compartment- and cell-specific expression of coagulation and fibrinolysis factors in the murine lung undergoing inhalational versus intravenous endotoxin application
    Malgorzata Wygrecka
    Department of Internal Medicine, Faculty of Medicine, Justus Liebig University Giessen, Klinikstr 36, 35392 Giessen, Germany
    Thromb Haemost 92:529-40. 2004
    ....
  23. doi request reprint Reduced expression of arrestin beta 2 by graft monocytes during acute rejection of rat kidneys
    Anna Zakrzewicz
    Laboratory of Experimental Surgery, Department of General and Thoracic Surgery, Justus Liebig University Giessen, Rudolf Buchheim Strasse 7, Giessen, Germany
    Immunobiology 216:854-61. 2011
    ..Our results suggest that activation of blood monocytes in renal isografts is dampened by high ARRB2 levels. During acute rejection, ARRB2 levels are reduced and classical monocyte activation is enabled via NF-κB activation...
  24. pmc Patients with ARDS show improvement but not normalisation of alveolar surface activity with surfactant treatment: putative role of neutral lipids
    Philipp Markart
    Department of Internal Medicine, Faculty of Medicine, University of Giessen Lung Center, Klinikstrasse 36, 35392 Giessen, Germany
    Thorax 62:588-94. 2007
    ..Extensive biochemical and biophysical changes of the pulmonary surfactant system occur in the acute respiratory distress syndrome (ARDS)...
  25. doi request reprint Loss of RAGE in pulmonary fibrosis: molecular relations to functional changes in pulmonary cell types
    Markus A Queisser
    Department of Biochemistry, University of Giessen Lung Center, Justus Liebig University, Giessen, Germany
    Am J Respir Cell Mol Biol 39:337-45. 2008
    ..These results indicate that RAGE serves a protective role in the lung, and that loss of the receptor is related to functional changes of pulmonary cell types, with the consequences of fibrotic disease...
  26. pmc Protein Arginine Methyltransferases (PRMTs): Promising Targets for the Treatment of Pulmonary Disorders
    Dariusz Zakrzewicz
    Department of Biochemistry, Faculty of Medicine, University of Giessen Lung Center, Friedrichstrasse 24, 35392 Giessen, Germany
    Int J Mol Sci 13:12383-400. 2012
    ..This article will also highlight novel directions for possible future investigations to evaluate the functional contribution of arginine methylation in lung homeostasis and disease...
  27. ncbi request reprint Host-derived extracellular nucleic acids enhance innate immune responses, induce coagulation, and prolong survival upon infection in insects
    Boran Altincicek
    Institute of Phytopathology and Applied Zoology, Justus Liebig University of Giessen, Heinrich Buff Ring 26 32, Giessen, Germany
    J Immunol 181:2705-12. 2008
    ....
  28. pmc Inhibition of PDGF-BB by Factor VII-activating protease (FSAP) is neutralized by protease nexin-1, and the FSAP-inhibitor complexes are internalized via LRP
    Lars Muhl
    Institute for Biochemistry, Justus Liebig University, 35392 Giessen, Germany
    Biochem J 404:191-6. 2007
    ..Hence, PN-1 inhibits the enzymatic activity of FSAP and neutralizes its effect on PDGF-BB-mediated VSMC proliferation. The FSAP-inhibitor complexes are internalized via LRP without influencing the PDGF-BB signal transduction pathway...
  29. doi request reprint Testosterone replacement effectively inhibits the development of experimental autoimmune orchitis in rats: evidence for a direct role of testosterone on regulatory T cell expansion
    Monika Fijak
    Department of Anatomy and Cell Biology, Justus Liebig University Giessen, 35385 Giessen, Germany
    J Immunol 186:5162-72. 2011
    ..Thus, our study shows an immunomodulatory and protective effect of testosterone substitution in the pathogenesis of EAO and suggests androgens as a new factor in the differentiation of regulatory T cells...