Research Topics
Genomes and Genes | Malgorzata WygreckaSummaryAffiliation: University of Giessen Country: Germany Publications
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Publications
TGF-β1 induces tissue factor expression in human lung fibroblasts in a PI3K/JNK/Akt-dependent and AP-1-dependent mannerMalgorzata Wygrecka
Department of Biochemistry, Faculty of Medicine, University of Giessen Lung Center, Friedrichstrasse 24, 35392 Giessen, Germany
Am J Respir Cell Mol Biol 47:614-27. 2012....- PAR-2 inhibition reverses experimental pulmonary hypertensionGrazyna Kwapiszewska
Department of Internal Medicine, University of Giessen Lung Centre, Germany
Circ Res 110:1179-91. 2012..Accumulating evidence suggests that mast cell mediators play a role in the pathogenesis of PH... - Role of protease-activated receptor-2 in idiopathic pulmonary fibrosisMalgorzata Wygrecka
Department of Biochemistry, Faculty of Medicine, University of Giessen Lung Center, Friedrichstrasse 24, 35392 Giessen, Germany
Am J Respir Crit Care Med 183:1703-14. 2011..Activation of the coagulation cascade has been demonstrated in pulmonary fibrosis. In addition to its procoagulant function, various coagulation proteases exhibit cellular effects that may also contribute to fibrotic processes in the lung... - Current view on alveolar coagulation and fibrinolysis in acute inflammatory and chronic interstitial lung diseasesMalgorzata Wygrecka
Department of Biochemistry, Faculty of Medicine, University of Giessen Lung Center, Friedrichstrasse 24, 35392 Giessen, Germany
Thromb Haemost 99:494-501. 2008..In the current article, the role of the alveolar coagulation and fibrinolysis systems in acute inflammatory and chronic interstitial lung diseases is discussed with regard to pathomechanisms and modalities of intervention... 
Plasminogen activator inhibitor-1 is an inhibitor of factor VII-activating protease in patients with acute respiratory distress syndromeMalgorzata Wygrecka
Department of Biochemistry, Faculty of Medicine, Justus Liebig University Giessen, Giessen, Germany
J Biol Chem 282:21671-82. 2007....
Raised protein levels and altered cellular expression of factor VII activating protease (FSAP) in the lungs of patients with acute respiratory distress syndrome (ARDS)Malgorzata Wygrecka
Department of Biochemistry, Faculty of Medicine, University of Giessen Lung Center, Friedrichstrasse 24, 35392 Giessen, Germany
Thorax 62:880-8. 2007..Factor VII activating protease (FSAP) is a recently described serine protease in plasma and tissues known to be involved in haemostasis, cell proliferation and migration...- Enolase-1 promotes plasminogen-mediated recruitment of monocytes to the acutely inflamed lungMalgorzata Wygrecka
Department of Biochemistry, Faculty of Medicine, University of Giessen Lung Center, Giessen, Germany
Blood 113:5588-98. 2009..These data suggest an important mechanism of inflammatory cell invasion mediated by increased cell-surface expression of ENO-1... - Time-dependent changes in pulmonary surfactant function and composition in acute respiratory distress syndrome due to pneumonia or aspirationReinhold Schmidt
University of Giessen Lung Center, Medical Clinic II, Giessen, Germany
Respir Res 8:55. 2007..We therefore examined the time-course of surfactant changes in 15 patients with direct ARDS (pneumonia, aspiration) over the first 8 days after onset of mechanical ventilation... - Comparative proteomic analysis of lung tissue from patients with idiopathic pulmonary fibrosis (IPF) and lung transplant donor lungsMartina Korfei
University of Giessen Lung Center, Department of Internal Medicine II, Klinikstrasse 36, Justus Liebig University Giessen, Germany
J Proteome Res 10:2185-205. 2011..In summary, our results indicate that IPF is characterized by epithelial cell injury, apoptosis, and aberrant epithelial proliferation... - Transforming growth factor-β1 induces expression of human coagulation factor XII via Smad3 and JNK signaling pathways in human lung fibroblastsEwa Jablonska
Department of Biochemistry, Faculty of Medicine, Justus Liebig University, 35392 Giessen, Germany
J Biol Chem 285:11638-51. 2010..Our results show that JNK/Smad3 pathway plays a critical role in TGF-beta1-induced FXII expression in human lung fibroblasts and implicate its possible involvement in pathological conditions characterized by elevated TGF-beta1 levels... - Shedding of low-density lipoprotein receptor–related protein-1 in acute respiratory distress syndromeMalgorzata Wygrecka
Department of Biochemistry, University of Giessen Lung Center, Giessen, Germany
Am J Respir Crit Care Med 184:438-48. 2011..The ectodomain of LRP-1 can be shed from the cell surface, releasing a soluble form of this receptor (sLRP-1), which antagonizes ligand endocytosis by cellular LRP-1... - Fhl-1, a new key protein in pulmonary hypertensionGrazyna Kwapiszewska
Med Klinik II, University of Giessen Lung Center, Klinik Strasse 36, 35392 Giessen, Germany
Circulation 118:1183-94. 2008..We hypothesized that underlying key factors can be identified at the onset of the disease. Thus, we screened for alterations to protein expression in lung tissue at the onset of PH in a mouse model of hypoxia-induced PH... - Safety and tolerability of inhaled heparin in idiopathic pulmonary fibrosisPhilipp Markart
Department of Internal Medicine, Faculty of Medicine, Justus Liebig University, Giessen, Germany
J Aerosol Med Pulm Drug Deliv 23:161-72. 2010..In this study, we first examined the pharmacokinetics of inhaled heparin in healthy subjects. Second, we investigated the safety and tolerability of heparin inhalation in IPF patients... - Alveolar oxidative stress is associated with elevated levels of nonenzymatic low-molecular-weight antioxidants in patients with different forms of chronic fibrosing interstitial lung diseasesPhilipp Markart
Department of Internal Medicine, Faculty of Medicine, University of Giessen Lung Center, Giessen, Germany
Antioxid Redox Signal 11:227-40. 2009..This increase may be part of an adaptive response to oxidative stress. However, a leakage from the blood may also contribute to our findings... - Hyperoxia modulates TGF-beta/BMP signaling in a mouse model of bronchopulmonary dysplasiaMiguel A Alejandre Alcazar
Department of Internal Medicine, University of Giessen Lung Center, Justus Liebig University, Giessen, Germany
Am J Physiol Lung Cell Mol Physiol 292:L537-49. 2007..The amenability of these pathways to genetic and pharmacological manipulation may provide alternative avenues for the management of BPD... - Recombinant production of a hybrid plasminogen activator composed of surfactant protein B and low-molecular-weight urokinaseClemens Ruppert
Department of Internal Medicine, University of Giessen Lung Center, Giessen, Germany
Thromb Haemost 100:1185-92. 2008..We conclude that recombinant production of a fusion protein consisting of mature SP-B and uPA is feasible, when the SP-B moiety is fused to the C-terminus of urokinase... - Compartment- and cell-specific expression of coagulation and fibrinolysis factors in the murine lung undergoing inhalational versus intravenous endotoxin applicationMalgorzata Wygrecka
Department of Internal Medicine, Faculty of Medicine, Justus-Liebig-University Giessen, Klinikstr. 36, 35392 Giessen, Germany
Thromb Haemost 92:529-40. 2004.... - Reduced expression of arrestin beta 2 by graft monocytes during acute rejection of rat kidneysAnna Zakrzewicz
Laboratory of Experimental Surgery, Department of General and Thoracic Surgery, Justus Liebig University Giessen, Rudolf Buchheim Strasse 7, Giessen, Germany
Immunobiology 216:854-61. 2011..Our results suggest that activation of blood monocytes in renal isografts is dampened by high ARRB2 levels. During acute rejection, ARRB2 levels are reduced and classical monocyte activation is enabled via NF-κB activation... - Patients with ARDS show improvement but not normalisation of alveolar surface activity with surfactant treatment: putative role of neutral lipidsPhilipp Markart
Department of Internal Medicine, Faculty of Medicine, University of Giessen Lung Center, Klinikstrasse 36, 35392 Giessen, Germany
Thorax 62:588-94. 2007..Extensive biochemical and biophysical changes of the pulmonary surfactant system occur in the acute respiratory distress syndrome (ARDS)... - Protein Arginine Methyltransferases (PRMTs): Promising Targets for the Treatment of Pulmonary DisordersDariusz Zakrzewicz
Department of Biochemistry, Faculty of Medicine, University of Giessen Lung Center, Friedrichstrasse 24, 35392 Giessen, Germany
Int J Mol Sci 13:12383-400. 2012..This article will also highlight novel directions for possible future investigations to evaluate the functional contribution of arginine methylation in lung homeostasis and disease... - Host-derived extracellular nucleic acids enhance innate immune responses, induce coagulation, and prolong survival upon infection in insectsBoran Altincicek
Institute of Phytopathology and Applied Zoology, Justus Liebig University of Giessen, Heinrich Buff Ring 26 32, Giessen, Germany
J Immunol 181:2705-12. 2008.... - Loss of RAGE in pulmonary fibrosis: molecular relations to functional changes in pulmonary cell typesMarkus A Queisser
Department of Biochemistry, University of Giessen Lung Center, Justus Liebig University, Giessen, Germany
Am J Respir Cell Mol Biol 39:337-45. 2008..These results indicate that RAGE serves a protective role in the lung, and that loss of the receptor is related to functional changes of pulmonary cell types, with the consequences of fibrotic disease... - Inhibition of PDGF-BB by Factor VII-activating protease (FSAP) is neutralized by protease nexin-1, and the FSAP-inhibitor complexes are internalized via LRPLars Muhl
Institute for Biochemistry, Justus Liebig University, 35392 Giessen, Germany
Biochem J 404:191-6. 2007..Hence, PN-1 inhibits the enzymatic activity of FSAP and neutralizes its effect on PDGF-BB-mediated VSMC proliferation. The FSAP-inhibitor complexes are internalized via LRP without influencing the PDGF-BB signal transduction pathway... - Testosterone replacement effectively inhibits the development of experimental autoimmune orchitis in rats: evidence for a direct role of testosterone on regulatory T cell expansionMonika Fijak
Department of Anatomy and Cell Biology, Justus Liebig University Giessen, 35385 Giessen, Germany
J Immunol 186:5162-72. 2011..Thus, our study shows an immunomodulatory and protective effect of testosterone substitution in the pathogenesis of EAO and suggests androgens as a new factor in the differentiation of regulatory T cells...