Christoph Jan Wruck

Summary

Affiliation: University Hospital
Country: Germany

Publications

  1. pmc Involvement of formyl peptide receptors in receptor for advanced glycation end products (RAGE)--and amyloid beta 1-42-induced signal transduction in glial cells
    Alexander Slowik
    Department of Anatomy and Cell Biology, RWTH Aachen University, Wendlingweg 2, 52074 Aachen, Germany
    Mol Neurodegener 7:55. 2012
  2. pmc Sulforaphane has opposing effects on TNF-alpha stimulated and unstimulated synoviocytes
    Athanassios Fragoulis
    Arthritis Res Ther 14:R220. 2012
  3. pmc The formyl peptide receptor like-1 and scavenger receptor MARCO are involved in glial cell activation in bacterial meningitis
    Benedikt J Braun
    Department of Anatomy and Cell Biology, RWTH Aachen University, Germany
    J Neuroinflammation 8:11. 2011
  4. pmc Nrf2 induces interleukin-6 (IL-6) expression via an antioxidant response element within the IL-6 promoter
    Christoph Jan Wruck
    Department of Anatomy and Cell Biology, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany
    J Biol Chem 286:4493-9. 2011
  5. doi request reprint Kavalactones protect neural cells against amyloid beta peptide-induced neurotoxicity via extracellular signal-regulated kinase 1/2-dependent nuclear factor erythroid 2-related factor 2 activation
    Christoph J Wruck
    Department of Anatomy and Cell Biology, RWTH Aachen, Wendlingweg 2, 52074 Aachen, Germany
    Mol Pharmacol 73:1785-95. 2008
  6. doi request reprint Impact of Nrf2 on esophagus epithelium cornification
    Christoph J Wruck
    Department of Anatomy and Cell Biology, Medical Faculty, Rheinisch Westfälische Technische Hochschule Aachen University, Aachen, Germany
    Int J Dermatol 50:1362-5. 2011
  7. doi request reprint Role of a fetal defence mechanism against oxidative stress in the aetiology of preeclampsia
    Christoph Jan Wruck
    Department of Anatomy and Cell Biology, RWTH Aachen University, Aachen, Germany
    Histopathology 55:102-6. 2009
  8. doi request reprint Role of oxidative stress in rheumatoid arthritis: insights from the Nrf2-knockout mice
    Christoph Jan Wruck
    Correspondence to Christoph J Wruck, Department of Anatomy and Cell Biology, Medical Faculty, RWTH Aachen University, Wendlingweg 2, 52074 Aachen, Germany
    Ann Rheum Dis 70:844-50. 2011
  9. ncbi request reprint Role of platelet-released growth factors in detoxification of reactive oxygen species in osteoblasts
    Mersedeh Tohidnezhad
    Department of Anatomy and Cell Biology, RWTH Aachen University, Wendlingweg 2, D 52074 Aachen, Germany Electronic address
    Bone 65:9-17. 2014
  10. pmc A role for Nrf2 in redox signalling of the invasive extravillous trophoblast in severe early onset IUGR associated with preeclampsia
    Nisreen Kweider
    Department of Anatomy and Cell Biology, Medical Faculty, RWTH Aachen University, Germany
    PLoS ONE 7:e47055. 2012

Collaborators

Detail Information

Publications27

  1. pmc Involvement of formyl peptide receptors in receptor for advanced glycation end products (RAGE)--and amyloid beta 1-42-induced signal transduction in glial cells
    Alexander Slowik
    Department of Anatomy and Cell Biology, RWTH Aachen University, Wendlingweg 2, 52074 Aachen, Germany
    Mol Neurodegener 7:55. 2012
    ..Formyl peptide receptors and RAGE were inhibited by a small synthetic antagonist WRW4 and an inactive receptor variant delta-RAGE, lacking the intracytoplasmatic domains...
  2. pmc Sulforaphane has opposing effects on TNF-alpha stimulated and unstimulated synoviocytes
    Athanassios Fragoulis
    Arthritis Res Ther 14:R220. 2012
    ..These findings indicate that the use of sulforaphane might be considered as an adjunctive therapeutic strategy to combat inflammation, pannus formation, and cartilage destruction in RA...
  3. pmc The formyl peptide receptor like-1 and scavenger receptor MARCO are involved in glial cell activation in bacterial meningitis
    Benedikt J Braun
    Department of Anatomy and Cell Biology, RWTH Aachen University, Germany
    J Neuroinflammation 8:11. 2011
    ..Expression of the antimicrobial peptide cathelicidin CRAMP/LL-37 is up-regulated in bacterial meningitis, but the mechanisms underlying CRAMP expression are far from clear...
  4. pmc Nrf2 induces interleukin-6 (IL-6) expression via an antioxidant response element within the IL-6 promoter
    Christoph Jan Wruck
    Department of Anatomy and Cell Biology, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany
    J Biol Chem 286:4493-9. 2011
    ..Our findings suggest a possible role of IL-6 in oxidative stress defense and also give indication about an important function for Nrf2 in the regulation of hematopoietic and inflammatory processes...
  5. doi request reprint Kavalactones protect neural cells against amyloid beta peptide-induced neurotoxicity via extracellular signal-regulated kinase 1/2-dependent nuclear factor erythroid 2-related factor 2 activation
    Christoph J Wruck
    Department of Anatomy and Cell Biology, RWTH Aachen, Wendlingweg 2, 52074 Aachen, Germany
    Mol Pharmacol 73:1785-95. 2008
    ..These findings indicate that the use of purified kavalactones might be considered as an adjunct therapeutic strategy to combat neural demise in Alzheimer disease and other oxidative stress-related diseases...
  6. doi request reprint Impact of Nrf2 on esophagus epithelium cornification
    Christoph J Wruck
    Department of Anatomy and Cell Biology, Medical Faculty, Rheinisch Westfälische Technische Hochschule Aachen University, Aachen, Germany
    Int J Dermatol 50:1362-5. 2011
    ..Nrf2 is a transcription factor that is known to maintain cellular defense against the toxicity of electrophiles and reactive oxygen species (ROS)...
  7. doi request reprint Role of a fetal defence mechanism against oxidative stress in the aetiology of preeclampsia
    Christoph Jan Wruck
    Department of Anatomy and Cell Biology, RWTH Aachen University, Aachen, Germany
    Histopathology 55:102-6. 2009
    ..The aim of this study was to elucidate the placental defence mechanisms employed against oxidative stress and, in particular, the specific role of nuclear factor erythroid 2-related factor 2 (Nrf2)...
  8. doi request reprint Role of oxidative stress in rheumatoid arthritis: insights from the Nrf2-knockout mice
    Christoph Jan Wruck
    Correspondence to Christoph J Wruck, Department of Anatomy and Cell Biology, Medical Faculty, RWTH Aachen University, Wendlingweg 2, 52074 Aachen, Germany
    Ann Rheum Dis 70:844-50. 2011
    ..The aim of this study was to elucidate the role of nuclear factor erythroid 2-related factor 2 (Nrf2), a transcription factor that maintains the cellular defence against oxidative stress, in RA...
  9. ncbi request reprint Role of platelet-released growth factors in detoxification of reactive oxygen species in osteoblasts
    Mersedeh Tohidnezhad
    Department of Anatomy and Cell Biology, RWTH Aachen University, Wendlingweg 2, D 52074 Aachen, Germany Electronic address
    Bone 65:9-17. 2014
    ..The aim of the present study was to elucidate if platelets can lead to upregulation of VEGF and if platelets can regulate the activity of Nrf2-ARE system in primary human osteoblast (hOB) and in osteoblast-like cell line (SAOS-2)...
  10. pmc A role for Nrf2 in redox signalling of the invasive extravillous trophoblast in severe early onset IUGR associated with preeclampsia
    Nisreen Kweider
    Department of Anatomy and Cell Biology, Medical Faculty, RWTH Aachen University, Germany
    PLoS ONE 7:e47055. 2012
    ....
  11. pmc Nrf2 protects against TWEAK-mediated skeletal muscle wasting
    Othman Al-Sawaf
    Department of Anatomy and Cell Biology, University Hospital, RWTH Aachen University, Aachen, Germany
    Sci Rep 4:3625. 2014
    ..In summary, we show that Nrf2 protects SM from TWEAK-induced cell death in vitro and that Nrf2-deficient mice therefore have poorer muscle regeneration. ..
  12. pmc Interplay between vascular endothelial growth factor (VEGF) and nuclear factor erythroid 2-related factor-2 (Nrf2): implications for preeclampsia
    Nisreen Kweider
    Department of Anatomy and Cell Biology, RWTH Aachen University, 52074 Aachen, Germany
    J Biol Chem 286:42863-72. 2011
    ..Therefore, decreased VEGF bioavailability during preeclampsia may result in higher vulnerability to placental oxidative cell damage and a further reduction of VEGF bioavailability, a vicious circle that may end up in preeclampsia...
  13. doi request reprint Thrombocytes are effectors of the innate immune system releasing human beta defensin-3
    Mersedeh Tohidnezhad
    Department of Anatomy and Cell Biology, RWTH Aachen University, Germany
    Injury 42:682-6. 2011
    ..In this study we investigated the antimicrobial effect of PRP against gram-negative microbes which frequently cause severe complications in orthopaedic trauma surgery...
  14. doi request reprint Nrf2 expression by neurons, astroglia, and microglia in the cerebral cortical penumbra of ischemic rats
    Jon Dang
    Institute of Neuroanatomy, Medical Faculty, RWTH Aachen University, Aachen, Germany
    J Mol Neurosci 46:578-84. 2012
    ..These results provide strong evidence that Nrf2 is involved in acute stroke-dependent neurodegeneration in the penumbra but not core region and indicate the presence of a systemic Nrf2 activator independent from oxidative stress...
  15. doi request reprint Platelets display potent antimicrobial activity and release human beta-defensin 2
    Mersedeh Tohidnezhad
    Department of Anatomy and Cell Biology, RWTH Aachen University, Wendlingweg 2 D 52074, Aachen, Germany
    Platelets 23:217-23. 2012
    ..coli and P. mirabilis for this effect by the detection of an antimicrobial peptide (hBD-2). This study may advocate the clinical use of PRP by highlighting a new aspect of platelet action...
  16. ncbi request reprint Programmable cells of monocytic origin (PCMO): a source of peripheral blood stem cells that generate collagen type II-producing chondrocytes
    Thomas Pufe
    Institute for Anatomy, Faculty of Medicine RWTH Aachen, Wendlingweg 2, 52057 Aachen, Germany
    J Orthop Res 26:304-13. 2008
    ..The ability to reprogram and differentiate PCMOs from peripheral blood into sizable quantities might enable their clinical application in cartilage repair after mechanical injury or in cases of osteoarthritis...
  17. doi request reprint Role of glial cells in the functional expression of LL-37/rat cathelin-related antimicrobial peptide in meningitis
    Lars Ove Brandenburg
    Department of Anatomy and Cell Biology, RWTH Aachen University, Aachen, Germany
    J Neuropathol Exp Neurol 67:1041-54. 2008
    ..Together, these results suggest that cathelicidins produced by glia and other cells play an important part in the innate immune response against pathogens in central nervous system bacterial infections...
  18. doi request reprint Sulforaphane suppresses LPS-induced inflammation in primary rat microglia
    Lars Ove Brandenburg
    Department of Anatomy and Cell Biology, RWTH Aachen University, Wendlingweg 2, 52074 Aachen, Germany
    Inflamm Res 59:443-50. 2010
    ..Additionally, we investigated the effects of SF and LPS on the activity of Nrf2...
  19. doi request reprint Internalization and signal transduction of PrP(106-126) in neuronal cells
    Lars Ove Brandenburg
    Department of Anatomy and Cell Biology, Medical Faculty, RWTH Aachen University, Wendlingweg 2, 52074 Aachen, Germany Department of Anatomy, University of Kiel, Germany
    Ann Anat 191:459-68. 2009
    ....
  20. doi request reprint Expression and regulation of antimicrobial peptide rCRAMP after bacterial infection in primary rat meningeal cells
    Lars Ove Brandenburg
    Department of Anatomy and Cell Biology, RWTH Aachen University, Germany
    J Neuroimmunol 217:55-64. 2009
    ..These results suggest that cathelicidins produced by meningeal cells play an important part in the innate immune response against pathogens in CNS bacterial infections...
  21. doi request reprint Antimicrobial peptide rCRAMP induced glial cell activation through P2Y receptor signalling pathways
    Lars Ove Brandenburg
    Department of Anatomy and Cell Biology, University Hospital Aachen, Aachen, Germany
    Mol Immunol 47:1905-13. 2010
    ..This study provides evidence that rCRAMP participates in brain immunity by stimulating cytokine production and glial cell activation, and aid in the protection of brain cells by inducing neurotrophic factors...
  22. doi request reprint ADAM12 is expressed by astrocytes during experimental demyelination
    Fabian Baertling
    Institute of Neuroanatomy, Faculty of Medicine, RWTH Aachen University, Aachen, Germany
    Brain Res 1326:1-14. 2010
    ..In summary, we demonstrated that ADAM12 is not a suitable marker for oligodendrocytes. Our results further suggest that ADAM12 might be implicated in the course of distinct CNS diseases such as demyelinating disorders...
  23. doi request reprint Functional and physical interactions between formyl-peptide-receptors and scavenger receptor MARCO and their involvement in amyloid beta 1-42-induced signal transduction in glial cells
    Lars Ove Brandenburg
    Department of Anatomy and Cell Biology, RWTH Aachen University, Aachen, Germany
    J Neurochem 113:749-60. 2010
    ..These results suggest that FPRL1 plays a pivotal role for Abeta1-42-induced signal transduction in glial cells and the interaction with MARCO could explain the broad ligand spectrum of formyl peptide receptors...
  24. pmc A novel laser-Doppler flowmetry assisted murine model of acute hindlimb ischemia-reperfusion for free flap research
    Tolga Taha Sönmez
    Department of Oral and Maxillofacial Surgery, Medical Faculty, RWTH Aachen University, Aachen, Germany
    PLoS ONE 8:e66498. 2013
    ..These data indicate that our model is suitable to investigate cellular and molecular tissue alterations from ischemia-reperfusion such as occur during free flap procedures. ..
  25. doi request reprint Involvement of Phospholipase D 1 and 2 in the subcellular localization and activity of formyl-peptide-receptors in the human colonic cell line HT29
    Lars Ove Brandenburg
    Department of Anatomy and Cell Biology, RWTH Aachen University, Wendlingweg 2, Aachen, Germany
    Mol Membr Biol 26:371-83. 2009
    ..The constitutive internalization rate was unaffected. Our results support the importance of PLD1 and 2 in formyl peptide receptor function and the role of endocytosis, receptor recycling and reactivation for receptor activity...
  26. pmc Reactive oxygen species induce expression of vascular endothelial growth factor in chondrocytes and human articular cartilage explants
    Jakob Fay
    Department of Trauma Surgery, University Hospital Schleswig Holstein, Campus Kiel, Arnold Heller Strasse 7, 24105 Kiel, Germany
    Arthritis Res Ther 8:R189. 2006
    ..Our findings indicate ROS-mediated induction of VEGF and VEGF receptors in chondrocytes and cartilage explants. These results demonstrate a relationship between ROS and VEGF as multiplex mediators in articular cartilage degeneration...
  27. ncbi request reprint Regulation of transport of the angiotensin AT2 receptor by a novel membrane-associated Golgi protein
    Christoph J Wruck
    Institute of Pharmacology, University Hospital Schleswig Holstein, Campus Kiel, Germany
    Arterioscler Thromb Vasc Biol 25:57-64. 2005
    ..Little is known concerning the regulation of G protein-coupled receptor transport from the endoplasmic reticulum to the cell surface...