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Genomes and Genes | Christoph Jan WruckSummaryAffiliation: University Hospital Country: Germany Publications
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Publications
The formyl peptide receptor like-1 and scavenger receptor MARCO are involved in glial cell activation in bacterial meningitisBenedikt J Braun
Department of Anatomy and Cell Biology, RWTH Aachen University, Germany
J Neuroinflammation 8:11. 2011..Expression of the antimicrobial peptide cathelicidin CRAMP/LL-37 is up-regulated in bacterial meningitis, but the mechanisms underlying CRAMP expression are far from clear...
Role of oxidative stress in rheumatoid arthritis: insights from the Nrf2-knockout miceChristoph Jan Wruck
Correspondence to Christoph J Wruck, Department of Anatomy and Cell Biology, Medical Faculty, RWTH Aachen University, Wendlingweg 2, 52074 Aachen, Germany
Ann Rheum Dis 70:844-50. 2011..The aim of this study was to elucidate the role of nuclear factor erythroid 2-related factor 2 (Nrf2), a transcription factor that maintains the cellular defence against oxidative stress, in RA...- Nrf2 induces interleukin-6 (IL-6) expression via an antioxidant response element within the IL-6 promoterChristoph Jan Wruck
Department of Anatomy and Cell Biology, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany
J Biol Chem 286:4493-9. 2011..Our findings suggest a possible role of IL-6 in oxidative stress defense and also give indication about an important function for Nrf2 in the regulation of hematopoietic and inflammatory processes... - Role of a fetal defence mechanism against oxidative stress in the aetiology of preeclampsiaChristoph Jan Wruck
Department of Anatomy and Cell Biology, RWTH Aachen University, Aachen, Germany
Histopathology 55:102-6. 2009..The aim of this study was to elucidate the placental defence mechanisms employed against oxidative stress and, in particular, the specific role of nuclear factor erythroid 2-related factor 2 (Nrf2)... - Kavalactones protect neural cells against amyloid beta peptide-induced neurotoxicity via extracellular signal-regulated kinase 1/2-dependent nuclear factor erythroid 2-related factor 2 activationChristoph J Wruck
Department of Anatomy and Cell Biology, RWTH Aachen, Wendlingweg 2, 52074 Aachen, Germany
Mol Pharmacol 73:1785-95. 2008..These findings indicate that the use of purified kavalactones might be considered as an adjunct therapeutic strategy to combat neural demise in Alzheimer disease and other oxidative stress-related diseases... - Impact of Nrf2 on esophagus epithelium cornificationChristoph J Wruck
Department of Anatomy and Cell Biology, Medical Faculty, Rheinisch Westfälische Technische Hochschule Aachen University, Aachen, Germany
Int J Dermatol 50:1362-5. 2011..Nrf2 is a transcription factor that is known to maintain cellular defense against the toxicity of electrophiles and reactive oxygen species (ROS)... - Interplay between vascular endothelial growth factor (VEGF) and nuclear factor erythroid 2-related factor-2 (Nrf2): implications for preeclampsiaNisreen Kweider
Department of Anatomy and Cell Biology, RWTH Aachen University, 52074 Aachen, Germany
J Biol Chem 286:42863-72. 2011..Therefore, decreased VEGF bioavailability during preeclampsia may result in higher vulnerability to placental oxidative cell damage and a further reduction of VEGF bioavailability, a vicious circle that may end up in preeclampsia... - A role for Nrf2 in redox signalling of the invasive extravillous trophoblast in severe early onset IUGR associated with preeclampsiaNisreen Kweider
Department of Anatomy and Cell Biology, Medical Faculty, RWTH Aachen University, Germany
PLoS ONE 7:e47055. 2012.... - Thrombocytes are effectors of the innate immune system releasing human beta defensin-3Mersedeh Tohidnezhad
Department of Anatomy and Cell Biology, RWTH Aachen University, Germany
Injury 42:682-6. 2011..In this study we investigated the antimicrobial effect of PRP against gram-negative microbes which frequently cause severe complications in orthopaedic trauma surgery... - Nrf2 expression by neurons, astroglia, and microglia in the cerebral cortical penumbra of ischemic ratsJon Dang
Institute of Neuroanatomy, Medical Faculty, RWTH Aachen University, Aachen, Germany
J Mol Neurosci 46:578-84. 2012..These results provide strong evidence that Nrf2 is involved in acute stroke-dependent neurodegeneration in the penumbra but not core region and indicate the presence of a systemic Nrf2 activator independent from oxidative stress... - Platelets display potent antimicrobial activity and release human beta-defensin 2Mersedeh Tohidnezhad
Department of Anatomy and Cell Biology, RWTH Aachen University, Wendlingweg 2 D 52074, Aachen, Germany
Platelets 23:217-23. 2012..coli and P. mirabilis for this effect by the detection of an antimicrobial peptide (hBD-2). This study may advocate the clinical use of PRP by highlighting a new aspect of platelet action... - Antimicrobial peptide rCRAMP induced glial cell activation through P2Y receptor signalling pathwaysLars Ove Brandenburg
Department of Anatomy and Cell Biology, University Hospital Aachen, Aachen, Germany
Mol Immunol 47:1905-13. 2010..This study provides evidence that rCRAMP participates in brain immunity by stimulating cytokine production and glial cell activation, and aid in the protection of brain cells by inducing neurotrophic factors... - ADAM12 is expressed by astrocytes during experimental demyelinationFabian Baertling
Institute of Neuroanatomy, Faculty of Medicine, RWTH Aachen University, Aachen, Germany
Brain Res 1326:1-14. 2010..In summary, we demonstrated that ADAM12 is not a suitable marker for oligodendrocytes. Our results further suggest that ADAM12 might be implicated in the course of distinct CNS diseases such as demyelinating disorders... 
Programmable cells of monocytic origin (PCMO): a source of peripheral blood stem cells that generate collagen type II-producing chondrocytesThomas Pufe
Institute for Anatomy, Faculty of Medicine RWTH Aachen, Wendlingweg 2, 52057 Aachen, Germany
J Orthop Res 26:304-13. 2008..The ability to reprogram and differentiate PCMOs from peripheral blood into sizable quantities might enable their clinical application in cartilage repair after mechanical injury or in cases of osteoarthritis...- Role of glial cells in the functional expression of LL-37/rat cathelin-related antimicrobial peptide in meningitisLars Ove Brandenburg
Department of Anatomy and Cell Biology, RWTH Aachen University, Aachen, Germany
J Neuropathol Exp Neurol 67:1041-54. 2008..Together, these results suggest that cathelicidins produced by glia and other cells play an important part in the innate immune response against pathogens in central nervous system bacterial infections... - Internalization and signal transduction of PrP(106-126) in neuronal cellsLars Ove Brandenburg
Department of Anatomy and Cell Biology, Medical Faculty, RWTH Aachen University, Wendlingweg 2, 52074 Aachen, Germany Department of Anatomy, University of Kiel, Germany
Ann Anat 191:459-68. 2009.... - Expression and regulation of antimicrobial peptide rCRAMP after bacterial infection in primary rat meningeal cellsLars Ove Brandenburg
Department of Anatomy and Cell Biology, RWTH Aachen University, Germany
J Neuroimmunol 217:55-64. 2009..These results suggest that cathelicidins produced by meningeal cells play an important part in the innate immune response against pathogens in CNS bacterial infections... - Sulforaphane suppresses LPS-induced inflammation in primary rat microgliaLars Ove Brandenburg
Department of Anatomy and Cell Biology, RWTH Aachen University, Wendlingweg 2, 52074 Aachen, Germany
Inflamm Res 59:443-50. 2010..Additionally, we investigated the effects of SF and LPS on the activity of Nrf2... - Functional and physical interactions between formyl-peptide-receptors and scavenger receptor MARCO and their involvement in amyloid beta 1-42-induced signal transduction in glial cellsLars Ove Brandenburg
Department of Anatomy and Cell Biology, RWTH Aachen University, Aachen, Germany
J Neurochem 113:749-60. 2010..These results suggest that FPRL1 plays a pivotal role for Abeta1-42-induced signal transduction in glial cells and the interaction with MARCO could explain the broad ligand spectrum of formyl peptide receptors... - Involvement of Phospholipase D 1 and 2 in the subcellular localization and activity of formyl-peptide-receptors in the human colonic cell line HT29Lars Ove Brandenburg
Department of Anatomy and Cell Biology, RWTH Aachen University, Wendlingweg 2, Aachen, Germany
Mol Membr Biol 26:371-83. 2009..The constitutive internalization rate was unaffected. Our results support the importance of PLD1 and 2 in formyl peptide receptor function and the role of endocytosis, receptor recycling and reactivation for receptor activity... - Reactive oxygen species induce expression of vascular endothelial growth factor in chondrocytes and human articular cartilage explantsJakob Fay
Department of Trauma Surgery, University Hospital Schleswig Holstein, Campus Kiel, Arnold Heller Strasse 7, 24105 Kiel, Germany
Arthritis Res Ther 8:R189. 2006..Our findings indicate ROS-mediated induction of VEGF and VEGF receptors in chondrocytes and cartilage explants. These results demonstrate a relationship between ROS and VEGF as multiplex mediators in articular cartilage degeneration... - Regulation of transport of the angiotensin AT2 receptor by a novel membrane-associated Golgi proteinChristoph J Wruck
Institute of Pharmacology, University Hospital Schleswig Holstein, Campus Kiel, Germany
Arterioscler Thromb Vasc Biol 25:57-64. 2005..Little is known concerning the regulation of G protein-coupled receptor transport from the endoplasmic reticulum to the cell surface...