Gunter Wolf

Summary

Affiliation: University of Hamburg
Country: Germany

Publications

  1. ncbi request reprint An expensive multifactorial renal failure
    Gunter Wolf
    Division of Nephrology and Osteology, Department of Medicine, University of Hamburg, Germany
    Nephrol Dial Transplant 19:2921-2. 2004
  2. ncbi request reprint Angiotensin II-induced hypertrophy of proximal tubular cells requires p27Kip1
    Gunter Wolf
    Division of Nephrology and Osteology, Department of Medicine, University of Hamburg, Hamburg, Germany
    Kidney Int 64:71-81. 2003
  3. ncbi request reprint The renin-angiotensin system and progression of renal disease: from hemodynamics to cell biology
    Gunter Wolf
    Department of Medicine, Division of Nephrology and Osteology, University of Hamburg, Germany
    Nephron Physiol 93:P3-13. 2003
  4. ncbi request reprint Friedrich Theodor von Frerichs (1819-1885) and Bright's disease
    Gunter Wolf
    Division of Nephrology and Osteology, Department of Medicine, University of Hamburg, Germany
    Am J Nephrol 22:596-602. 2002
  5. ncbi request reprint Angiotensin II's antiproliferative effects mediated through AT2-receptors depend on down-regulation of SM-20
    Gunter Wolf
    Department of Medicine, Division of Nephrology and Osteology, University of Hamburg, Hamburg, Germany
    Lab Invest 82:1305-17. 2002
  6. ncbi request reprint Existence of a regulatory loop between MCP-1 and TGF-beta in glomerular immune injury
    Gunter Wolf
    Division of Nephrology, Department of Medicine, University of Hamburg, 20246 Hamburg, Germany
    Am J Physiol Renal Physiol 283:F1075-84. 2002
  7. ncbi request reprint A woman with increasing weakness of the legs and irregular heartbeat who took her husband's medication
    Gunter Wolf
    Department of Medicine, Division of Nephrology and Osteology, University of Hamburg, Germany
    Nephrol Dial Transplant 17:1698-701. 2002
  8. ncbi request reprint No association between a genetic variant of the p22(phox) component of NAD(P)H oxidase and the incidence and progression of IgA nephropathy
    Gunter Wolf
    Department of Medicine, Division of Nephrology and Osteology, University of Hamburg, Hamburg, Germany
    Nephrol Dial Transplant 17:1509-12. 2002
  9. ncbi request reprint Angiotensin II activates nuclear transcription factor-kappaB through AT1 and AT2 receptors
    Gunter Wolf
    Division of Nephrology and Osteology, Department of Medicine, University of Hamburg, Hamburg, Germany
    Kidney Int 61:1986-95. 2002
  10. ncbi request reprint Remembrance of things past: tumoural calcifications in a haemodialysis patient
    Gunter Wolf
    Department of Medicine, Division of Nephrology and Osteology, University of Hamburg, University Hospital Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    Nephrol Dial Transplant 17:304-7. 2002

Collaborators

Detail Information

Publications99

  1. ncbi request reprint An expensive multifactorial renal failure
    Gunter Wolf
    Division of Nephrology and Osteology, Department of Medicine, University of Hamburg, Germany
    Nephrol Dial Transplant 19:2921-2. 2004
  2. ncbi request reprint Angiotensin II-induced hypertrophy of proximal tubular cells requires p27Kip1
    Gunter Wolf
    Division of Nephrology and Osteology, Department of Medicine, University of Hamburg, Hamburg, Germany
    Kidney Int 64:71-81. 2003
    ....
  3. ncbi request reprint The renin-angiotensin system and progression of renal disease: from hemodynamics to cell biology
    Gunter Wolf
    Department of Medicine, Division of Nephrology and Osteology, University of Hamburg, Germany
    Nephron Physiol 93:P3-13. 2003
    ..Finally, clinical implications are suggested based on data from clinical studies. A thorough understanding of the RAS is important to recognize the potential of nephroprotective strategies through inhibition of its components...
  4. ncbi request reprint Friedrich Theodor von Frerichs (1819-1885) and Bright's disease
    Gunter Wolf
    Division of Nephrology and Osteology, Department of Medicine, University of Hamburg, Germany
    Am J Nephrol 22:596-602. 2002
    ..Friedrich Theodor von Frerichs (1819-1885) performed microscopic studies on Bright's disease and wrote the first German textbook of nephrology. The present contribution analyzes Frerichs' work...
  5. ncbi request reprint Angiotensin II's antiproliferative effects mediated through AT2-receptors depend on down-regulation of SM-20
    Gunter Wolf
    Department of Medicine, Division of Nephrology and Osteology, University of Hamburg, Hamburg, Germany
    Lab Invest 82:1305-17. 2002
    ..This gene apparently plays an important role in the regulatory processes determining whether a cell should undergo differentiation, apoptosis, or proliferation...
  6. ncbi request reprint Existence of a regulatory loop between MCP-1 and TGF-beta in glomerular immune injury
    Gunter Wolf
    Division of Nephrology, Department of Medicine, University of Hamburg, 20246 Hamburg, Germany
    Am J Physiol Renal Physiol 283:F1075-84. 2002
    ..Our data demonstrate an intrinsic regulatory loop in which increased MCP-1 levels stimulate TGF-beta formation in resident glomerular cells in the absence of infiltrating immune competent cells...
  7. ncbi request reprint A woman with increasing weakness of the legs and irregular heartbeat who took her husband's medication
    Gunter Wolf
    Department of Medicine, Division of Nephrology and Osteology, University of Hamburg, Germany
    Nephrol Dial Transplant 17:1698-701. 2002
  8. ncbi request reprint No association between a genetic variant of the p22(phox) component of NAD(P)H oxidase and the incidence and progression of IgA nephropathy
    Gunter Wolf
    Department of Medicine, Division of Nephrology and Osteology, University of Hamburg, Hamburg, Germany
    Nephrol Dial Transplant 17:1509-12. 2002
    ..Patients with lupus nephritis were also investigated. The distribution of the C242T gene variation of p22(phox) has not been previously studied in patients with renal disease...
  9. ncbi request reprint Angiotensin II activates nuclear transcription factor-kappaB through AT1 and AT2 receptors
    Gunter Wolf
    Division of Nephrology and Osteology, Department of Medicine, University of Hamburg, Hamburg, Germany
    Kidney Int 61:1986-95. 2002
    ..We focused particularly on the Ang II subtype 2 (AT2) receptor because we previously observed that Ang II-induction of the chemokine RANTES in vitro and in vivo is mediated through AT2 receptors...
  10. ncbi request reprint Remembrance of things past: tumoural calcifications in a haemodialysis patient
    Gunter Wolf
    Department of Medicine, Division of Nephrology and Osteology, University of Hamburg, University Hospital Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    Nephrol Dial Transplant 17:304-7. 2002
  11. ncbi request reprint Erk 1,2 phosphorylates p27(Kip1): Functional evidence for a role in high glucose-induced hypertrophy of mesangial cells
    G Wolf
    Department of Medicine, University of Hamburg, University Hospital Eppendorf, 20246 Hamburg, Germany
    Diabetologia 46:1090-9. 2003
    ..However, it remains poorly understood how high glucose stimulates p27(Kip1) expression in mesangial cells...
  12. ncbi request reprint New insights into the pathophysiology of diabetic nephropathy: from haemodynamics to molecular pathology
    G Wolf
    Department of Medicine, Division of Nephrology, Osteology and Rheumatology, University of Hamburg, Hamburg, Germany
    Eur J Clin Invest 34:785-96. 2004
    ..Recent evidence suggests that regression of diabetic nephropathy could be achieved under certain circumstances...
  13. ncbi request reprint Albumin up-regulates the type II transforming growth factor-beta receptor in cultured proximal tubular cells
    Gunter Wolf
    Department of Medicine, Division of Nephrology and Osteology, University of Hamburg, Hamburg, Germany
    Kidney Int 66:1849-58. 2004
    ..We studied in an in vitro system using a well-defined mouse proximal tubular cell line (MCT cells) whether fatty acid-free bovine albumin modulates expression of specific receptors for TGF-beta...
  14. ncbi request reprint Angiotensin II induces hypoxia-inducible factor-1 alpha in PC 12 cells through a posttranscriptional mechanism: role of AT2 receptors
    Gunter Wolf
    Department of Medicine, Division of Nephrology and Osteology, University of Hamburg, DE 20246 Hamburg, Germany
    Am J Nephrol 24:415-21. 2004
    ..The present study was undertaken to investigate whether the ANG-II-mediated suppression of SM-20/PHD3/PHD3 may be associated with an increase in HIF-1 alpha...
  15. ncbi request reprint Georg Büchner's Woyzeck. A tragic example of human experimentation without informed consent
    Gunter Wolf
    Department of Medicine, Division of Nephrology and Osteology, University of Hamburg, University Hospital Eppendorf, Pavilion N26, Martinistrasse 52, D 20246 Hamburg, Germany
    Pharos Alpha Omega Alpha Honor Med Soc 67:23-8. 2004
  16. ncbi request reprint Not known from ADAM(TS-13)--novel insights into the pathophysiology of thrombotic microangiopathies
    Gunter Wolf
    Department of Medicine, University of Hamburg, Hamburg, Germany
    Nephrol Dial Transplant 19:1687-93. 2004
  17. ncbi request reprint Angiotensin II and cell cycle regulation
    Gunter Wolf
    Department of Medicine, Division of Nephrology and Osteology, University of Hamburg, University Hospital, Germany
    Hypertension 43:693-8. 2004
    ..We review the various angiotensin II-mediated growth processes and their relationship to events governing cell cycle regulation...
  18. ncbi request reprint A 63-year-old man with acute abdominal pain and laboratory signs of rapid progressive renal disease
    Gunter Wolf
    Department of Medicine, Division of Nephrology and Osteology, University of Hamburg, Hamburg, Germany
    Nephrol Dial Transplant 19:742-4. 2004
  19. ncbi request reprint CD2-associated protein and glomerular disease
    Gunter Wolf
    Department of Medicine, Division of Nephrology, Rheumatology, and Osteology, University of Hamburg, D 20246, Hamburg, Germany
    Lancet 362:1746-8. 2003
    ..CD2AP localises to the slit diaphragm and links nephrin and podocin to phosphoinositide 3-OH kinase; this complex has cell-signalling properties...
  20. ncbi request reprint Growth factors and the development of diabetic nephropathy
    Gunter Wolf
    University of Hamburg, University Hospital Eppendorf, Department of Medicine, Division of Nephrology, Rheumatology, and Osteology, Hamburg, Germany
    Curr Diab Rep 3:485-90. 2003
    ..However, the pleiotropic function of many of these factors and their physiologic role in normal renal homeostasis may make this approach difficult...
  21. ncbi request reprint After all those fat years: renal consequences of obesity
    Gunter Wolf
    Department of Medicine, Division of Nephrology, Rheumatology and Osteology, University of Hamburg, University Hospital Eppendorf, Pavilion N26, Martinistrasse 52, D 20246 Hamburg, Germany
    Nephrol Dial Transplant 18:2471-4. 2003
  22. ncbi request reprint Angiotensin II induces p27(Kip1) expression in renal tubules in vivo: role of reactive oxygen species
    G Wolf
    Department of Medicine, Division of Nephrology and Osteology, University of Hamburg, University Hospital Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    J Mol Med (Berl) 79:382-9. 2001
    ....
  23. ncbi request reprint [Hypertensive disorders in pregnancy]
    G Wolf
    Medizinische Klinik, Abteilung Nephrologie und Osteologie, Universitatsklinikum Hamburg Eppendorf
    Med Klin (Munich) 96:78-86. 2001
    ..Diagnosis of these diseases requires an understanding of the normal physiological adaptations during pregnancy...
  24. ncbi request reprint Molecular mechanisms of renal hypertrophy: role of p27Kip1
    G Wolf
    Department of Medicine, Division of Nephrology and Osteology, University of Hamburg, Germany
    Kidney Int 56:1262-5. 1999
    ..This article examines the mechanisms of the proliferative growth response following acute tubular necrosis, and compensatory hypertrophy of glomerular and tubule cells, with a particular focus on the protein p27Kip1...
  25. ncbi request reprint Angiotensin II stimulates expression of transforming growth factor beta receptor type II in cultured mouse proximal tubular cells
    G Wolf
    University of Hamburg, University Hospital Eppendorf, Department of Medicine, Germany
    J Mol Med (Berl) 77:556-64. 1999
    ..Interference with an activated renin-angiotensin system could therefore counteract the profibrogenic effects of TGF-beta by abolishing ANG II induced expression of TGF-beta receptor type II...
  26. ncbi request reprint Free radical production and angiotensin
    G Wolf
    University of Hamburg, University Hospital Eppendorf, Department of Medicine, Division of Nephrology and Osteology, Pavilion 61, Martinistrasse 52, D 20246 Hamburg, Germany
    Curr Hypertens Rep 2:167-73. 2000
    ..In fact, only specific risk groups, such as patients with diabetes mellitus or renal insufficiency, may benefit from ACE inhibitors, whereas hard endpoints showed no advantage for ACE inhibitors in patients with essential hypertension...
  27. ncbi request reprint Cell cycle regulation in diabetic nephropathy
    G Wolf
    Department of Medicine, University of Hamburg, Germany
    Kidney Int Suppl 77:S59-66. 2000
    ..The recent observation that glomerular hypertrophy and proteinuria do not develop in diabetic p21CiP1 knockout mice indicates that this approach is feasible...
  28. ncbi request reprint Leptin stimulates proliferation and TGF-beta expression in renal glomerular endothelial cells: potential role in glomerulosclerosis [seecomments]
    G Wolf
    Department of Medicine, Division of Nephrology and Osteology, University of Hamburg, Germany
    Kidney Int 56:860-72. 1999
    ..Because individuals with massive obesity who may exhibit increased leptin serum concentrations develop renal glomerulosclerosis, we studied whether leptin can influence renal growth and profibrogenic processes...
  29. ncbi request reprint Antioxidant treatment induces transcription and expression of transforming growth factor beta in cultured renal proximal tubular cells
    G Wolf
    Department of Medicine, University Hospital Eppendorf, University of Hamburg, Germany
    FEBS Lett 488:154-9. 2001
    ..Thus, antioxidant therapy may increase local synthesis of TGF-beta1 in the tubulointerstitium...
  30. pmc High glucose-induced hypertrophy of mesangial cells requires p27(Kip1), an inhibitor of cyclin-dependent kinases
    G Wolf
    University of Hamburg, University Hospital Eppendorf, Department of Medicine, Division of Nephrology and Osteology, Pavilion 61, Martinistrasse 52, D 20246 Hamburg, Germany
    Am J Pathol 158:1091-100. 2001
    ..These results show that p27Kip1 is required for glucose-induced mesangial cell hypertrophy and cell cycle arrest...
  31. ncbi request reprint Vasoactive factors and tubulointerstitial injury
    G Wolf
    Department of Medicine, Division of Nephrology and Osteology, University of Hamburg, Germany
    Kidney Blood Press Res 22:62-70. 1999
    ....
  32. ncbi request reprint Angiotensin II is involved in the progression of renal disease: importance of non-hemodynamic mechanisms
    G Wolf
    Department of Medicine, University of Hamburg, Germany
    Nephrologie 19:451-6. 1998
    ..In conclusion, Ang II has emerged as a multifunctional acting as a growth factor and a profibrogenic cytokine, and even having inflammatory properties...
  33. ncbi request reprint AT1-receptor antagonists abolish glomerular MCP-1 expression in a model of mesangial proliferative glomerulonephritis
    G Wolf
    Department of Medicine, University Hospital Eppendorf, Hamburg, Germany
    Exp Nephrol 6:112-20. 1998
    ..The present study was undertaken to test the effect of two angiotensin II type 1 (AT1) receptor antagonists, losartan and irbesartan, on ATS-stimulated MCP-1 expression as well as glomerular influx of M/M...
  34. ncbi request reprint Thrombosis associated with cytomegalovirus infection in patients with ANCA-positive vasculitis
    G Wolf
    Department of Medicine, Division of Nephrology and Osteology, University of Hamburg, Hamburg, Germany
    Am J Kidney Dis 38:E27. 2001
    ..Patients with ANCA-positive vasculitis and CMV infection may profit from prophylactic anticoagulant therapy with heparin or low-molecular-weight heparin...
  35. ncbi request reprint Overexpression of aminopeptidase A abolishes the growth promoting effects of angiotensin II in cultured mouse mesangial cells
    G Wolf
    Department of Medicine, University of Hamburg, Germany
    Kidney Int 52:1250-60. 1997
    ..These experiments are a first step toward the development of novel strategies to selectively antagonize locally generated Ang II in the kidney...
  36. ncbi request reprint Link between angiotensin II and TGF-beta in the kidney
    G Wolf
    Department of Medicine, University of Hamburg, Germany
    Miner Electrolyte Metab 24:174-80. 1998
    ..Therefore, these drugs should not only be considered as antihypertensive medications, but should rather be viewed as renoprotective substances influencing renal remodeling by preventing local TGF-beta expression...
  37. ncbi request reprint Glomerular expression of p27Kip1 in diabetic db/db mouse: role of hyperglycemia
    G Wolf
    Department of Medicine, University of Hamburg, Germany
    Kidney Int 53:869-79. 1998
    ..This induction appears to be due to hyperglycemia. Expression of p27Kip1 may be important in cell cycle arrest and hypertrophy of mesangial cells during early diabetic nephropathy...
  38. ncbi request reprint Franz Volhard and his students' tortuous road to renovascular hypertension
    G Wolf
    Department of Medicine, Division of Nephrology and Osteology, University of Hamburg, Germany
    Kidney Int 57:2156-66. 2000
    ..Franz Volhard was a colorful figure whose contributions extended far beyond classifying renal diseases...
  39. ncbi request reprint Angiotensin II infusion ameliorates the early phase of a mesangioproliferative glomerulonephritis
    Ulrich O Wenzel
    Division of Nephrology, Department of Medicine, University of Hamburg, Martinistrasse 52, 20246 Hamburg, Germany
    Kidney Int 61:1020-9. 2002
    ..Inhibition of the renin-angiotensin system slows the progression of chronic renal disease...
  40. ncbi request reprint Effects of different PPARgamma-agonists on MCP-1 expression and monocyte recruitment in experimental glomerulonephritis
    Ulf Panzer
    Zentrum fur Innere Medizin, Medizinische Klinik IV, University of Hamburg, Hamburg, Germany
    Kidney Int 62:455-64. 2002
    ..We evaluated the effects of different forms of PPARgamma activators in a model of experimental glomerulonephritis (GN) in rats...
  41. ncbi request reprint Resolution of renal inflammation: a new role for NF-kappaB1 (p50) in inflammatory kidney diseases
    Ulf Panzer
    III Medizinische Klinik, Zentrum fur Innere Medizin, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    Am J Physiol Renal Physiol 297:F429-39. 2009
    ..In conclusion, our studies indicate that NF-kappaB subunit p50 proteins have critical in vivo functions in immunologically mediated renal disease by downregulating inflammation during the resolution period...
  42. ncbi request reprint High glucose stimulates expression of p27Kip1 in cultured mouse mesangial cells: relationship to hypertrophy
    G Wolf
    Department of Medicine, University of Hamburg, Germany
    Am J Physiol 273:F348-56. 1997
    ..These findings may be important in the deciphering of molecular processes causing diabetic glomerular hypertrophy...
  43. ncbi request reprint The novel WD-repeat protein Morg1 acts as a molecular scaffold for hypoxia-inducible factor prolyl hydroxylase 3 (PHD3)
    Ulrike Hopfer
    Department of Medicine, University of Hamburg, Martinistr 52, D 20246 Hamburg
    J Biol Chem 281:8645-55. 2006
    ..These results indicate that Morg1 specifically interacts with PHD3 most likely by acting as a molecular scaffold. This interaction may provide a molecular framework between HIF regulation and other signaling pathways...
  44. doi request reprint 15-deoxy-Delta12,14-prostaglandin J2 inhibits INF-gamma-induced JAK/STAT1 signalling pathway activation and IP-10/CXCL10 expression in mesangial cells
    Ulf Panzer
    Medizinische Klinik III, University of Hamburg, Hamburg, Germany
    Nephrol Dial Transplant 23:3776-85. 2008
    ....
  45. ncbi request reprint Compartment-specific expression and function of the chemokine IP-10/CXCL10 in a model of renal endothelial microvascular injury
    Ulf Panzer
    Medizinische Klinik IV, Zentrum fur Innere Medizin, University of Hamburg, Martinistrasse 52, Hamburg 20246, Germany
    J Am Soc Nephrol 17:454-64. 2006
    ....
  46. ncbi request reprint Cyclooxygenase-2 overexpression inhibits platelet-derived growth factor-induced mesangial cell proliferation through induction of the tumor suppressor gene p53 and the cyclin-dependent kinase inhibitors p21waf-1/cip-1 and p27kip-1
    Gunther Zahner
    Department of Medicine, Division of Nephrology and Osteology, University of Hamburg, 20246 Hamburg, Germany
    J Biol Chem 277:9763-71. 2002
    ..These data suggest that COX-2 inhibits mesangial cell proliferation by a novel mechanism that is independent of prostaglandin synthesis, but involves p53, p21(cip-1), and p27(kip-1)...
  47. pmc Lack of type VIII collagen in mice ameliorates diabetic nephropathy
    Ulrike Hopfer
    Department of Medicine, University of Hamburg, Hamburg, Germany
    Diabetes 58:1672-81. 2009
    ....
  48. ncbi request reprint Chronic anti-Thy-1 nephritis is aggravated in the nonclipped but not in the clipped kidney of Goldblatt hypertensive rats
    Ulrich O Wenzel
    Division of Nephrology, Department of Medicine, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Kidney Int 61:2119-31. 2002
    ..To test whether a chronic model of the Thy-1 nephritis is more susceptible to high blood pressure, the repetitive hit model was evaluated in rats with 2-kidney, 1-clip Goldblatt hypertension...
  49. pmc The IL-23/Th17 axis contributes to renal injury in experimental glomerulonephritis
    Hans Joachim Paust
    Universitatsklinikum Hamburg Eppendorf, III Medizinische Klinik, Martinistrasse 52, 20246 Hamburg, Germany
    J Am Soc Nephrol 20:969-79. 2009
    ..Targeting the IL-23/Th17 axis may be a promising therapeutic strategy for the treatment of proliferative and crescentic glomerulonephritis...
  50. ncbi request reprint Role of reactive oxygen species in angiotensin II-mediated renal growth, differentiation, and apoptosis
    Gunter Wolf
    Department of Medicine, Division of Nephrology, University of Jena, Jena, Germany
    Antioxid Redox Signal 7:1337-45. 2005
    ..Thus, ANG II-induced ROS generation plays a pivotal role in several pathophysiological situations, leading to renal growth regulation and remodeling after injury...
  51. ncbi request reprint Oxidized LDL induces proliferation and hypertrophy in human umbilical vein endothelial cells via regulation of p27Kip1 expression: role of RhoA
    Stefan Seibold
    Department of Medicine, University Hospital Wurzburg, Joseph Schneider Strasse 2, D 97080 Wurzburg, Germany
    J Am Soc Nephrol 15:3026-34. 2004
    ..OxLDL may importantly contribute to vascular hyperplasia in atherosclerosis and other diseases associated with increased levels of OxLDL...
  52. ncbi request reprint Gastrin/cholecystokinin type B receptors in the kidney: molecular, pharmacological, functional characterization, and localization
    A De Weerth
    Universitats Krankenhaus Eppendorf, Hamburg, Germany
    Eur J Clin Invest 28:592-601. 1998
    ..Recent cloning studies indicate that this is receptor type might also be expressed in the kidney...
  53. ncbi request reprint Angiotensin II down-regulates the SR-BI HDL receptor in proximal tubular cells
    Gunter Wolf
    Department of Medicine, University of Jena, Germany
    Nephrol Dial Transplant 20:1222-7. 2005
    ..Therefore, the present study sought to gain insight into the expression of the HDL receptor scavenger receptor class B type I (SR-BI) in cultured renal cells and a potential regulation by angiotensin II (ANG II)...
  54. ncbi request reprint Combination therapy with ACE inhibitors and angiotensin II receptor blockers to halt progression of chronic renal disease: pathophysiology and indications
    Gunter Wolf
    Department of Medicine, Division of Nephrology, Osteology, and Rheumatology, University of Hamburg, Hamburg, Germany
    Kidney Int 67:799-812. 2005
    ..In our opinion patients with proteinuria >1 g/day despite optimal blood pressure control under RAS-blocking monotherapy are a high-risk group which will presumably benefit from combination therapy...
  55. ncbi request reprint Extracellular actin impairs glomerular capillary repair in experimental mesangioproliferative glomerulonephritis
    Ulf Janssen
    Division of Nephrology, Universitie of Aachen, Germany
    Nephron Exp Nephrol 93:e158-67. 2003
    ..Our combined in vivo and in vitro observations suggest that the release of intracellular actin during mesangiolysis is an endogenous pathway by which glomerular capillary damage is augmented...
  56. ncbi request reprint Kidney diseases and chemokines
    Ulf Panzer
    Medizinische Klinik IV, Universtätsklinikum Hamburg Eppendorf, Hamburg, Germany
    Curr Drug Targets 7:65-80. 2006
    ..This suggests that inhibition of chemokine expression and action must be time and compartment specific to provide therapeutic benefit for renal structure and function...
  57. ncbi request reprint Inhibition of platelet-derived growth factor-induced mesangial cell proliferation by cyclooxygenase-2 overexpression is abolished through reactive oxygen species
    Gunther Zahner
    Department of Medicine, Division of Nephrology and Osteology, University of Hamburg, Martinistr 52, 20246 Hamburg, Germany
    FEBS Lett 580:2523-8. 2006
    ..The data suggest that COX-2 decreases ROS formation which consequently leads to the PDGF-induced inhibition of MC proliferation...
  58. ncbi request reprint Beneficial and adverse renal and vascular effects of the vasopeptidase inhibitor omapatrilat in renovascular hypertensive rats
    Ulrich O Wenzel
    University Hospital of Hamburg Eppendorf, Department of Medicine, Division of Nephrology, Pav 61, Martinistrasse 52, D 20246 Hamburg, Germany
    Nephrol Dial Transplant 18:2005-13. 2003
    ....
  59. doi request reprint Renal IL-17 expression in human ANCA-associated glomerulonephritis
    Joachim Velden
    Nierenregister, Institut fur Pathologie, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    Am J Physiol Renal Physiol 302:F1663-73. 2012
    ..IL-17 may thus be a target for treating acute ANCA-associated glomerulonephritis...
  60. ncbi request reprint Collagen VIII influences epithelial phenotypic changes in experimental diabetic nephropathy
    Ivonne Loeffler
    Department of Internal Medicine III, University Hospital, University of Jena, Erlanger Allee 101, Jena, Germany
    Am J Physiol Renal Physiol 303:F733-45. 2012
    ....
  61. ncbi request reprint The hypertrophic effect of transforming growth factor-beta is reduced in the absence of cyclin-dependent kinase-inhibitors p21 and p27
    Toshiaki Monkawa
    Department of Medicine, Division of Nephrology, University of Washington, Seattle, Washington 98195, USA
    J Am Soc Nephrol 13:1172-8. 2002
    ..However, the hypertrophic growth effects of TGF-beta are reduced in the absence of both p21 and p27. These data suggest that the regulation of the antiproliferative and hypertrophic effects of TGF-beta may be distinct processes...
  62. ncbi request reprint Cell cycle control in glomerular disease
    Gunter Wolf
    Department of Medicine, Division of Nephrology, University of Hamburg, Hamburg, Germany
    Prog Cell Cycle Res 5:71-9. 2003
    ..Each leads to glomerular scarring, and a decline in renal function. Studies have shown that these events are critically controlled by cell cycle regulatory proteins, providing potential targets for the development of future therapeutics...
  63. ncbi request reprint Atrial natriuretic peptide attenuates ANG II-induced hypertrophy of renal tubular cells
    T Hannken
    Department of Medicine, Division of Nephrology and Osteology, University of Hamburg, D-20246 Hamburg, Germany
    Am J Physiol Renal Physiol 281:F81-90. 2001
    ..Although ANP and ANG II both stimulate generation of reactive oxygen species, ANP additionally induces expression of MKP-1, leading to interference with ANG II-mediated MAP kinase phosphorylation...
  64. ncbi request reprint Cell cycle regulatory proteins in renal disease: role in hypertrophy, proliferation, and apoptosis
    S J Shankland
    Department of Medicine, Division of Nephrology, University of Washington Seattle, Washington 98195 6521, USA
    Am J Physiol Renal Physiol 278:F515-29. 2000
    ..With increasing understanding of the role for cell cycle regulatory proteins in renal disease comes the hope for potential therapeutic interventions...
  65. ncbi request reprint Angiotensin II-induced reactive oxygen species and the kidney
    Anja Sachse
    Department of Medicine, University of Jena, Jena, Germany
    J Am Soc Nephrol 18:2439-46. 2007
    ..Although the concept that AngII mediates oxidative stress in the kidney has been validated in experimental models, the exact role is still incompletely understood in human renal diseases...
  66. ncbi request reprint Rapid development of severe end-organ damage in C57BL/6 mice by combining DOCA salt and angiotensin II
    F Kirchhoff
    Division of Nephrology, Department of Medicine, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Kidney Int 73:643-50. 2008
    ..Our study describes a new model of hypertensive end-organ damage and repair in C57BL/6 mice...
  67. pmc MicroRNA-155 drives TH17 immune response and tissue injury in experimental crescentic GN
    Christian F Krebs
    III Medizinische Klinik, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    J Am Soc Nephrol 24:1955-65. 2013
    ..These findings indicate that miR-155 drives the TH17 immune response and tissue injury in experimental crescentic GN and show that miR-155 is a potential therapeutic target in TH17-mediated diseases. ..
  68. ncbi request reprint Leptin and renal disease
    Gunter Wolf
    Department of Medicine, Division of Nephrology and Osteology, University of Hamburg, Germany
    Am J Kidney Dis 39:1-11. 2002
    ..These findings collectively suggest that the kidney is not only a site of leptin metabolism, but also a target organ for leptin action in pathophysiological states...
  69. ncbi request reprint CCKB/gastrin receptors mediate changes in sodium and potassium absorption in the isolated perfused rat kidney
    T von Schrenck
    Department of Medicine, Divisions of Nephrology and Clinical Chemistry, University Hospital Eppendorf, Hamburg, and Institute of Pathology, University of Rostock, Rostock, Germany
    Kidney Int 58:995-1003. 2000
    ..The functional effects of gastrin were studied under standardized in vitro conditions using the isolated perfused kidney...
  70. ncbi request reprint Renovascular hypertension does not influence repair of glomerular lesions induced by anti-thymocyte glomerulonephritis
    U O Wenzel
    Division of Nephrology, Department of Medicine, and Department of Pathology, University Hospital Hamburg, Germany
    Kidney Int 58:1135-47. 2000
    ..To evaluate this effect, we applied a model of glomerulonephritis in rats with two-kidney, one-clip hypertension and studied the effect of hypertension on the healing process of this nephritis...
  71. ncbi request reprint Monocyte chemoattractant protein-1 and osteopontin differentially regulate monocytes recruitment in experimental glomerulonephritis
    U Panzer
    Department of Medicine, Division of Nephrology, University of Hamburg, Hamburg, Germany
    Kidney Int 59:1762-9. 2001
    ..The roles of chemokines and osteopontin may thus be dependent on the renal compartment and on the disease model...
  72. ncbi request reprint Angiotensin II and tubular development
    Gunter Wolf
    Department of Medicine, Division of Nephrology and Osteology, University of Hamburg, University Hospital Eppendorf, Hamburg, Germany
    Nephrol Dial Transplant 17:48-51. 2002
    ..Therefore, alterations in AT2 receptor signalling may alter the delicate balance between growth stimulation and inhibition, leading to alterations in tubular formation...
  73. ncbi request reprint Diabetic nephropathy in type 2 diabetes prevention and patient management
    Gunter Wolf
    Department of Medicine, Division of Nephrology, University of Hamburg, Hamburg, Germany
    J Am Soc Nephrol 14:1396-405. 2003
  74. doi request reprint A kidney from hell? A nephrological view of the Whitechapel murders in 1888
    Gunter Wolf
    Department of Medicine, University of Jena, Jena, Germany
    Nephrol Dial Transplant 23:3343-9. 2008
    ..We will never know who this mentally disturbed 'nephrophilic' was. Today, the story of Jack the Ripper is part of contemporary culture...
  75. ncbi request reprint Renal handling of human apolipoprotein(a) and its fragments in the rat
    T Reblin
    Department of Medicine, Divisions of Cardiology and Nephrology and Osteology, University Hospital Eppendorf, Hamburg, Germany
    Am J Kidney Dis 38:619-30. 2001
    ..Despite the fact that rodents lack endogenous Lp(a), rats injected with human Lp(a) may provide a useful heterologous animal model to study the renal metabolism of Lp(a) further...
  76. doi request reprint No association between transmembrane protein-tyrosine-phosphatase receptor type C (CD45) exon A 77C>G transversion and Hashimoto's thyroiditis in a German population
    H Thude
    University Clinic Hamburg Eppendorf, Transplantation Centre, Department of Hepatobiliary and Transplant Surgery, Hamburg, Germany
    Hum Immunol 71:220-3. 2010
    ..2%, which did not significantly differ from 1.3% in controls (p = 0.871). Our data did not reveal any association between CD45 77C>G transversion and susceptibility to HT in a German population...
  77. ncbi request reprint The role of chemokines and chemokine receptors in diabetic nephropathy
    Christiane Ruster
    Friedrich Schiller University Jena, Department of Internal Medicine III, Erlanger Allee 101, D 07740 Jena, Germany
    Front Biosci 13:944-55. 2008
    ..Newer strategies point to chemokine receptor antagonists and even to immunosuppressive therapy, but still remain in the experimental stage...
  78. doi request reprint Advanced glycation end-products induce cell cycle arrest and hypertrophy in podocytes
    Christiane Ruster
    Klinik fur Innere Medizin III, Friedrich Schiller University, Jena, Germany
    Nephrol Dial Transplant 23:2179-91. 2008
    ..We and others have previously described that mice with a deletion in the gene for the cell cycle regulatory p27(Kip1) are protected from some features of diabetic nephropathy...
  79. doi request reprint Serum levels of the advanced glycation end products Nepsilon-carboxymethyllysine and pentosidine are not influenced by treatment with the angiotensin receptor II type 1 blocker irbesartan in patients with type 2 diabetic nephropathy and hypertension
    Martin Busch
    Department of Internal Medicine III, University of Jena, Jena, Germany
    Nephron Clin Pract 108:c291-7. 2008
    ....
  80. ncbi request reprint New aspects of the relationship among hypertension, obesity, and the kidneys
    Anja Sachse
    Klinik fur Innere Medizin III, University of Jena, Erlanger Allee 101, D 07347 Jena, Germany
    Curr Hypertens Rep 10:138-42. 2008
    ..The causal pathways linking excess weight to chronic kidney disease and hypertension are briefly reviewed in this article, and therapeutic approaches to combat this growing health problem are highlighted...
  81. ncbi request reprint Induction of p27KIP1 after unilateral ureteral obstruction is independent of angiotensin II
    Jens H Gerth
    Klinik für Innere Medizin IV der Universität Jena, Germany
    Kidney Int 61:68-79. 2002
    ..The current study tested the hypothesis that interference with the RAS may modulate renal expression of p27KIP1 after UUO...
  82. ncbi request reprint Molecular mechanisms of diabetic mesangial cell hypertrophy: a proliferation of novel factors
    Gunter Wolf
    J Am Soc Nephrol 13:2611-3. 2002
  83. ncbi request reprint Rosiglitazone increases PPARgamma in renal tubular epithelial cells and protects against damage by hydrogen peroxide
    Manfred Sommer
    Department of Internal Medicine III, University of Jena, Jena, Germany
    Am J Nephrol 27:425-34. 2007
    ....
  84. ncbi request reprint Age-related changes in the frequency of mesenchymal stem cells in the bone marrow of rats
    Sergey V Tokalov
    OncoRay Radiation Research in Oncology, Medical Faculty Carl Gustav Carus, University of Technology Dresden, 01307 Dresden, Germany
    Stem Cells Dev 16:439-46. 2007
    ....
  85. ncbi request reprint Angiotensin II stimulates alpha3(IV) collagen production in mouse podocytes via TGF-beta and VEGF signalling: implications for diabetic glomerulopathy
    Sheldon Chen
    Renal Electrolyte and Hypertension Division of the University of Pennsylvania, Philadelphia, PA, USA
    Nephrol Dial Transplant 20:1320-8. 2005
    ..Podocyte expression of alpha3(IV) collagen may involve the transforming growth factor-beta (TGF-beta) and vascular endothelial growth factor (VEGF) systems...
  86. ncbi request reprint New selective AT2 receptor ligands encompassing a gamma-turn mimetic replacing the amino acid residues 4-5 of angiotensin II act as agonists
    Ulrika Rosenström
    Department of Medicinal Chemistry, BMC, Uppsala University, Sweden
    J Med Chem 48:4009-24. 2005
    ..The pseudopeptides selected for agonist studies were shown to act as AT(2) receptor agonists being able to induce outgrowth of neurite cells, stimulate p42/p44(mapk), and suppress proliferation of PC12 cells...
  87. ncbi request reprint [The renin-angiotensin-aldosterone system -- more complex as previously thought]
    Gunter Wolf
    Klinik fur Innere Medizin III, Klinikum der Friedrich Schiller Universitat Jena, Jena
    Med Klin (Munich) 100:471-7. 2005
    ..ANG II has many pleiotropic effects on the kidney such as pro-inflammatory and profibrotic actions besides the well-known blood pressure-increasing effect...
  88. ncbi request reprint Why should an angiogenic factor modulate tubular structure in diabetic nephropathy? Some answers, more questions
    Fuad N Ziyadeh
    Kidney Int 64:758-9. 2003
  89. ncbi request reprint p27(Kip1) Knockout mice are protected from diabetic nephropathy: evidence for p27(Kip1) haplotype insufficiency
    Gunter Wolf
    Klinik fur Innere Medizin III, University of Jena, Jena, Germany
    Kidney Int 68:1583-9. 2005
    ..However, it is unclear whether deletion of p27(Kip1) protects the kidneys of diabetic nephropathy in vivo...
  90. ncbi request reprint "As time goes by": angiotensin II-mediated transactivation of the EGF receptor comes of age
    Gunter Wolf
    Department of Internal Medicine III, University Hospital Jena, Erlanger Allee 101, D 07740 Jena, Germany
    Nephrol Dial Transplant 20:2050-3. 2005
  91. ncbi request reprint P27Kip1: the "rosebud" of diabetic nephropathy?
    Gunter Wolf
    J Am Soc Nephrol 14:819-22. 2003
  92. ncbi request reprint Angiotensin II upregulates toll-like receptor 4 on mesangial cells
    Gunter Wolf
    Klinik fur Innere Medizin III, University of Jena, Germany, and Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    J Am Soc Nephrol 17:1585-93. 2006
    ..g., extracellular matrix components) in addition to microbial products, AngII-mediated upregulation of TLR4 also could be relevant for the development of inflammation in many noninfectious renal diseases...
  93. ncbi request reprint [Prevalence of renal insufficiency in the diabetes TUV of the Deutsche BKK]
    Gunter Wolf
    Klinik für Innere Medizin III der Friedrich Schiller Universität Jena, Jena
    Med Klin (Munich) 101:441-7. 2006
    ..The aim of this retrospective study was to screen the diabetes TUV registry data regarding nephropathy...
  94. ncbi request reprint Renal Angiotensin receptor type 1 and 2 upregulation in intrauterine growth restriction of newborn piglets
    Michael Ruster
    Department of Internal Medicine III, Universitatsklinikum Jena, Friedrich Schiller University, Germany
    Cells Tissues Organs 182:106-14. 2006
    ..Thus, IUGR is accompanied by an upregulation of angiotensin II receptor expression in the kidneys of newborn piglets. This may indicate an alteration of the RAS in newborns suffering from naturally occurring IUGR...
  95. ncbi request reprint [A rare cause of anemia in a kidney-transplant recipient]
    Jan von Ohsen
    Klinik für Innere Medizin III der Friedrich Schiller Universität Jena, Jena
    Med Klin (Munich) 101:577-82. 2006
    ..Anemia is a phenomenon frequently observed after kidney transplantation and differential diagnosis is broad...
  96. ncbi request reprint Leptin and renal fibrosis
    Gunter Wolf
    Department of Internal Medicine III, Friedrich Schiller University, Jena, Germany
    Contrib Nephrol 151:175-83. 2006
    ..These findings collectively suggest that the kidney is a target organ for leptin and that this hormone might play an important role in renal pathophysiology...
  97. ncbi request reprint The advanced glycation end product N(epsilon)-carboxymethyllysine is not a predictor of cardiovascular events and renal outcomes in patients with type 2 diabetic kidney disease and hypertension
    Martin Busch
    Department of Internal Medicine III and Institute of Medical Statistics and Computer Sciences, University of Jena, Germany
    Am J Kidney Dis 48:571-9. 2006
    ..The oxidatively formed AGE N(epsilon)-carboxymethyllysine (CML) is thought to be a marker of oxidative stress...
  98. ncbi request reprint Differential regulation of Toll-like receptor 4 gene expression in renal cells by angiotensin II: dependency on AP1 and PU.1 transcriptional sites
    Tzvetanka Bondeva
    Clinic of Internal Medicine III, University of Jena, Jena, Germany
    Am J Nephrol 27:308-14. 2007
    ..However, the factors controlling transcriptional activation of the Tlr4 gene in mesangial cells are not known, and the specificity of this response for other renal cells is unclear...
  99. ncbi request reprint A Friday afternoon case of apparent anti-glomerular basement nephritis
    Michael Ruster
    Department of Internal Medicine III, University Hospital Jena, Erlanger Allee 101, D 07747 Jena, Germany
    Nephrol Dial Transplant 21:2328-30. 2006