Research Topics
| Claus WittekindtSummaryAffiliation: University of Cologne Country: Germany Publications
| Collaborators
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Detail Information
Publications
Immunohistochemical expression of VEGF and VEGF receptors in nasal polyps as compared to normal turbinate mucosaClaus Wittekindt
Department of Otorhinolaryngology, University of Koln, Joseph Stelzmannstr 9, 50924 Köln, Germany
Eur Arch Otorhinolaryngol 259:294-8. 2002..These findings support a role for VEGF and its receptors, VEGFR-1 and VEGFR-2, in the development and perpetuation of edema and angiogenesis in nasal polyps...- Lymphatic malformations of the head and neck: introduction of a disease score for children, Cologne Disease Score (CDS)Claus Wittekindt
Clinic of Otorhinolaryngology, Head and Neck Surgery, University of Cologne, Cologne, Germany
Int J Pediatr Otorhinolaryngol 70:1205-12. 2006..A clinical staging system for children with lymphatic malformations that would allow for a standardized comparison of disease and treatment outcomes... - Botulinum toxin A for neuropathic pain after neck dissection: a dose-finding studyClaus Wittekindt
Department of Otorhinolaryngology, School of Medicine, Cologne, Germany
Laryngoscope 116:1168-71. 2006..Botulinum toxin type A (BtxA) has been reported to be feasible in chronic neuropathic pain after neck dissection. The impact of the dose on the outcome has not been investigated yet... - Expression of p16 protein is associated with human papillomavirus status in tonsillar carcinomas and has implications on survivalClaus Wittekindt
Department of Oto Rhino Laryngology, Head and Neck Surgery, Cologne, Germany
Adv Otorhinolaryngol 62:72-80. 2005..02). These data indicate that p16 is a technically simple immunohistological marker, applicable for routine pathological histology, and its prognostic value for survival is fully equivalent to HPV DNA detection... - [ANCA-negative subglottic laryngeal stenosis in childhood]C Wittekindt
Klinik und Poliklinik Fur Hals, Nasen, Ohren Heilkunde, Kopf und Hals Chirurgie am Klinikum der Universität zu Köln
HNO 55:807-11. 2007..Surgical interventions within the larynx or trachea might only be considered after ineffective therapy with immunosuppressive drugs... - Immunohistochemistry of whole-organ sections of advanced human laryngeal cancerClaus Wittekindt
Department of Otorhinolaryngology, Head and Neck Surgery, University of Cologne, Kerpener Str 62, 50924, Cologne, Germany
Eur Arch Otorhinolaryngol 263:741-6. 2006..By analyzation of color-coded fusion images the spatial expression of the respective antibodies could be visualized... - [Vascularized tumor of the scalp]C Wittekindt
, Nasen- und Ohrenkrankenheiten, , Cologne
HNO 51:737-8. 2003 - Rupture of the larynx in a newbornClaus Wittekindt
Departments of Otorhinolaryngology and Neonatology, Children s Hospital, University of Cologne, Cologne, Germany
Obstet Gynecol 99:904-6. 2002..Lesions of the laryngotrachea due to repeated intubation trauma after birth are reported... - Duplication of the external auditory canal: a report of three casesC Wittekindt
Department of Otorhinolaryngology, University of Cologne, Cologne, Germany
Int J Pediatr Otorhinolaryngol 58:179-84. 2001..In this retrospective study, clinical features and anatomical relationships are described in three pediatric cases. Therapeutical guidelines for surgical management of first branchial cleft anomalies are discussed... 
Electromyographic facial nerve monitoring during parotidectomy for benign lesions does not improve the outcome of postoperative facial nerve function: a prospective two-center trialMaria Grosheva
Department of Otorhinolaryngology, Head and Neck Surgery, University of Cologne, Jena, Germany
Laryngoscope 119:2299-305. 2009..To analyze the benefit of electromyographic (EMG) neuromonitoring during primary surgery on benign parotid lesions for postoperative facial function compared to visual observation only...- Prognostic impact of pretherapeutic laboratory values in head and neck cancer patientsFranziska Peter
Department of Otorhinolaryngology, Jena University Hospital, Lessingstrasse 2, 07740 Jena, Germany
J Cancer Res Clin Oncol 139:171-8. 2013..We investigated whether HNC and its comorbidity also influence routine laboratory values and whether these values have influence on overall survival... - Impact of lateral parotidectomy for benign tumors on quality of lifeDirk Beutner
Department of Otorhinolaryngology, Head and Neck Surgery, University of Cologne, Cologne, Germany
Acta Otolaryngol 126:1091-5. 2006..This study supports the use of lateral parotidectomy as a safe and standardized type of surgery for benign parotid gland disease... - Mapping of Ki-67 protein distribution on whole organ serial sections of the larynxClaus Wittekindt
Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Jena, Jena, Germany
Acta Otolaryngol 128:207-12. 2008..Immunostaining of whole organ serial sections of the larynx is feasible and will allow analysis of cellular alterations in the undisturbed anatomical context of whole organ serial sections of the larynx... - Recurrent pleomorphic adenoma of the parotid gland: analysis of 108 consecutive patientsClaus Wittekindt
Clinic of Otorhinolaryngology, Head and Neck Surgery, University of Cologne, D 50924 Cologne, Germany
Head Neck 29:822-8. 2007..Surgery for recurrent parotid pleomorphic adenoma is a challenging problem... - Diversity of treatment of T2N0 glottic cancer of the larynx: lessons to learn from epidemiological cancer registry dataMira Pantel
Department of Otorhinolaryngology, University Hospital, Friedrich Schiller University Jena, Jena, Germany
Acta Otolaryngol 131:1205-13. 2011..This should be the basis for future treatment standardization. Obligatory documentation of the R status and cause of death in the cancer registries will improve the data interpretation in the future... - High risk for bilateral Warthin tumor in heavy smokers--review of 185 casesJens Peter Klussmann
Department of Oto-Rhino-Laryngology, Head and Neck Surgery, University of Cologne, Cologne, Germany
Acta Otolaryngol 126:1213-7. 2006..Evaluation of risk factors revealed that 89% of the subjects were smokers and 66% were heavy smokers. The risk for bilateral Warthin tumors correlated significantly with the amount of nicotine intake (p=0.003)... - Safety and efficacy of botulinum toxin therapy in otorhinolaryngology: experience from 1,000 treatmentsVictor Helmstaedter
Department of Otorhinolaryngology Head and Neck Surgery, University of Cologne, Cologne, Germany
Laryngoscope 118:790-6. 2008.... - Evaluation of peripheral vocal cord paralysis by electromyographyMaria Grosheva
Department of Otorhinolaryngology, Head and Neck Surgery, University of Cologne, Germany
Laryngoscope 118:987-90. 2008..To analyze the predictive value of electromyography (EMG) after peripheral vocal cord paralysis and to estimate regeneration time... - Submandibular gland excision: 15 years of experienceSimon Florian Preuss
Department of Otorhinolaryngology, Head and Neck Surgery, University of Cologne, Cologne, Germany
J Oral Maxillofac Surg 65:953-7. 2007..The aim of this study was to review a single institution's experience of a nonselected case series of submandibular gland excision over 15 years... - Stent migration to the ileum: a potentially lethal complication after Montgomery salivary bypass tube placement for hypopharyngeal stenosis after laryngectomyThomas Bitter
Department of Otorhinolaryngology, Friedrich Schiller University, Jena, Germany
Head Neck 34:135-7. 2012..Generally, MSBT use is not associated with serious complications. Only a small number of cases with severe MSBT-associated complications have been reported in the literature... - Is there a need for positron emission tomography imaging to stage the N0 neck in T1-T2 squamous cell carcinoma of the oral cavity or oropharynx?Ursula Schroeder
Department of Otolaryngology Head and Neck Surgery, University of Cologne Medical Center, Cologne, Germany
Ann Otol Rhinol Laryngol 117:854-63. 2008.... - New aspects in parotid gland surgeryEberhard Stennert
Clinic of Oto-Rhino-Laryngology, Head and Neck Surgery, University of Cologne, Germany
Otolaryngol Pol 58:109-14. 2004..Of the 139 patients with clinical N0 neck 45% had occult neck metastasis. In conclusion neck dissection should be considered as an integral part of the surgical concept in major salivary gland cancer patients... - Carcinoma ex pleomorphic adenoma of the parotid gland. Study and implications for diagnostics and therapyJan Christoffer Luers
Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Cologne, Cologne, Germany
Acta Oncol 48:132-6. 2009..Prognosis is thought to be poorer than for other parotid malignancies. We sought to describe a general diagnostic and therapy strategy and assess factors predicting the outcome... - Expression of matrix metalloproteinase-9 (MMP-9) and blood vessel density in laryngeal squamous cell carcinomasClaus Wittekindt
Department of Otorhinolaryngology, Justus Liebig University, Giessen, Germany
Acta Otolaryngol 131:101-6. 2011..In this study we found that inflammatory cells may be a source of MMP-9 in laryngeal cancer. MMP-9 was correlated with blood vessel density. MMP-9 may be a potential target to disrupt tumor neovascularization... - Successful OK-432 therapy for a supraclavicular lymphocele: report of a caseSimon Florian Preuss
Department of Otorhinolaryngology, Head and Neck Surgery, School of Medicine, University of Cologne, Josef Stelzmann Str 9, 50924, Cologne, Germany
Eur Arch Otorhinolaryngol 263:692-4. 2006..Thus, intralesional application of OK-432 is considered a highly effective treatment for cystic masses such as lymphoceles... - Successful adjuvant tamoxifen therapy for estrogen receptor-positive metastasizing sweat gland adenocarcinoma: need for a clinical trial?Ursula Schröder
Clinic of Otorhinolaryngology Head and Neck Surgery, University of Cologne, Cologne, Germany
Ann Otol Rhinol Laryngol 113:242-4. 2004..We suggest examining the hormone receptor expression in these neoplasms regularly. A prospective study should be commenced to assess the benefit of adjuvant antihormonal therapy in eccrine gland adenocarcinomas... - Immunohistochemical detection of vascular endothelial growth factor (VEGF) and VEGF-receptors Flt-1 and KDR/Flk-1 in the vestibule of guinea pigsA Hess
Department of Oto Rhino Laryngology, University of Cologne, Joseph Stelzmannstr 9, D 50924, Cologne, France
Neurosci Lett 280:147-50. 2000..These findings give evidence that VEGF, Flt-1 and KDR/Flk-1 are constitutively expressed in the vestibule... - Hoarseness after laryngeal blunt trauma: a differential diagnosis between an injury to the external branch of the superior laryngeal nerve and an arytenoid subluxation. A case report and literature reviewU Schroeder
ENT Department, University of Cologne, Joseph Stelzmann Str 9, 50924, Cologne, Germany
Eur Arch Otorhinolaryngol 260:304-7. 2003..Although the clinical findings are familiar sequelae of thyroid surgery, they may be misdiagnosed as arytenoid subluxation after laryngeal blunt trauma. Stroboscopy and electromyography permitted the correct diagnosis... - The role of growth factors for disease and therapy in diseases of the head and neckO Guntinas-Lichius
Clinic of Otolaryngology, Head and Neck Surgery, University of Cologne, Germany
DNA Cell Biol 22:593-606. 2003..This review provides a brief account of what we know regarding growth factors in otorhinolaryngology, particularly in the field of otology, wound healing, oncology, peripheral nerve regeneration, and rhinology... - Textured polydimethylsiloxane elastomers in the human larynx: safety and efficiency of useC Sittel
Department of Otorhinolaryngology Head and Neck Surgery, University of Cologne, Germany
J Biomed Mater Res 53:646-50. 2000..Their use is a valuable and safe alternative when a definitive one-step procedure seems advantageous. However, further studies are needed to assess voice improvement in comparison to other materials... 
Nuclear survivin expression is associated with HPV-independent carcinogenesis and is an indicator of poor prognosis in oropharyngeal cancerS F Preuss
Department of Otorhinolaryngology, Head and Neck Surgery, School of Medicine, University Hospital of Cologne, Cologne, Germany
Br J Cancer 98:627-32. 2008..975; 95% CI=2.377-107.360; P=0.004, respectively). Our data show that nuclear accumulation of survivin correlates with HPV-independent carcinogenesis and is an independent predictor of poor survival in patients with OSCC...- [HPV-associated tonsillar cancer. An update]J P Klussmann
Klinik und Poliklinik für Hals Nasen Ohren Heilkunde des Klinikum der Universität zu Köln, Cologne
HNO 52:208-18. 2004..New insights and increasing evidence for the analogy of HPV-positive HNSCC with cervical cancer are discussed. The definition of HPV-positive HNSCC has become more important due to the implications for risk factors and prognosis... - [Indolent neck tumour. A 47 year old patient with a painless tumour in the area of the left mandibular angle]S F Preuss
, Nasen, Ohrenheilkunde,
HNO 53:876-8. 2005 - Detection of extracellular signal-regulated kinase1/2 in the inner ear of guinea pigsA Hess
Department of Oto Rhino Laryngology, University of Cologne, Joseph Stelzmannstrasse 9, D 50924, Cologne, Germany
Neurosci Lett 289:72-4. 2000..These findings provide evidence that activated ERK1/2, as a general downstream signal of growth factors, may be contributed in the inner ear physiology... - Long-term results of the combined modality therapy for advanced cervical metastatic head and neck squamous cell carcinomaS F Preuss
Department of Otorhinolaryngology, Head and Neck Surgery, Medical School, University of Cologne, Josef Stelzmann Str 9, 50924 Cologne, Germany
Eur J Surg Oncol 33:358-63. 2007..The aim of this retrospective study was to investigate the outcome of these patients uniformely using a strategy which consists of surgery for the primary tumor and the neck metastases followed by postoperative radio(chemo)therapy... - [Painful swelling of the soft tissue of the neck]D Beutner
HNO 53:637-8. 2005 - [An accessory retropharyngeal bone as a rare cause of dysphagia]D Beutner
Universitäts HNO Klinik Köln
HNO 54:473-4, 476. 2006..Dysphagia due to cervical spine osteophytes, Forestier's disease or progressive ossifying fibrodysplasia is well known. This case adds an isolated retropharyngeal bone formation as a rare cause of dysphagia to the literature... - [Chronic-persistent infection of the auricle]G Quante
, Nasen, Ohren-Heilkunde, Kopf- und Hals-Chirurgie,
HNO 54:35-6. 2006 - Botulinum toxin type b for the treatment of a sialocele after parotidectomyMira Pantel
Department of Otorhinolaryngology, University Hospital, Friedrich Schiller University Jena, Jena, Germany
Head Neck 35:E11-2. 2013..The sialocele was effectively treated by a single injection with botulinum toxin type B combined with multiple needle aspirations... - Prognostic value of anterior rhinomanometry in diode laser turbinoplastyGerd Fabian Volk
Department of Otorhinolaryngology, Friedrich Schiller Universitat, Lessingstraße 2, D 07743 Jena, Germany
Arch Otolaryngol Head Neck Surg 136:1015-9. 2010..To identify objective criteria predicting the success of diode laser-assisted turbinoplasty... - Management of bilateral arytenoid cartilage fixation versus recurrent laryngeal nerve paralysisHans Edmund Eckel
Department of Otorhinolaryngology, University of Cologne Medical School, Cologne, Germany
Ann Otol Rhinol Laryngol 112:103-8. 2003..Additional sites of stenosis were more frequent in ACF patients. Stenosis due to RLNP could be managed endoscopically without preliminary tracheotomy, while ACF frequently required open surgery and temporary tracheotomy... - Radiology quiz case 1: Intracranial schwannoma originating from the greater petrosal nerveClaus Wittekindt
University of Cologne, Cologne, Germany
Arch Otolaryngol Head Neck Surg 132:102, 104. 2006 - Recurrent pleomorphic adenoma of the parotid gland: a prospective histopathological and immunohistochemical studyEberhard Stennert
Department of Otolaryngology-Head and Neck Surgery, University of Cologne, Koeln, Germany
Laryngoscope 114:158-63. 2004..Therefore, a total parotidectomy including removal of surrounding fat tissue seems to be appropriate for the initial treatment of recurrent pleomorphic adenoma... - Prognostic value of electroneurography and electromyography in facial palsyMaria Grosheva
Department of Otorhinolaryngology, Head and Neck Surgery, University of Cologne, Cologne, Germany
Laryngoscope 118:394-7. 2008..To compare the prognostic value of electroneurography (ENG) and needle electromyography (EMG) to estimate facial function outcome after acute facial palsy... - Parotidectomy for benign parotid disease at a university teaching hospital: outcome of 963 operationsOrlando Guntinas-Lichius
Department of Otorhinolaryngology, Head and Neck Surgery, University of Cologne, Koeln, Germany
Laryngoscope 116:534-40. 2006..All teaching operations were performed under strict microscopic control and supervision of experienced surgeons... - Basics of tumor development and importance of human papilloma virus (HPV) for head and neck cancerClaus Wittekindt
University Hospital Giessen and Marburg, Department of Otorhinolaryngology, Head and Neck Surgery, Giessen, Germany
GMS Curr Top Otorhinolaryngol Head Neck Surg 11:Doc09. 2012..Future therapy concepts may vary for the two subgroups of patients, particularly patients with HPV-associated OSCC may take advantage of less aggressive treatments. Finally, an outlook will be given on possible targeted therapies... - Postoperative pain assessment after functional endoscopic sinus surgery (FESS) for chronic pansinusitisMira Finkensieper
Department of Otorhinolaryngology, University Hospital Jena, Lessingstrasse 2, 07740, Jena, Germany
Eur Arch Otorhinolaryngol 270:157-66. 2013..We conclude that QUIPS could help to optimize the quality of postoperative pain management following FESS... - Pyoderma gangrenosum in the head and neckClaus Wittekindt
Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Cologne, Cologne, Germany
Arch Otolaryngol Head Neck Surg 133:83-5. 2007 - Complications of suspension laryngoscopyJens Peter Klussmann
Department of Otorhinolaryngology-Head and Neck Surgery, University of Cologne, Cologne, Germany
Ann Otol Rhinol Laryngol 111:972-6. 2002..Although minor complications frequently occur during SL, it is a relatively safe procedure with a low risk of significant morbidity... - [Diagnostic and therapy of salivary gland diseases: relevant aspects for the pathologist from the clinical perspective]C Wittekindt
Klinik und Poliklinik Fur Hals, Nasen, Ohrenheilkunde, Universitatsklinikum, Friedrich Schiller Universitat, Lessingstr 2, 07740 Jena
Pathologe 30:424-31. 2009..Intraglandular injections have been shown to induce salivary gland atrophy in animal experiments. The availability of biologicals is currently yielding new aspects for the treatment of Sjögren's disease... - [Permeability of the round window membrane for prednisolone-21-hydrogen succinate. Prednisolone content of the perilymph after local administration vs. systemic injection]G Bachmann
, Nasen, Ohrenheilkunde,
HNO 49:538-42. 2001..After application of 5 mg, the levels of prednisolone are measurable up to 16 h... - In reference to limited parotidectomy: the role of extracapsular dissection in parotid gland neoplasmsDirk Beutner
Laryngoscope 118:379; author reply 379-80. 2008