Karsten Witt

Summary

Affiliation: University of Kiel
Country: Germany

Publications

  1. doi Relation of lead trajectory and electrode position to neuropsychological outcomes of subthalamic neurostimulation in Parkinson's disease: results from a randomized trial
    Karsten Witt
    Department of Neurology, Kiel University, Kiel, Germany
    Brain 136:2109-19. 2013
  2. doi [Frontotemporal dementias]
    K Witt
    Klinik fur Neurologie, Universitatsklinikum Schleswig Holstein, Campus Kiel, Schittenhelmstr 10, 24105 Kiel, Deutschland
    Nervenarzt 84:20-32. 2013
  3. ncbi Neuropsychological consequences of endarterectomy and endovascular angioplasty with stent placement for treatment of symptomatic carotid stenosis: a prospective randomised study
    Karsten Witt
    Department of Neurology, University Medical Center Schleswig Holstein, Campus Kiel, Schittenhelmstrasse 10, 24105 Kiel, Germany
    J Neurol 254:1524-32. 2007
  4. ncbi Differential effects of L-dopa and subthalamic stimulation on depressive symptoms and hedonic tone in Parkinson's disease
    Karsten Witt
    Department of Neurology, University Schleswig Holstein, Kiel, Germany
    J Neuropsychiatry Clin Neurosci 18:397-401. 2006
  5. ncbi The impact of normal aging and Parkinson's disease on response preparation in task-switching behavior
    Karsten Witt
    Department of Neurology, University Medical Center Schleswig Holstein Campus Kiel, Schittenhelmstrasse 10, D 24105 Kiel, Germany
    Brain Res 1114:173-82. 2006
  6. ncbi Patients with Parkinson's disease learn to control complex systems-an indication for intact implicit cognitive skill learning
    Karsten Witt
    Department of Neurology, University Medical Center Schleswig Holstein, Campus Kiel, Germany
    Neuropsychologia 44:2445-51. 2006
  7. doi Sleep consolidates the effector-independent representation of a motor skill
    K Witt
    Department of Neurology, University Medical Center Schleswig Holstein, Campus Kiel, Schittenhelmstrasse 10, D 24105 Kiel, Germany
    Neuroscience 171:227-34. 2010
  8. doi Negative impact of borderline global cognitive scores on quality of life after subthalamic nucleus stimulation in Parkinson's disease
    Karsten Witt
    Department of Neurology, Christian Albrechts University, Kiel, Germany
    J Neurol Sci 310:261-6. 2011
  9. doi Factors associated with neuropsychiatric side effects after STN-DBS in Parkinson's disease
    Karsten Witt
    Department of Neurology, Christian Albrechts University, Kiel, Germany
    Parkinsonism Relat Disord 18:S168-70. 2012
  10. doi Neuropsychological and psychiatric changes after deep brain stimulation for Parkinson's disease: a randomised, multicentre study
    Karsten Witt
    Christian Albrechts University, Kiel, Germany
    Lancet Neurol 7:605-14. 2008

Collaborators

Detail Information

Publications28

  1. doi Relation of lead trajectory and electrode position to neuropsychological outcomes of subthalamic neurostimulation in Parkinson's disease: results from a randomized trial
    Karsten Witt
    Department of Neurology, Kiel University, Kiel, Germany
    Brain 136:2109-19. 2013
    ..This study also stresses the importance of precise positioning of the active stimulating contact within the subthalamic volume to avoid adverse effects on semantic verbal fluency and response inhibition. ..
  2. doi [Frontotemporal dementias]
    K Witt
    Klinik fur Neurologie, Universitatsklinikum Schleswig Holstein, Campus Kiel, Schittenhelmstr 10, 24105 Kiel, Deutschland
    Nervenarzt 84:20-32. 2013
    ..Non-pharmacological therapies such as physiotherapy, occupational therapy, speech therapy and disease-specific education of the patient and their relatives are important to ensure a safe residential environment and daily routine...
  3. ncbi Neuropsychological consequences of endarterectomy and endovascular angioplasty with stent placement for treatment of symptomatic carotid stenosis: a prospective randomised study
    Karsten Witt
    Department of Neurology, University Medical Center Schleswig Holstein, Campus Kiel, Schittenhelmstrasse 10, 24105 Kiel, Germany
    J Neurol 254:1524-32. 2007
    ..The clinical relevance of these differences remains unknown. We therefore compared the neuropsychological consequences of CAS and CEA and additionally measured the S100beta protein, a marker of cerebral damage...
  4. ncbi Differential effects of L-dopa and subthalamic stimulation on depressive symptoms and hedonic tone in Parkinson's disease
    Karsten Witt
    Department of Neurology, University Schleswig Holstein, Kiel, Germany
    J Neuropsychiatry Clin Neurosci 18:397-401. 2006
    ..These results demonstrate a single dissociation of depressive symptoms and anhedonia in response to an acute L-dopa and STN-stimulation challenge...
  5. ncbi The impact of normal aging and Parkinson's disease on response preparation in task-switching behavior
    Karsten Witt
    Department of Neurology, University Medical Center Schleswig Holstein Campus Kiel, Schittenhelmstrasse 10, D 24105 Kiel, Germany
    Brain Res 1114:173-82. 2006
    ..This argues for different mechanisms that underlie the changes in task-switching behavior in healthy aging and PD...
  6. ncbi Patients with Parkinson's disease learn to control complex systems-an indication for intact implicit cognitive skill learning
    Karsten Witt
    Department of Neurology, University Medical Center Schleswig Holstein, Campus Kiel, Germany
    Neuropsychologia 44:2445-51. 2006
    ..These results demonstrate a functional independence of implicit cognitive skill learning and certain aspects of executive functions...
  7. doi Sleep consolidates the effector-independent representation of a motor skill
    K Witt
    Department of Neurology, University Medical Center Schleswig Holstein, Campus Kiel, Schittenhelmstrasse 10, D 24105 Kiel, Germany
    Neuroscience 171:227-34. 2010
    ..Sleep has the capacity to consolidate this transfer and, in this way, contributes to the generalisation of a motor skill...
  8. doi Negative impact of borderline global cognitive scores on quality of life after subthalamic nucleus stimulation in Parkinson's disease
    Karsten Witt
    Department of Neurology, Christian Albrechts University, Kiel, Germany
    J Neurol Sci 310:261-6. 2011
    ....
  9. doi Factors associated with neuropsychiatric side effects after STN-DBS in Parkinson's disease
    Karsten Witt
    Department of Neurology, Christian Albrechts University, Kiel, Germany
    Parkinsonism Relat Disord 18:S168-70. 2012
    ..In this review the role of the preoperative factors and also the relevance of the intraoperative and postoperative management is analyzed...
  10. doi Neuropsychological and psychiatric changes after deep brain stimulation for Parkinson's disease: a randomised, multicentre study
    Karsten Witt
    Christian Albrechts University, Kiel, Germany
    Lancet Neurol 7:605-14. 2008
    ..To assess the neuropsychiatric consequences of DBS in patients with PD we did an ancillary protocol as part of a randomised study that compared DBS with the best medical treatment...
  11. doi Is improvement in the quality of life after subthalamic nucleus stimulation in Parkinson's disease predictable?
    Christine Daniels
    Department of Neurology, Christian Albrechts University, Kiel, Germany
    Mov Disord 26:2516-21. 2011
    ..Improvement in QoL after STN-DBS is also correlated with changes in motor functions and changes in depression and anxiety...
  12. doi Risk factors for executive dysfunction after subthalamic nucleus stimulation in Parkinson's disease
    Christine Daniels
    Department of Neurology, Christian Albrechts University, Kiel, Germany
    Mov Disord 25:1583-9. 2010
    ....
  13. ncbi Deep brain stimulation of the subthalamic nucleus improves cognitive flexibility but impairs response inhibition in Parkinson disease
    Karsten Witt
    Department of Neurology, Christian Albrechts University Kiel, Kiel, Germany
    Arch Neurol 61:697-700. 2004
    ....
  14. ncbi Feedback-based versus observational classification learning in healthy aging and Parkinson's disease
    Julia Schmitt-Eliassen
    Department of Neurology, University Medical Center Schleswig Holstein, Campus Kiel, Kiel, Germany
    Brain Res 1142:178-88. 2007
    ..This finding questions the general role of the striatum in feedback-based learning and demonstrates that healthy aging particularly affects feedback-based learning...
  15. doi Influence of subthalamic deep brain stimulation versus levodopa on motor perseverations in Parkinson's disease
    Jan Herzog
    Department of Neurology, Christian Albrechts University, Schittenhelmstr 10, Kiel, Germany
    Mov Disord 24:1206-10. 2009
    ..7 +/- 2.6 (P < 0.001) whereas levodopa had no impact (R(2) reduction 3.7 +/- 1.6, P = 0.081). This demonstrates that STN-DBS, by reducing motor perseveration, influences higher order aspects of motor behavior of patients with PD...
  16. ncbi Subthalamic nucleus influences spatial orientation in extra-personal space
    Karsten Witt
    Department of Neurology, University Schleswig Holstein, Kiel, Germany
    Mov Disord 21:354-61. 2006
    ..These patterns of symptoms of neglect demonstrate the influence of the STN on the attentional system of the nondominant hemisphere...
  17. ncbi Manic episode with psychotic symptoms induced by subthalamic nucleus stimulation in a patient with Parkinson's disease
    Jan Herzog
    Department of Neurology, Christian Albrechts Universitat Kiel, Kiel, Germany
    Mov Disord 18:1382-4. 2003
    ..A manic episode with psychotic symptoms induced by STN-DBS occurred in a previously psychiatrically healthy patient, focusing on the role of STN-DBS in influencing not only motor but also emotional behaviour...
  18. pmc Skill memory escaping from distraction by sleep--evidence from dual-task performance
    Denis Ertelt
    Department of Neurology, University of Lubeck, Lubeck, Germany
    PLoS ONE 7:e50983. 2012
    ..In the present study we investigated the role of sleep in the off-line consolidation of procedural skills when attention is diverted from the procedural task because of interference from a concurrent task...
  19. ncbi Subthalamic nucleus stimulation for Parkinson's disease preferentially improves akinesia of proximal arm movements compared to finger movements
    Roland Wenzelburger
    Department of Neurology, Christian Albrechts Universitat Kiel, Kiel, Germany
    Mov Disord 18:1162-9. 2003
    ..Other akinesia items and the time for build-up of lifting force were equally improved in both conditions. This suggests that routine STN-DBS might not be equally effective on all aspects of fine motor functions...
  20. doi Neuropsychiatric effects of subthalamic neurostimulation in Parkinson disease
    Jens Volkmann
    Department of Neurology, Universitatsklinikum Schleswig Holstein, Campus Kiel, Arnold Heller Strasse 3, Haus 41, 24105 Kiel, Germany
    Nat Rev Neurol 6:487-98. 2010
    ..Here, we summarize the neuropsychiatric changes observed after STN HFS and try to disentangle their various etiologies...
  21. doi Subthreshold depression in Parkinson's disease
    Julia Reiff
    Department of Psychiatry, Zentrum für Integrative Psychiatrie, Kiel, Germany
    Mov Disord 26:1741-4. 2011
    ..Quality of life in Parkinson patients with subthreshold depression could be improved if the prevalence and symptom profile were better understood...
  22. doi Provocation of Parkinsonian tremor
    Jan Raethjen
    Department of Neurology, University of Kiel, Schittenhelmstr 10, Kiel, Germany
    Mov Disord 23:1019-23. 2008
    ..We therefore suggest that each assessment of Parkinsonian rest tremor should include a systematic provocation and this should be formally included in future versions of the UPDRS...
  23. ncbi Unusual presentation of carcinomatous meningitis: case report and review of typical CSF findings
    Jörn A Zeller
    Department of Neurology, Christian Albrechts University Kiel, Germany
    Neurol Res 24:652-4. 2002
    ..In cases of suspected carcinomatous meningitis the clustering of increased CSF protein, lactate, decreased glucose, and a high opening pressure is suggestive of the diagnosis...
  24. doi The subthalamic nucleus influences visuospatial attention in humans
    Barbara Schmalbach
    Christian Albrecht University, Kiel, Germany
    J Cogn Neurosci 26:543-50. 2014
    ..These results support the involvement of the subthalamic nucleus in modulating spatial attention. Therefore, the subthalamic nucleus is part of the subcortical network that subserves spatial attention. ..
  25. doi Clinical outcome of deep brain stimulation for Parkinson's disease
    Gunther Deuschl
    Department of Neurology, University Hospital Schleswig Holstein, Kiel Campus, Christian Albrechts University Kiel, Kiel, Germany
    Handb Clin Neurol 116:107-28. 2013
    ....
  26. doi Parkinson's disease and dementia: a longitudinal study (DEMPARK)
    Monika Balzer-Geldsetzer
    Department of Neurology, Philipps University Marburg, Marburg, Germany
    Neuroepidemiology 37:168-76. 2011
    ..Parkinson's disease (PD) is a progressive neurodegenerative motor disorder. However, non-motor complications frequently alter the course of the disease. A particularly disabling non-motor symptom is dementia...
  27. doi Rotated alphanumeric characters do not automatically activate frontoparietal areas subserving mental rotation
    Michael M Weiss
    Department of Neurology, Christian Albrechts University, Kiel, Germany
    Neuroimage 44:1063-73. 2009
    ..These results suggest that at least for alphanumerical characters, areas implicated in mental rotation will only be called into action if the task requires a rotational transformation...
  28. ncbi Decision-making in Parkinson's disease
    Karsten Witt
    Mov Disord 22:1371-2. 2007