Karsten Witt

..Non-pharmacological therapies such as physiotherapy, occupational therapy, speech therapy and disease-specific education of the patient and their relatives are important to ensure a safe residential environment and daily routine...

..In this review the role of the preoperative factors and also the relevance of the intraoperative and postoperative management is analyzed...

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..Sleep has the capacity to consolidate this transfer and, in this way, contributes to the generalisation of a motor skill...

..These results demonstrate a functional independence of implicit cognitive skill learning and certain aspects of executive functions...

..This argues for different mechanisms that underlie the changes in task-switching behavior in healthy aging and PD...

..These results demonstrate a single dissociation of depressive symptoms and anhedonia in response to an acute L-dopa and STN-stimulation challenge...

..The clinical relevance of these differences remains unknown. We therefore compared the neuropsychological consequences of CAS and CEA and additionally measured the S100beta protein, a marker of cerebral damage...

..To assess the neuropsychiatric consequences of DBS in patients with PD we did an ancillary protocol as part of a randomised study that compared DBS with the best medical treatment...

..Improvement in QoL after STN-DBS is also correlated with changes in motor functions and changes in depression and anxiety...

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..This finding questions the general role of the striatum in feedback-based learning and demonstrates that healthy aging particularly affects feedback-based learning...

..CONCLUSIONS: Short-term STN stimulation improves cognitive flexibility (giving up habitual responses) but impairs response inhibition. Long-term STN stimulation does not change global cognitive function...

..7 +/- 2.6 (P < 0.001) whereas levodopa had no impact (R(2) reduction 3.7 +/- 1.6, P = 0.081). This demonstrates that STN-DBS, by reducing motor perseveration, influences higher order aspects of motor behavior of patients with PD...

..These patterns of symptoms of neglect demonstrate the influence of the STN on the attentional system of the nondominant hemisphere...

..A manic episode with psychotic symptoms induced by STN-DBS occurred in a previously psychiatrically healthy patient, focusing on the role of STN-DBS in influencing not only motor but also emotional behaviour...

..Other akinesia items and the time for build-up of lifting force were equally improved in both conditions. This suggests that routine STN-DBS might not be equally effective on all aspects of fine motor functions...

..Quality of life in Parkinson patients with subthreshold depression could be improved if the prevalence and symptom profile were better understood...

..Here, we summarize the neuropsychiatric changes observed after STN HFS and try to disentangle their various etiologies...

..We therefore suggest that each assessment of Parkinsonian rest tremor should include a systematic provocation and this should be formally included in future versions of the UPDRS...

..In cases of suspected carcinomatous meningitis the clustering of increased CSF protein, lactate, decreased glucose, and a high opening pressure is suggestive of the diagnosis...

..Parkinson's disease (PD) is a progressive neurodegenerative motor disorder. However, non-motor complications frequently alter the course of the disease. A particularly disabling non-motor symptom is dementia...

..These results suggest that at least for alphanumerical characters, areas implicated in mental rotation will only be called into action if the task requires a rotational transformation...