Affiliation: University Hospital
- Animal models for Klinefelter's syndrome and their relevance for the clinicJoachim Wistuba
Institute of Reproductive and Regenerative Biology, Centre of Reproductive Medicine and Andrology, University Clinics, Domagkstrasse 11, 48149 Munster, Germany
Mol Hum Reprod 16:375-85. 2010....
- Male congenital hypothyroid Pax8-/- mice are infertile despite adequate treatment with thyroid hormoneJoachim Wistuba
Institute of Reproductive Medicine of the University, Domagkstr 11, 48149 Munster, Germany
J Endocrinol 192:99-109. 2007..It remains to be elucidated whether congenital hypothyroid male patients with mutations in the Pax8 gene are similarly affected...
- Male 41, XXY* mice as a model for klinefelter syndrome: hyperactivation of leydig cellsJoachim Wistuba
Centre of Reproductive Medicine and Andrology, University Clinics, Domagkstrasse 11, 48149 Muenster, Germany
Endocrinology 151:2898-910. 2010..We suggest that the embedding of Leydig cells into the changed testicular environment in 41 XX(Y)* males as such influences their endocrine function...
- Meiosis in autologous ectopic transplants of immature testicular tissue grafted to Callithrix jacchusJoachim Wistuba
Institute of Reproductive Medicine, University Munster, 48129 Munster, Germany
Biol Reprod 74:706-13. 2006..Further studies have to be performed to overcome the meiotic arrest to explore the model further and to develop therapeutic options...
- Changes in endocrine profile and reproductive organs during puberty in the male marmoset monkey (Callithrix jacchus)Ramesh K Chandolia
Institute for Reproductive Medicine of the University, Domagkstr 11, D-48129 Muenster, Germany
Reproduction 132:355-63. 2006....
- New horizons for in vitro spermatogenesis? An update on novel three-dimensional culture systems as tools for meiotic and post-meiotic differentiation of testicular germ cellsJan Bernd Stukenborg
Institute of Reproductive and Regenerative Biology of the Centre of Reproductive Medicine and Andrology, University Munster, Domagkstrasse 11 48129, Munster, Germany
Mol Hum Reprod 15:521-9. 2009..Further research efforts are required to reveal the applicability of this culture technique for human germ cells and the functionality of the spermatozoa for generating offspring...
- Complete spermatogenesis in orthotopic but not in ectopic transplants of autologously grafted marmoset testicular tissueC Marc Luetjens
Institute of Reproductive Medicine of the University, Domagkstrasse 11, Munster, Germany
Endocrinology 149:1736-47. 2008..Autologous grafting of nonhuman primate testicular tissues can result in complete spermatogenesis. Our findings indicate that transplantation site and developmental age of the tissue play a role more important than the endocrine milieu...
- Norethisterone enanthate has neither a direct effect on the testis nor on the epididymis: a study in adult male cynomolgus monkeys (Macaca fascicularis)Aris Junaidi
Institute of Reproductive Medicine of the University, , Germany
Eur J Endocrinol 152:655-61. 2005..CONCLUSIONS: Short-term NETE treatment has neither a direct effect on the testis nor on the epididymis in this nonhuman primate model and its contraceptive effects appear to be exerted exclusively through gonadotropin suppression...
- Coculture of spermatogonia with somatic cells in a novel three-dimensional soft-agar-culture-systemJan Bernd Stukenborg
Institute of Reproductive Medicine of the University, Domagkstrasse 11, 48129 Munster, Germany
J Androl 29:312-29. 2008..We conclude that our enrichment and culture approach is highly useful for exploration of SSC expansion and have found indications that the system supports differentiation up to the level of postmeiotic germ cells...
- LHR splicing variants and gene expression in the marmoset monkeyCaroline Michel
Institute of Reproductive Medicine of the University, Domagkstrasse 11, D 48149 Muenster, Germany
Mol Cell Endocrinol 279:9-15. 2007..We conclude that LHR splicing in the marmoset displays a homogenous pattern and that the main function of the LHR is established in the testis, reaching its highest efficiency during pubertal maturation...
- Organization of seminiferous epithelium in primates: relationship to spermatogenic efficiency, phylogeny, and mating systemJoachim Wistuba
Institute of Reproductive Medicine of the University, Domagkstrasse 11, , Germany
Biol Reprod 69:582-91. 2003..We speculate that the presence of a single-stage/multistage organization might simply reflect germ cell clonal size. Our findings further indicate that sperm competition in primates is not reflected at the level of testicular function...
- Pharmacokinetics and pharmacodynamics of injectable testosterone undecanoate in castrated cynomolgus monkeys (Macaca fascicularis) are independent of different oil vehiclesJoachim Wistuba
Institute of Reproductive Medicine of the University, , Germany
J Med Primatol 34:178-87. 2005..The results suggest that TU in soybean oil produces similar effects as TU in the other vehicles. This study in non-human primates provides no objection to testing of this new preparation in humans...
- Primate spermatogenesis: new insights into comparative testicular organisation, spermatogenic efficiency and endocrine controlC Marc Luetjens
Institute of Reproductive Medicine of the University, Domagkstrasse 11, D-48129 Minster, Germany
Biol Rev Camb Philos Soc 80:475-88. 2005..In summary, key spermatogenic features are preserved across all primate taxa whereas male reproductive endocrinology features appear substantially different in the neotropical primates compared to other primate lineages...
- Experimental endocrine manipulation by contraceptive regimen in the male marmoset (Callithrix jacchus)Joachim Wistuba
Institute of Reproductive and Regenerative Biology, Centre of Reproductive Medicine and Andrology, University of Munster, Albert Schweitzer Campus 1, Building D11, 48129 Munster, Germany
Reproduction 145:439-51. 2013..In conclusion, marmosets showed a different response to regimens of male contraception from macaques or men and have to be considered as a problematic model for preclinical trials of male hormonal contraception...
- Cografting of hamster (Phodopus sungorus) and marmoset (Callithrix jacchus) testicular tissues into nude mice does not overcome blockade of early spermatogenic differentiation in primate graftsJoachim Wistuba
Institute of Reproductive Medicine, , , Germany
Biol Reprod 71:2087-91. 2004..Our results indicate that the conditions needed for initiation of spermatogenesis in the marmoset are remarkably different from those present in most other mammals...
- A new subclass of the luteinizing hormone/chorionic gonadotropin receptor lacking exon 10 messenger RNA in the New World monkey (Platyrrhini) lineageJorg Gromoll
Institute of Reproductive Medicine of the University, University of Munster, D 48129 Munster, Germany
Biol Reprod 69:75-80. 2003..In addition, the high expression of CG beta in the marmoset pituitary suggests a physiological role of CG in the reproductive function of these primates beyond pregnancy...
- Minutes of the 14th European workshop on molecular and cellular endocrinology of the testisJorg Gromoll
Institute of Reproductive Medicine of the University, Domagkstrasse 11, D 48129 Munster, Germany
Mol Cell Endocrinol 257:1-5. 2006
- Expression of selected genes escaping from X inactivation in the 41, XX(Y)* mouse model for Klinefelter's syndromeSteffi Werler
Institute of Reproductive and Regenerative Biology, Centre of Reproductive Medicine and Andrology, University Clinics, Muenster, Germany
Acta Paediatr 100:885-91. 2011..We evaluated the expression of selected X-linked genes in our 41, XX(Y)* male mice to determine whether these genes escape inactivation and whether tissue-specific differences occur...
- Testosterone-induced prostate growth is blocked by co- and preadministration of norethisterone enanthate in castrated cynomolgus monkeysJoachim Wistuba
Centre of Reproductive Medicine and Andrology, University Hospital, Munster, Germany joachim wistuba ukmuenster de
Urol Int 88:358-64. 2012..Examining the role of progestins, we studied the effects of norethisterone (NET) on testosterone undecanoate (TU)-induced prostate growth in castrated macaques...
- Transgenic mouse models and germ cell transplantation: two excellent tools for the analysis of genes regulating male fertilityJoachim Wistuba
Institute of Reproductive Medicine of the University, Domagkstr. 11, 48149, , Germany
Mol Genet Metab 77:61-7. 2002..The successful culture, cryopreservation, and stable transfection of spermatogonial stem cells combined with the germ cell transplantation technique provide an alternative route for manipulation of the male germ line...
- Intrauterine bisphenol A exposure leads to stimulatory effects on Sertoli cell number in ratsJoachim Wistuba
Institute of Reproductive Medicine of the University, Domagkstrasse11, , Germany
Environ Res 91:95-103. 2003....
- Transplantation of wild-type spermatogonia leads to complete spermatogenesis in testes of cyclic 3',5'-adenosine monophosphate response element modulator-deficient miceJoachim Wistuba
Institute of Reproductive Medicine of the University, D 48129 Munster, Germany
Biol Reprod 67:1052-7. 2002..The testicular environment of CREM-deficient mice is not essentially affected and is able to support complete spermatogenesis in the presence of wild-type germ cells...
- Comparative marker analysis after isolation and culture of testicular cells from the immature marmosetSilvia Albert
Center of Reproductive Medicine and Andrology, Institute of Reproductive and Regenerative Biology, Albert Schweitzer Campus 1, University of Munster, Munster, Germany
Cells Tissues Organs 196:543-54. 2012..The PTC culture system established in this study will facilitate the identification of factors influencing male sex differentiation and spermatogenesis...