Stefan Wirtz

Summary

Affiliation: University of Erlangen-Nuremberg
Country: Germany

Publications

  1. pmc Interleukin-35 mediates mucosal immune responses that protect against T-cell-dependent colitis
    Stefan Wirtz
    Medical Department 1, University of Erlangen Nuremberg, Erlangen, Germany
    Gastroenterology 141:1875-86. 2011
  2. doi request reprint Confocal laser endomicroscopy and narrow-band imaging-aided endoscopy for in vivo imaging of colitis and colon cancer in mice
    Maximilian J Waldner
    Department of Medicine I, University of Erlangen Nuremberg, Erlangen, Germany
    Nat Protoc 6:1471-81. 2011
  3. doi request reprint TH9 cells that express the transcription factor PU.1 drive T cell-mediated colitis via IL-9 receptor signaling in intestinal epithelial cells
    Katharina Gerlach
    Department of Medicine 1, University of Erlangen Nuremberg, Kussmaul Campus for Medical Research, Erlangen, Germany
    Nat Immunol 15:676-86. 2014
  4. doi request reprint A variant of Smurf2 protects mice against colitis-associated colon cancer by inducing transforming growth factor β signaling
    Heike Dornhoff
    Department of Medicine, University of Erlangen Nuremberg, Erlangen and Nuremberg, Germany
    Gastroenterology 142:1183-1194.e4. 2012
  5. pmc Interleukin-33-dependent innate lymphoid cells mediate hepatic fibrosis
    Tamar McHedlidze
    Medical Department 1, Friedrich Alexander University Erlangen Nuremberg, 91054 Erlangen, Germany
    Immunity 39:357-71. 2013
  6. doi request reprint Interferon Gamma Counteracts the Angiogenic Switch and Induces Vascular Permeability in Dextran Sulfate Sodium Colitis in Mice
    Lisa Haep
    Division of Molecular and Experimental Surgery, Department of Surgery, University Medical Center Erlangen, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany Roche Pharma Research and Early Development, Oncology Discovery, Roche Innovation Center Penzberg, Penzberg, Germany Institute of Molecular Immunology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Munich, Germany Department of Medicine I, University Medical Center Erlangen, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany and Institute of Pathology, Klinikum Bayreuth, Bayreuth, Germany
    Inflamm Bowel Dis 21:2360-71. 2015
  7. doi request reprint Externalized decondensed neutrophil chromatin occludes pancreatic ducts and drives pancreatitis
    Moritz Leppkes
    Department of Medicine 1, University Clinics Erlangen, University of Erlangen Nuremberg, 91054 Erlangen, Germany
    Nat Commun 7:10973. 2016
  8. pmc The Mincle-activating adjuvant TDB induces MyD88-dependent Th1 and Th17 responses through IL-1R signaling
    Christiane Desel
    Institute of Clinical Microbiology, Immunology and Hygiene, University Hospital Erlangen, Erlangen, Germany
    PLoS ONE 8:e53531. 2013
  9. doi request reprint Assessment of tumor development and wound healing using endoscopic techniques in mice
    Markus F Neurath
    Medical Clinic 1, Friedrich Alexander University, Erlangen, Germany
    Gastroenterology 139:1837-1843.e1. 2010

Collaborators

Detail Information

Publications9

  1. pmc Interleukin-35 mediates mucosal immune responses that protect against T-cell-dependent colitis
    Stefan Wirtz
    Medical Department 1, University of Erlangen Nuremberg, Erlangen, Germany
    Gastroenterology 141:1875-86. 2011
    ..We investigated the roles of IL-27 and IL-35 in chronic inflammation of the intestine...
  2. doi request reprint Confocal laser endomicroscopy and narrow-band imaging-aided endoscopy for in vivo imaging of colitis and colon cancer in mice
    Maximilian J Waldner
    Department of Medicine I, University of Erlangen Nuremberg, Erlangen, Germany
    Nat Protoc 6:1471-81. 2011
    ..Mouse NBI endoscopy and CLE represent reliable and fast high-quality techniques for the endoscopic characterization and molecular imaging of the mucosa in colitis and colon cancer...
  3. doi request reprint TH9 cells that express the transcription factor PU.1 drive T cell-mediated colitis via IL-9 receptor signaling in intestinal epithelial cells
    Katharina Gerlach
    Department of Medicine 1, University of Erlangen Nuremberg, Kussmaul Campus for Medical Research, Erlangen, Germany
    Nat Immunol 15:676-86. 2014
    ....
  4. doi request reprint A variant of Smurf2 protects mice against colitis-associated colon cancer by inducing transforming growth factor β signaling
    Heike Dornhoff
    Department of Medicine, University of Erlangen Nuremberg, Erlangen and Nuremberg, Germany
    Gastroenterology 142:1183-1194.e4. 2012
    ..We identified a splice variant of Smurf2 (ΔE2Smurf2) and investigated its role in colon carcinogenesis in mice...
  5. pmc Interleukin-33-dependent innate lymphoid cells mediate hepatic fibrosis
    Tamar McHedlidze
    Medical Department 1, Friedrich Alexander University Erlangen Nuremberg, 91054 Erlangen, Germany
    Immunity 39:357-71. 2013
    ..Our data reveal key immunological networks implicated in hepatic fibrosis and support the concept of modulation of IL-33 bioactivity for therapeutic purposes. ..
  6. doi request reprint Interferon Gamma Counteracts the Angiogenic Switch and Induces Vascular Permeability in Dextran Sulfate Sodium Colitis in Mice
    Lisa Haep
    Division of Molecular and Experimental Surgery, Department of Surgery, University Medical Center Erlangen, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany Roche Pharma Research and Early Development, Oncology Discovery, Roche Innovation Center Penzberg, Penzberg, Germany Institute of Molecular Immunology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Munich, Germany Department of Medicine I, University Medical Center Erlangen, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany and Institute of Pathology, Klinikum Bayreuth, Bayreuth, Germany
    Inflamm Bowel Dis 21:2360-71. 2015
    ..Based on previous studies showing that IFN-γ acts antiangiogenic in colorectal carcinoma, we investigated the effects of IFN-γ on the vascular system in IBD...
  7. doi request reprint Externalized decondensed neutrophil chromatin occludes pancreatic ducts and drives pancreatitis
    Moritz Leppkes
    Department of Medicine 1, University Clinics Erlangen, University of Erlangen Nuremberg, 91054 Erlangen, Germany
    Nat Commun 7:10973. 2016
    ..Ductal occlusion by aggregated NETs emerges as a pathomechanism with relevance in a plethora of inflammatory conditions involving secretory ducts. ..
  8. pmc The Mincle-activating adjuvant TDB induces MyD88-dependent Th1 and Th17 responses through IL-1R signaling
    Christiane Desel
    Institute of Clinical Microbiology, Immunology and Hygiene, University Hospital Erlangen, Erlangen, Germany
    PLoS ONE 8:e53531. 2013
    ..Our data suggest that the glycolipid adjuvant TDB triggers Mincle-dependent IL-1 production to induce MyD88-dependent Th1/Th17 responses in vivo...
  9. doi request reprint Assessment of tumor development and wound healing using endoscopic techniques in mice
    Markus F Neurath
    Medical Clinic 1, Friedrich Alexander University, Erlangen, Germany
    Gastroenterology 139:1837-1843.e1. 2010
    ..Finally, mouse endoscopy can help to reduce animal numbers needed to gain significant experimental data...