Michael Winkler

Summary

Affiliation: University of Ulm
Country: Germany

Publications

  1. pmc Human cytomegalovirus tegument protein ppUL35 is important for viral replication and particle formation
    Karina Schierling
    Abteilung Virologie, Universitatsklinikum Ulm, Albert Einstein Allee 11, D 89081 Ulm, Germany
    J Virol 79:3084-96. 2005
  2. pmc Human cytomegalovirus tegument proteins ppUL82 (pp71) and ppUL35 interact and cooperatively activate the major immediate-early enhancer
    Karina Schierling
    Abteilung Virologie, Universitatsklinikum Ulm, Ulm, Germany
    J Virol 78:9512-23. 2004
  3. pmc RBP-Jkappa/SHARP recruits CtIP/CtBP corepressors to silence Notch target genes
    Franz Oswald
    Department of Internal Medicine I, University of Ulm, Robert Koch Strasse 8, D 89081 Ulm, Germany
    Mol Cell Biol 25:10379-90. 2005
  4. ncbi request reprint Human cytomegalovirus-induced reduction of extracellular matrix proteins in vascular smooth muscle cell cultures: a pathomechanism in vasculopathies?
    Barbara Reinhardt
    Institute of Virology, Department of Clinical Chemistry, University of Ulm, Albert Einstein Allee 11, 89081 Ulm, Germany
    J Gen Virol 87:2849-58. 2006
  5. pmc Open reading frame UL26 of human cytomegalovirus encodes a novel tegument protein that contains a strong transcriptional activation domain
    Thomas Stamminger
    Institut für Klinische und Molekulare Virologie der Universität Erlangen Nürnberg, 91054 Erlangen, Germany
    J Virol 76:4836-47. 2002
  6. pmc A nonconventional nuclear localization signal within the UL84 protein of human cytomegalovirus mediates nuclear import via the importin alpha/beta pathway
    Peter Lischka
    Institut für Klinische und Molekulare Virologie der Universität Erlangen Nürnberg, D 91054 Erlangen, Germany
    J Virol 77:3734-48. 2003
  7. doi request reprint Fluorescence-based antiviral assay for the evaluation of compounds against vaccinia virus, varicella zoster virus and human cytomegalovirus
    Fabiana Dal Pozzo
    Rega Institute for Medical Research, K U Leuven, Minderbroedersstraat 10, 3000 Leuven, Belgium
    J Virol Methods 151:66-73. 2008

Collaborators

  • Franz Oswald
  • T Stamminger
  • G Andrei
  • E De Clercq
  • D Michel
  • Erik De Clercq
  • Karina Schierling
  • Thomas Mertens
  • Fabiana Dal Pozzo
  • Barbara Reinhardt
  • Peter Lischka
  • Robert Snoeck
  • Jacques Piette
  • Dirk Daelemans
  • Shaoxia Zhou
  • Bianca Vaida
  • Robert Pretsch
  • Peter Schaarschmidt
  • Max Bachem
  • Paul Walther
  • Alexandra Schmid-Kotsas
  • Christopher Buser
  • Michael Kann
  • Gabriele Sorg

Detail Information

Publications7

  1. pmc Human cytomegalovirus tegument protein ppUL35 is important for viral replication and particle formation
    Karina Schierling
    Abteilung Virologie, Universitatsklinikum Ulm, Albert Einstein Allee 11, D 89081 Ulm, Germany
    J Virol 79:3084-96. 2005
    ..However, the particles produced by wild-type and mutant viruses did not show significant ultrastructural differences. These results suggest an important role for ppUL35 in immediate-early gene expression and virus assembly...
  2. pmc Human cytomegalovirus tegument proteins ppUL82 (pp71) and ppUL35 interact and cooperatively activate the major immediate-early enhancer
    Karina Schierling
    Abteilung Virologie, Universitatsklinikum Ulm, Ulm, Germany
    J Virol 78:9512-23. 2004
    ..These results suggest an important role for this interaction in the stimulation of viral immediate-early gene expression and viral infection...
  3. pmc RBP-Jkappa/SHARP recruits CtIP/CtBP corepressors to silence Notch target genes
    Franz Oswald
    Department of Internal Medicine I, University of Ulm, Robert Koch Strasse 8, D 89081 Ulm, Germany
    Mol Cell Biol 25:10379-90. 2005
    ..Furthermore, the endogenous Hey1 promoter is derepressed in CtBP-deficient cells. We propose that a corepressor complex containing CtIP/CtBP facilitates RBP-Jkappa/SHARP-mediated repression of Notch target genes...
  4. ncbi request reprint Human cytomegalovirus-induced reduction of extracellular matrix proteins in vascular smooth muscle cell cultures: a pathomechanism in vasculopathies?
    Barbara Reinhardt
    Institute of Virology, Department of Clinical Chemistry, University of Ulm, Albert Einstein Allee 11, 89081 Ulm, Germany
    J Gen Virol 87:2849-58. 2006
    ..These may represent molecular mechanisms for HCMV-induced pathogenesis of inflammatory vasculopathies and may facilitate dissemination of HCMV by promoting the detachment of infected cells in vivo...
  5. pmc Open reading frame UL26 of human cytomegalovirus encodes a novel tegument protein that contains a strong transcriptional activation domain
    Thomas Stamminger
    Institut für Klinische und Molekulare Virologie der Universität Erlangen Nürnberg, 91054 Erlangen, Germany
    J Virol 76:4836-47. 2002
    ..Our data suggest that pUL26 is a novel tegument protein of HCMV with a strong transcriptional activation domain that could play an important role during initiation of the viral replicative cycle...
  6. pmc A nonconventional nuclear localization signal within the UL84 protein of human cytomegalovirus mediates nuclear import via the importin alpha/beta pathway
    Peter Lischka
    Institut für Klinische und Molekulare Virologie der Universität Erlangen Nürnberg, D 91054 Erlangen, Germany
    J Virol 77:3734-48. 2003
    ..Although containing a cluster of basic amino acids similar to classical NLSs, this cluster did not contain the NLS activity. Thus, a complex structure appears to be essential for importin alpha binding and import activity...
  7. doi request reprint Fluorescence-based antiviral assay for the evaluation of compounds against vaccinia virus, varicella zoster virus and human cytomegalovirus
    Fabiana Dal Pozzo
    Rega Institute for Medical Research, K U Leuven, Minderbroedersstraat 10, 3000 Leuven, Belgium
    J Virol Methods 151:66-73. 2008
    ..Furthermore the fluorimetric data could be confirmed by a flow cytometry assay. GFP- and EYFP-recombinant viruses proved to be a convenient tool for the evaluation of antiviral agents...