Harriet Wikman

Summary

Affiliation: University of Hamburg
Country: Germany

Publications

  1. pmc Relevance of PTEN loss in brain metastasis formation in breast cancer patients
    Harriet Wikman
    Institute of Tumor Biology, University Medical Center Hamburg Eppendorf, Martinistreet 52, 20246 Hamburg, Germany
    Breast Cancer Res 14:R49. 2012
  2. ncbi request reprint Regulation of the G1/S phase of the cell cycle and alterations in the RB pathway in human lung cancer
    Harriet Wikman
    Institute of Tumor Biology, Center of Experimental Medicine, University Medical Center Hamburg Eppendorf Martinistrasse 52, D 20246 Hamburg, Germany
    Expert Rev Anticancer Ther 6:515-30. 2006
  3. pmc Clinical relevance of loss of 11p15 in primary and metastatic breast cancer: association with loss of PRKCDBP expression in brain metastases
    Harriet Wikman
    Institute of Tumor Biology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    PLoS ONE 7:e47537. 2012
  4. doi request reprint Frequent genetic alterations in EGFR- and HER2-driven pathways in breast cancer brain metastases
    Ina Hohensee
    Department of Tumor Biology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Am J Pathol 183:83-95. 2013
  5. doi request reprint Opposite roles of FOXA1 and NKX2-1 in lung cancer progression
    Lena Deutsch
    Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg Eppendorf, Germany
    Genes Chromosomes Cancer 51:618-29. 2012
  6. doi request reprint Biologic role of activated leukocyte cell adhesion molecule overexpression in breast cancer cell lines and clinical tumor tissue
    Sibyll Hein
    Department of Gynecology, University Medical Center Hamburg Eppendorf, Martinistr 52, 20246, Hamburg, Germany
    Breast Cancer Res Treat 129:347-60. 2011
  7. doi request reprint Genomic profiles associated with early micrometastasis in lung cancer: relevance of 4q deletion
    Michaela Wrage
    Institute of Tumor Biology and Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Clin Cancer Res 15:1566-74. 2009
  8. doi request reprint Cancer micrometastasis and tumour dormancy
    Harriet Wikman
    Institute of Tumour Biology, University Medical Center Hamburg Eppendorf, Germany
    APMIS 116:754-70. 2008
  9. doi request reprint Review: Biological relevance of disseminated tumor cells in cancer patients
    Sabine Riethdorf
    Institute of Tumor Biology, Center of Experimental Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Int J Cancer 123:1991-2006. 2008
  10. doi request reprint Molecular and genetic changes in asbestos-related lung cancer
    Penny Nymark
    Finnish Institute of Occupational Health, 00250 Helsinki, Finland
    Cancer Lett 265:1-15. 2008

Collaborators

  • Manfred Westphal
  • Guido Sauter
  • Karin Milde-Langosch
  • Bauke Ylstra
  • Burkhard Brandt
  • Robert Vessella
  • Emre F Yekebas
  • Jussuf T Kaifi
  • Sisko Anttila
  • Klaus Pantel
  • Sabine Riethdorf
  • Penny Nymark
  • Markus Glatzel
  • Michaela Wrage
  • Jaakko Hollmén
  • Ina Hohensee
  • Volkmar Muller
  • Lena Deutsch
  • Sibyll Hein
  • Jakob R Izbicki
  • Thomas Streichert
  • Salla Ruosaari
  • Antti Karjalainen
  • Sakari Knuutila
  • Eeva Kettunen
  • Jakob Matschke
  • Isabell Witzel
  • Katrin Lamszus
  • Sönke Meyer-Staeckling
  • Asad Kutup
  • Susann Koops
  • Faik G Uzunoglu
  • Andrea Hinsch
  • Michaela Schweizer
  • Nadine Köhler
  • Maike Ihnen
  • Fritz Janicke
  • Rana Issa
  • Volker Assmann
  • Katrin Beck
  • Sylke Krenkel
  • Paul P Eijk
  • Ruud H Brakenhoff
  • Tuija Hienonen-Kempas
  • Esa Vanhala
  • Irmeli Lindström
  • Jarmo Salo
  • Reijo Salovaara
  • Jouni K Seppänen
  • Karin Mattson
  • Henrik Edgren
  • Anna Maria Nissén

Detail Information

Publications15

  1. pmc Relevance of PTEN loss in brain metastasis formation in breast cancer patients
    Harriet Wikman
    Institute of Tumor Biology, University Medical Center Hamburg Eppendorf, Martinistreet 52, 20246 Hamburg, Germany
    Breast Cancer Res 14:R49. 2012
    ..Therefore, our aim was to identify molecular markers associated with the development of brain metastases in breast cancer...
  2. ncbi request reprint Regulation of the G1/S phase of the cell cycle and alterations in the RB pathway in human lung cancer
    Harriet Wikman
    Institute of Tumor Biology, Center of Experimental Medicine, University Medical Center Hamburg Eppendorf Martinistrasse 52, D 20246 Hamburg, Germany
    Expert Rev Anticancer Ther 6:515-30. 2006
    ..This review summarizes recent experiments describing the variable roles of key-player molecules of the RB pathway and different mechanisms by which the RB pathway can be altered in lung cancer...
  3. pmc Clinical relevance of loss of 11p15 in primary and metastatic breast cancer: association with loss of PRKCDBP expression in brain metastases
    Harriet Wikman
    Institute of Tumor Biology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    PLoS ONE 7:e47537. 2012
    ..In conclusion, we found loss at 11p15 to be a marker for TNBC primary tumors and BCBM and PRKCDBP to be a potential target gene in this locus...
  4. doi request reprint Frequent genetic alterations in EGFR- and HER2-driven pathways in breast cancer brain metastases
    Ina Hohensee
    Department of Tumor Biology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Am J Pathol 183:83-95. 2013
    ..In contrast, none of these pathways was associated with an increased risk of bone metastasis. These findings highlight the importance of both pathways as possible targets in the treatment of brain metastases in breast cancer...
  5. doi request reprint Opposite roles of FOXA1 and NKX2-1 in lung cancer progression
    Lena Deutsch
    Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg Eppendorf, Germany
    Genes Chromosomes Cancer 51:618-29. 2012
    ..039). These results suggest that both FOXA1 and NKX2-1 may act as lineage-specific target genes within the 14q amplicon with opposite functions in lung cancer...
  6. doi request reprint Biologic role of activated leukocyte cell adhesion molecule overexpression in breast cancer cell lines and clinical tumor tissue
    Sibyll Hein
    Department of Gynecology, University Medical Center Hamburg Eppendorf, Martinistr 52, 20246, Hamburg, Germany
    Breast Cancer Res Treat 129:347-60. 2011
    ..048) and overall survival (OAS, P=0.003). Our results indicate that the biologic role of ALCAM in breast cancer is complex, but overexpression might be relevant for outcome in ductal carcinomas...
  7. doi request reprint Genomic profiles associated with early micrometastasis in lung cancer: relevance of 4q deletion
    Michaela Wrage
    Institute of Tumor Biology and Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Clin Cancer Res 15:1566-74. 2009
    ..It is still unclear whether the shedding of DTC from the primary tumor is a random process or a selective release driven by a specific genomic pattern...
  8. doi request reprint Cancer micrometastasis and tumour dormancy
    Harriet Wikman
    Institute of Tumour Biology, University Medical Center Hamburg Eppendorf, Germany
    APMIS 116:754-70. 2008
    ..e., cancer patient). In this review, we will summarize the key findings of research on micrometastatic cancer cells and discuss these findings in the context of the concept of tumour dormancy...
  9. doi request reprint Review: Biological relevance of disseminated tumor cells in cancer patients
    Sabine Riethdorf
    Institute of Tumor Biology, Center of Experimental Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Int J Cancer 123:1991-2006. 2008
    ..Our review will focus on breast, colon, lung, and prostate cancer as the main tumor entities in Europe and the United States...
  10. doi request reprint Molecular and genetic changes in asbestos-related lung cancer
    Penny Nymark
    Finnish Institute of Occupational Health, 00250 Helsinki, Finland
    Cancer Lett 265:1-15. 2008
    ..Specific asbestos-associated molecular signatures can assist the development of early biomarkers, molecular diagnosis, and molecular targeted treatments for asbestos-exposed lung cancer patients...
  11. ncbi request reprint Identification of specific gene copy number changes in asbestos-related lung cancer
    Penny Nymark
    Department of Pathology, Haartman Institute, University of Helsinki and Helsinki University Central Hospital Diagnostics Laboratory, Helsinki University Central Hospital, Finland
    Cancer Res 66:5737-43. 2006
    ..08), which may imply preferentially caused DNA damage at these sites. Our findings are the first evidence, indicating that asbestos exposure may produce a specific DNA damage profile...
  12. ncbi request reprint CDK4 is a probable target gene in a novel amplicon at 12q13.3-q14.1 in lung cancer
    Harriet Wikman
    Department of Occupational Medicine, Finnish Institute of Occupational Health, Helsinki, Finland
    Genes Chromosomes Cancer 42:193-9. 2005
    ..Although CDK4 amplification seems to be a relatively rare event (4.3%) in lung tumors, it indicates the significance of the RB1-CCND1 pathway in lung tumorigenesis...
  13. ncbi request reprint Caveolins as tumour markers in lung cancer detected by combined use of cDNA and tissue microarrays
    Harriet Wikman
    Departments of Medical Genetics and Pathology, Haartman Institute, University of Helsinki and Helsinki University Central Hospital Laboratory Diagnostics, Helsinki, Finland
    J Pathol 203:584-93. 2004
    ..Some of these genes may provide novel diagnostic markers for lung cancer...
  14. ncbi request reprint Differentially expressed genes in nonsmall cell lung cancer: expression profiling of cancer-related genes in squamous cell lung cancer
    Eeva Kettunen
    Department of Pathology and Medical Genetics, Haartman Institute, University of Helsinki, Helsinki FIN 00029 HUS, Finland
    Cancer Genet Cytogenet 149:98-106. 2004
    ..Our study revealed new candidate genes involved in NSCLC...
  15. ncbi request reprint Identification of differentially expressed genes in pulmonary adenocarcinoma by using cDNA array
    Harriet Wikman
    Department of Medical Genetics, Haartman Institute and Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland
    Oncogene 21:5804-13. 2002
    ..In conclusion, by using the cDNA array technique we were able to reveal marked differences in the gene expression level between normal lung and tumour tissue and find possible new tumour markers for pulmonary adenocarcinoma...