Affiliation: University of Hamburg
- Relevance of PTEN loss in brain metastasis formation in breast cancer patientsHarriet Wikman
Institute of Tumor Biology, University Medical Center Hamburg Eppendorf, Martinistreet 52, 20246 Hamburg, Germany
Breast Cancer Res 14:R49. 2012..Therefore, our aim was to identify molecular markers associated with the development of brain metastases in breast cancer...
- Regulation of the G1/S phase of the cell cycle and alterations in the RB pathway in human lung cancerHarriet Wikman
Institute of Tumor Biology, Center of Experimental Medicine, University Medical Center Hamburg Eppendorf Martinistrasse 52, D 20246 Hamburg, Germany
Expert Rev Anticancer Ther 6:515-30. 2006..This review summarizes recent experiments describing the variable roles of key-player molecules of the RB pathway and different mechanisms by which the RB pathway can be altered in lung cancer...
- Clinical relevance of loss of 11p15 in primary and metastatic breast cancer: association with loss of PRKCDBP expression in brain metastasesHarriet Wikman
Institute of Tumor Biology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
PLoS ONE 7:e47537. 2012..In conclusion, we found loss at 11p15 to be a marker for TNBC primary tumors and BCBM and PRKCDBP to be a potential target gene in this locus...
- Frequent genetic alterations in EGFR- and HER2-driven pathways in breast cancer brain metastasesIna Hohensee
Department of Tumor Biology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Am J Pathol 183:83-95. 2013..In contrast, none of these pathways was associated with an increased risk of bone metastasis. These findings highlight the importance of both pathways as possible targets in the treatment of brain metastases in breast cancer...
- Opposite roles of FOXA1 and NKX2-1 in lung cancer progressionLena Deutsch
Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg Eppendorf, Germany
Genes Chromosomes Cancer 51:618-29. 2012..039). These results suggest that both FOXA1 and NKX2-1 may act as lineage-specific target genes within the 14q amplicon with opposite functions in lung cancer...
- Biologic role of activated leukocyte cell adhesion molecule overexpression in breast cancer cell lines and clinical tumor tissueSibyll Hein
Department of Gynecology, University Medical Center Hamburg Eppendorf, Martinistr 52, 20246, Hamburg, Germany
Breast Cancer Res Treat 129:347-60. 2011..048) and overall survival (OAS, P=0.003). Our results indicate that the biologic role of ALCAM in breast cancer is complex, but overexpression might be relevant for outcome in ductal carcinomas...
- Genomic profiles associated with early micrometastasis in lung cancer: relevance of 4q deletionMichaela Wrage
Institute of Tumor Biology and Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Clin Cancer Res 15:1566-74. 2009..It is still unclear whether the shedding of DTC from the primary tumor is a random process or a selective release driven by a specific genomic pattern...
- Cancer micrometastasis and tumour dormancyHarriet Wikman
Institute of Tumour Biology, University Medical Center Hamburg Eppendorf, Germany
APMIS 116:754-70. 2008..e., cancer patient). In this review, we will summarize the key findings of research on micrometastatic cancer cells and discuss these findings in the context of the concept of tumour dormancy...
- Review: Biological relevance of disseminated tumor cells in cancer patientsSabine Riethdorf
Institute of Tumor Biology, Center of Experimental Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Int J Cancer 123:1991-2006. 2008..Our review will focus on breast, colon, lung, and prostate cancer as the main tumor entities in Europe and the United States...
- Molecular and genetic changes in asbestos-related lung cancerPenny Nymark
Finnish Institute of Occupational Health, 00250 Helsinki, Finland
Cancer Lett 265:1-15. 2008..Specific asbestos-associated molecular signatures can assist the development of early biomarkers, molecular diagnosis, and molecular targeted treatments for asbestos-exposed lung cancer patients...
- Identification of specific gene copy number changes in asbestos-related lung cancerPenny Nymark
Department of Pathology, Haartman Institute, University of Helsinki and Helsinki University Central Hospital Diagnostics Laboratory, Helsinki University Central Hospital, Finland
Cancer Res 66:5737-43. 2006..08), which may imply preferentially caused DNA damage at these sites. Our findings are the first evidence, indicating that asbestos exposure may produce a specific DNA damage profile...
- CDK4 is a probable target gene in a novel amplicon at 12q13.3-q14.1 in lung cancerHarriet Wikman
Department of Occupational Medicine, Finnish Institute of Occupational Health, Helsinki, Finland
Genes Chromosomes Cancer 42:193-9. 2005..Although CDK4 amplification seems to be a relatively rare event (4.3%) in lung tumors, it indicates the significance of the RB1-CCND1 pathway in lung tumorigenesis...
- Caveolins as tumour markers in lung cancer detected by combined use of cDNA and tissue microarraysHarriet Wikman
Departments of Medical Genetics and Pathology, Haartman Institute, University of Helsinki and Helsinki University Central Hospital Laboratory Diagnostics, Helsinki, Finland
J Pathol 203:584-93. 2004..Some of these genes may provide novel diagnostic markers for lung cancer...
- Differentially expressed genes in nonsmall cell lung cancer: expression profiling of cancer-related genes in squamous cell lung cancerEeva Kettunen
Department of Pathology and Medical Genetics, Haartman Institute, University of Helsinki, Helsinki FIN 00029 HUS, Finland
Cancer Genet Cytogenet 149:98-106. 2004..Our study revealed new candidate genes involved in NSCLC...
- Identification of differentially expressed genes in pulmonary adenocarcinoma by using cDNA arrayHarriet Wikman
Department of Medical Genetics, Haartman Institute and Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland
Oncogene 21:5804-13. 2002..In conclusion, by using the cDNA array technique we were able to reveal marked differences in the gene expression level between normal lung and tumour tissue and find possible new tumour markers for pulmonary adenocarcinoma...