Manfred Westphal

Summary

Affiliation: University of Hamburg
Country: Germany

Publications

  1. ncbi request reprint Gliadel wafer in initial surgery for malignant glioma: long-term follow-up of a multicenter controlled trial
    M Westphal
    Department of Neurosurgery, University Hospital Eppendorf, Hamburg, Germany
    Acta Neurochir (Wien) 148:269-75; discussion 275. 2006
  2. pmc A phase 3 trial of local chemotherapy with biodegradable carmustine (BCNU) wafers (Gliadel wafers) in patients with primary malignant glioma
    Manfred Westphal
    Department of Neurosurgery, University Hospital Eppendorf, Hamburg, Germany
    Neuro Oncol 5:79-88. 2003
  3. doi request reprint The neurobiology of gliomas: from cell biology to the development of therapeutic approaches
    Manfred Westphal
    Department of Neurosurgery, University Hospital Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Nat Rev Neurosci 12:495-508. 2011
  4. ncbi request reprint Perspectives of cellular and molecular neurosurgery
    Manfred Westphal
    Department of Neurosurgery, University Hospital Hamburg Eppendorf, Hamburg, Germany
    J Neurooncol 70:255-69. 2004
  5. ncbi request reprint Intracavitary chemotherapy for glioblastoma: present status and future directions
    M Westphal
    Klinik und Poliklinik fur Neurochirurgie, Universitätskrankenhaus Hamburg Eppendorf, Hamburg, Germany
    Acta Neurochir Suppl 88:61-7. 2003
  6. doi request reprint [Local therapy of primary brain tumors]
    M Westphal
    Kopf und Neurozentrum, Klinik und Poliklinik fur Neurochirurgie, Universitatsklinikum Hamburg Eppendorf, Martinistrasse 52, 20246, Hamburg, Deutschland
    Nervenarzt 81:913-4, 916-7. 2010
  7. ncbi request reprint Contactin is expressed in human astrocytic gliomas and mediates repulsive effects
    Carmen Eckerich
    Department of Neurosurgery, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Glia 53:1-12. 2006
  8. pmc Activity parameters of subthalamic nucleus neurons selectively predict motor symptom severity in Parkinson's disease
    Andrew Sharott
    Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg Eppendorf, 20246 Hamburg, Germany, Medical Research Council Anatomical Neuropharmacology Unit, Department of Pharmacology, University of Oxford, Oxford OX1 3TH, United Kingdom, Department of Neurology, University Medical Center Hamburg Eppendorf, 20246 Hamburg, Germany, Department of Pediatric and Adult Movement Disorders and Neuropsychiatry, Institute of Neurology, University Medical Center Schleswig Holstein, Campus Lubeck, 23538 Lubeck, Germany, and Department of Neurosurgery, University Medical Centre Hamburg Eppendorf, 20246 Hamburg, Germany
    J Neurosci 34:6273-85. 2014
  9. ncbi request reprint Hypoxia can induce c-Met expression in glioma cells and enhance SF/HGF-induced cell migration
    Carmen Eckerich
    Department of Neurosurgery, University Medical Center Hamburg Eppendorf, Germany
    Int J Cancer 121:276-83. 2007
  10. ncbi request reprint Inhibition of intracerebral glioblastoma growth by local treatment with the scatter factor/hepatocyte growth factor-antagonist NK4
    Marc A Brockmann
    Department of Neurosurgery, University Hospital Hamburg Eppendorf, 20246 Hamburg, Germany
    Clin Cancer Res 9:4578-85. 2003

Detail Information

Publications103 found, 100 shown here

  1. ncbi request reprint Gliadel wafer in initial surgery for malignant glioma: long-term follow-up of a multicenter controlled trial
    M Westphal
    Department of Neurosurgery, University Hospital Eppendorf, Hamburg, Germany
    Acta Neurochir (Wien) 148:269-75; discussion 275. 2006
    ..03) in the BCNU wafer-treated group over the course of the 30-month trial. Long-term follow-up of these patients was undertaken to determine the survival benefit at 2 and 3 years...
  2. pmc A phase 3 trial of local chemotherapy with biodegradable carmustine (BCNU) wafers (Gliadel wafers) in patients with primary malignant glioma
    Manfred Westphal
    Department of Neurosurgery, University Hospital Eppendorf, Hamburg, Germany
    Neuro Oncol 5:79-88. 2003
    ..1% in the BCNU wafer-treated group vs. 1.7% in the placebo group). This study confirms that local chemotherapy with BCNU wafers is well tolerated and offers a survival benefit to patients with newly diagnosed malignant glioma...
  3. doi request reprint The neurobiology of gliomas: from cell biology to the development of therapeutic approaches
    Manfred Westphal
    Department of Neurosurgery, University Hospital Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Nat Rev Neurosci 12:495-508. 2011
    ..Combining this enhanced understanding of the relationship between neural stem cell biology and the cell lineage relationships of tumour cells with model systems offers new opportunities to develop specific and effective therapies...
  4. ncbi request reprint Perspectives of cellular and molecular neurosurgery
    Manfred Westphal
    Department of Neurosurgery, University Hospital Hamburg Eppendorf, Hamburg, Germany
    J Neurooncol 70:255-69. 2004
    ....
  5. ncbi request reprint Intracavitary chemotherapy for glioblastoma: present status and future directions
    M Westphal
    Klinik und Poliklinik fur Neurochirurgie, Universitätskrankenhaus Hamburg Eppendorf, Hamburg, Germany
    Acta Neurochir Suppl 88:61-7. 2003
    ..Since all agents so far show only limited activity against solid tumor, complete resection seems to be the prerequisite for effective local therapies...
  6. doi request reprint [Local therapy of primary brain tumors]
    M Westphal
    Kopf und Neurozentrum, Klinik und Poliklinik fur Neurochirurgie, Universitatsklinikum Hamburg Eppendorf, Martinistrasse 52, 20246, Hamburg, Deutschland
    Nervenarzt 81:913-4, 916-7. 2010
    ....
  7. ncbi request reprint Contactin is expressed in human astrocytic gliomas and mediates repulsive effects
    Carmen Eckerich
    Department of Neurosurgery, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Glia 53:1-12. 2006
    ..The repulsive properties of contactin may be a key factor in glioma disaggregation, and may contribute to the diffuse infiltration pattern characteristic of glioma cells in human brain...
  8. pmc Activity parameters of subthalamic nucleus neurons selectively predict motor symptom severity in Parkinson's disease
    Andrew Sharott
    Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg Eppendorf, 20246 Hamburg, Germany, Medical Research Council Anatomical Neuropharmacology Unit, Department of Pharmacology, University of Oxford, Oxford OX1 3TH, United Kingdom, Department of Neurology, University Medical Center Hamburg Eppendorf, 20246 Hamburg, Germany, Department of Pediatric and Adult Movement Disorders and Neuropsychiatry, Institute of Neurology, University Medical Center Schleswig Holstein, Campus Lubeck, 23538 Lubeck, Germany, and Department of Neurosurgery, University Medical Centre Hamburg Eppendorf, 20246 Hamburg, Germany
    J Neurosci 34:6273-85. 2014
    ..Our results demonstrate that the occurrence of alterations in the rate and pattern of basal ganglia neurons could partly underlie the variability in parkinsonian phenotype...
  9. ncbi request reprint Hypoxia can induce c-Met expression in glioma cells and enhance SF/HGF-induced cell migration
    Carmen Eckerich
    Department of Neurosurgery, University Medical Center Hamburg Eppendorf, Germany
    Int J Cancer 121:276-83. 2007
    ..These findings suggest that approximately half of all human glioblastomas respond to hypoxia with an induction of c-Met, which can enhance the stimulating effect of SF/HGF on tumor cell migration...
  10. ncbi request reprint Inhibition of intracerebral glioblastoma growth by local treatment with the scatter factor/hepatocyte growth factor-antagonist NK4
    Marc A Brockmann
    Department of Neurosurgery, University Hospital Hamburg Eppendorf, 20246 Hamburg, Germany
    Clin Cancer Res 9:4578-85. 2003
    ..The SF/HGF-MET system contributes to glioma invasion and angiogenesis via autocrine and paracrine mechanisms. We analyzed whether local treatment with NK4, an antagonistic fragment of SF/HGF, could inhibit glioma growth in vivo...
  11. doi request reprint Inhibition of glioblastoma growth in a highly invasive nude mouse model can be achieved by targeting epidermal growth factor receptor but not vascular endothelial growth factor receptor-2
    Tobias Martens
    Department of Neurosurgery, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Clin Cancer Res 14:5447-58. 2008
    ..Such models are thus of limited value for preclinical studies. We established a highly invasive model to evaluate the effect of antibodies against EGFR (cetuximab) and vascular endothelial growth factor receptor-2 (antibody DC101)...
  12. doi request reprint RON receptor tyrosine kinase in human gliomas: expression, function, and identification of a novel soluble splice variant
    Carmen Eckerich
    Department of Neurosurgery, Laboratory for Brain Tumor Biology, University Medical Center Hamburg Eppendorf, Martinistrasse, Hamburg, Germany
    J Neurochem 109:969-80. 2009
    ..The expression of several oncogenic RON splice variants in malignant gliomas suggests that these could represent candidate targets for treatment with agents inhibiting RON activity...
  13. ncbi request reprint Hypoxia and oxygenation induce a metabolic switch between pentose phosphate pathway and glycolysis in glioma stem-like cells
    Annegret Kathagen
    Laboratory for Brain Tumor Biology, Department of Neurosurgery, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany
    Acta Neuropathol 126:763-80. 2013
    ....
  14. doi request reprint Glioblastoma stem-like cell lines with either maintenance or loss of high-level EGFR amplification, generated via modulation of ligand concentration
    Alexander Schulte
    Departments of Neurosurgery and Tumor Biology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Clin Cancer Res 18:1901-13. 2012
    ....
  15. ncbi request reprint RNA interference targeting protein tyrosine phosphatase zeta/receptor-type protein tyrosine phosphatase beta suppresses glioblastoma growth in vitro and in vivo
    Ulrike Ulbricht
    Department of Neurosurgery, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    J Neurochem 98:1497-506. 2006
    ..Our findings suggest that antagonization of PTPzeta/RPTPbeta expression can inhibit glioma growth in vivo and may thus represent a potentially promising treatment strategy...
  16. ncbi request reprint The impact of esophagus retraction on early dysphagia after anterior cervical surgery: does a correlation exist?
    Luca Papavero
    University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Spine (Phila Pa 1976) 32:1089-93. 2007
    ..Prospective study of 92 patients who underwent anterior cervical surgery. Intraoperative esophagus retraction and postoperative dysphagia were recorded and evaluated...
  17. ncbi request reprint Inhibition of glioblastoma angiogenesis and invasion by combined treatments directed against vascular endothelial growth factor receptor-2, epidermal growth factor receptor, and vascular endothelial-cadherin
    Katrin Lamszus
    Department of Neurosurgery, Institute for Anatomy II, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Clin Cancer Res 11:4934-40. 2005
    ..In addition, we analyzed whether blockade of vascular endothelial (VE)-cadherin as a different antiangiogenic target could also inhibit glioblastoma angiogenesis and growth...
  18. ncbi request reprint Intraoperative measurement of pharynx/esophagus retraction during anterior cervical surgery. Part I: pressure
    Oliver Heese
    University Hospital Hamburg Eppendorf, Hamburg, Germany
    Eur Spine J 15:1833-7. 2006
    ..Over time the pharynx/esophageal wall adapts to the applied pressure induced by the retractor blade. The contact area between them influences the retraction pressure...
  19. doi request reprint A distinct subset of glioma cell lines with stem cell-like properties reflects the transcriptional phenotype of glioblastomas and overexpresses CXCR4 as therapeutic target
    Alexander Schulte
    Department of Neurosurgery, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Glia 59:590-602. 2011
    ..We thus demonstrate the utility of GSf lines in testing therapeutic agents and validate CXCR4 as a target to block the growth of invasive tumor-initiating glioma stem cells in vivo...
  20. pmc Intranasal delivery of neural stem/progenitor cells: a noninvasive passage to target intracerebral glioma
    Matthias Reitz
    Department of Neurosurgery, Medical Center, Eppendorf, Hamburg, Germany
    Stem Cells Transl Med 1:866-73. 2012
    ....
  21. pmc Erlotinib resistance in EGFR-amplified glioblastoma cells is associated with upregulation of EGFRvIII and PI3Kp110δ
    Alexander Schulte
    Corresponding Author Dr Alexander Schulte, PhD, Laboratory for Brain Tumor Biology, Department of Neurosurgery, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Neuro Oncol 15:1289-301. 2013
    ..We determined possible mechanisms of therapy resistance using the unique BS153 glioblastoma cell line, which has retained amplification of the egfr gene and expression of EGFR variant (v)III...
  22. doi request reprint Frequent genetic alterations in EGFR- and HER2-driven pathways in breast cancer brain metastases
    Ina Hohensee
    Department of Tumor Biology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Am J Pathol 183:83-95. 2013
    ..In contrast, none of these pathways was associated with an increased risk of bone metastasis. These findings highlight the importance of both pathways as possible targets in the treatment of brain metastases in breast cancer...
  23. pmc A 3-dimensional extracellular matrix as a delivery system for the transplantation of glioma-targeting neural stem/progenitor cells
    Katharina Hansen
    Department of Neurosurgery, University Medical Center Hamburg Eppendorf, Martinistrasse 52, Hamburg 20246, Germany
    Neuro Oncol 12:645-54. 2010
    ....
  24. ncbi request reprint Pattern of recurrence following local chemotherapy with biodegradable carmustine (BCNU) implants in patients with glioblastoma
    Alf Giese
    Department of Neurosurgery, University Hospital Lubeck, Lubeck, Germany
    J Neurooncol 66:351-60. 2004
    ..A local chemotherapy applied directly to the resection cavity may act directly on residual tumor cells in adjacent brain possibly leading to a local control of the tumor and increased survival...
  25. doi request reprint Vascular endothelial growth factor-stimulated cerebral microvascular endothelial cells mediate the recruitment of neural stem cells to the neurovascular niche
    Nils O Schmidt
    Department of Neurosurgery, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Brain Res 1268:24-37. 2009
    ..Our findings support the hypothesis that the angiogenically active microvasculature modulates the local guidance of NSC through endothelial cell-derived chemoattractants...
  26. doi request reprint STN stimulation in general anaesthesia: evidence beyond 'evidence-based medicine'
    Christian K E Moll
    Department of Neurophysiology and Pathophysiology, Center of Experimental Medicine, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany
    Acta Neurochir Suppl 117:19-25. 2013
    ..Our results indicate that STN surgery in GA can be performed in a safe manner. It can be offered to anxious patients, and represents a viable option when awake surgery bears a risk for the patient...
  27. doi request reprint Patient satisfaction after anterior cervical discectomy and fusion is primarily driven by relieving pain
    Christian Hessler
    Department of Neurosurgery, University Medical Center Hamburg Eppendorf, Germany
    Clin J Pain 28:398-403. 2012
    ....
  28. pmc Neural stem cell migration toward gliomas in vitro
    Oliver Heese
    Department of Neurosurgery, University Hospital Hamburg Eppendorf, Martinistr 52, 20246 Hamburg, Germany
    Neuro Oncol 7:476-84. 2005
    ..The extent to which NSCs infiltrate three-dimensional glioma cell aggregates appears to depend on additional factors, which are likely to include cell-to-cell contacts and interaction with extracellular matrix proteins...
  29. ncbi request reprint High-frequency ultrasound confirmation of positional plagiocephaly
    Jan Regelsberger
    Department of Neurosurgery, Institute of Osteopathology, University Hospital, Hamburg, Germany
    J Neurosurg 105:413-7. 2006
    ..Near-field high-frequency ultrasound has been used to evaluate the sonographic findings of suture anatomy and confirm the diagnosis of positional plagiocephaly as well as provide information of prognostic value...
  30. ncbi request reprint Expression and function of the receptor protein tyrosine phosphatase zeta and its ligand pleiotrophin in human astrocytomas
    Ulrike Ulbricht
    Department of Neurosurgery, University Hospital Hamburg Eppendorf, Hamburg, Germany
    J Neuropathol Exp Neurol 62:1265-75. 2003
    ..Although PTN is a secreted growth factor, it appears to exert its mitogenic effects mostly in a matrix-immobilized form, serving as a substrate for migrating tumor cells...
  31. ncbi request reprint A novel one-armed anti-c-Met antibody inhibits glioblastoma growth in vivo
    Tobias Martens
    Department of Neurosurgery, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Clin Cancer Res 12:6144-52. 2006
    ..We used a novel one-armed anti-c-Met antibody to inhibit glioblastoma growth in vivo...
  32. ncbi request reprint Glioblastoma and cerebral microvascular endothelial cell migration in response to tumor-associated growth factors
    Marc Alexander Brockmann
    Hans Dietrich Herrmann Laboratory for Brain Tumor Biology, Department of Neurosurgery, University Hospital Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Neurosurgery 52:1391-9; discussion 1399. 2003
    ..Several growth factors are thought to be involved in glioma cell migration; however, little is known about their motogenic potency relative to one another...
  33. ncbi request reprint Giant cell glioblastoma is associated with altered aurora b expression and concomitant p53 mutation
    Achim Temme
    Department of Neurosurgery, Section Experimental Neurosurgery Tumor Immunology, University Hospital Carl Gustav Carus, TU Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
    J Neuropathol Exp Neurol 69:632-42. 2010
    ..These results suggest that loss of p53 function and dysregulated Aurora B protein levels might represent factors that drive the development of multinucleated cells in gcGB...
  34. ncbi request reprint Vascular events after transsylvian selective amygdalohippocampectomy and impact on epilepsy outcome
    Tobias Martens
    Department of Neurological Surgery, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Epilepsia 55:763-9. 2014
    ....
  35. doi request reprint Case report: surviving a tiger attack
    Pedram Emami
    Department of Neurological Surgery, University Medical Center Hamburg Eppendorf, Martinistr 52, 20246, Hamburg, Germany
    Neurosurg Rev 35:621-4; discussion 624. 2012
    ..This seems to be related to the specific dynamics of the cranial assault and the reduced forces applied to the patient's head demonstrated in a 3D bite simulation...
  36. doi request reprint Clinical relevance of associated aneurysms with arteriovenous malformations of the posterior fossa
    Nils Ole Schmidt
    Department of Neurosurgery, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Acta Neurochir Suppl 112:131-5. 2011
    ..We therefore recommend aggressive AVM treatment including the exclusion of associated aneurysms as a minimal therapeutic goal whenever possible...
  37. pmc Well-differentiated neurocytoma: what is the best available treatment?
    Dirk Rades
    Department of Radiation Oncology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Neuro Oncol 7:77-83. 2005
    ..A radiation dose of 54 Gy appeared sufficient. Application of postoperative radiotherapy should be decided individually, taking into account the risk of local failure, the need for another craniotomy, and potential radiation toxicity...
  38. doi request reprint Cytoreductive surgery of glioblastoma as the key to successful adjuvant therapies: new arguments in an old discussion
    Walter Stummer
    Department of Neurosurgery, University of Munster, Albert Schweitzer Str 33, 48149, Munster, Germany
    Acta Neurochir (Wien) 153:1211-8. 2011
    ..This article discusses data from 3 randomized phase 3 trials, supporting a role for surgery in glioblastoma...
  39. ncbi request reprint Loss of CADM1 expression is associated with poor prognosis and brain metastasis in breast cancer patients
    Harriet Wikman
    Institute of Tumor Biology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Oncotarget 5:3076-87. 2014
    ..Loss of CADM1 expression is an independent prognostic factor especially associated with the development of brain metastases in breast cancer patients. ..
  40. doi request reprint Adenovirus-mediated gene therapy with sitimagene ceradenovec followed by intravenous ganciclovir for patients with operable high-grade glioma (ASPECT): a randomised, open-label, phase 3 trial
    Manfred Westphal
    University Hospital Eppendorf, Hamburg, Germany
    Lancet Oncol 14:823-33. 2013
    ....
  41. ncbi request reprint The influence of tamoxifen on the secretion of transforming growth factor-beta2 (TGF-beta2) in glioblastomas: in vitro and in vivo findings
    Maximilian J A Puchner
    Department of Neurosurgery, University Hospital Eppendorf, Hamburg, Germany
    Anticancer Res 22:45-51. 2002
    ..Analogous to previous studies in breast cancer patients, we investigated whether the dynamics of TGF-beta2 plasma levels allow the prediction of response to TAM-treatment in glioblastoma patients as well...
  42. ncbi request reprint Autophagic cell death induced by TrkA receptor activation in human glioblastoma cells
    Katharina Hansen
    Department of Neurosurgery, University Medical Center Hamburg Eppendorf, Martinistrasse, Hamburg, Germany
    J Neurochem 103:259-75. 2007
    ..Our findings suggest that TrkA activation in human glioblastomas might be beneficial therapeutically, especially as several of the currently used chemotherapeutics also induce autophagic cell death...
  43. ncbi request reprint Low-grade and anaplastic gliomas: differences in architecture evaluated with diffusion-tensor MR imaging
    Einar Goebell
    Department of Neuroradiology, University of Hamburg, Martinistrasse 52, 20251 Hamburg, Germany
    Radiology 239:217-22. 2006
    ..To prospectively evaluate whether diffusion-tensor magnetic resonance (MR) imaging depicts differences in World Health Organization (WHO) grade II and III glial brain tumors on the basis of tumor architecture and peritumoral tract invasion...
  44. doi request reprint Other experimental therapies for glioma
    Manfred Westphal
    Department of Neurosurgery, University Hospital Hamburg Eppendorf, Martinistrasse 52, Hamburg 20251, Germany
    Recent Results Cancer Res 171:155-64. 2009
    ..In general, there is a wide spectrum of specific neuro-oncological therapy developments, which are not only extrapolated from general oncology but also based on translational research in the field of glioma biology...
  45. pmc High-frequency stimulation of the subthalamic nucleus counteracts cortical expression of major histocompatibility complex genes in a rat model of Parkinson's disease
    Benjamin Grieb
    Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg Eppendorf, Hamburg, Germany Department of General Psychiatry, Center for Psychosocial Medicine, University of Heidelberg, Heidelberg, Germany
    PLoS ONE 9:e91663. 2014
    ..Hence, our data suggest the possible association of altered microglial activity and synaptic transmission by STN-HFS within the sensorimotor cortex of 6-hydroxydopamine treated rats. ..
  46. pmc Inhibition of thromboxane synthase activity improves glioblastoma response to alkylation chemotherapy
    Nils Ole Schmidt
    Department of Neurosurgery, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Transl Oncol 3:43-9. 2010
    ..Our study supports the role of TXSA activity for the progression of malignant glioma and the potential utility of its therapeutic modulation for glioma treatment...
  47. pmc Clinical relevance of loss of 11p15 in primary and metastatic breast cancer: association with loss of PRKCDBP expression in brain metastases
    Harriet Wikman
    Institute of Tumor Biology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    PLoS ONE 7:e47537. 2012
    ..In conclusion, we found loss at 11p15 to be a marker for TNBC primary tumors and BCBM and PRKCDBP to be a potential target gene in this locus...
  48. ncbi request reprint Levels of soluble vascular endothelial growth factor (VEGF) receptor 1 in astrocytic tumors and its relation to malignancy, vascularity, and VEGF-A
    Katrin Lamszus
    Department of Neuropathology, University Hospital Hamburg Eppendorf, 20246 Hamburg, Germany
    Clin Cancer Res 9:1399-405. 2003
    ..In several animal models sVEGFR-1 inhibited angiogenesis and tumor growth. We analyzed the levels of endogenous sVEGFR-1 in gliomas of different malignancy grades in relation to tumor vascularity and VEGF-A...
  49. doi request reprint Blister-like aneurysms--a diagnostic and therapeutic challenge
    Jan Regelsberger
    Universitatsklinikum Hamburg Eppendorf, Neurochirurgische Klinik, Hamburg, Germany
    Neurosurg Rev 34:409-16. 2011
    ..If endovascular treatment is not promising, wrapping and revascularization techniques come true to still be an important part of the neurosurgeons toolbox for reconstructing a vessel lumen and preserving a sufficient cerebral blood flow...
  50. doi request reprint The translaminar approach to lumbar disc herniations impinging the exiting root
    Luca Papavero
    Department of Neurosurgery, University Medical Center Eppendorf, Hamburg, Germany
    Neurosurgery 62:173-7; discussion 177-8. 2008
    ..We undertook a prospective, non-randomized study on the translaminar approach for the treatment of cephalad extruded disc fragments impinging the exiting root...
  51. pmc Oncoretrovirus and lentivirus vectors pseudotyped with lymphocytic choriomeningitis virus glycoprotein: generation, concentration, and broad host range
    Winfried R Beyer
    Heinrich Pette Institut fur experimentelle Virologie und Immunologie an der Universitat Hamburg, Germany
    J Virol 76:1488-95. 2002
    ..The recombinant LCMV-GP-pseudotyped vectors will also allow functional characterization of naturally occurring and recombinant LCMV-GP variants...
  52. pmc Secretory meningiomas: a benign subgroup causing life-threatening complications
    Jan Regelsberger
    Departments of Neurosurgery, University Medical Center Hamburg Eppendorf, Martinistr 52, D 20246 Hamburg, Germany
    Neuro Oncol 11:819-24. 2009
    ..Extended perifocal edema in meningiomas is an unusual finding and should alert the neurosurgeon that surgery may aggravate edema excessively, leading to a life-threatening postoperative situation...
  53. doi request reprint Complementary therapy use in patients with glioma: an observational study
    O Heese
    Department of Neurological Surgery, University Medical Center Hamburg Eppendorf, Hamburg 20246, Germany
    Neurology 75:2229-35. 2010
    ..We used a questionnaire and the database of the German Glioma Network to evaluate these questions...
  54. doi request reprint Intracranial aneurysms in childhood: report of 8 cases and review of the literature
    J Regelsberger
    Neurochirurgische Klinik, Universitatsklinikum Hamburg Eppendorf, Germany
    Cent Eur Neurosurg 70:79-85. 2009
    ....
  55. ncbi request reprint Diagnosis and treatment of an intramedullary cavernoma in a young male with an implanted cardiac pacemaker
    E Fritzsche
    Clinic of Neurosurgery, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Acta Neurochir (Wien) 148:1213-5; discussion 1215. 2006
  56. doi request reprint Therapeutic clues in spinal dural arteriovenous fistulas - a 30 year experience of 156 cases
    C Hessler
    University Hospital Hamburg Eppendorf, Neurosurgery, Hamburg, Germany
    Cent Eur Neurosurg 71:8-12. 2010
    ..But the optimal treatment paradigm has yet to be defined and may well be an individualized interdisciplinary combinatorial approach...
  57. ncbi request reprint Disarrangement of fiber tracts and decline of neuronal density correlate in glioma patients--a combined diffusion tensor imaging and 1H-MR spectroscopy study
    E Goebell
    Department of Neuroradiology, University of Hamburg, Martinistrasse 52, 20246 Hamburg, Germany
    AJNR Am J Neuroradiol 27:1426-31. 2006
    ..This investigation examines changes of FA and NAA and compares these different aspects in architecture of gliomas after spatial coregistration...
  58. ncbi request reprint Treatment of malignant glioma: a problem beyond the margins of resection
    A Giese
    Department of Neurosurgery, University Hospital Eppendorf, 20246 Hamburg, Germany
    J Cancer Res Clin Oncol 127:217-25. 2001
    ..Several theoretical considerations suggest that these approaches may be promising in the treatment of brain tumors...
  59. pmc Expression and localization of scatter factor/hepatocyte growth factor in human astrocytomas
    P Kunkel
    Department of Neurosurgery, University Hospital Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Neuro Oncol 3:82-8. 2001
    ..Lack of SF/HGF expression by most cultured glioblastoma cells is not representative of the in vivo situation and most likely represents a culture artifact...
  60. ncbi request reprint Molecular genetic alterations on chromosomes 11 and 22 in ependymomas
    K Lamszus
    Department of Neuropathology, University Hospital Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Int J Cancer 91:803-8. 2001
    ..To conclude, our findings provide evidence for different genetic pathways involved in ependymoma formation and progression, which may allow to define genetically and clinically distinct tumor entities...
  61. ncbi request reprint Surgical treatment of a basilar perforator aneurysm not accessible to endovascular treatment
    W Hamel
    Klinik für Neurochirurgie, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    Acta Neurochir (Wien) 147:1283-6. 2005
    ..Additional aneurysms of the anterior communicating artery and right middle cerebral artery were clipped several months later. The patient recovered well, and except for slight gait ataxia no other deficit remained...
  62. ncbi request reprint [Hypothalamic deep brain stimulation in patients with chronic cluster headaches. Suggestions for patient selection]
    A May
    Neurologische Universitätsklinik Hamburg Eppendorf UKE
    Schmerz 19:544-8. 2005
    ....
  63. ncbi request reprint Clinical significance of pedicle aneurysms on feeding vessels, especially those located in infratentorial arteriovenous malformations
    M Westphal
    Department of Neurosurgery, University Hospital Eppendorf, Hamburg, Germany
    J Neurosurg 92:995-1001. 2000
    ..The goal of the present study is to demonstrate the significance of feeding vessel pedicle aneurysms, especially those found in infratentorial AVMs...
  64. ncbi request reprint Hollow mandrin facilitates external ventricular drainage placement
    O Heese
    Department of Neurosurgery, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Acta Neurochir (Wien) 147:759-62; discussion 762. 2005
    ..Incorrect placement makes further punctures necessary. The newly developed device allows CSF flow observation during the puncture procedure and in addition precise intracranial pressure (ICP) measurement...
  65. ncbi request reprint Scatter factor/hepatocyte growth factor (SF/HGF) content and function in human gliomas
    K Lamszus
    Department of Neuropathology, University Hospital Eppendorf, Hamburg, Germany
    Int J Dev Neurosci 17:517-30. 1999
    ..In conclusion, we showed that SF/HGF may contribute to glioma progression by stimulating tumor invasiveness, proliferation and neovascularization...
  66. ncbi request reprint Glioma cell adhesion and migration on human brain sections
    A Giese
    Department of Neurosurgery, University Hospital Eppendorf, Hamburg, Germany
    Anticancer Res 18:2435-47. 1998
    ..Our findings indicate that adhesion of glioma cells to brain sections most rapidly takes place on ECM protein containing regions, especially blood vessels which may serve as guiding structures for glioma dissemination...
  67. ncbi request reprint Invasion as limitation to anti-angiogenic glioma therapy
    K Lamszus
    Department of Neurosurgery, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Acta Neurochir Suppl 88:169-77. 2003
    ....
  68. pmc End-of-life caregivers' perception of medical and psychological support during the final weeks of glioma patients: a questionnaire-based survey
    Oliver Heese
    Department of Neurological Surgery, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Neuro Oncol 15:1251-6. 2013
    ..To obtain information about this period, we surveyed caregivers of patients who were registered in the German Glioma Network and who died from the disease...
  69. doi request reprint Neuropsychological assessments in patients with aneurysmal subarachnoid hemorrhage, perimesencephalic SAH, and incidental aneurysms
    Kara Krajewski
    Department of Neurosurgery, University Medical Center Hamburg Eppendorf, Martinistrase 52, 20246, Hamburg, Germany
    Neurosurg Rev 37:55-62. 2014
    ..Therefore, even more specific rehabilitation programs are required following inpatient treatment to attain full recovery. ..
  70. ncbi request reprint Intraoperative measurement of pharynx/esophagus retraction during anterior cervical surgery. Part II: perfusion
    Oliver Heese
    Department of Neurosurgery, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Eur Spine J 15:1839-43. 2006
    ..The local ischemia of the pharynx/esophagus wall may be a crucial step in the development of postoperative dysphagia...
  71. ncbi request reprint Stem cells in neuro-oncology--development, regeneration and treatment
    M Kirsch
    Klinik und Poliklinik fur Neurochirurgie, Universitätsklinikum Dresden der Technischen Universität Dresden, Dresden, Germany
    Acta Neurochir Suppl 88:143-51. 2003
  72. ncbi request reprint Cyclo-oxygenase inhibitors and thromboxane synthase inhibitors differentially regulate migration arrest, growth inhibition and apoptosis in human glioma cells
    F Kürzel
    Department of Neurosurgery, University Hospital Eppendorf, Hamburg, Germany
    Acta Neurochir (Wien) 144:71-87. 2002
    ..This effect may be independent of prostaglandin synthesis controlled by cyclo-oxygenases...
  73. ncbi request reprint Tamoxifen sensitivity-testing of glioblastomas: comparison of in vitro and in vivo results
    M J Puchner
    Department of Neurosurgery, University Hospital Eppendorf, Hamburg, Germany
    Acta Neurochir (Wien) 143:563-73. 2001
    ..INTERPRETATION: Combining the results obtained from our human and mouse studies, it has to be postulated that host factors other than the sensitivity to TAM of the individual cell, determine the efficacy of TAM-treatment in vivo...
  74. ncbi request reprint Improved method for the intracerebral engraftment of tumour cells and intratumoural treatment using a guide screw system in mice
    M A Brockmann
    Department of Neurosurgery, Laboratory for Brain Tumour Biology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Acta Neurochir (Wien) 145:777-81; discussion 781. 2003
    ..Here we report our experience with this system, and describe several modifications which we introduced to improve its reliability and to simplify its application...
  75. ncbi request reprint Cost of migration: invasion of malignant gliomas and implications for treatment
    A Giese
    Department of Neurosurgery, University Hospital Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    J Clin Oncol 21:1624-36. 2003
    ....
  76. ncbi request reprint Inhibition of glioma angiogenesis and growth in vivo by systemic treatment with a monoclonal antibody against vascular endothelial growth factor receptor-2
    P Kunkel
    Department of Neurosurgery, University Hospital Hamburg-Eppendorf, 20246 Hamburg, Germany
    Cancer Res 61:6624-8. 2001
    ..Therefore, a combination of different treatment modalities which also include anti-invasive therapy may be needed for an effective therapy against glioblastoma, and the use of an antibody against VEGFR-2 may be one effective component...
  77. ncbi request reprint Glioma invasion in the central nervous system
    A Giese
    Department of Neurosurgery, University Hospital Eppendorf, Hamburg, Germany
    Neurosurgery 39:235-50; discussion 250-2. 1996
    ..This review focuses on the composition of central nervous system ECM and the recent evidence for the use by glioma cells of multiple invasion mechanisms in response to this unique environment...
  78. ncbi request reprint Gene therapy of gliomas
    W Hamel
    Klinik für Neurochirurgie, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    Acta Neurochir Suppl 88:125-35. 2003
    ..This has led to increased interest in distinct but related strategies, e.g. oncolytic viruses or direct intra-tumoral delivery of anti-sense oligonucleotides...
  79. ncbi request reprint September 2002: 24-year-old female with a 6-month history of seizures
    Katrin Lamszus
    Department of Neuropathology, University Hospital Hamburg Eppendorf, Germany
    Brain Pathol 13:115-7. 2003
    ..The diagnosis was papillary glioneuronal tumor (PGNT), a relatively recently described lesion that may be a variant of ganglioglioma. The current literature on PGNTs is reviewed...
  80. pmc Incomplete tumour control following DNA vaccination against rat gliomas expressing a model antigen
    Christian Ginzkey
    Department of Neurosurgery, University of Schleswig Holstein, Campus Kiel, Kiel, Germany
    Acta Neurochir (Wien) 155:51-8; discussion 59. 2013
    ..Vaccination against tumour-associated antigens is one approach to elicit anti-tumour responses. We investigated the effect of polynucleotide (DNA) vaccination using a model antigen (E. coli lacZ) in a syngeneic gliosarcoma model (9L)...
  81. ncbi request reprint Waking up the brain: a case study of stimulation-induced wakeful unawareness during anaesthesia
    Christian K E Moll
    Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Prog Brain Res 177:125-45. 2009
    ....
  82. ncbi request reprint Glioblastoma-derived stem cell-enriched cultures form distinct subgroups according to molecular and phenotypic criteria
    H S Gunther
    Department of Neurosurgery, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Oncogene 27:2897-909. 2008
    ....
  83. ncbi request reprint [Intraoperative ultrasound of intra- and extramedullary tumours]
    J Regelsberger
    Department of Neurosurgery, University Hospital of Hamburg, Hamburg, Germany
    Ultraschall Med 24:399-403. 2003
    ..Spinal tumours can be diagnosed precisely by magnetic resonance imaging (MRI). Planning the surgical procedure of intradural tumours, intraoperative ultrasound (IOUS) has been used to evaluate its diagnostic potential...
  84. ncbi request reprint Retention of imprinting of the human apoptosis-related gene TSSC3 in human brain tumors
    S Muller
    University Hospital Eppendorf, Department of Neurosurgery, Hamburg, Germany
    Hum Mol Genet 9:757-63. 2000
    ..The results demonstrate for the first time that the tumors under investigation are associated with a retention of imprinting of a potential growth inhibitory gene...
  85. pmc Relevance of PTEN loss in brain metastasis formation in breast cancer patients
    Harriet Wikman
    Institute of Tumor Biology, University Medical Center Hamburg Eppendorf, Martinistreet 52, 20246 Hamburg, Germany
    Breast Cancer Res 14:R49. 2012
    ..Therefore, our aim was to identify molecular markers associated with the development of brain metastases in breast cancer...
  86. ncbi request reprint Ultrasound in the diagnosis of craniosynostosis
    Jan Regelsberger
    Department of Neurosurgery, University Hospital, Hamburg, Germany
    J Craniofac Surg 17:623-5; discussion 626-8. 2006
    ..Sonography offers the potential to be a standard investigation for infants with head deformities suspecting a suture pathology and has been therefore integrated in our craniofacial outpatient clinic as a daily routine method...
  87. ncbi request reprint Thromboxane synthase inhibitors induce apoptosis in migration-arrested glioma cells
    Kimio Yoshizato
    Department of Neurosurgery, University Hospital Eppendorf, Hamburg, Germany
    Neurosurgery 50:343-54. 2002
    ..Interference with this inherent phenotype of malignant gliomas also affects glioma cell proliferation and apoptosis...
  88. ncbi request reprint Intraoperative sonography of intra- and extramedullary tumors
    Jan Regelsberger
    Department of Neurosurgery, University Hospital of Hamburg, Martinistrasse 52, 20246 Hamburg, Germany
    Ultrasound Med Biol 31:593-8. 2005
    ..Our experiences have shown that IOUS may reduce the procedure-related morbidity and should, therefore, be used as a standard intraoperative tool in these high-risk surgical entities. (E-mail: )...
  89. ncbi request reprint Diffuse arachnoidal enhancement of a well differentiated choroid plexus papilloma
    O Heese
    Department of Neurosurgery, University Hospital Hamburg Eppendorf, Germany
    Acta Neurochir (Wien) 144:723-8. 2002
    ..Up to this point this particular growth pattern has not been published and is a rare presentation for this tumour...
  90. ncbi request reprint Intracranial metastases: therapeutic options
    M Westphal
    Department of Neurosurgery, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Ann Oncol 14:iii4-10. 2003
  91. ncbi request reprint Outcome prediction of third ventriculostomy: a proposed hydrocephalus grading system
    U Kehler
    Neurosurgical Department, Asklepios Clinic Altona, Hamburg, Germany
    Minim Invasive Neurosurg 49:238-43. 2006
    ..This standardised grading system predicts the outcome of 3rd VS and helps in decision making for 3rd VS versus VP shunting...
  92. ncbi request reprint Comparative assessment of the functional p53 status in glioma cells
    E L Kim
    Department of Neurosurgery, University of Schleswig Holstein, Campus Lubeck, Germany
    Anticancer Res 25:213-24. 2005
    ..In clinical specimens the functional status of p53 is, therefore, often evaluated by direct mutation analysis of exons 5-8 or indirectly by immunostaining and evaluation of the subcellular localization pattern or protein accumulation...
  93. ncbi request reprint Head injury by gunshots from blank cartridges
    A Giese
    Department of Neurosurgery, University Hospital Eppendorf, Hamburg, Germany
    Surg Neurol 57:268-77. 2002
    ..The predominant reasons for these injuries are suicide or suicide attempts, followed by accidental injuries...
  94. ncbi request reprint Ultrasound-guided surgery of deep seated brain lesions
    J Regelsberger
    Department of Neurosurgery, University Hospital of Hamburg, Martinistrasse 52, 20246, Hamburg, Germany
    Eur J Ultrasound 12:115-21. 2000
    ..In this context we present our experiences with intraoperative ultrasound which represents a real-time navigation system...
  95. ncbi request reprint Combined 1p/19q loss in oligodendroglial tumors: predictive or prognostic biomarker?
    Michael Weller
    Department of General Neurology, University of Tubingen, Tubingen, Germany
    Clin Cancer Res 13:6933-7. 2007
    ..Importantly, the possible effect of combined 1p/19q loss has not been studied in patients who were not treated with radiotherapy or chemotherapy...
  96. ncbi request reprint A role for receptor tyrosine phosphatase zeta in glioma cell migration
    Sabine Muller
    AGY Therapeutics, Inc, 290 Utah Avenue, South San Francisco, CA 94080, USA
    Oncogene 22:6661-8. 2003
    ..Our results suggest a novel function for RPTPzeta in regulating glioblastoma cell motility and point to the therapeutic utility of RPTPzeta as a target for antibody-mediated therapy of brain tumors...
  97. ncbi request reprint Methods to study angiogenesis in vitro
    Katrin Lamszus
    Department of Neurosurgery, University Hospital Hamburg Eppendorf Germany
    Cancer Treat Res 117:141-6. 2004
  98. ncbi request reprint Angiogenesis-related growth factors in brain tumors
    Katrin Lamszus
    Department of Neurosurgery, University Hospital Hamburg Eppendorf Germany
    Cancer Treat Res 117:169-90. 2004
    ....
  99. ncbi request reprint Safety, tolerability, and tumor response of IL4-Pseudomonas exotoxin (NBI-3001) in patients with recurrent malignant glioma
    Friedrich Weber
    Department of Neurological Surgery, Heinrich Heine University, Dusseldorf, Germany
    J Neurooncol 64:125-37. 2003
    ..This was an open-label, dose-escalation trial of intratumoral administration of IL-4 Pseudomonas exotoxin (NBI-3001) in patients with recurrent malignant glioma...
  100. ncbi request reprint Receptor protein tyrosine phosphatase zeta as a therapeutic target for glioblastoma therapy
    Sabine Muller
    AGY Therapeutics, 270 East Grant Avenue, South San Francisco, CA 94080, USA
    Expert Opin Ther Targets 8:211-20. 2004
    ..This review will summarise recent advances in GBM therapies focusing on RPTPzeta as a target for immunotherapeutics...
  101. ncbi request reprint August 2004: 64-year-old man with intermittent paresthesia of the abdomen and of the legs
    Luca Papavero
    Brain Pathol 15:91-2, 95. 2005
    ..In our surgical experience with 226 intramedullary tumors and with 117 patients affected by intracranial pilocytic astrocytoma this case is unique because of its combination of tumor location, growth pattern and age of the patient...