B Westermann

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. pmc The inner membrane protein Mdm33 controls mitochondrial morphology in yeast
    Marlies Messerschmitt
    Institut fur Physiologische Chemie, Universitat Munchen, D 81377 Munchen, Germany
    J Cell Biol 160:553-64. 2003
  2. pmc Connection of the mitochondrial outer and inner membranes by Fzo1 is critical for organellar fusion
    S Fritz
    Institut fur Physiologische Chemie, Universitat Munchen, 80336 Munchen, Germany
    J Cell Biol 152:683-92. 2001
  3. ncbi request reprint Mitochondrial membrane fusion
    Benedikt Westermann
    Institut für Physiologische Chemie der Universität München, Butenandtstr 5, 81377, Munchen, Germany
    Biochim Biophys Acta 1641:195-202. 2003
  4. ncbi request reprint Mitochondria-targeted green fluorescent proteins: convenient tools for the study of organelle biogenesis in Saccharomyces cerevisiae
    B Westermann
    Institut fur Physiologische Chemie, Ludwig Maximilians Universitat Munchen, 80336 Munchen, Germany
    Yeast 16:1421-7. 2000
  5. pmc Merging mitochondria matters: cellular role and molecular machinery of mitochondrial fusion
    Benedikt Westermann
    Institut für Physiologische Chemie der Universität München, Butenandtstrasse 5, D 81377 Munchen, Germany
    EMBO Rep 3:527-31. 2002
  6. pmc The nucleotide exchange factor MGE exerts a key function in the ATP-dependent cycle of mt-Hsp70-Tim44 interaction driving mitochondrial protein import
    H C Schneider
    Institut fur Physiologische Chemie, Universitat Munchen, Germany
    EMBO J 15:5796-803. 1996
  7. ncbi request reprint Fzo1p is a mitochondrial outer membrane protein essential for the biogenesis of functional mitochondria in Saccharomyces cerevisiae
    D Rapaport
    Institut fur Physiologische Chemie, Physikalische Biochemie und Zellbiologie der Universität München, Goethestrabetae 33, 80336 Munchen, Germany
    J Biol Chem 273:20150-5. 1998
  8. ncbi request reprint Mdj2p, a novel DnaJ homolog in the mitochondrial inner membrane of the yeast Saccharomyces cerevisiae
    B Westermann
    Institut für Physiologische Chemie der Universität München, Goethestrasse 33, Munchen, D 80336, Germany
    J Mol Biol 272:477-83. 1997
  9. pmc Role of MMM1 in maintaining mitochondrial morphology in Neurospora crassa
    H Prokisch
    Institut für Physiologische Chemie der Universität München, Goethestrasse 33, 80336 Munchen, Germany
    Mol Biol Cell 11:2961-71. 2000
  10. ncbi request reprint The mitochondrial proteins Ssq1 and Jac1 are required for the assembly of iron sulfur clusters in mitochondria
    T Lutz
    Institut für Physiologische, Chemie der Universität München, Goethestrasse 33, Munchen, 80336, Germany
    J Mol Biol 307:815-25. 2001

Collaborators

  • E Schwarz
  • Walter Neupert
  • Kai Stefan Dimmer
  • H Prokisch
  • S Jakobs
  • T Langer
  • Nikolaus Pfanner
  • Johannes M Herrmann
  • Mafalda Escobar-Henriques
  • Katrin Altmann
  • Mark Dürr
  • Florian Fuchs
  • Sandra Merz
  • Stefan Fritz
  • Carsten Merkwirth
  • Stefan Geimer
  • Luiza K Sanjuán Szklarz
  • Ravi Jagasia
  • D Rapaport
  • Marlies Messerschmitt
  • S Fritz
  • T Lutz
  • F Thomas Wunderlich
  • Daniel Neumann
  • Ari Waisman
  • Martina Frank
  • Takashi Tatsuta
  • Sascha Dargazanli
  • Jürgen Christoph von Kleist-Retzow
  • Beatrix Löwer
  • Sandra Vogel
  • Agnieszka Chacinska
  • Vera Kozjak-Pavlovic
  • Chris Meisinger
  • Jean Claude Martinou
  • Miriam Hammermeister
  • Bernard Guiard
  • Dusanka Milenkovic
  • F Nora Vögtle
  • Christoph Borner
  • Barbara Conradt
  • Phillip Grote
  • M Brunner
  • Frank Vogel
  • Nadja Weinbach
  • H C Schneider
  • E Klanner

Detail Information

Publications33

  1. pmc The inner membrane protein Mdm33 controls mitochondrial morphology in yeast
    Marlies Messerschmitt
    Institut fur Physiologische Chemie, Universitat Munchen, D 81377 Munchen, Germany
    J Cell Biol 160:553-64. 2003
    ..Our results indicate that Mdm33 plays a distinct role in the mitochondrial inner membrane to control mitochondrial morphology. We propose that Mdm33 is involved in fission of the mitochondrial inner membrane...
  2. pmc Connection of the mitochondrial outer and inner membranes by Fzo1 is critical for organellar fusion
    S Fritz
    Institut fur Physiologische Chemie, Universitat Munchen, 80336 Munchen, Germany
    J Cell Biol 152:683-92. 2001
    ..A fusion machinery that is in contact with both mitochondrial membranes appears to be functionally important for coordinated fusion of four mitochondrial membranes...
  3. ncbi request reprint Mitochondrial membrane fusion
    Benedikt Westermann
    Institut für Physiologische Chemie der Universität München, Butenandtstr 5, 81377, Munchen, Germany
    Biochim Biophys Acta 1641:195-202. 2003
    ..Additional components have been identified by genetic screens. These findings suggest a unique and evolutionarily conserved mechanism for mitochondrial membrane fusion...
  4. ncbi request reprint Mitochondria-targeted green fluorescent proteins: convenient tools for the study of organelle biogenesis in Saccharomyces cerevisiae
    B Westermann
    Institut fur Physiologische Chemie, Ludwig Maximilians Universitat Munchen, 80336 Munchen, Germany
    Yeast 16:1421-7. 2000
    ....
  5. pmc Merging mitochondria matters: cellular role and molecular machinery of mitochondrial fusion
    Benedikt Westermann
    Institut für Physiologische Chemie der Universität München, Butenandtstrasse 5, D 81377 Munchen, Germany
    EMBO Rep 3:527-31. 2002
    ..Mechanistic studies have provided the first insights into how the problem of faithfully fusing a double membrane-bounded organelle in a coordinated manner is solved...
  6. pmc The nucleotide exchange factor MGE exerts a key function in the ATP-dependent cycle of mt-Hsp70-Tim44 interaction driving mitochondrial protein import
    H C Schneider
    Institut fur Physiologische Chemie, Universitat Munchen, Germany
    EMBO J 15:5796-803. 1996
    ..Subsequently, the release of mt-Hsp70 from the polypeptide chain is triggered by Mge1p which promotes release of ADP from mt-Hsp70. Rebinding of ATP to mt-Hsp70 completes the reaction cycle...
  7. ncbi request reprint Fzo1p is a mitochondrial outer membrane protein essential for the biogenesis of functional mitochondria in Saccharomyces cerevisiae
    D Rapaport
    Institut fur Physiologische Chemie, Physikalische Biochemie und Zellbiologie der Universität München, Goethestrabetae 33, 80336 Munchen, Germany
    J Biol Chem 273:20150-5. 1998
    ..It is imported into the outer membrane in a receptor-dependent manner. Fzo1p is part of a larger protein complex of 800 kDa, and presumably is the first identified component of the yeast mitochondrial fusion machinery...
  8. ncbi request reprint Mdj2p, a novel DnaJ homolog in the mitochondrial inner membrane of the yeast Saccharomyces cerevisiae
    B Westermann
    Institut für Physiologische Chemie der Universität München, Goethestrasse 33, Munchen, D 80336, Germany
    J Mol Biol 272:477-83. 1997
    ..Deletion of the MDJ2 gene did not result in a detectable growth defect. Double mutants of mdj1 and mdj2 showed severe growth defects at elevated temperature, indicating a distinct overlap of the functions of Mdj1p and Mdj2p...
  9. pmc Role of MMM1 in maintaining mitochondrial morphology in Neurospora crassa
    H Prokisch
    Institut für Physiologische Chemie der Universität München, Goethestrasse 33, 80336 Munchen, Germany
    Mol Biol Cell 11:2961-71. 2000
    ..Our findings suggest that MMM1 is a factor of general importance for mitochondrial morphology independent of the cytoskeletal system used for mitochondrial transport...
  10. ncbi request reprint The mitochondrial proteins Ssq1 and Jac1 are required for the assembly of iron sulfur clusters in mitochondria
    T Lutz
    Institut für Physiologische, Chemie der Universität München, Goethestrasse 33, Munchen, 80336, Germany
    J Mol Biol 307:815-25. 2001
    ..Furthermore, the presence of frataxin is necessary for FeS cluster assembly into ferredoxin suggesting a role for frataxin at the level of the formation of holo-ferredoxin...
  11. pmc Role of the mitochondrial DnaJ homolog Mdj1p as a chaperone for mitochondrially synthesized and imported proteins
    B Westermann
    Institut für Physiologische Chemie der Universität München, Germany
    Mol Cell Biol 16:7063-71. 1996
    ..Our results suggest that Mdj1p together with mt-Hsp70 plays an important role as a chaperone for mitochondrially synthesized polypeptide chains emerging from the ribosome and for translocating proteins at a late import step...
  12. ncbi request reprint XDJ1, a gene encoding a novel non-essential DnaJ homologue from Saccharomyces cerevisiae
    E Schwarz
    Institut fur Physiologische Chemie, Munchen, Germany
    Gene 145:121-4. 1994
    ..Thus, XDJ1 is either expressed only under very specific conditions or represents a silent gene...
  13. ncbi request reprint Molecular machinery of mitochondrial dynamics in yeast
    Sandra Merz
    Institut fur Zellbiologie, Universitat Bayreuth, D 95440 Bayreuth, Germany
    Biol Chem 388:917-26. 2007
    ..Taken together, these findings reveal a comprehensive picture that shows the cellular processes and molecular components required for mitochondrial inheritance and morphogenesis in a simple eukaryotic cell...
  14. ncbi request reprint Analysis of protein-protein interactions in mitochondria
    Johannes M Herrmann
    Institut fur Zellbiologie, Universitat Kaiserslautern, 67663 Kaiserslautern, Germany
    Methods Cell Biol 80:743-59. 2007
  15. ncbi request reprint Preprotein transport machineries of yeast mitochondrial outer membrane are not required for Bax-induced release of intermembrane space proteins
    Luiza K Sanjuán Szklarz
    Institut fur Biochemie und Molekularbiologie, Zentrum für Biochemie und Molekulare Zellforschung, Universitat Freiburg, Hermann Herder Strasse 7, D 79104 Freiburg, Germany
    J Mol Biol 368:44-54. 2007
    ..Inactivation of the known protein import and sorting machineries of the outer membrane does not impair the function of Bax at the mitochondria...
  16. pmc Nonredundant roles of mitochondria-associated F-box proteins Mfb1 and Mdm30 in maintenance of mitochondrial morphology in yeast
    Mark Dürr
    Institut fur Zellbiologie, Universitat Bayreuth, 95440 Bayreuth, Germany
    Mol Biol Cell 17:3745-55. 2006
    ..We propose that mitochondria-associated F-box proteins Mfb1 and Mdm30 are key components of a complex machinery that regulates mitochondrial dynamics throughout yeast's entire life cycle...
  17. pmc Regulation of mitochondrial fusion by the F-box protein Mdm30 involves proteasome-independent turnover of Fzo1
    Mafalda Escobar-Henriques
    Institute of Genetics and Center for Molecular Medicine, University of Cologne, D 50923 Cologne, Germany
    J Cell Biol 173:645-50. 2006
    ....
  18. pmc Mdm31 and Mdm32 are inner membrane proteins required for maintenance of mitochondrial shape and stability of mitochondrial DNA nucleoids in yeast
    Kai Stefan Dimmer
    Institut fur Physiologische Chemie, Universitat Munchen, 81377 Munchen, Germany
    J Cell Biol 168:103-15. 2005
    ..We propose that Mdm31 and Mdm32 cooperate with Mmm1, Mmm2, Mdm10, and Mdm12 in maintenance of mitochondrial morphology and mtDNA...
  19. pmc Prohibitins control cell proliferation and apoptosis by regulating OPA1-dependent cristae morphogenesis in mitochondria
    Carsten Merkwirth
    Institute for Genetics, Centre for Molecular Medicine, University of Cologne, 50674 Cologne, Germany
    Genes Dev 22:476-88. 2008
    ..Our results therefore assign an essential function for the formation of mitochondrial cristae to prohibitins and suggest a coupling of cell proliferation to mitochondrial morphogenesis...
  20. pmc Mdm30 is an F-box protein required for maintenance of fusion-competent mitochondria in yeast
    Stefan Fritz
    Institut fur Physiologische Chemie, Universitat Munchen, Germany
    Mol Biol Cell 14:2303-13. 2003
    ..Our results suggest that Mdm30 controls mitochondrial shape by regulating the steady-state level of Fzo1 and point to a connection of the ubiquitin/26S proteasome system and mitochondria...
  21. ncbi request reprint Spatial and temporal dynamics of budding yeast mitochondria lacking the division component Fis1p
    Stefan Jakobs
    Department of NanoBiophotonics, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Gottingen, Germany
    J Cell Sci 116:2005-14. 2003
    ..The data suggest that different molecular machineries are responsible for the separation of the matrix and the fission of the outer membrane in budding yeast...
  22. ncbi request reprint Interaction of mitochondria with microtubules in the filamentous fungus Neurospora crassa
    Florian Fuchs
    Institut für Physiologische Chemie der Universität München, Butenandtstrasse 5, D 81377 Munich, Germany
    J Cell Sci 115:1931-7. 2002
    ..We conclude that mitochondrial morphology is maintained by a complex interplay of extrinsic and intrinsic factors, including ATP-dependent proteins on the organellar surface...
  23. pmc Role of Unc104/KIF1-related motor proteins in mitochondrial transport in Neurospora crassa
    Florian Fuchs
    Institut fur Physiologische Chemie, Universitat Munchen, 81377 Munchen, Germany
    Mol Biol Cell 16:153-61. 2005
    ....
  24. doi request reprint Molecular machinery of mitochondrial fusion and fission
    Benedikt Westermann
    Institut für Zellbiologie and the Bayreuther Zentrum für Molekulare Biowissenschaften, Universitat Bayreuth, 95440 Bayreuth, Germany
    J Biol Chem 283:13501-5. 2008
  25. ncbi request reprint Saccharomyces cerevisiae as a model organism to study mitochondrial biology: general considerations and basic procedures
    Katrin Altmann
    Institut fur Zellbiologie, Universitat Bayreuth, Germany
    Methods Mol Biol 372:81-90. 2007
    ..Furthermore, this chapter provides protocols describing yeast culture conditions and procedures for isolation and purification of mitochondria...
  26. pmc Genetic basis of mitochondrial function and morphology in Saccharomyces cerevisiae
    Kai Stefan Dimmer
    Institut für Physiologische Chemie der Universität München, D 81377 Munchen, Germany
    Mol Biol Cell 13:847-53. 2002
    ..These data provide a comprehensive picture of the cellular processes and molecular components required for mitochondrial function and structure in a simple eukaryotic cell...
  27. ncbi request reprint Focus on mitochondria: introducing a new series in Trends in Cell Biology
    Benedikt Westermann
    Trends Cell Biol 17:417-8. 2007
  28. ncbi request reprint Protein import into mitochondria of Neurospora crassa
    Holger Prokisch
    Institut fur Physiologische Chemie, Universitat Munchen, Butenandtstr 5, 81377 Munich, Germany
    Fungal Genet Biol 36:85-90. 2002
    ..This review focuses on the contributions of the filamentous fungus Neurospora crassa to our current understanding of mitochondrial protein import, with special emphasis on the structure and function of the TOM complex...
  29. ncbi request reprint Mitochondrial dynamics in filamentous fungi
    Benedikt Westermann
    Institut fur Physiologische Chemie, Universitat Munchen, Butenandtstr 5, 81377 Munich, Germany
    Fungal Genet Biol 36:91-7. 2002
    ..Here, we review the contributions of fungi, with special emphasis on the filamentous fungus Neurospora crassa, to our current understanding of mitochondrial morphogenesis and inheritance...
  30. ncbi request reprint 'Omics' of the mitochondrion
    Benedikt Westermann
    Nat Biotechnol 21:239-40. 2003
  31. pmc Role of essential genes in mitochondrial morphogenesis in Saccharomyces cerevisiae
    Katrin Altmann
    Institut fur Zellbiologie, Universitat Bayreuth, Germany
    Mol Biol Cell 16:5410-7. 2005
    ..We conclude that these cellular pathways play an important role in mitochondrial morphogenesis and inheritance...
  32. ncbi request reprint DRP-1-mediated mitochondrial fragmentation during EGL-1-induced cell death in C. elegans
    Ravi Jagasia
    Max Planck Institute of Neurobiology, Am Klopferspitz 18a, D 82152 Planegg Martinsried, Germany
    Nature 433:754-60. 2005
    ..elegans development. These results assign an important role to mitochondria in the cell-death pathway in C. elegans...
  33. pmc The class V myosin motor protein, Myo2, plays a major role in mitochondrial motility in Saccharomyces cerevisiae
    Katrin Altmann
    Institut fur Zellbiologie, Universitat Bayreuth, 95440 Bayreuth, Germany
    J Cell Biol 181:119-30. 2008
    ..We conclude that Myo2 plays an important and direct role for mitochondrial motility and inheritance in budding yeast...