N Werner

Summary

Affiliation: University of Bonn
Country: Germany

Publications

  1. ncbi request reprint In vitro differentiation characteristics of cultured human mononuclear cells-implications for endothelial progenitor cell biology
    Katrin Walenta
    Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, 66421 Homburg Saar, Germany
    Biochem Biophys Res Commun 333:476-82. 2005
  2. ncbi request reprint Influence of cardiovascular risk factors on endothelial progenitor cells: limitations for therapy?
    Nikos Werner
    Medizinischen Klinik und Poliklinik II, Universitatsklinikum Bonn, Germany
    Arterioscler Thromb Vasc Biol 26:257-66. 2006
  3. ncbi request reprint Endothelial progenitor cells in health and atherosclerotic disease
    Nikos Werner
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Bonn, Bonn, Germany
    Ann Med 39:82-90. 2007
  4. ncbi request reprint Endothelial progenitor cells correlate with endothelial function in patients with coronary artery disease
    Nikos Werner
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Bonn, Bonn, Germany
    Basic Res Cardiol 102:565-71. 2007
  5. ncbi request reprint Clinical and therapeutical implications of EPC biology in atherosclerosis
    N Werner
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Bonn, Germany
    J Cell Mol Med 10:318-32. 2006
  6. ncbi request reprint Innovations and novel technologies in TAVI. Second generation transcatheter heart valves
    J M Sinning
    Herzzentrum Bonn, Medizinische Klinik und Poliklinik II, Universitatsklinikum Bonn, Germany
    Minerva Cardioangiol 61:155-63. 2013
  7. doi request reprint Regeneration of the vascular compartment
    M U Becher
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Bonn, Sigmund Freud Strasse 25, Bonn, Germany
    Herz 35:342-51. 2010
  8. ncbi request reprint Circulating CD31+/annexin V+ apoptotic microparticles correlate with coronary endothelial function in patients with coronary artery disease
    Nikos Werner
    Klinik fur Innere Medizin II, Universitatsklinikum Bonn, Bonn, Germany
    Arterioscler Thromb Vasc Biol 26:112-6. 2006
  9. ncbi request reprint Improvement of endothelial function by systemic transfusion of vascular progenitor cells
    Sven Wassmann
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    Circ Res 99:e74-83. 2006
  10. doi request reprint Endothelial damage and regeneration: the role of the renin-angiotensin-aldosterone system
    Ulrich M Becher
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Bonn, Sigmund Freud Strasse 25, Bonn, Germany
    Curr Hypertens Rep 13:86-92. 2011

Collaborators

Detail Information

Publications32

  1. ncbi request reprint In vitro differentiation characteristics of cultured human mononuclear cells-implications for endothelial progenitor cell biology
    Katrin Walenta
    Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, 66421 Homburg Saar, Germany
    Biochem Biophys Res Commun 333:476-82. 2005
    ..Careful surface marker analysis might be necessary when using in vitro EPC differentiation systems...
  2. ncbi request reprint Influence of cardiovascular risk factors on endothelial progenitor cells: limitations for therapy?
    Nikos Werner
    Medizinischen Klinik und Poliklinik II, Universitatsklinikum Bonn, Germany
    Arterioscler Thromb Vasc Biol 26:257-66. 2006
    ....
  3. ncbi request reprint Endothelial progenitor cells in health and atherosclerotic disease
    Nikos Werner
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Bonn, Bonn, Germany
    Ann Med 39:82-90. 2007
    ..We discuss new insights into vascular stem cell biology derived from experimental and clinical studies...
  4. ncbi request reprint Endothelial progenitor cells correlate with endothelial function in patients with coronary artery disease
    Nikos Werner
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Bonn, Bonn, Germany
    Basic Res Cardiol 102:565-71. 2007
    ..Endothelial function closely correlates with the number of circulating EPC providing new mechanistic insights and options for risk assessment in patients with coronary heart disease...
  5. ncbi request reprint Clinical and therapeutical implications of EPC biology in atherosclerosis
    N Werner
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Bonn, Germany
    J Cell Mol Med 10:318-32. 2006
    ..In this review we focus on the role of circulating endothelial progenitor cells in endothelial cell repair mechanisms at the vascular wall and their potentially protective and therapeutic role in atherosclerotic disease...
  6. ncbi request reprint Innovations and novel technologies in TAVI. Second generation transcatheter heart valves
    J M Sinning
    Herzzentrum Bonn, Medizinische Klinik und Poliklinik II, Universitatsklinikum Bonn, Germany
    Minerva Cardioangiol 61:155-63. 2013
    ....
  7. doi request reprint Regeneration of the vascular compartment
    M U Becher
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Bonn, Sigmund Freud Strasse 25, Bonn, Germany
    Herz 35:342-51. 2010
    ....
  8. ncbi request reprint Circulating CD31+/annexin V+ apoptotic microparticles correlate with coronary endothelial function in patients with coronary artery disease
    Nikos Werner
    Klinik fur Innere Medizin II, Universitatsklinikum Bonn, Bonn, Germany
    Arterioscler Thromb Vasc Biol 26:112-6. 2006
    ..Endothelial dysfunction predicts morbidity and mortality in patients at cardiovascular risk. Endothelial function may be decisively influenced by the degree of endothelial cell apoptosis...
  9. ncbi request reprint Improvement of endothelial function by systemic transfusion of vascular progenitor cells
    Sven Wassmann
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    Circ Res 99:e74-83. 2006
    ..More than 1 subpopulation of the MNC fraction seems to be involved in this effect...
  10. doi request reprint Endothelial damage and regeneration: the role of the renin-angiotensin-aldosterone system
    Ulrich M Becher
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Bonn, Sigmund Freud Strasse 25, Bonn, Germany
    Curr Hypertens Rep 13:86-92. 2011
    ..This review focuses on the growing knowledge about regenerating vascular cells, their response to RAAS effectors, and RAAS-modulating pharmacotherapy in the context of endothelial cell damage and regeneration...
  11. doi request reprint Risk and fate of cerebral embolism after transfemoral aortic valve implantation: a prospective pilot study with diffusion-weighted magnetic resonance imaging
    Alexander Ghanem
    Department of Medicine Cardiology, University of Bonn, Bonn, Germany
    J Am Coll Cardiol 55:1427-32. 2010
    ..The aim of this study was prospective investigation of silent and clinically apparent cerebral embolic events and neurological impairment after transfemoral aortic valve implantation (TAVI)...
  12. doi request reprint Microparticles--messengers of biological information
    Friedrich Felix Hoyer
    Department of Cardiology, University Hospital Bonn, Bonn, Germany
    J Cell Mol Med 14:2250-6. 2010
    ..In this review, we focus on the emerging role of circulating MP as transmitters of biological information in cardiovascular disease...
  13. doi request reprint [Perspectives of regenerative mechanisms in cardiovascular disease spotlighting endothelial progenitor cells]
    Martin Steinmetz
    Medizinische Klinik und Poliklinik II, Kardiologie, Pulmologie und Angiologie, Universitatsklinikum Bonn
    Med Klin (Munich) 104:287-95. 2009
    ..This article offers a review of state-of-the-art regenerative mechanisms in cardiovascular disease spotlighting endothelial progenitor cells, and further features the perspectives of regenerative medicine in vascular biology...
  14. ncbi request reprint [Stem cells in cardiovascular medicine]
    N Werner
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Bonn
    Dtsch Med Wochenschr 131:1438-40. 2006
  15. doi request reprint High-density lipoprotein exerts vasculoprotection via endothelial progenitor cells
    Vasileios Petoumenos
    Department of Internal Medicine II, University Hospital Bonn, Bonn, Germany
    J Cell Mol Med 13:4623-35. 2009
    ..We provide evidence that HDL mediates important vasculoprotective action via the improvement of function of circulating EPC...
  16. doi request reprint Symptomatic paravalvular leakage after mechanical aortic valve replacement in a critically ill patient: why not just "plug" the hole?
    C Hammerstingl
    Medizinische Klinik II, Universitatsklinikum Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Eur J Echocardiogr 10:576-8. 2009
    ....
  17. doi request reprint Hotline update of clinical trials and registries presented at the 77th spring meeting of the German Society of Cardiology 2011
    J M Sinning
    Medizinische Klinik und Poliklinik II, Innere Medizin Kardiologie, Angiologie, Pneumologie und Internistische Intensivmedizin, Universitatsklinikum Bonn, Sigmund Freud Str 25, 53105, Bonn, Germany
    Clin Res Cardiol 100:553-60. 2011
    ..The data were presented by leading experts in the field with relevant positions in the trials...
  18. doi request reprint Endothelial-regenerating cells: an expanding universe
    Martin Steinmetz
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Bonn, Bonn, Germany
    Hypertension 55:593-9. 2010
    ....
  19. pmc Essential role of bone marrow fibroblast growth factor-2 in the effect of estradiol on reendothelialization and endothelial progenitor cell mobilization
    Vincent Fontaine
    INSERM U589, Institut L Bugnard, Centre Hospitalier Universitaire Rangueil, Toulouse Cedex, France
    Am J Pathol 169:1855-62. 2006
    ..In conclusion, FGF2, specifically medullary FGF2, is necessary and sufficient to mediate the accelerative effect of E2 on both reendothelialization and EPC mobilization...
  20. ncbi request reprint Tracking of systemically administered mononuclear cells in the ischemic brain by high-field magnetic resonance imaging
    Albrecht Stroh
    Department of Radiology, Charite Universitaetsmedizin Berlin, Schumannstrasse 20 21, 10117 Berlin, Germany
    Neuroimage 33:886-97. 2006
    ..Taken together, our results demonstrate that brain engraftment of systemically administered mononuclear cells can be visualized non-invasively over time and space using high-resolution MRI...
  21. ncbi request reprint Bone marrow-derived progenitor cells modulate vascular reendothelialization and neointimal formation: effect of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibition
    Nikos Werner
    Medizinische Klinik und Poliklinik, Innere Medizin III, Universitat des Saarlandes, Homburg Saar, Germany
    Arterioscler Thromb Vasc Biol 22:1567-72. 2002
    ..Despite the anticipated stem cell plasticity, the role of bone marrow-derived endothelial progenitor cells has not been clarified in vascular lesion development...
  22. ncbi request reprint Estrogen increases bone marrow-derived endothelial progenitor cell production and diminishes neointima formation
    Kerstin Strehlow
    Klinik und Poliklinik Innere Medizin III, Universitat des Saarlandes, 66421 Homburg Saar, Germany
    Circulation 107:3059-65. 2003
    ..Bone marrow-derived endothelial progenitor cells (EPCs) are thought to positively influence endothelialization, vascular repair, and angiogenesis...
  23. ncbi request reprint Intravenous transfusion of endothelial progenitor cells reduces neointima formation after vascular injury
    Nikos Werner
    Klinik und Poliklinik, Innere Medizin III, Universitat des Saarlandes, 66421 Homburg Saar, Germany
    Circ Res 93:e17-24. 2003
    ..The full text of this article is available online at http://www.circresaha.org...
  24. ncbi request reprint Physical training increases endothelial progenitor cells, inhibits neointima formation, and enhances angiogenesis
    Ulrich Laufs
    Medizinische Klinik und Poliklinik der Universität des Saarlandes, Innere Medizin III, Homburg, Germany
    Circulation 109:220-6. 2004
    ..Bone marrow-derived endothelial progenitor cells (EPCs) are thought to exert beneficial effects on atherosclerosis, angiogenesis, and vascular repair...
  25. ncbi request reprint Running exercise of different duration and intensity: effect on endothelial progenitor cells in healthy subjects
    Ulrich Laufs
    Medizinische Klinik und Poliklinik der Universität des Saarlandes, Innere Medizin III, 66421 Homburg, Germany
    Eur J Cardiovasc Prev Rehabil 12:407-14. 2005
    ..Exercise is a central component of the primary prevention of vascular diseases. The effect of physical activity on circulating EPC in healthy individuals is not known...
  26. ncbi request reprint Circulating endothelial progenitor cells and cardiovascular outcomes
    Nikos Werner
    Division of Cardiology, Angiology, and Intensive Care Medicine, Department of Internal Medicine, University of Saarland, Homburg Saar, Germany
    N Engl J Med 353:999-1007. 2005
    ..The number and function of endothelial progenitor cells correlate inversely with cardiovascular risk factors, but the prognostic value associated with circulating endothelial progenitor cells has not been defined...
  27. ncbi request reprint Circulating endothelial progenitor cells correlate with erectile function in patients with coronary heart disease
    Magnus Baumhakel
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, D 66421 Homburg Saar, Germany
    Eur Heart J 27:2184-8. 2006
    ..The aim of the study was to determine the influence of endothelial progenitor cells (EPC) on erectile dysfunction (ED). EPC play a major role in repair mechanisms of the endothelial monolayer, but the role of EPC in ED is unclear...
  28. ncbi request reprint From fat fighter to risk factor: the zigzag trek of leptin
    Nikos Werner
    Arterioscler Thromb Vasc Biol 24:7-9. 2004
  29. ncbi request reprint CD34-/CD133+/VEGFR-2+ endothelial progenitor cell subpopulation with potent vasoregenerative capacities
    Erik B Friedrich
    Department for Internal Medicine III, University Hospital of the Saarland, Germany
    Circ Res 98:e20-5. 2006
    ..We identified a new CD34-/133+ EPC subpopulation, which is apparently a precursor of "classical" CD34+/133+ EPC, and functionally more potent than these with respect to homing and vascular repair...
  30. ncbi request reprint Clinical Trial Updates and Hotline Sessions presented at the European Society of Cardiology Congress 2007: (FINESSE, CARESS, OASIS 5, PRAGUE-8, OPTIMIST, GRACE, STEEPLE, SCAAR, STRATEGY, DANAMI-2, ExTRACT-TIMI-25, ISAR-REACT 2, ACUITY, ALOFT, 3CPO, PROSPE
    Michael Kindermann
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, 66421, Homburg Saar, Germany
    Clin Res Cardiol 96:767-86. 2007
    ..The comprehensive summaries have been generated from the oral presentation and the webcasts of the European Society of Cardiology and should provide the readers with the most comprehensive information of relevant publications...
  31. ncbi request reprint Role of integrin-linked kinase in vascular smooth muscle cells: regulation by statins and angiotensin II
    Erik B Friedrich
    Klinik für Innere Medizin III Kardiologie, Angiologie, Internistische Intensivmedizin, Universitatskliniken des Saarlandes, 66421 Homburg Saar, Germany
    Biochem Biophys Res Commun 349:883-9. 2006
    ..These data identify ILK as a novel target in VSMC for anti-atherosclerotic therapy...
  32. ncbi request reprint Redox-sensitive vascular smooth muscle cell proliferation is mediated by GKLF and Id3 in vitro and in vivo
    Georg Nickenig
    Universitatskliniken des Saarlandes, Medizinische Klinik und Poliklinik, Innere Medizin III, 66424 Homburg Saar, Germany
    FASEB J 16:1077-86. 2002
    ..These findings reveal novel mechanisms of redox-controlled cellular proliferation involving GKLF and Id3 that may have general implications for our understanding of vascular and nonvascular growth control...