Research Topics
Species | Joerg WenzelSummaryAffiliation: University of Bonn Country: Germany Publications
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Detail Information
Publications
Treatment of recalcitrant dermatomyositis with efalizumabAndrea Huber
Acta Derm Venereol 86:254-5. 2006
Pathogenesis of cutaneous lupus erythematosus: common and different features in distinct subsetsJ Wenzel
Department of Dermatology, University of Bonn, Germany
Lupus 19:1020-8. 2010..Here we review the main pathological features described in CLE patients against the background of the clinical diversity of different CLE subtypes...- Role of the chemokine receptor CCR4 and its ligand thymus- and activation-regulated chemokine/CCL17 for lymphocyte recruitment in cutaneous lupus erythematosusJoerg Wenzel
Department of Dermatology, University of Bonn, Bonn, Germany
J Invest Dermatol 124:1241-8. 2005..Our investigations suggest that CCR4 and TARC/CCL17 play a role in the pathophysiology of CLE. In particular, cytotoxic CD8+ T cells expressing CCR4 appear to be involved in scarring subtypes of CLE... - Efficacy and safety of methotrexate in recalcitrant cutaneous lupus erythematosus: results of a retrospective study in 43 patientsJ Wenzel
Department of Dermatology, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
Br J Dermatol 153:157-62. 2005..In recent years several other immunosuppressive agents have been successfully applied in CLE. However, there are no large studies or explicit guidelines on the use of these drugs in CLE... - The role of cytotoxic skin-homing CD8+ lymphocytes in cutaneous cytotoxic T-cell lymphoma and pityriasis lichenoidesJoerg Wenzel
Department of Dermatology, Institute of Pathology, University of Bonn, Bonn, Germany
J Am Acad Dermatol 53:422-7. 2005..This case prompted us to reinvestigate the role of cytotoxic T lymphocytes in PL and its relationship to antiviral immunity... - Scarring skin lesions of discoid lupus erythematosus are characterized by high numbers of skin-homing cytotoxic lymphocytes associated with strong expression of the type I interferon-induced protein MxAJ Wenzel
Department of Dermatology, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
Br J Dermatol 153:1011-5. 2005..Because recent investigations have highlighted the relevance of cytotoxic lymphocytes in autoimmune tissue destruction, we hypothesized that the scarring CDLE lesions might be caused by cytotoxic T lymphocytes... - [Systemic treatment of cutaneous lupus erythematosus]Joerg Wenzel
Klinik und Poliklinik fur Dermatologie, Universitatsklinikum Bonn
J Dtsch Dermatol Ges 1:694-704. 2003.... - [Topical treatment of bullous pemphigoid with tacrolimus. Case report with brief literature review]Joerg Wenzel
Klinik und Poliklinik fur Dermatologie, Universitatsklinikum Bonn
J Dtsch Dermatol Ges 3:207-10. 2005..He was treated with 0.1% tacrolimus ointment, which was able to control the disease. We briefly review the literature and discuss the potential role of tacrolimus as a novel option for the topical treatment of BP... - CXCR3-mediated recruitment of cytotoxic lymphocytes in lupus erythematosus profundusJoerg Wenzel
Department of Dermatology, University of Bonn, Germany
J Am Acad Dermatol 56:648-50. 2007..Recently, we observed a case of LEP involving the lower right eyelid. Our immunohistological analyses of lesional skin biopsies revealed a type I IFN signature in the context of cytotoxic lobular panniculitis... - Type I interferon-associated skin recruitment of CXCR3+ lymphocytes in dermatomyositisJ Wenzel
Department of Dermatology, University of Bonn, Germany
Clin Exp Dermatol 31:576-82. 2006..We hypothesized that a similar mechanism might also be involved in the pathogenesis of DM skin lesions... - Type I interferon-associated cytotoxic inflammation in lichen planusJoerg Wenzel
Department of Dermatology, University of Bonn, Bonn, Germany
J Cutan Pathol 33:672-8. 2006..Here, we investigated whether type I IFNs are also involved in the pathogenesis of LP... - IP10/CXCL10 - CXCR3 interaction: a potential self-recruiting mechanism for cytotoxic lymphocytes in lichen sclerosus et atrophicusJoerg Wenzel
Department of Dermatology, University of Bonn, Germany
Acta Derm Venereol 87:112-7. 2007..Infiltrating lymphocytes, containing IP10 in their granules, could provide an important self-perpetuating mechanism... - Identification of type I interferon-associated inflammation in the pathogenesis of cutaneous lupus erythematosus opens up options for novel therapeutic approachesJoerg Wenzel
Department of Dermatology, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
Exp Dermatol 16:454-63. 2007..Here, we review the role of type I IFNs, adhesion molecules and chemokine receptors in CLE and discuss options for novel therapeutic approaches... - Gene expression profiling of lichen planus reflects CXCL9+-mediated inflammation and distinguishes this disease from atopic dermatitis and psoriasisJoerg Wenzel
Department of Dermatology, University of Bonn, Bonn, Germany
J Invest Dermatol 128:67-78. 2008..Gene expression profiling might complement the diagnostic spectrum in dermatology and may provide new pathogenetic insights... - The expression pattern of interferon-inducible proteins reflects the characteristic histological distribution of infiltrating immune cells in different cutaneous lupus erythematosus subsetsJ Wenzel
Department of Dermatology, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
Br J Dermatol 157:752-7. 2007..We hypothesized that the expression pattern of IFN-inducible proteins reflects the characteristic distribution of the inflammatory infiltrate in different subsets of cutaneous LE... - CXCR3 <-> ligand-mediated skin inflammation in cutaneous lichenoid graft-versus-host diseaseJoerg Wenzel
Department of Dermatology at the Universitie of Bonn, Bonn, Germany
J Am Acad Dermatol 58:437-42. 2008.... - An IFN-associated cytotoxic cellular immune response against viral, self-, or tumor antigens is a common pathogenetic feature in "interface dermatitis"Joerg Wenzel
Department of Dermatology, University of Bonn, Bonn, Germany
J Invest Dermatol 128:2392-402. 2008.... - Transcriptional profiling identifies an interferon-associated host immune response in invasive squamous cell carcinoma of the skinJoerg Wenzel
Department of Dermatology, University of Bonn, Bonn, Germany
Int J Cancer 123:2605-15. 2008..Collectively, our findings support the concept that IFN-associated host responses play an important role in tumor immunosurveillance in the skin... - Type I interferon-associated cytotoxic inflammation in cutaneous lupus erythematosusJoerg Wenzel
Department of Dermatology, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
Arch Dermatol Res 301:83-6. 2009..These and other studies suggest that a complex network of IFN-associated cytokines, chemokines and adhesion molecules orchestrates and promotes tissue injury observed in LE skin... - The expression of human leukocyte antigen-DR and CD25 on circulating T cells in cutaneous lupus erythematosus and correlation with disease activityJoerg Wenzel
Department of Dermatology, University of Bonn, Bonn, Germany
Exp Dermatol 14:454-9. 2005..In patients with SLE, the expression of activation markers on circulating T cells reflects disease activity. Here, we investigated whether this also holds true for patients with CLE... - Flame figures in urticarial lesions accompanying systemic lupus erythematosusJ Wenzel
Department of Dermatology, University of Bonn, Germany
Am J Dermatopathol 23:533-5. 2001..Hematoxylin-eosin-stained sections revealed flame figures. We review urticarial lesions in lupus erythematosus and discuss the possible pathomechanisms... - Association of inclusion body myositis with subacute cutaneous lupus erythematosusJ Wenzel
Department of Dermatology, University of Bonn, Germany
Rheumatol Int 21:75-7. 2001..The presented case is discussed in the context of earlier reports of inclusion body myositis and lupus erythematosus... - Successful treatment of Dowling-Degos disease with Er:YAG laserJoerg Wenzel
Department of Dermatology, University of Bonn, Bonn, Germany
Dermatol Surg 28:748-50. 2002..The typical clinical picture is a reticulate pigmentation of the flexures, genital folds, and pectoral skin areas. Many different treatment options have been tried in recent years without a convincing therapeutic benefit... - Bullous lupus erythematosus in a patient with pre-existing dermatomyositisJoerg Wenzel
Department of Dermatology, University of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany
Rheumatol Int 24:114-6. 2004..Observations of transitions between DM and LE are extremely rare. Nevertheless, this case demonstrates the close relationship between these two disorders in the context of autoimmune connective tissue disease... - [Cutaneous lesions in lupus erythematosus]J Wenzel
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Dtsch Med Wochenschr 128:1655-8. 2003 - Topical treatment of pyoderma gangraenosumJoerg Wenzel
Department of Dermatology, University of Bonn, Germany
Dermatology 205:221-3. 2002..We give a review about these topically used drugs and the mechanisms probably involved... - Infraorbital eyelid edema as the presenting sign of bronchogenic carcinomaJoerg Wenzel
Department of Dermatology, University of Bonn, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany
Int J Dermatol 41:386-7. 2002 - Enhanced type I interferon signalling promotes Th1-biased inflammation in cutaneous lupus erythematosusJoerg Wenzel
Department of Dermatology, University of Bonn, Germany
J Pathol 205:435-42. 2005..It is proposed that type I IFNs induce a Th1-biased inflammatory immune response, with recruitment of CXCR3-expressing T-lymphocytes into the skin... - The value of lymphocytopenia as a marker of systemic involvement in cutaneous lupus erythematosusJ Wenzel
Department of Dermatology, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
Br J Dermatol 146:869-71. 2002..Recent studies revealed some markers indicating systemic manifestations of CLE patients. However, the significance of diminished peripheral lymphocyte numbers as a marker of systemic involvement in CLE has not been investigated before... - Enhanced type I interferon signaling and recruitment of chemokine receptor CXCR3-expressing lymphocytes into the skin following treatment with the TLR7-agonist imiquimodJoerg Wenzel
Department of Dermatology, University of Bonn, Bonn, Germany
J Cutan Pathol 32:257-62. 2005..We hypothesize that TLR7-signaling strongly induces the production of interferon (IFN) alpha, which is able to enhance Th1-mediated cellular antiviral and antitumor immunity... 
Indoleamine 2,3-dioxygenase (IDO): the antagonist of type I interferon-driven skin inflammation?Marina Scheler
Department of Dermatology, Friedrich Wilhelms University, Sigmund Freud Strasse 25, 53105 Bonn, Germany
Am J Pathol 171:1936-43. 2007..These findings reveal that both proinflammatory and counterregulatory mechanisms are operative in cutaneous lesions of LP. We propose that the balance of these mechanisms may be involved in the pathogenesis of this disorder...- Type I interferon-associated recruitment of cytotoxic lymphocytes: a common mechanism in regressive melanocytic lesionsJoerg Wenzel
Department of Dermatology, University of Bonn, Bonn, Germany
Am J Clin Pathol 124:37-48. 2005..We believe this cytotoxic immune response represents an evolutionarily conserved pathway against intracellular pathogens... - Sentinel lymph node status as most important prognostic factor in patients with high-risk cutaneous melanomas (tumour thickness >4.00 mm): outcome analysis from a single institutionTorsten Hinz
Department of Dermatology and Allergology, Center of Integrated Oncology Cologne Bonn University of Bonn, Bonn, Germany
Eur J Nucl Med Mol Imaging 39:1316-25. 2012..The purpose of the current study was to determine the prognostic value of SLNB in patients with thick cutaneous melanomas (tumour thickness >4.0 mm) in terms of progression-free survival (PFS) and overall survival (OS)... - Role of High-Resolution Ultrasound and PET/CT Imaging for Preoperative Characterization of Sentinel Lymph Nodes in Cutaneous MelanomaTorsten Hinz
Department of Dermatology and Allergy, University of Bonn, Bonn, Germany
Ultrasound Med Biol 39:30-6. 2013.... - Indoleamine 2,3-dioxygenase-expressing antigen-presenting cells and peripheral T-cell tolerance: another piece to the atopic puzzle?Dagmar von Bubnoff
Department of Dermatology, Friedrich Wilhelms University, Bonn, Germany
J Allergy Clin Immunol 112:854-60. 2003..We introduce the hypothesis that tryptophan degradation might add to the ability to control and downregulate allergen-specific T-cell responses in atopic individuals... - Generalized lichen nitidus with involvement of the palms following interferon alpha treatmentMarina Scheler
Department of Dermatology, University of Bonn, Bonn, Germany
Dermatology 215:236-9. 2007..Furthermore in our patient we could show a strong lesional expression of MxA, a protein specifically induced by type I interferon. It is tempting to speculate that interferon alpha may be involved in the pathogenesis of lichen nitidus... - Tryptase detection in bone-marrow blood: a new diagnostic tool in systemic mastocytosisJulia Proelss
Department of Dermatology, University of Bonn, Bonn, Germany
J Am Acad Dermatol 56:453-7. 2007..The diagnosis of systemic mastocytosis is substantially based on the histologic examination of bone-marrow biopsy specimens... - High-resolution ultrasound combined with power Doppler sonography can reduce the number of sentinel lymph node biopsies in cutaneous melanomaTorsten Hinz
Department of Dermatology and Allergology, Center of Integrated Oncology Cologne Bonn, University of Bonn, Bonn, Germany
Dermatology 222:180-8. 2011..Disadvantages of the SLNB procedure are the overall costs and potential side effects of the operation [J Dtsch Dermatol Ges 2009;7:318-327; J Am Dermatol 2010;62:737-748]... - Kaposi's sarcoma of the gastrointestinal tract: report of two cases and review of the literaturePhilip Kahl
Department of Pathology, University of Bonn Medical School, Sigmund Freud Street 25, 53127 Bonn, Germany
Pathol Res Pract 203:227-31. 2007..Nevertheless, Kaposi's sarcoma must always be considered in lesions of the gastrointestinal tract or in gastrointestinal bleeding and should lead to further elucidation of the causes... - [Multiple skin cancers in a patient treated with hydroxyurea]A Wiechert
Dermatologische Klinik, Universitatsklinikum Bonn, Sigmund Freud Strasse 25, 53105 Bonn
Hautarzt 60:651-2, 654. 2009..An association with multiple skin tumors has been reported. The presented case emphasizes this potential risk of hydroxyurea therapy. Continuous dermatologic monitoring of patients treated with hydroxyurea is recommended... - Successful treatment of acrodermatitis continua suppurativa with topical tacrolimus 0.1% ointmentD Wilsmann-Theis
Department of Dermatology, University of Bonn, 53105, Germany
Br J Dermatol 150:1194-7. 2004..1% ointment. Our observations raise hopes that this new treatment strategy for ACS may constitute a novel effective therapeutic option for this recalcitrant condition... - New reasons for histopathological nail-clipping examination in the diagnosis of onychomycosisD Wilsmann-Theis
Department of Dermatology and Allergy, University of Bonn, Bonn, Germany
J Eur Acad Dermatol Venereol 25:235-7. 2011..In addition, in cases of controlling the antifungal treatment course, the present gold standard is often not a reliable tool because of the inhibition of the fungal growth in the culture... - Efficacy of ablative laser treatment in Galli-Galli diseaseHarald Voth
Department of Dermatology and Allergy, University of Bonn, Germany
Arch Dermatol 147:317-20. 2011..To date, no convincing treatment options are known for GGD. We sought to examine the therapeutic potential of ablative laser treatment in a patient with genetically confirmed GGD... - Scleroderma and malignancy. Mechanisms of interrelationshipJoerg Wenzel
Department of Dermatology, University of Bonn, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany. joerg.wenzel.ukb.uni-bonn.de
Eur J Dermatol 12:296-300. 2002..This paper reviews the mechanisms described in earlier studies and discusses their possible pathogenetic meaning for the interrelationship and the pathogenesis of scleroderma and neoplasia... - Periodic genital pruritus caused by syringoma of the vulvaRainer Gerdsen
Department of Dermatology, University of Bonn, Germany, Bonn, Germany
Acta Obstet Gynecol Scand 81:369-70. 2002 - Lymphocytopenia in lupus erythematosus: close in vivo association to autoantibodies targeting nuclear antigensJ Wenzel
Department of Dermatology, University of Bonn, Bonn, Germany
Br J Dermatol 150:994-8. 2004..Antilymphocyte antibodies are regarded as the most likely rationale for the decreased cell numbers; however, their relevance has not been confirmed so far... - Circulating clonal CLA(+) and CD4(+) T cells in Sezary syndrome express the skin-homing chemokine receptors CCR4 and CCR10 as well as the lymph node-homing chemokine receptor CCR7M Sokolowska-Wojdylo
Laboratory of Experimental Dermatology, Department of Dermatology, Rheinische Friedrich Wilhelm-University, Sigmund Freud Str. 25, 53105 Bonn, Germany
Br J Dermatol 152:258-64. 2005.... - Suppression of UV-induced damage by a liposomal sunscreen: a prospective, open-label study in patients with cutaneous lupus erythematosus and healthy controlsNikolaos Patsinakidis
Department of Dermatology, University of Muenster, Muenster, Germany
Exp Dermatol 21:958-61. 2012..Histological analysis of skin biopsy specimens confirmed the clinical results. In conclusion, the use of a high-protection, broad-spectrum sunscreen can prevent UV-induced damage in patients with CLE and HCs... - Loss-of-function mutations in the keratin 5 gene lead to Dowling-Degos diseaseRegina C Betz
Institute of Human Genetics, University of Bonn, D 53111 Bonn, Germany
Am J Hum Genet 78:510-9. 2006.... - Resolving lesions in human cutaneous leishmaniasis predominantly harbour chemokine receptor CXCR3-positive T helper 1/T cytotoxic type 1 cellsB Geiger
Department of Dermatology, Universitatsmedizin, Johannes Gutenberg University, Langenbeckstr 1, 55131 Mainz, Germany
Br J Dermatol 162:870-4. 2010..Cutaneous leishmaniasis (CL) is an epidemic disease affecting millions of individuals worldwide. Treatment options have several side-effects and a vaccine does not exist at present... - Absence of CD26 expression on skin-homing CLA+ CD4+ T lymphocytes in peripheral blood is a highly sensitive marker for early diagnosis and therapeutic monitoring of patients with Sézary syndromeM Sokolowska-Wojdylo
Laboratory of Experimental Dermatology, Department of Dermatology, University of Bonn, Germany
Clin Exp Dermatol 30:702-6. 2005..We conclude that the absence of CD26 expression on skin-homing CLA+ CD4+ T-helper cells is a very sensitive and highly specific parameter for early diagnosis and therapeutic monitoring of patients with SS... - Systematic mutation screening of KRT5 supports the hypothesis that Galli-Galli disease is a variant of Dowling-Degos diseaseS Hanneken
Department of Dermatology, University Hospital Dusseldorf, Moorenstrasse 5, 40225 Dusseldorf, Germany
Br J Dermatol 163:197-200. 2010..Mutations in the keratin 5 gene (KRT5) have been identified in the majority of patients with DDD and in a small number of patients with GGD... - Successful treatment of bullous congenital ichthyosiform erythroderma with erythromycinKatharina ten Freyhaus
Dermatology 215:81-3. 2007 - Successful treatment of chronic discoid lupus erythematosus of the scalp with imiquimodRainer Gerdsen
Dermatology 205:416-8. 2002 - Enhanced expression levels of IL-31 correlate with IL-4 and IL-13 in atopic and allergic contact dermatitisMark M Neis
Department of Dermatology and Allergology, University Hospital RWTH Aachen, Germany
J Allergy Clin Immunol 118:930-7. 2006..IL-31 is produced by activated T lymphocytes, preferentially by TH2 cells. Transgenic mice overexpressing IL-31 have a phenotype resembling allergic dermatitis in human subjects... - Successful rituximab treatment of severe pemphigus vulgaris resistant to multiple immunosuppressantsJoerg Wenzel
Acta Derm Venereol 85:185-6. 2005 - Granuloma annulare induced by scabiesDagmar Wilsmann-Theis
Acta Derm Venereol 83:318. 2003