Clemens Martin Wendtner

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. ncbi request reprint Treatment of primary, recurrent or inadequately resected high-risk soft-tissue sarcomas (STS) of adults: results of a phase II pilot study (RHT-95) of neoadjuvant chemotherapy combined with regional hyperthermia
    C Wendtner
    Department of Internal Medicine III, Klinikum Grosshadern Medical Center KGMC, Ludwig Maximilians University, D 81377, Munich, Germany
    Eur J Cancer 37:1609-16. 2001
  2. ncbi request reprint The potential of gene transfer into primary B-CLL cells using recombinant virus vectors
    C M Wendtner
    Medical Clinic III, Klinikum Grosshadern Medical Center, Munchen, German
    Leuk Lymphoma 45:897-904. 2004
  3. ncbi request reprint High level of transgene expression in primary chronic lymphocytic leukemia cells using helper-virus-free recombinant Epstein-Barr virus vectors
    Clemens Martin Wendtner
    Medical Clinic III, University Hospital Grosshadern, Ludwig Maximilians University, Marchioninistrasse 15, D 81377 Munich, Germany
    Exp Hematol 31:99-108. 2003
  4. ncbi request reprint Response to neoadjuvant chemotherapy combined with regional hyperthermia predicts long-term survival for adult patients with retroperitoneal and visceral high-risk soft tissue sarcomas
    Clemens M Wendtner
    Department of Internal Medicine III, Diagnostic Radiology and Institute for Biostatistics and Epidemiology, Klinikum Grosshadern Medical Center, Ludwig Maximilians University, Munich, Germany
    J Clin Oncol 20:3156-64. 2002
  5. pmc Neo-adjuvant chemotherapy alone or with regional hyperthermia for localised high-risk soft-tissue sarcoma: a randomised phase 3 multicentre study
    Rolf D Issels
    Klinikum der Universität München Campus Grosshadern, Munchen, Germany
    Lancet Oncol 11:561-70. 2010
  6. ncbi request reprint Enhancement of gene transfer with recombinant adeno-associated virus (rAAV) vectors into primary B-cell chronic lymphocytic leukemia cells by CpG-oligodeoxynucleotides
    Hans D Theiss
    KKG Gene Therapy, GSF National Research Center for Environment and Health, Munich, Germany
    Exp Hematol 31:1223-9. 2003
  7. ncbi request reprint Efficient gene transfer of CD40 ligand into primary B-CLL cells using recombinant adeno-associated virus (rAAV) vectors
    Clemens Martin Wendtner
    Medical Clinic III, University Hospital Grosshadern and Gene Center, Ludwig Maximilians University, Munich, Germany
    Blood 100:1655-61. 2002
  8. ncbi request reprint MDM2 is recognized as a tumor-associated antigen in chronic lymphocytic leukemia by CD8+ autologous T lymphocytes
    Christine Mayr
    KKG Gene Therapy, GSF National Research Center for Environment and Health, Munich, Germany
    Exp Hematol 34:44-53. 2006
  9. ncbi request reprint Fibromodulin as a novel tumor-associated antigen (TAA) in chronic lymphocytic leukemia (CLL), which allows expansion of specific CD8+ autologous T lymphocytes
    Christine Mayr
    Klinische Kooperationsgruppe Gene Therapy, Munich, Germany
    Blood 105:1566-73. 2005
  10. ncbi request reprint Efficacy of consolidation high-dose chemotherapy with ifosfamide, carboplatin and etoposide (HD-ICE) followed by autologous peripheral blood stem cell rescue in chemosensitive patients with metastatic soft tissue sarcomas
    Marcus Schlemmer
    Department of Internal Medicine III, Klinikum Grosshadern Medical Center, Munich, Germany
    Oncology 71:32-9. 2006

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Treatment of primary, recurrent or inadequately resected high-risk soft-tissue sarcomas (STS) of adults: results of a phase II pilot study (RHT-95) of neoadjuvant chemotherapy combined with regional hyperthermia
    C Wendtner
    Department of Internal Medicine III, Klinikum Grosshadern Medical Center KGMC, Ludwig Maximilians University, D 81377, Munich, Germany
    Eur J Cancer 37:1609-16. 2001
    ..027), but this did not affect DMFS (P=0.558) or OS (P=0.126). Hence, postsurgical thermochemotherapy seems critical for local tumour control without affecting survival...
  2. ncbi request reprint The potential of gene transfer into primary B-CLL cells using recombinant virus vectors
    C M Wendtner
    Medical Clinic III, Klinikum Grosshadern Medical Center, Munchen, German
    Leuk Lymphoma 45:897-904. 2004
    ..This will make it possible to establish the potential clinical role of gene therapy for CLL patients...
  3. ncbi request reprint High level of transgene expression in primary chronic lymphocytic leukemia cells using helper-virus-free recombinant Epstein-Barr virus vectors
    Clemens Martin Wendtner
    Medical Clinic III, University Hospital Grosshadern, Ludwig Maximilians University, Marchioninistrasse 15, D 81377 Munich, Germany
    Exp Hematol 31:99-108. 2003
    ..Recombinant EBV was explored for transduction of primary human B-cell chronic lymphocytic leukemia (CLL) cells...
  4. ncbi request reprint Response to neoadjuvant chemotherapy combined with regional hyperthermia predicts long-term survival for adult patients with retroperitoneal and visceral high-risk soft tissue sarcomas
    Clemens M Wendtner
    Department of Internal Medicine III, Diagnostic Radiology and Institute for Biostatistics and Epidemiology, Klinikum Grosshadern Medical Center, Ludwig Maximilians University, Munich, Germany
    J Clin Oncol 20:3156-64. 2002
    ....
  5. pmc Neo-adjuvant chemotherapy alone or with regional hyperthermia for localised high-risk soft-tissue sarcoma: a randomised phase 3 multicentre study
    Rolf D Issels
    Klinikum der Universität München Campus Grosshadern, Munchen, Germany
    Lancet Oncol 11:561-70. 2010
    ..We designed a parallel-group randomised controlled trial to assess the safety and efficacy of regional hyperthermia with chemotherapy...
  6. ncbi request reprint Enhancement of gene transfer with recombinant adeno-associated virus (rAAV) vectors into primary B-cell chronic lymphocytic leukemia cells by CpG-oligodeoxynucleotides
    Hans D Theiss
    KKG Gene Therapy, GSF National Research Center for Environment and Health, Munich, Germany
    Exp Hematol 31:1223-9. 2003
    ..CpG-oligodeoxynucleotides (CpG-ODNs) are able to activate cytokine production and proliferation of B-CLL cells. Therefore CpG-ODNs were tested for their potential to enhance transgene expression in CLL cells...
  7. ncbi request reprint Efficient gene transfer of CD40 ligand into primary B-CLL cells using recombinant adeno-associated virus (rAAV) vectors
    Clemens Martin Wendtner
    Medical Clinic III, University Hospital Grosshadern and Gene Center, Ludwig Maximilians University, Munich, Germany
    Blood 100:1655-61. 2002
    ..Vaccination strategies for patients with B-CLL using leukemia cells infected ex vivo by rAAV vectors now seems possible in the near future...
  8. ncbi request reprint MDM2 is recognized as a tumor-associated antigen in chronic lymphocytic leukemia by CD8+ autologous T lymphocytes
    Christine Mayr
    KKG Gene Therapy, GSF National Research Center for Environment and Health, Munich, Germany
    Exp Hematol 34:44-53. 2006
    ..The human homolog of the murine double-minute 2 oncoprotein (MDM2) is a putative TAA because it is overexpressed in several malignancies, including chronic lymphocytic leukemia (CLL) cells compared with normal B lymphocytes...
  9. ncbi request reprint Fibromodulin as a novel tumor-associated antigen (TAA) in chronic lymphocytic leukemia (CLL), which allows expansion of specific CD8+ autologous T lymphocytes
    Christine Mayr
    Klinische Kooperationsgruppe Gene Therapy, Munich, Germany
    Blood 105:1566-73. 2005
    ..In summary, FMOD was shown for the first time to be naturally processed and presented as TAA in primary CLL cells, enabling the expansion of autologous tumor-specific T cells...
  10. ncbi request reprint Efficacy of consolidation high-dose chemotherapy with ifosfamide, carboplatin and etoposide (HD-ICE) followed by autologous peripheral blood stem cell rescue in chemosensitive patients with metastatic soft tissue sarcomas
    Marcus Schlemmer
    Department of Internal Medicine III, Klinikum Grosshadern Medical Center, Munich, Germany
    Oncology 71:32-9. 2006
    ..We report phase II data of high-dose chemotherapy and peripheral blood stem cell (PBSC) rescue in patients with MSTS responding to AI-G chemotherapy...
  11. ncbi request reprint Chromosomal translocations are associated with poor prognosis in chronic lymphocytic leukemia
    Christine Mayr
    Gesellschaft für Strahlenforschung GSF National Research Center for Environment and Health, Munich, Germany
    Blood 107:742-51. 2006
    ..Our data may facilitate the identification of molecular events crucial for transforming activity in this disease and should have implications for risk-adapted clinical management of patients with CLL...
  12. ncbi request reprint Transduction of CLL cells by CD40 ligand enhances an antigen-specific immune recognition by autologous T cells
    Christine Mayr
    KKG Gene Therapy, GSF National Research Center for Environment and Health, Munich, Germany
    Blood 106:3223-6. 2005
    ..001). Thus, CD40L-transduced CLL cells are able to induce an antigen-specific T-cell response and might be superior to CD40-CLL cells for immune-based therapeutic strategies in CLL...
  13. ncbi request reprint Human Ly9 (CD229) as novel tumor-associated antigen (TAA) in chronic lymphocytic leukemia (B-CLL) recognized by autologous CD8+ T cells
    Dagmar Bund
    KKG Gene Therapy, GSF National Research Center for Environment and Health, Munich, Germany
    Exp Hematol 34:860-9. 2006
    ..CD229, a cell-surface molecule being involved in cell adhesion, is overexpressed in B-CLL cells. In this study we wanted to explore whether CD229 might function as B-CLL-specific tumor-associated antigen (TAA)...
  14. doi request reprint Evaluation of the proposed reporting system of the European LeukemiaNet and recommendations for prognosis of acute myeloid leukemia
    Tamara Alpermann
    MLL Munich Leukemia Laboratory, Munich, Germany
    Leuk Res 37:197-200. 2013
    ..5), and adverse (adverse cytogenetics). Significant differences in outcomes between all four subgroups were found...
  15. doi request reprint A novel hierarchical prognostic model of AML solely based on molecular mutations
    Vera Grossmann
    MLL Munich Leukemia Laboratory, Munich, Germany
    Blood 120:2963-72. 2012
    ..9%); and (5) very unfavorable: TP53 mutation (n = 80; OS at 3 years: 0%; P < .001). This comprehensive molecular characterization provides a more powerful model for prognostication than cytogenetics...
  16. ncbi request reprint CD23 is recognized as tumor-associated antigen (TAA) in B-CLL by CD8+ autologous T lymphocytes
    Dagmar Bund
    KKG Gene Therapy, GSF National Research Center for Environment and Health, Munich, Germany
    Exp Hematol 35:920-30. 2007
    ..CD23 is constitutively and atypically expressed on malignant B cells in patients with chronic lymphocytic leukemia (B-CLL). Here, we investigated whether CD23-derived peptides might function as B-CLL-specific tumor-associated antigen (TAA)...