Thilo Welsch

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. doi request reprint Actinin-4 expression in primary and metastasized pancreatic ductal adenocarcinoma
    Thilo Welsch
    Department of General, Visceral, and Transplant Surgery, University of Heidelberg, Heidelberg, Germany
    Pancreas 38:968-76. 2009
  2. doi request reprint Comparative analysis of tumorbiology and CD133 positivity in primary and recurrent pancreatic ductal adenocarcinoma
    Thilo Welsch
    Department of General, Visceral and Transplant Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany
    Clin Exp Metastasis 26:701-11. 2009
  3. ncbi request reprint Eps8 is recruited to lysosomes and subjected to chaperone-mediated autophagy in cancer cells
    Thilo Welsch
    Department of General, Visceral and Transplant Surgery, University of Heidelberg, Im Neuenheimer Feld 110, Heidelberg, Germany
    Exp Cell Res 316:1914-24. 2010
  4. ncbi request reprint Huge primitive neuroectodermal tumor of the pancreas: report of a case and review of the literature
    Thilo Welsch
    Deptartment of Surgery, University of Heidelberg, D 69120 Heidelberg, Germany
    World J Gastroenterol 12:6070-3. 2006
  5. ncbi request reprint Eps8 is increased in pancreatic cancer and required for dynamic actin-based cell protrusions and intercellular cytoskeletal organization
    Thilo Welsch
    Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Im Neuenheimer Feld 110, D 69120 Heidelberg, Germany
    Cancer Lett 255:205-18. 2007
  6. doi request reprint Feasibility and effectiveness of a new algorithm in preventing hepatic artery thrombosis after liver transplantation
    Sascha A Müller
    Department of General, Visceral and Transplant Surgery, University of Heidelberg, Heidelberg, Germany
    J Gastrointest Surg 13:702-12. 2009
  7. doi request reprint Validation of the International Study Group of Rectal Cancer definition and severity grading of anastomotic leakage
    Yakup Kulu
    Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany
    Surgery 153:753-61. 2013
  8. doi request reprint Expression of galectin-3 in pancreatic ductal adenocarcinoma
    Matthias M Gaida
    Institute of Pathology, University of Heidelberg, 69120, Heidelberg, Germany
    Pathol Oncol Res 18:299-307. 2012
  9. doi request reprint Vascular resection in pancreatic cancer surgery: survival determinants
    Sascha A Müller
    Department of General, Visceral, and Transplant Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany
    J Gastrointest Surg 13:784-92. 2009
  10. ncbi request reprint Transplantation of a severely lacerated liver--a case report with review of the literature
    Arianeb Mehrabi
    Division of Visceral Transplantation, Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany
    Clin Transplant 23:321-8. 2009

Collaborators

Detail Information

Publications34

  1. doi request reprint Actinin-4 expression in primary and metastasized pancreatic ductal adenocarcinoma
    Thilo Welsch
    Department of General, Visceral, and Transplant Surgery, University of Heidelberg, Heidelberg, Germany
    Pancreas 38:968-76. 2009
    ..The present study analyzed the expression of actinin-4 in the pancreas, in localized and metastasized pancreatic ductal adenocarcinoma (PDAC), and the correlation with clinical outcome...
  2. doi request reprint Comparative analysis of tumorbiology and CD133 positivity in primary and recurrent pancreatic ductal adenocarcinoma
    Thilo Welsch
    Department of General, Visceral and Transplant Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany
    Clin Exp Metastasis 26:701-11. 2009
    ..The apical membrane CD133 positivity of normal and inflammatorily altered ductal structures and its lack in tumor cells bring the role of CD133 as a specific CSC marker in PDAC into question...
  3. ncbi request reprint Eps8 is recruited to lysosomes and subjected to chaperone-mediated autophagy in cancer cells
    Thilo Welsch
    Department of General, Visceral and Transplant Surgery, University of Heidelberg, Im Neuenheimer Feld 110, Heidelberg, Germany
    Exp Cell Res 316:1914-24. 2010
    ..These results open a new field for the investigation of how Eps8 is regulated and contributes to tumor promotion in human cancers...
  4. ncbi request reprint Huge primitive neuroectodermal tumor of the pancreas: report of a case and review of the literature
    Thilo Welsch
    Deptartment of Surgery, University of Heidelberg, D 69120 Heidelberg, Germany
    World J Gastroenterol 12:6070-3. 2006
    ..This alarming case particularly illustrates that PNET in the pancreas although in an advanced stage can present with only a short history of mild symptoms...
  5. ncbi request reprint Eps8 is increased in pancreatic cancer and required for dynamic actin-based cell protrusions and intercellular cytoskeletal organization
    Thilo Welsch
    Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Im Neuenheimer Feld 110, D 69120 Heidelberg, Germany
    Cancer Lett 255:205-18. 2007
    ..We concluded that Eps8 is increased in pancreatic cancer and correlates with migratory potential and tumor progression in vitro. Eps8 is essential for actin dynamics and cell interactions, independent of Eps8-like gene products...
  6. doi request reprint Feasibility and effectiveness of a new algorithm in preventing hepatic artery thrombosis after liver transplantation
    Sascha A Müller
    Department of General, Visceral and Transplant Surgery, University of Heidelberg, Heidelberg, Germany
    J Gastrointest Surg 13:702-12. 2009
    ..The incidence of hepatic artery thrombosis (HAT) after liver transplantation (LTx) is up to 9% in adult recipients...
  7. doi request reprint Validation of the International Study Group of Rectal Cancer definition and severity grading of anastomotic leakage
    Yakup Kulu
    Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany
    Surgery 153:753-61. 2013
    ..The International Study Group of Rectal Cancer (ISREC) has proposed a generally applicable definition and severity grading of (AL) after sphincter-preserving resection of the rectum. This work has been carried out to test for validity...
  8. doi request reprint Expression of galectin-3 in pancreatic ductal adenocarcinoma
    Matthias M Gaida
    Institute of Pathology, University of Heidelberg, 69120, Heidelberg, Germany
    Pathol Oncol Res 18:299-307. 2012
    ..In conclusion, galectin-3 is expressed in PDAC tissues suggesting a role in tumor development; however, no relationship between expression and clinical findings could be established...
  9. doi request reprint Vascular resection in pancreatic cancer surgery: survival determinants
    Sascha A Müller
    Department of General, Visceral, and Transplant Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany
    J Gastrointest Surg 13:784-92. 2009
    ..The aim of this study was to investigate morbidity, mortality, and survival of patients with advanced PDAC following PD with venous resection and to identify significant survival determinants...
  10. ncbi request reprint Transplantation of a severely lacerated liver--a case report with review of the literature
    Arianeb Mehrabi
    Division of Visceral Transplantation, Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany
    Clin Transplant 23:321-8. 2009
    ..Because of complexity of the management, procurement and transplantation should be done by experienced liver surgeons. These organs are marginal grafts and should be offered to selected patients...
  11. ncbi request reprint Expression of the Shwachman-Bodian-Diamond syndrome (SBDS) protein in human pancreatic cancer and chronic pancreatitis
    Hany Kayed
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Histol Histopathol 23:819-26. 2008
    ..The Shwachman-Bodian-Diamond syndrome (SBDS) protein is a member of a highly conserved family which influences RNA activation and is associated with pancreatic, skeletal and bone marrow deficiencies, as well as hematological malignancies...
  12. ncbi request reprint Persisting elevation of C-reactive protein after pancreatic resections can indicate developing inflammatory complications
    Thilo Welsch
    Department of General Surgery, University of Heidelberg, 69120 Heidelberg, Germany
    Surgery 143:20-8. 2008
    ....
  13. doi request reprint Reduced hydrophobicity of the colonic mucosal surface in ulcerative colitis as a hint at a physicochemical barrier defect
    Annika Braun
    Department of Gastroenterology, University Hospital Heidelberg, INF 410, 69120, Heidelberg, Germany
    Int J Colorectal Dis 26:989-98. 2011
    ..The hydrophobicity of the colonic mucosal surface is a measure of its resistance to luminal antigens, e.g. of bacterial origin. Therefore, the purpose of this study was to determine this parameter in patients suffering from IBD...
  14. pmc Prognostic significance of erythropoietin in pancreatic adenocarcinoma
    Thilo Welsch
    Department of General, Visceral and Transplantation Surgery, University Hospital Heidelberg, Heidelberg, Germany
    PLoS ONE 6:e23151. 2011
    ..Erythropoietin (Epo) administration has been reported to have tumor-promoting effects in anemic cancer patients. We investigated the prognostic impact of endogenous Epo in patients with pancreatic ductal adenocarcinoma (PDAC)...
  15. doi request reprint MHC class II expression in pancreatic tumors: a link to intratumoral inflammation
    Matthias M Gaida
    Institute of Pathology, University of Heidelberg, Im Neuenheimer Feld 220, Heidelberg, Germany
    Virchows Arch 460:47-60. 2012
    ..Our findings suggest that MHC class II expression on pancreatic tumor cells is induced by the intratumoral inflammatory reaction in pancreatic tumors...
  16. ncbi request reprint Critical appraisal of the International Study Group of Pancreatic Surgery (ISGPS) consensus definition of postoperative hemorrhage after pancreatoduodenectomy
    Thilo Welsch
    Department of General, Visceral and Transplantation Surgery, University Hospital Heidelberg, Heidelberg, Germany
    Langenbecks Arch Surg 396:783-91. 2011
    ..This study analyzed and validated the International Study Group of Pancreatic Surgery (ISGPS) definition of PPH and aimed to identify risk factors for early (<24 h) and late PPH...
  17. doi request reprint The need for extended intensive care after pancreaticoduodenectomy for pancreatic ductal adenocarcinoma
    Thilo Welsch
    Department of General, Visceral and Transplant Surgery, University of Heidelberg, Im Neuenheimer Feld 110, Heidelberg, Germany
    Langenbecks Arch Surg 396:353-62. 2011
    ..This study aimed to identify risk factors for extended postoperative intensive care unit (ICU) admission and assess the impact of ICU treatment on patient survival...
  18. doi request reprint Comparative analysis of late functional outcome following preoperative radiation therapy or chemoradiotherapy and surgery or surgery alone in rectal cancer
    Pietro Contin
    Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany
    Int J Colorectal Dis 29:165-75. 2014
    ..This study evaluates the anorectal and genitourinary function of patients treated by preoperative short-term radiotherapy (RT) or chemoradiotherapy (CRT) followed by surgery and surgery alone for rectal cancer...
  19. doi request reprint Results of extralevator abdominoperineal resection for low rectal cancer including quality of life and long-term wound complications
    Thilo Welsch
    Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    Int J Colorectal Dis 28:503-10. 2013
    ..Extralevator abdominoperineal resection (APR) for low rectal cancer has been adopted by centers to improve oncological outcome. The present study aimed to investigate oncological results, wound complications, and quality of life (QoL)...
  20. pmc Low expression of aldehyde dehydrogenase 1A1 (ALDH1A1) is a prognostic marker for poor survival in pancreatic cancer
    Christoph Kahlert
    Department of General, Visceral and Transplantation Surgery, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    BMC Cancer 11:275. 2011
    ..Recently, ALDH1A1 has been described as a prognostic marker in a pancreatic cancer tissue microarray. The aim of this study was to reevaluate the expression of ALDH1A1 as a prognostic marker on whole-mount tissue sections...
  21. doi request reprint Long-term success rate after surgical treatment of anorectal and rectovaginal fistulas in Crohn's disease
    Thorsten Löffler
    Department of Surgery, University Hospital of Heidelberg, Heidelberg, Germany
    Int J Colorectal Dis 24:521-6. 2009
    ..The aim of this study was to summarize the results after surgical treatment of such fistulas in a large consecutive series of patients...
  22. ncbi request reprint Autoimmune pancreatitis associated with a large pancreatic pseudocyst
    Thilo Welsch
    Department of General Surgery, University of Heidelberg, Im Neuenheimer Feld 110, Heidelberg 69120, Germany
    World J Gastroenterol 12:5904-6. 2006
    ..Early examination of serum IgG, IgG4 and auto-antibodies might save these patients from unnecessary endoscopical and surgical procedures...
  23. ncbi request reprint Early re-laparotomy for post-operative complications is a significant risk factor for recurrence after ileocaecal resection for Crohn's disease
    Thilo Welsch
    Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    Int J Colorectal Dis 22:1043-9. 2007
    ..The aim of this study was to compare these two clinical presentations with regards to anastomotic recurrence after ileocaecal resection and identify other relevant risk factors...
  24. doi request reprint Use and results of consensus definitions in pancreatic surgery: a systematic review
    Julian C Harnoss
    Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany
    Surgery 155:47-57. 2014
    ..The aim of the current study was to systematically review the available consensus definitions and to report their use, acceptance, and results...
  25. ncbi request reprint Molecular pathogenesis of pancreatic cancer: advances and challenges
    Thilo Welsch
    Department of General Surgery, University of Heidelberg, Germany
    Curr Mol Med 7:504-21. 2007
    ..Thus our primary challenge remains to translate the solid knowledge of genetic and epigenetic alterations in PDAC into clinical tools which can be used for early diagnosis and effective therapy...
  26. ncbi request reprint Update on pancreatic cancer and alcohol-associated risk
    Thilo Welsch
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    J Gastroenterol Hepatol 21:S69-75. 2006
    ....
  27. ncbi request reprint Quality of life after restorative proctocolectomy for ulcerative colitis: preoperative status and long-term results
    Mirjam Tariverdian
    Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany
    Inflamm Bowel Dis 13:1228-35. 2007
    ..Restorative proctocolectomy has become the surgical procedure of choice in patients with ulcerative colitis. Only smaller studies have compared postoperative to preoperative quality of life (QoL)...
  28. ncbi request reprint Elevated L1CAM expression in precursor lesions and primary and metastastic tissues of pancreatic ductal adenocarcinoma
    Frank Bergmann
    Institute of Pathology, University of Heidelberg, Heidelberg, Germany
    Oncol Rep 24:909-15. 2010
    ..Furthermore, its broad expression in primary tumors as well as in metastases of PDAC patients provide a rationale to further explore the value of L1CAM as a therapeutic target in the treatment of this highly malignant tumor...
  29. ncbi request reprint Management of a rare case of fulminant hemobilia due to arteriobiliary fistula following total pancreatectomy
    Thilo Welsch
    Department of Surgery, University of Heidelberg, Im Neuenheimer Feld 110, Heidelberg 69120, Germany
    J Gastroenterol 41:1116-9. 2006
    ....
  30. doi request reprint Impact of the histone deacetylase inhibitor 4-phenylbutyrate on the clearance of apoptotic pancreatic carcinoma cells by human macrophages
    Lena Welsch
    Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany
    Int J Oncol 40:427-35. 2012
    ..Thus, the potential of 4-PB as an anticancer agent against PDAC cannot be reliably assessed without taking into account the complex tumour microenvironment...
  31. ncbi request reprint Alterations of phospholipid concentration and species composition of the intestinal mucus barrier in ulcerative colitis: a clue to pathogenesis
    Annika Braun
    Department of Gastroenterology, University Hospital Heidelberg, Heidelberg, Germany
    Inflamm Bowel Dis 15:1705-20. 2009
    ..The objective of this study was to systematically investigate phospholipids in the intestinal mucus of humans suffering from inflammatory bowel diseases, where a barrier defect is strongly supposed to be pathogenetic...
  32. ncbi request reprint Recalling superior mesenteric artery syndrome
    Thilo Welsch
    Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany
    Dig Surg 24:149-56. 2007
    ..This review updates etiology, epidemiology, diagnosis, treatment and outcome of the superior mesenteric artery syndrome...
  33. ncbi request reprint Association of CD2AP with dynamic actin on vesicles in podocytes
    Thilo Welsch
    Department of Anatomy and Cell Biology, University of Heidelberg, D 69120 Heidelberg, Germany
    Am J Physiol Renal Physiol 289:F1134-43. 2005
    ....
  34. ncbi request reprint Partial liver transplantation-living donor liver transplantation and split liver transplantation
    Sascha A Müller
    Department of Surgery, University of Heidelberg, Im Neuenheimer Feld 110, D 69120 Heidelberg, Germany
    Nephrol Dial Transplant 22:viii13-viii22. 2007
    ..Major centers around the world now routinely perform partial LTx in infants and adults with survival success equivalent to that after full-size liver transplantation...