Research Topics
Genomes and Genes | Thilo WelschSummaryAffiliation: University of Heidelberg Country: Germany Publications
| Collaborators
|
Detail Information
Publications
Comparative analysis of tumorbiology and CD133 positivity in primary and recurrent pancreatic ductal adenocarcinomaThilo Welsch
Department of General, Visceral and Transplant Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany
Clin Exp Metastasis 26:701-11. 2009..The apical membrane CD133 positivity of normal and inflammatorily altered ductal structures and its lack in tumor cells bring the role of CD133 as a specific CSC marker in PDAC into question...- Actinin-4 expression in primary and metastasized pancreatic ductal adenocarcinomaThilo Welsch
Department of General, Visceral, and Transplant Surgery, University of Heidelberg, Heidelberg, Germany
Pancreas 38:968-76. 2009..The present study analyzed the expression of actinin-4 in the pancreas, in localized and metastasized pancreatic ductal adenocarcinoma (PDAC), and the correlation with clinical outcome... 
Huge primitive neuroectodermal tumor of the pancreas: report of a case and review of the literatureThilo Welsch
Deptartment of Surgery, University of Heidelberg, D 69120 Heidelberg, Germany
World J Gastroenterol 12:6070-3. 2006..This alarming case particularly illustrates that PNET in the pancreas although in an advanced stage can present with only a short history of mild symptoms...- Eps8 is recruited to lysosomes and subjected to chaperone-mediated autophagy in cancer cellsThilo Welsch
Department of General, Visceral and Transplant Surgery, University of Heidelberg, Im Neuenheimer Feld 110, Heidelberg, Germany
Exp Cell Res 316:1914-24. 2010..These results open a new field for the investigation of how Eps8 is regulated and contributes to tumor promotion in human cancers... - Eps8 is increased in pancreatic cancer and required for dynamic actin-based cell protrusions and intercellular cytoskeletal organizationThilo Welsch
Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Im Neuenheimer Feld 110, D 69120 Heidelberg, Germany
Cancer Lett 255:205-18. 2007..We concluded that Eps8 is increased in pancreatic cancer and correlates with migratory potential and tumor progression in vitro. Eps8 is essential for actin dynamics and cell interactions, independent of Eps8-like gene products... - Feasibility and effectiveness of a new algorithm in preventing hepatic artery thrombosis after liver transplantationSascha A Müller
Department of General, Visceral and Transplant Surgery, University of Heidelberg, Heidelberg, Germany
J Gastrointest Surg 13:702-12. 2009..The incidence of hepatic artery thrombosis (HAT) after liver transplantation (LTx) is up to 9% in adult recipients... - Expression of galectin-3 in pancreatic ductal adenocarcinomaMatthias M Gaida
Institute of Pathology, University of Heidelberg, 69120, Heidelberg, Germany
Pathol Oncol Res 18:299-307. 2012..In conclusion, galectin-3 is expressed in PDAC tissues suggesting a role in tumor development; however, no relationship between expression and clinical findings could be established... - Expression of the Shwachman-Bodian-Diamond syndrome (SBDS) protein in human pancreatic cancer and chronic pancreatitisHany Kayed
Department of General Surgery, University of Heidelberg, Heidelberg, Germany
Histol Histopathol 23:819-26. 2008..The Shwachman-Bodian-Diamond syndrome (SBDS) protein is a member of a highly conserved family which influences RNA activation and is associated with pancreatic, skeletal and bone marrow deficiencies, as well as hematological malignancies... - Vascular resection in pancreatic cancer surgery: survival determinantsSascha A Müller
Department of General, Visceral, and Transplant Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany
J Gastrointest Surg 13:784-92. 2009..The aim of this study was to investigate morbidity, mortality, and survival of patients with advanced PDAC following PD with venous resection and to identify significant survival determinants... - Transplantation of a severely lacerated liver--a case report with review of the literatureArianeb Mehrabi
Division of Visceral Transplantation, Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany
Clin Transplant 23:321-8. 2009..Because of complexity of the management, procurement and transplantation should be done by experienced liver surgeons. These organs are marginal grafts and should be offered to selected patients... - Persisting elevation of C-reactive protein after pancreatic resections can indicate developing inflammatory complicationsThilo Welsch
Department of General Surgery, University of Heidelberg, 69120 Heidelberg, Germany
Surgery 143:20-8. 2008.... 
Prognostic significance of erythropoietin in pancreatic adenocarcinomaThilo Welsch
Department of General, Visceral and Transplantation Surgery, University Hospital Heidelberg, Heidelberg, Germany
PLoS ONE 6:e23151. 2011..Erythropoietin (Epo) administration has been reported to have tumor-promoting effects in anemic cancer patients. We investigated the prognostic impact of endogenous Epo in patients with pancreatic ductal adenocarcinoma (PDAC)...- Reduced hydrophobicity of the colonic mucosal surface in ulcerative colitis as a hint at a physicochemical barrier defectAnnika Braun
Department of Gastroenterology, University Hospital Heidelberg, INF 410, 69120, Heidelberg, Germany
Int J Colorectal Dis 26:989-98. 2011..The hydrophobicity of the colonic mucosal surface is a measure of its resistance to luminal antigens, e.g. of bacterial origin. Therefore, the purpose of this study was to determine this parameter in patients suffering from IBD... - MHC class II expression in pancreatic tumors: a link to intratumoral inflammationMatthias M Gaida
Institute of Pathology, University of Heidelberg, Im Neuenheimer Feld 220, Heidelberg, Germany
Virchows Arch 460:47-60. 2012..Our findings suggest that MHC class II expression on pancreatic tumor cells is induced by the intratumoral inflammatory reaction in pancreatic tumors... - Critical appraisal of the International Study Group of Pancreatic Surgery (ISGPS) consensus definition of postoperative hemorrhage after pancreatoduodenectomyThilo Welsch
Department of General, Visceral and Transplantation Surgery, University Hospital Heidelberg, Heidelberg, Germany
Langenbecks Arch Surg 396:783-91. 2011..This study analyzed and validated the International Study Group of Pancreatic Surgery (ISGPS) definition of PPH and aimed to identify risk factors for early (<24 h) and late PPH... - The need for extended intensive care after pancreaticoduodenectomy for pancreatic ductal adenocarcinomaThilo Welsch
Department of General, Visceral and Transplant Surgery, University of Heidelberg, Im Neuenheimer Feld 110, Heidelberg, Germany
Langenbecks Arch Surg 396:353-62. 2011..This study aimed to identify risk factors for extended postoperative intensive care unit (ICU) admission and assess the impact of ICU treatment on patient survival... - Low expression of aldehyde dehydrogenase 1A1 (ALDH1A1) is a prognostic marker for poor survival in pancreatic cancerChristoph Kahlert
Department of General, Visceral and Transplantation Surgery, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
BMC Cancer 11:275. 2011..Recently, ALDH1A1 has been described as a prognostic marker in a pancreatic cancer tissue microarray. The aim of this study was to reevaluate the expression of ALDH1A1 as a prognostic marker on whole-mount tissue sections... - Long-term success rate after surgical treatment of anorectal and rectovaginal fistulas in Crohn's diseaseThorsten Löffler
Department of Surgery, University Hospital of Heidelberg, Heidelberg, Germany
Int J Colorectal Dis 24:521-6. 2009..The aim of this study was to summarize the results after surgical treatment of such fistulas in a large consecutive series of patients... - Autoimmune pancreatitis associated with a large pancreatic pseudocystThilo Welsch
Department of General Surgery, University of Heidelberg, Im Neuenheimer Feld 110, Heidelberg 69120, Germany
World J Gastroenterol 12:5904-6. 2006..Early examination of serum IgG, IgG4 and auto-antibodies might save these patients from unnecessary endoscopical and surgical procedures... - Early re-laparotomy for post-operative complications is a significant risk factor for recurrence after ileocaecal resection for Crohn's diseaseThilo Welsch
Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
Int J Colorectal Dis 22:1043-9. 2007..The aim of this study was to compare these two clinical presentations with regards to anastomotic recurrence after ileocaecal resection and identify other relevant risk factors... - Quality of life after restorative proctocolectomy for ulcerative colitis: preoperative status and long-term resultsMirjam Tariverdian
Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany
Inflamm Bowel Dis 13:1228-35. 2007..Restorative proctocolectomy has become the surgical procedure of choice in patients with ulcerative colitis. Only smaller studies have compared postoperative to preoperative quality of life (QoL)... - Elevated L1CAM expression in precursor lesions and primary and metastastic tissues of pancreatic ductal adenocarcinomaFrank Bergmann
Institute of Pathology, University of Heidelberg, Heidelberg, Germany
Oncol Rep 24:909-15. 2010..Furthermore, its broad expression in primary tumors as well as in metastases of PDAC patients provide a rationale to further explore the value of L1CAM as a therapeutic target in the treatment of this highly malignant tumor... - Management of a rare case of fulminant hemobilia due to arteriobiliary fistula following total pancreatectomyThilo Welsch
Department of Surgery, University of Heidelberg, Im Neuenheimer Feld 110, Heidelberg 69120, Germany
J Gastroenterol 41:1116-9. 2006.... - Impact of the histone deacetylase inhibitor 4-phenylbutyrate on the clearance of apoptotic pancreatic carcinoma cells by human macrophagesLena Welsch
Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany
Int J Oncol 40:427-35. 2012..Thus, the potential of 4-PB as an anticancer agent against PDAC cannot be reliably assessed without taking into account the complex tumour microenvironment... - Alterations of phospholipid concentration and species composition of the intestinal mucus barrier in ulcerative colitis: a clue to pathogenesisAnnika Braun
Department of Gastroenterology, University Hospital Heidelberg, Heidelberg, Germany
Inflamm Bowel Dis 15:1705-20. 2009..The objective of this study was to systematically investigate phospholipids in the intestinal mucus of humans suffering from inflammatory bowel diseases, where a barrier defect is strongly supposed to be pathogenetic... - Update on pancreatic cancer and alcohol-associated riskThilo Welsch
Department of General Surgery, University of Heidelberg, Heidelberg, Germany
J Gastroenterol Hepatol 21:S69-75. 2006.... - Recalling superior mesenteric artery syndromeThilo Welsch
Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany
Dig Surg 24:149-56. 2007..This review updates etiology, epidemiology, diagnosis, treatment and outcome of the superior mesenteric artery syndrome... - Molecular pathogenesis of pancreatic cancer: advances and challengesThilo Welsch
Department of General Surgery, University of Heidelberg, Germany
Curr Mol Med 7:504-21. 2007..Thus our primary challenge remains to translate the solid knowledge of genetic and epigenetic alterations in PDAC into clinical tools which can be used for early diagnosis and effective therapy... - Association of CD2AP with dynamic actin on vesicles in podocytesThilo Welsch
Department of Anatomy and Cell Biology, University of Heidelberg, D 69120 Heidelberg, Germany
Am J Physiol Renal Physiol 289:F1134-43. 2005.... - Partial liver transplantation-living donor liver transplantation and split liver transplantationSascha A Müller
Department of Surgery, University of Heidelberg, Im Neuenheimer Feld 110, D 69120 Heidelberg, Germany
Nephrol Dial Transplant 22:viii13-viii22. 2007..Major centers around the world now routinely perform partial LTx in infants and adults with survival success equivalent to that after full-size liver transplantation...