R Weisshorn

Summary

Affiliation: University of Hamburg
Country: Germany

Publications

  1. ncbi Ryanodine contracture threshold times for diagnosis of malignant hyperthermia susceptibility: an experimental approach from a single laboratory
    Ralf Weisshorn
    Department of Anesthesiology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    J Clin Anesth 16:353-7. 2004
  2. ncbi [In-vitro-effects of cocaine in skeletal muscle specimens of patients susceptible to malignant hyperthermia]
    R Weisshorn
    Klinik und Poliklinik für Anästhesiologie, Universitatsklinikum Hamburg Eppendorf
    Anasthesiol Intensivmed Notfallmed Schmerzther 37:138-43. 2002
  3. ncbi 4-chloro-m-cresol is a trigger of malignant hyperthermia in susceptible swine
    F Wappler
    Department of Anesthesiology, University Hospital Eppendorf, Hamburg, Germany
    Anesthesiology 90:1733-40. 1999
  4. ncbi Effects of the phosphodiesterase-III inhibitor enoximone on skeletal muscle specimens from malignant hyperthermia susceptible patients
    M Fiege
    Department of Anesthesiology, University Hospital Eppendorf, Hamburg, Germany
    J Clin Anesth 12:123-8. 2000
  5. ncbi [Is a presymptomatic malignant hyperthermia in-vitro diagnosis with 4-chloro-3-ethyl phenol possible? A study using porcine skeletal preparations]
    M U Gerbershagen
    Klinik und Poliklinik für Anästhesiologie, Universitatsklinikum Hamburg Eppendorf
    Anasthesiol Intensivmed Notfallmed Schmerzther 39:81-6. 2004
  6. ncbi Phosphodiesterase-III-inhibition with amrinone leads to contracture development in skeletal muscle preparations of malignant hyperthermia susceptible swine
    M Fiege
    University Hospital Hamburg Eppendorf, Department of Anaesthesiology, Hamburg, Germany
    Eur J Anaesthesiol 22:283-8. 2005
  7. ncbi 5-HT2 receptor antagonist-mediated inhibition of halothane-induced contractures in skeletal muscle specimens from malignant hyperthermia susceptible patients
    F Wappler
    Department of Anaesthesiology, University Hospital Eppendorf, Hamburg, Germany
    Naunyn Schmiedebergs Arch Pharmacol 360:376-81. 1999
  8. ncbi Multicentre evaluation of in vitro contracture testing with bolus administration of 4-chloro-m-cresol for diagnosis of malignant hyperthermia susceptibility
    F Wappler
    University Hospital Hamburg Eppendorf, Department of Anaesthesiology, Hamburg, Germany
    Eur J Anaesthesiol 20:528-36. 2003
  9. ncbi Effects of a 5HT(2) receptor agonist on anaesthetized pigs susceptible to malignant hyperthermia
    M U Gerbershagen
    Department of Anaesthesiology, University Hospital Hamburg Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    Br J Anaesth 91:281-4. 2003
  10. ncbi Dantrolene--a review of its pharmacology, therapeutic use and new developments
    T Krause
    Department of Anaesthesiology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Anaesthesia 59:364-73. 2004

Detail Information

Publications11

  1. ncbi Ryanodine contracture threshold times for diagnosis of malignant hyperthermia susceptibility: an experimental approach from a single laboratory
    Ralf Weisshorn
    Department of Anesthesiology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    J Clin Anesth 16:353-7. 2004
    ..To define threshold times for ryanodine contracture testing (RCT) using skeletal muscle specimens from malignant hyperthermia-susceptible (MHS) and control individuals...
  2. ncbi [In-vitro-effects of cocaine in skeletal muscle specimens of patients susceptible to malignant hyperthermia]
    R Weisshorn
    Klinik und Poliklinik für Anästhesiologie, Universitatsklinikum Hamburg Eppendorf
    Anasthesiol Intensivmed Notfallmed Schmerzther 37:138-43. 2002
    ..Therefore, aim of this study was to investigate the in-vitro effects of cocaine in skeletal muscle specimens of MH susceptible (MHS) and normal (MHN) patients...
  3. ncbi 4-chloro-m-cresol is a trigger of malignant hyperthermia in susceptible swine
    F Wappler
    Department of Anesthesiology, University Hospital Eppendorf, Hamburg, Germany
    Anesthesiology 90:1733-40. 1999
    ..g., insulin, heparin, succinylcholine), and it has been suggested that 4-CmC might trigger malignant hyperthermia. This study was designed to investigate the effects of 4-CmC in vivo and in vitro in the same animals...
  4. ncbi Effects of the phosphodiesterase-III inhibitor enoximone on skeletal muscle specimens from malignant hyperthermia susceptible patients
    M Fiege
    Department of Anesthesiology, University Hospital Eppendorf, Hamburg, Germany
    J Clin Anesth 12:123-8. 2000
    ..To study the in vitro effects of the phosphodiesterase-III inhibitor enoximone on skeletal muscle specimens from malignant hyperthermia susceptible (MHS) and normal (MHN) patients...
  5. ncbi [Is a presymptomatic malignant hyperthermia in-vitro diagnosis with 4-chloro-3-ethyl phenol possible? A study using porcine skeletal preparations]
    M U Gerbershagen
    Klinik und Poliklinik für Anästhesiologie, Universitatsklinikum Hamburg Eppendorf
    Anasthesiol Intensivmed Notfallmed Schmerzther 39:81-6. 2004
    ..The pur-pose of this study was to investigate the ability of bolus CEP-applications to distinguish between porcine MHS- and MHN-muscle specimens using the IVCT...
  6. ncbi Phosphodiesterase-III-inhibition with amrinone leads to contracture development in skeletal muscle preparations of malignant hyperthermia susceptible swine
    M Fiege
    University Hospital Hamburg Eppendorf, Department of Anaesthesiology, Hamburg, Germany
    Eur J Anaesthesiol 22:283-8. 2005
    ..Whether this is a substance specific effect of enoximone or caused by inhibition of PDE-III remained unclear. Therefore, the effects of the PDE-III inhibitor amrinone in porcine MH normal (MHN) and MHS skeletal muscles were investigated...
  7. ncbi 5-HT2 receptor antagonist-mediated inhibition of halothane-induced contractures in skeletal muscle specimens from malignant hyperthermia susceptible patients
    F Wappler
    Department of Anaesthesiology, University Hospital Eppendorf, Hamburg, Germany
    Naunyn Schmiedebergs Arch Pharmacol 360:376-81. 1999
    ..Further studies have to determine the pathophysiological role of the 5-HT system in MH, and whether ritanserin could be an alternative for treatment or prevention of halothane-induced MH...
  8. ncbi Multicentre evaluation of in vitro contracture testing with bolus administration of 4-chloro-m-cresol for diagnosis of malignant hyperthermia susceptibility
    F Wappler
    University Hospital Hamburg Eppendorf, Department of Anaesthesiology, Hamburg, Germany
    Eur J Anaesthesiol 20:528-36. 2003
    ..This multicentre study was designed to investigate whether an in vitro contracture test with bolus administration of 4-chloro-m-cresol can improve the accuracy of the diagnosis of susceptibility to MH...
  9. ncbi Effects of a 5HT(2) receptor agonist on anaesthetized pigs susceptible to malignant hyperthermia
    M U Gerbershagen
    Department of Anaesthesiology, University Hospital Hamburg Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    Br J Anaesth 91:281-4. 2003
    ..In this study the in vivo effects of DOI on anaesthetized (and thus stress-protected) MHS and MH-normal (MHN) pigs were investigated...
  10. ncbi Dantrolene--a review of its pharmacology, therapeutic use and new developments
    T Krause
    Department of Anaesthesiology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Anaesthesia 59:364-73. 2004
    ..Due to economic considerations, no other similar drugs have been introduced into routine clinical practice...
  11. ncbi [Theophylline induces contractures in porcine skeletal muscle preparations with the disposition to malignant hyperthermia]
    M U Gerbershagen
    Klinik und Poliklinik für Anästhesiologie Universitätsklinikum Hamburg Eppendorf
    Anasthesiol Intensivmed Notfallmed Schmerzther 39:147-52. 2004
    ....