M Wegner

Summary

Affiliation: University of Hamburg
Country: Germany

Publications

  1. pmc From head to toes: the multiple facets of Sox proteins
    M Wegner
    Zentrum für Molekulare Neurobiologie, Universitat Hamburg, Martinistrasse 52, D 20246 Hamburg, Germany
    Nucleic Acids Res 27:1409-20. 1999
  2. ncbi request reprint Cooperative function of POU proteins and SOX proteins in glial cells
    K Kuhlbrodt
    Zentrum für Molekulare Neurobiologie, Universitat Hamburg, Martinistr 52, D 20246 Hamburg, Germany
    J Biol Chem 273:16050-7. 1998
  3. ncbi request reprint Development and degeneration of dorsal root ganglia in the absence of the HMG-domain transcription factor Sox10
    E Sonnenberg-Riethmacher
    Zentrum für Molekulare Neurobiologie, Universitat Hamburg, Falkenried 94, 20251, Hamburg, Germany
    Mech Dev 109:253-65. 2001
  4. ncbi request reprint Functional analysis of Sox10 mutations found in human Waardenburg-Hirschsprung patients
    K Kuhlbrodt
    Zentrum für Molekulare Neurobiologie, Universitat Hamburg, 20246 Hamburg, Germany
    J Biol Chem 273:23033-8. 1998
  5. pmc Protein zero gene expression is regulated by the glial transcription factor Sox10
    R I Peirano
    Zentrum für Molekulare Neurobiologie, Universitat Hamburg, D 20246 Hamburg, Germany
    Mol Cell Biol 20:3198-209. 2000
  6. pmc The J domain of papovaviral large tumor antigen is required for synergistic interaction with the POU-domain protein Tst-1/Oct6/SCIP
    E Sock
    Zentrum für Molekulare Neurobiologie, Universitat Hamburg, D 20246 Hamburg, Germany
    Mol Cell Biol 19:2455-64. 1999
  7. pmc Structural requirements for DNA binding of GCM proteins
    J Schreiber
    Zentrum für Molekulare Neurobiologie, Universitat Hamburg, Martinistrasse 52, D 20246 Hamburg, Germany
    Nucleic Acids Res 26:2337-43. 1998
  8. pmc The regulator of early gliogenesis glial cells missing is a transcription factor with a novel type of DNA-binding domain
    J Schreiber
    Zentrum für Molekulare Neurobiologie, Universitat Hamburg, Martinistrasse 52, D 20246 Hamburg, Germany
    Proc Natl Acad Sci U S A 94:4739-44. 1997
  9. pmc Mutation of the Sry-related Sox10 gene in Dominant megacolon, a mouse model for human Hirschsprung disease
    B Herbarth
    Zentrum für Molekulare Neurobiologie, Universitat Hamburg, 20246 Hamburg, Germany
    Proc Natl Acad Sci U S A 95:5161-5. 1998
  10. ncbi request reprint Sox10, a novel transcriptional modulator in glial cells
    K Kuhlbrodt
    Zentrum für Molekulare Neurobiologie, Universitat Hamburg, D 20246 Hamburg, Germany
    J Neurosci 18:237-50. 1998

Collaborators

  • C Schmidt
  • V Pingault
  • C Richter-Landsberg
  • R M Nitsch
  • M Mayhaus
  • Michael Rosenfeld
  • E Sock
  • J Schreiber
  • K Kuhlbrodt
  • J Enderich
  • N Bondurand
  • D E Goerich
  • D Riethmacher
  • M Goossens
  • B Herbarth
  • R I Peirano
  • I Hermans-Borgmeyer
  • E Sonnenberg-Riethmacher
  • S Britsch
  • C Paratore
  • M R Bösl
  • R Reifegerste
  • N Lemort
  • H von Der Kammer
  • U Suter
  • I Hermanns-Borgmeyer
  • M Rossner
  • C Birchmeier
  • C C Stolt
  • L Sommer
  • K Schmidt
  • K A Nave
  • M Miehe
  • E Riethmacher-Sonnenberg
  • H Leger
  • C Le Caignec
  • E E Tuerk
  • R C Hennekam
  • A Lüdemann
  • A P Read
  • M Sajus
  • M Warburg
  • N Tommerup
  • S Gulland
  • C Albrecht
  • A Puliti
  • F Grummt
  • K Renner
  • D W Drolet
  • K M Scully
  • L W Swanson
  • D M Simmons
  • K T Chu

Detail Information

Publications26

  1. pmc From head to toes: the multiple facets of Sox proteins
    M Wegner
    Zentrum für Molekulare Neurobiologie, Universitat Hamburg, Martinistrasse 52, D 20246 Hamburg, Germany
    Nucleic Acids Res 27:1409-20. 1999
    ..Sox proteins perform their function in a complex interplay with other transcription factors in a manner highly dependent on cell type and promoter context. They exhibit a remarkable crosstalk and functional redundancy among each other...
  2. ncbi request reprint Cooperative function of POU proteins and SOX proteins in glial cells
    K Kuhlbrodt
    Zentrum für Molekulare Neurobiologie, Universitat Hamburg, Martinistr 52, D 20246 Hamburg, Germany
    J Biol Chem 273:16050-7. 1998
    ..Our data suggest the existence of a specific code in which POU proteins require specific Sox proteins to exhibit cooperative effects in glial cells...
  3. ncbi request reprint Development and degeneration of dorsal root ganglia in the absence of the HMG-domain transcription factor Sox10
    E Sonnenberg-Riethmacher
    Zentrum für Molekulare Neurobiologie, Universitat Hamburg, Falkenried 94, 20251, Hamburg, Germany
    Mech Dev 109:253-65. 2001
    ..5 and E 11.5). We show that both increased apoptosis as well as decreased proliferation of neural crest cells contribute to the observed hypomorphism...
  4. ncbi request reprint Functional analysis of Sox10 mutations found in human Waardenburg-Hirschsprung patients
    K Kuhlbrodt
    Zentrum für Molekulare Neurobiologie, Universitat Hamburg, 20246 Hamburg, Germany
    J Biol Chem 273:23033-8. 1998
    ..Those mutants that failed to synergize were unable to bind to DNA. Analysis of the naturally occurring Sox10 mutations not only helps to dissect Sox10 structure, but also allows limited predictions on the severity of the disease...
  5. pmc Protein zero gene expression is regulated by the glial transcription factor Sox10
    R I Peirano
    Zentrum für Molekulare Neurobiologie, Universitat Hamburg, D 20246 Hamburg, Germany
    Mol Cell Biol 20:3198-209. 2000
    ..5 of embryogenesis. To our knowledge this is the most conclusive link to date between a glial transcription factor and cell-specific activation of myelin gene expression...
  6. pmc The J domain of papovaviral large tumor antigen is required for synergistic interaction with the POU-domain protein Tst-1/Oct6/SCIP
    E Sock
    Zentrum für Molekulare Neurobiologie, Universitat Hamburg, D 20246 Hamburg, Germany
    Mol Cell Biol 19:2455-64. 1999
    ..Given the general role of J domains, we propose chaperone activity as the underlying mechanism for synergy between Tst-1/Oct6/SCIP and large T antigens...
  7. pmc Structural requirements for DNA binding of GCM proteins
    J Schreiber
    Zentrum für Molekulare Neurobiologie, Universitat Hamburg, Martinistrasse 52, D 20246 Hamburg, Germany
    Nucleic Acids Res 26:2337-43. 1998
    ..Our results give insights into the exact nature of the GCM binding sites expected in target genes and point to a role for redox regulation in the function of GCM proteins...
  8. pmc The regulator of early gliogenesis glial cells missing is a transcription factor with a novel type of DNA-binding domain
    J Schreiber
    Zentrum für Molekulare Neurobiologie, Universitat Hamburg, Martinistrasse 52, D 20246 Hamburg, Germany
    Proc Natl Acad Sci U S A 94:4739-44. 1997
    ..In transiently transfected cells, GCM also activated transcription from promoters consisting of the newly identified GCM-binding site and a TATA box. Thus, GCM is a novel type of transcription factor involved in early gliogenesis...
  9. pmc Mutation of the Sry-related Sox10 gene in Dominant megacolon, a mouse model for human Hirschsprung disease
    B Herbarth
    Zentrum für Molekulare Neurobiologie, Universitat Hamburg, 20246 Hamburg, Germany
    Proc Natl Acad Sci U S A 95:5161-5. 1998
    ....
  10. ncbi request reprint Sox10, a novel transcriptional modulator in glial cells
    K Kuhlbrodt
    Zentrum für Molekulare Neurobiologie, Universitat Hamburg, D 20246 Hamburg, Germany
    J Neurosci 18:237-50. 1998
    ..We propose a role for Sox10 in conferring cell specificity to the function of other transcription factors in developing and mature glia...
  11. ncbi request reprint Redundancy of class III POU proteins in the oligodendrocyte lineage
    J Schreiber
    Zentrum für Molekulare Neurobiologie, Universitat Hamburg, Martinistrasse 52, D 20246 Hamburg, Germany
    J Biol Chem 272:32286-93. 1997
    ..Taken together, our data imply a partial, but not complete redundancy between POU proteins in oligodendrocytes...
  12. ncbi request reprint Identification of the nuclear localization signal of the POU domain protein Tst-1/Oct6
    E Sock
    Zentrum für Molekulare Neurobiologie, Universitat Hamburg, Martinistrasse 52, D 20246 Hamburg, Federal Republic of Germany
    J Biol Chem 271:17512-8. 1996
    ....
  13. ncbi request reprint Muscarinic acetylcholine receptors activate expression of the EGR gene family of transcription factors
    H von Der Kammer
    Center for Molecular Neurobiology and Alzheimer s Disease Research Group, University of Hamburg, Martinistrasse 52, D 20246 Hamburg, Germany
    J Biol Chem 273:14538-44. 1998
    ..The data suggest that transcription of EGR-dependent target genes, including the AChE gene, can be under the control of extracellular and intracellular signals coupled to muscarinic receptors...
  14. pmc Placental failure in mice lacking the mammalian homolog of glial cells missing, GCMa
    J Schreiber
    Zentrum für Molekulare Neurobiologie, Universitat Hamburg, D 20246 Hamburg, Germany
    Mol Cell Biol 20:2466-74. 2000
    ..Our results indicate that mGCMa plays a critical role in trophoblast differentiation and the signal transduction processes required for normal vascularization of the placenta...
  15. pmc Functional interaction between the POU domain protein Tst-1/Oct-6 and the high-mobility-group protein HMG-I/Y
    H Leger
    Zentrum für Molekulare Neurobiologie, Universitat Hamburg, Germany
    Mol Cell Biol 15:3738-47. 1995
    ....
  16. ncbi request reprint Chronicles of a switch hunt: gcm genes in development
    M Wegner
    Institut fur Biochemie, Universitat Erlangen Nurnberg, Fahrstrasse 17, 91054 Erlangen, Germany
    Trends Genet 17:286-90. 2001
    ..Apparently, structure and function sometimes can go separate ways...
  17. ncbi request reprint Expression of transcription factors during oligodendroglial development
    M Wegner
    Institut fur Biochemie, Universitat Erlangen Nurnberg, Fahrstrasse 17, 91054 Erlangen, Germany
    Microsc Res Tech 52:746-52. 2001
    ..Although so far only a small percentage of oligodendroglial transcription factors has been identified, these are excellent candidates for regulators of cell type specification, lineage progression, and terminal differentiation...
  18. pmc The transcription factor Sox10 is a key regulator of peripheral glial development
    S Britsch
    Max Delbruck Center for Molecular Medicine, D 13122 Berlin, Germany
    Genes Dev 15:66-78. 2001
    ..Haploinsufficiency of Sox10 can thus cause pigmentation and megacolon defects, which are also observed in Sox10(Dom)/+ mice and in patients with Waardenburg-Hirschsprung disease caused by heterozygous SOX10 mutations...
  19. ncbi request reprint Survival and glial fate acquisition of neural crest cells are regulated by an interplay between the transcription factor Sox10 and extrinsic combinatorial signaling
    C Paratore
    Institute of Cell Biology, Swiss Federal Institute of Technology, ETH Honggerberg, CH 8093 Zurich, Switzerland
    Development 128:3949-61. 2001
    ..Failures in fate decision processes might thus contribute to the etiology of Waardenburg/Hirschsprung disease...
  20. ncbi request reprint Interaction among SOX10, PAX3 and MITF, three genes altered in Waardenburg syndrome
    N Bondurand
    Génétique Moléculaire et Physiopathologie, INSERM U468, et Laboratoire de Biochimie et Génétique Moléculaire, AP HP, Hopital Henri Mondor, Creteil Cedex, France
    Hum Mol Genet 9:1907-17. 2000
    ..These experiments, which demonstrate an interaction between three of the genes that are altered in WS, could explain the auditory-pigmentary symptoms of this disease...
  21. ncbi request reprint A molecular analysis of the yemenite deaf-blind hypopigmentation syndrome: SOX10 dysfunction causes different neurocristopathies
    N Bondurand
    Génétique Moléculaire et Physiopathologie, INSERM U468 et Laboratoire de Biochimie et Génétique Moléculaire, AP HP, Hopital Henri Mondor, 94010 Creteil Cedex, France
    Hum Mol Genet 8:1785-9. 1999
    ..Moreover, as mutations of the SOX10 transcription factor were previously described in Waardenburg-Hirschsprung disease, these results show that SOX10 mutations cause various types of neurocristopathy...
  22. ncbi request reprint mGCMa is a murine transcription factor that overrides cell fate decisions in Drosophila
    R Reifegerste
    Department of Cell Biology, Emory University, 1648 Pierce Drive, Atlanta, GA 30322 3030, USA
    Mech Dev 82:141-50. 1999
    ..The potent activity of mGCMa in Drosophila and its extensive functional similarities to GCM make mGCMa a candidate for a regulator of mouse glial development...
  23. ncbi request reprint SOX10 mutations in patients with Waardenburg-Hirschsprung disease
    V Pingault
    INSERM U468, Hopital Henri Mondor, Creteil, France
    Nat Genet 18:171-3. 1998
    ..Our findings further define the locus heterogeneity of Waardenburg-Hirschsprung syndromes, and point to an essential role of SOX10 in the development of two neural crest-derived human cell lineages...
  24. ncbi request reprint Calcium-regulated phosphorylation within the leucine zipper of C/EBP beta
    M Wegner
    Howard Hughes Medical Institute, University of California, San Diego, La Jolla 92093 0648
    Science 256:370-3. 1992
    ..Phosphorylation of serine at position 276 within the leucine zipper of C/EBP beta appeared to confer calcium-regulated transcriptional stimulation of a promoter that contained binding sites for C/EBP beta...
  25. ncbi request reprint TEF, a transcription factor expressed specifically in the anterior pituitary during embryogenesis, defines a new class of leucine zipper proteins
    D W Drolet
    Eukaryotic Regulatory Biology Program, University of California, San Diego, La Jolla 92093 0648
    Genes Dev 5:1739-53. 1991
    ..These data are consistent with a role for a member of a new class of bZIP transcription factors in activating gene expression in the developing thyrotroph...
  26. pmc Idiopathic weight reduction in mice deficient in the high-mobility-group transcription factor Sox8
    E Sock
    Institut fur Biochemie, Universitat Erlangen, D 91054 Erlangen, Germany
    Mol Cell Biol 21:6951-9. 2001
    ..Because of frequent coexpression with either Sox9 or Sox10, the mild phenotype of Sox8-deficient mice might at least in part be due to functional redundancy between group E Sox proteins...