M Wegner

Summary

Affiliation: University of Erlangen-Nuremberg
Country: Germany

Publications

  1. pmc The transcription factor encyclopedia
    Dimas Yusuf
    Department of Medical Genetics, Faculty of Medicine, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, Canada
    Genome Biol 13:R24. 2012
  2. doi request reprint Mighty bugs: leprosy bacteria turn schwann cells into stem cells
    Michael Wegner
    Institut fur Biochemie, Emil Fischer Zentrum, Universitat Erlangen Nurnberg, 91054 Erlangen, Germany
    Cell 152:15-6. 2013
  3. ncbi request reprint Expression of transcription factors during oligodendroglial development
    M Wegner
    Institut fur Biochemie, Universitat Erlangen Nurnberg, Fahrstrasse 17, 91054 Erlangen, Germany
    Microsc Res Tech 52:746-52. 2001
  4. doi request reprint A matter of identity: transcriptional control in oligodendrocytes
    Michael Wegner
    Institut fur Biochemie, Emil Fischer Zentrum, Universitat Erlangen, Fahrstrasse 17, 91054 Erlangen, Germany
    J Mol Neurosci 35:3-12. 2008
  5. ncbi request reprint Secrets to a healthy Sox life: lessons for melanocytes
    Michael Wegner
    Institut fur Biochemie, Universitat Erlangen Nurnberg, D 91054 Erlangen, Germany
    Pigment Cell Res 18:74-85. 2005
  6. ncbi request reprint From stem cells to neurons and glia: a Soxist's view of neural development
    Michael Wegner
    Institut fur Biochemie, Universitat Erlangen Nurnberg, D 91054 Erlangen, Germany
    Trends Neurosci 28:583-8. 2005
  7. doi request reprint All purpose Sox: The many roles of Sox proteins in gene expression
    Michael Wegner
    Institut fur Biochemie, Emil Fischer Zentrum, Universitat Erlangen Nurnberg, Fahrstrasse 17, 91054 Erlangen, Germany
    Int J Biochem Cell Biol 42:381-90. 2010
  8. ncbi request reprint Chronicles of a switch hunt: gcm genes in development
    M Wegner
    Institut fur Biochemie, Universitat Erlangen Nurnberg, Fahrstrasse 17, 91054 Erlangen, Germany
    Trends Genet 17:286-90. 2001
  9. pmc Sox12 deletion in the mouse reveals nonreciprocal redundancy with the related Sox4 and Sox11 transcription factors
    Melanie Hoser
    Institut fur Biochemie, Emil Fischer Zentrum, Universitat Erlangen, Erlangen, Germany
    Mol Cell Biol 28:4675-87. 2008
  10. ncbi request reprint SoxD proteins influence multiple stages of oligodendrocyte development and modulate SoxE protein function
    C Claus Stolt
    Institut fur Biochemie, Emil Fischer Zentrum, Universitat Erlangen, D 91054 Erlangen, Germany
    Dev Cell 11:697-709. 2006

Collaborators

Detail Information

Publications72

  1. pmc The transcription factor encyclopedia
    Dimas Yusuf
    Department of Medical Genetics, Faculty of Medicine, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, Canada
    Genome Biol 13:R24. 2012
    ..TFe aims to rapidly educate scientists about the TFs they encounter through the delivery of succinct summaries written and vetted by experts in the field. TFe is available at http://www.cisreg.ca/tfe...
  2. doi request reprint Mighty bugs: leprosy bacteria turn schwann cells into stem cells
    Michael Wegner
    Institut fur Biochemie, Emil Fischer Zentrum, Universitat Erlangen Nurnberg, 91054 Erlangen, Germany
    Cell 152:15-6. 2013
    ..show that the leprosy bacterium cleverly expands its repertoire by driving dedifferentiation of Schwann cells, their preferred host, to cells with stem cell properties that can subsequently redifferentiate into mesodermal lineages...
  3. ncbi request reprint Expression of transcription factors during oligodendroglial development
    M Wegner
    Institut fur Biochemie, Universitat Erlangen Nurnberg, Fahrstrasse 17, 91054 Erlangen, Germany
    Microsc Res Tech 52:746-52. 2001
    ..Although so far only a small percentage of oligodendroglial transcription factors has been identified, these are excellent candidates for regulators of cell type specification, lineage progression, and terminal differentiation...
  4. doi request reprint A matter of identity: transcriptional control in oligodendrocytes
    Michael Wegner
    Institut fur Biochemie, Emil Fischer Zentrum, Universitat Erlangen, Fahrstrasse 17, 91054 Erlangen, Germany
    J Mol Neurosci 35:3-12. 2008
    ....
  5. ncbi request reprint Secrets to a healthy Sox life: lessons for melanocytes
    Michael Wegner
    Institut fur Biochemie, Universitat Erlangen Nurnberg, D 91054 Erlangen, Germany
    Pigment Cell Res 18:74-85. 2005
    ..Both activities require cooperation with transcriptional partner proteins such as Pax-3, CREB and eventually Mitf. If predictions can be made from other cell lineages, further functions of Sox proteins in melanocytes may still lie ahead...
  6. ncbi request reprint From stem cells to neurons and glia: a Soxist's view of neural development
    Michael Wegner
    Institut fur Biochemie, Universitat Erlangen Nurnberg, D 91054 Erlangen, Germany
    Trends Neurosci 28:583-8. 2005
    ..In the peripheral nervous system (PNS) the same Sox proteins have different functions, uncovering important developmental differences between the CNS and PNS...
  7. doi request reprint All purpose Sox: The many roles of Sox proteins in gene expression
    Michael Wegner
    Institut fur Biochemie, Emil Fischer Zentrum, Universitat Erlangen Nurnberg, Fahrstrasse 17, 91054 Erlangen, Germany
    Int J Biochem Cell Biol 42:381-90. 2010
    ..Sox proteins may be additionally active on the posttranscriptional level and are therefore remarkably versatile regulators of gene expression...
  8. ncbi request reprint Chronicles of a switch hunt: gcm genes in development
    M Wegner
    Institut fur Biochemie, Universitat Erlangen Nurnberg, Fahrstrasse 17, 91054 Erlangen, Germany
    Trends Genet 17:286-90. 2001
    ..Apparently, structure and function sometimes can go separate ways...
  9. pmc Sox12 deletion in the mouse reveals nonreciprocal redundancy with the related Sox4 and Sox11 transcription factors
    Melanie Hoser
    Institut fur Biochemie, Emil Fischer Zentrum, Universitat Erlangen, Erlangen, Germany
    Mol Cell Biol 28:4675-87. 2008
    ..Because of differences in expression levels and transactivation rates, however, functional compensation is not reciprocal...
  10. ncbi request reprint SoxD proteins influence multiple stages of oligodendrocyte development and modulate SoxE protein function
    C Claus Stolt
    Institut fur Biochemie, Emil Fischer Zentrum, Universitat Erlangen, D 91054 Erlangen, Germany
    Dev Cell 11:697-709. 2006
    ..Our studies reveal a complex regulatory network between different groups of Sox proteins that is essential for proper progression of oligodendrocyte development...
  11. doi request reprint Sox9 and Sox10 influence survival and migration of oligodendrocyte precursors in the spinal cord by regulating PDGF receptor alpha expression
    Markus Finzsch
    Institut fur Biochemie, Emil Fischer Zentrum, Universitat Erlangen, Fahrstrasse 17, D 91054 Erlangen, Germany
    Development 135:637-46. 2008
    ..We thus conclude that Sox9 and Sox10 are required in a functionally redundant manner in oligodendrocyte precursors for PDGF-dependent survival and migration...
  12. pmc The class III POU domain protein Brn-1 can fully replace the related Oct-6 during schwann cell development and myelination
    Ralf P Friedrich
    Institut fur Biochemie, Universitat Erlangen, Fahrstrasse 17, 91054 Erlangen, Germany
    Mol Cell Biol 25:1821-9. 2005
    ..Similar to Oct-6, Brn-1 down-regulated its own expression at later stages of myelination. Thus, class III POU domain proteins can fully replace each other in Schwann cell development...
  13. ncbi request reprint Transcription factors Sox8 and Sox10 perform non-equivalent roles during oligodendrocyte development despite functional redundancy
    C Claus Stolt
    Institut fur Biochemie, Universitat Erlangen, Fahrstrasse 17, D 91054 Erlangen, Germany
    Development 131:2349-58. 2004
    ..Resulting differences in protein amounts might be a main reason for the weaker impact of Sox8 on oligodendrocyte development and for unidirectional compensation of the Sox8 loss by Sox10...
  14. ncbi request reprint Hypomorphic Sox10 alleles reveal novel protein functions and unravel developmental differences in glial lineages
    Silke Schreiner
    Institut fur Biochemie, Emil Fischer Zentrum, Universitat Erlangen, Fahrstrasse 17, D 91054 Erlangen, Germany
    Development 134:3271-81. 2007
    ....
  15. ncbi request reprint Sox8 is a specific marker for muscle satellite cells and inhibits myogenesis
    Katy Schmidt
    Institut für Biochemie der Universität Erlangen Nürnberg, D 91054 Erlangen, Germany
    J Biol Chem 278:29769-75. 2003
    ..Our data suggest that Sox8 acts as a specific negative regulator of skeletal muscle differentiation, possibly by interfering with the function of myogenic basic helix-loop-helix proteins...
  16. ncbi request reprint Interaction, cooperative promoter modulation, and renal colocalization of GCMa and Pitx2
    Steffen W Schubert
    Institut fur Biochemie, Universitat Erlangen Nurnberg, Fahrstrasse 17, D 91054 Erlangen, Germany
    J Biol Chem 279:50358-65. 2004
    ..This is the first description of a regulatory cross-talk between a transcription factor of the GCM family and a homeodomain protein...
  17. pmc Prolonged Sox4 expression in oligodendrocytes interferes with normal myelination in the central nervous system
    Michaela R Potzner
    Institut fur Biochemie, Emil Fischer Zentrum, Universitat Erlangen Nurnberg, Fahrstrasse 17, 91054 Erlangen, Germany
    Mol Cell Biol 27:5316-26. 2007
    ....
  18. pmc Cooperative binding of Sox10 to DNA: requirements and consequences
    Beate Schlierf
    Institut fur Biochemie, Fahrstrasse 17, 91054 Erlangen, Germany
    Nucleic Acids Res 30:5509-16. 2002
    ....
  19. pmc Terminal differentiation of myelin-forming oligodendrocytes depends on the transcription factor Sox10
    C Claus Stolt
    Institut fur Biochemie, Universitat Erlangen Nurnberg, 91054 Erlangen, Germany
    Genes Dev 16:165-70. 2002
    ..Sox10 directly regulates myelin gene expression in oligodendrocytes, but does not control erbB3 expression as in peripheral glia. Sox10 thus functions in peripheral and central glia at different stages and through different mechanisms...
  20. pmc The transcription factor Sox5 modulates Sox10 function during melanocyte development
    C Claus Stolt
    Institut fur Biochemie, Emil Fischer Zentrum, Universitat Erlangen, Fahrstrasse 17, D 91054 Erlangen, Germany
    Nucleic Acids Res 36:5427-40. 2008
    ..Both binding site competition and recruitment of corepressors thus help Sox5 to modulate the activity of Sox10 in the melanocyte lineage...
  21. pmc Sox10 is an active nucleocytoplasmic shuttle protein, and shuttling is crucial for Sox10-mediated transactivation
    Stephan Rehberg
    Institut fur Biochemie, Universitat Erlangen Nurnberg, D 91054 Erlangen, Germany
    Mol Cell Biol 22:5826-34. 2002
    ..To our knowledge this is the first time that nuclear export has been reported and shown to be functionally relevant for any Sox protein...
  22. ncbi request reprint The high-mobility group transcription factor Sox10 interacts with the N-myc-interacting protein Nmi
    Beate Schlierf
    Institut fur Biochemie, Universitat Erlangen Nurnberg, D 91054 Erlangen, Germany
    J Mol Biol 353:1033-42. 2005
    ..Importantly, Nmi modulated the transcriptional activity of Sox10 in reporter gene assays. Nmi effects varied between different Sox10 target gene promoters, indicating that Nmi function in vivo may be promoter-specific...
  23. ncbi request reprint Replacement of the Sox10 transcription factor by Sox8 reveals incomplete functional equivalence
    Susanne Kellerer
    Institut fur Biochemie, Universitat Erlangen, Fahrstrasse 17, D 91054 Erlangen, Germany
    Development 133:2875-86. 2006
    ..We conclude that the extent of functional equivalence depends on the tissue and that, despite their relatedness, Sox8 and Sox10 have more unique functions than previously appreciated...
  24. ncbi request reprint Loss of DNA-dependent dimerization of the transcription factor SOX9 as a cause for campomelic dysplasia
    Elisabeth Sock
    Institut fur Biochemie, Universitat Erlangen, D 91054 Erlangen, Germany
    Hum Mol Genet 12:1439-47. 2003
    ..These findings establish the dimerization domain as the third domain essential for SOX9 function during chondrogenesis...
  25. ncbi request reprint Sox10-rtTA mouse line for tetracycline-inducible expression of transgenes in neural crest cells and oligodendrocytes
    Andreas Ludwig
    Institut fur Biochemie, Universitat Erlangen Nurnberg, Fahrstrasse 17, 91054 Erlangen, Germany
    Genesis 40:171-5. 2004
    ..Shut-off, in contrast, exhibited delayed kinetics, which probably correlated with doxycycline clearance rates. This mouse provides a useful tool for generating tetracycline-controlled gene expression in neural crest and oligodendrocytes...
  26. doi request reprint SoxE function in vertebrate nervous system development
    C Claus Stolt
    Institut fur Biochemie, Emil Fischer Zentrum, Friedrich Alexander Universität Erlangen, Fahrstrasse 17, D 91054 Erlangen, Germany
    Int J Biochem Cell Biol 42:437-40. 2010
    ..The multiple functions in peripheral and central nervous system development also link SoxE proteins to various human diseases and identify these proteins as promising targets of future therapeutic approaches...
  27. pmc Multiple conserved regulatory elements with overlapping functions determine Sox10 expression in mouse embryogenesis
    Torsten Werner
    Institut fur Biochemie, Emil Fischer Zentrum, Universitat Erlangen Nurnberg, Erlangen and Max Planck Institut für Neurobiologie, Martinsried, Germany
    Nucleic Acids Res 35:6526-38. 2007
    ..They furthermore exhibit overlapping activities and share binding sites for Sox, Lef/Tcf, Pax and AP2 transcription factors. This may explain high level and robustness of Sox10 expression during embryonic development...
  28. ncbi request reprint Restricted expression of mouse GCMa/Gcm1 in kidney and thymus
    Said Hashemolhosseini
    Institut fur Biochemie, Universitat Erlangen, Fahrstrasse 17, D 91054 Erlangen, Germany
    Mech Dev 118:175-8. 2002
    ..In thymus, mGCMa is restricted to few small clusters of cells, in kidney to the S3 segment of proximal tubules. mGCMa expression is primarily postnatal, arguing for a role in organ function rather than organ development...
  29. pmc The Sox9 transcription factor determines glial fate choice in the developing spinal cord
    C Claus Stolt
    Institut fur Biochemie, Universität Erlangen Nuremberg, 91054 Erlangen, Germany
    Genes Dev 17:1677-89. 2003
    ....
  30. ncbi request reprint Structural requirements for nuclear localization of GCMa/Gcm-1
    Said Hashemolhosseini
    Institut fur Biochemie, Universitat Erlangen Nurnberg, Fahrstrasse 17, D 91054 Erlangen, Germany
    FEBS Lett 553:315-20. 2003
    ..Nuclear import was counteracted by an amino-terminal nuclear export activity. This complex regulation of subcellular localization has important implications for GCMa/Gcm-1 function...
  31. ncbi request reprint Impact of transcription factor Sox8 on oligodendrocyte specification in the mouse embryonic spinal cord
    C Claus Stolt
    Institut fur Biochemie, Universitat Erlangen Nurnberg, Fahrstrasse 17, 91054 Erlangen, Germany
    Dev Biol 281:309-17. 2005
    ..Oligodendrocyte development thus relies on the differential contribution of all three group E Sox proteins at various phases...
  32. pmc Gene targeting reveals a widespread role for the high-mobility-group transcription factor Sox11 in tissue remodeling
    Elisabeth Sock
    Institut fur Biochemie, Universitat Erlangen Nurnberg, Fahrstrasse 17, D 91054 Erlangen, Germany
    Mol Cell Biol 24:6635-44. 2004
    ..This phenotype suggests a prime function for Sox11 in tissue remodeling and identifies SOX11 as a potentially mutated gene in corresponding human malformation syndromes...
  33. ncbi request reprint Melanocyte-specific expression of dopachrome tautomerase is dependent on synergistic gene activation by the Sox10 and Mitf transcription factors
    Andreas Ludwig
    Institut fur Biochemie, Universitat Erlangen Nurnberg, Fahrstrasse 17, D 91054, Erlangen, Germany
    FEBS Lett 556:236-44. 2004
    ..Mitf synergistically enhanced Sox10-dependent activation of the Dct/Trp2 promoter. Synergy appears mechanistically complex and requires both direct binding of Sox10 to the promoter and the protein's transactivation domain...
  34. pmc Impacts of a new transcription factor family: mammalian GCM proteins in health and disease
    Said Hashemolhosseini
    Institut fur Biochemie, Universitat Erlangen Nurnberg, 91054 Erlangen, Germany
    J Cell Biol 166:765-8. 2004
    ..Recent data point to an involvement of GCM proteins in different pathological contexts, such as preeclampsia, hyper- or hypoparathyroidism, and parathyroid gland tumors...
  35. ncbi request reprint Conservation and variation of structure and function in a newly identified GCM homolog from chicken
    Said Hashemolhosseini
    Institut fur Biochemie, Universitat Erlangen, Fahrstrasse 17, D 91054, Erlangen, Germany
    J Mol Biol 336:441-51. 2004
    ..Taking the extraembryonic expression of chicken GCM and mammalian GCMa into account, it is tempting to speculate that a conserved extraembryonic function exists for GCM proteins in birds and mammals...
  36. pmc SoxE proteins are differentially required in mouse adrenal gland development
    Simone Reiprich
    Institut fur Biochemie, Emil Fischer Zentrum, Universitat Erlangen Nurnberg, D 91054 Erlangen, Germany
    Mol Biol Cell 19:1575-86. 2008
    ....
  37. doi request reprint Evolutionary conserved sequence elements with embryonic enhancer activity in the vicinity of the mammalian Sox8 gene
    Sabine I E Guth
    Institut fur Biochemie, Emil Fischer Zentrum, Universitat Erlangen Nurnberg, Erlangen, Germany
    Int J Biochem Cell Biol 42:465-71. 2010
    ....
  38. ncbi request reprint Prolonged glial expression of Sox4 in the CNS leads to architectural cerebellar defects and ataxia
    Melanie Hoser
    Institut fur Biochemie, Emil Fischer Zentrum, Universitat Erlangen, 91054 Erlangen, Germany
    J Neurosci 27:5495-505. 2007
    ..The cerebellar malformations can therefore be explained by the absence of functional Bergmann glia. We conclude that Sox4 expression counteracts differentiation of radial glia and has to be downregulated before full maturation can occur...
  39. doi request reprint Activation of Krox20 gene expression by Sox10 in myelinating Schwann cells
    Simone Reiprich
    Institut fur Biochemie, Emil Fischer Zentrum, Universitat Erlangen Nurnberg, 91054 Erlangen, Germany
    J Neurochem 112:744-54. 2010
    ..All required regions are conserved in several closely related POU and Sox proteins thus explaining why Oct6 and Sox10 can be replaced by their relatives during Krox20 induction in myelinating Schwann cells...
  40. ncbi request reprint Expression of connexin47 in oligodendrocytes is regulated by the Sox10 transcription factor
    Beate Schlierf
    Institut fur Biochemie, Universitat Erlangen Nurnberg, Germany
    J Mol Biol 361:11-21. 2006
    ....
  41. pmc The POU protein Oct-6 is a nucleocytoplasmic shuttling protein
    Constanze Baranek
    Institut fur Biochemie, Universität Erlangen Nürnberg D 91054 Erlangen, Germany
    Nucleic Acids Res 33:6277-86. 2005
    ..Importantly, the nuclear export signal identified for Oct-6 is conserved in most, if not all other vertebrate POU proteins. Nuclear export might therefore be of general relevance for POU protein function throughout development...
  42. pmc The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors
    Sandra Wissmüller
    Institut fur Biochemie, Universitat Erlangen Nurnberg, D 91054 Erlangen, Germany
    Nucleic Acids Res 34:1735-44. 2006
    ..The HMG domain thus not only possesses DNA-binding and DNA-bending but also protein-interacting ability which may be equally important for the architectural function of Sox proteins on their target gene promoters...
  43. doi request reprint Having it both ways: Sox protein function between conservation and innovation
    S I E Guth
    Institut fur Biochemie, Emil Fischer Zentrum, Universitat Erlangen Nurnberg, Fahrstr 17, 91054, Erlangen, Germany
    Cell Mol Life Sci 65:3000-18. 2008
    ..They have led to partial functional redundancies, but also to interesting species-specific variations in the developmental roles of Sox proteins as shown here for the SoxB and the SoxE groups...
  44. ncbi request reprint Identification of Sox8 as a modifier gene in a mouse model of Hirschsprung disease reveals underlying molecular defect
    Marzena Maka
    Institut fur Biochemie, Universitat Erlangen Nurnberg, D 91054 Erlangen, Germany
    Dev Biol 277:155-69. 2005
    ..Our study suggests that Sox8 and Sox10 are jointly required for the maintenance of these vagal neural crest stem cells...
  45. pmc Sequential requirement of Sox4 and Sox11 during development of the sympathetic nervous system
    Michaela R Potzner
    Institut fur Biochemie, Emil Fischer Zentrum, Universitat Erlangen Nurnberg, 91054 Erlangen, Germany
    Development 137:775-84. 2010
    ..As a consequence, sympathetic ganglia were rudimentary in the adult and sympathetic innervation of target tissues was impaired leading to severe dysautonomia...
  46. pmc Idiopathic weight reduction in mice deficient in the high-mobility-group transcription factor Sox8
    E Sock
    Institut fur Biochemie, Universitat Erlangen, D 91054 Erlangen, Germany
    Mol Cell Biol 21:6951-9. 2001
    ..Because of frequent coexpression with either Sox9 or Sox10, the mild phenotype of Sox8-deficient mice might at least in part be due to functional redundancy between group E Sox proteins...
  47. ncbi request reprint Expression of SoxE and SoxD genes in human gliomas
    B Schlierf
    Institut fur Biochemie, Universitat Erlangen Nurnberg, Erlangen, Germany
    Neuropathol Appl Neurobiol 33:621-30. 2007
    ..This is compatible with an origin of gliomas from neuroepithelial stem or precursor cells...
  48. pmc Sox10 is required for Schwann cell identity and progression beyond the immature Schwann cell stage
    Markus Finzsch
    Institut fur Biochemie, Emil Fischer Zentrum, Universitat Erlangen Nurnberg, 91054 Erlangen, Germany
    J Cell Biol 189:701-12. 2010
    ..Schwann cells failed to develop beyond the immature stage and were unable to maintain identity. Thus, our study identifies a novel cause for peripheral neuropathies in patients with SOX10 mutations...
  49. doi request reprint Replacement of related POU transcription factors leads to severe defects in mouse forebrain development
    Michael Wolf
    Institut fur Biochemie, Emil Fischer Zentrum Universität Erlangen Nürnberg, Erlangen, Germany
    Dev Biol 332:418-28. 2009
    ..The extent of functional equivalence between related transcription factors is thus strongly dependent on the analyzed tissue...
  50. doi request reprint Replacement of mouse Sox10 by the Drosophila ortholog Sox100B provides evidence for co-option of SoxE proteins into vertebrate-specific gene-regulatory networks through altered expression
    François Cossais
    Institut fur Biochemie, Emil Fischer Zentrum, Universitat Erlangen, Fahrstrasse 17, D 91054 Erlangen, Germany
    Dev Biol 341:267-81. 2010
    ....
  51. doi request reprint SOX10 structure-function analysis in the chicken neural tube reveals important insights into its role in human neurocristopathies
    François Cossais
    Institut fur Biochemie, Emil Fischer Zentrum, Universitat Erlangen, Erlangen, Germany
    Hum Mol Genet 19:2409-20. 2010
    ..This contributes to the phenotypic variability of human SOX10 mutations...
  52. pmc The closely related transcription factors Sox4 and Sox11 function as survival factors during spinal cord development
    Daniela C Thein
    Institut fur Biochemie, Emil Fischer Zentrum, Universitat Erlangen Nurnberg, Erlangen, Germany
    J Neurochem 115:131-41. 2010
    ..We therefore conclude that the two Sox proteins directly function as pro-survival factors during spinal cord development in neural cell types...
  53. pmc Adult-onset degeneration of adipose tissue in mice deficient for the Sox8 transcription factor
    Sabine I E Guth
    Institut fur Biochemie, Emil Fischer Zentrum, Universitat Erlangen, Erlangen, Germany
    J Lipid Res 50:1269-80. 2009
    ..We postulate a precursor-intrinsic role of Sox8 during replenishment of the adipocyte pool in adult mice and assume that disturbance of this function significantly contributes to adipose tissue degeneration in Sox8-deficient mice...
  54. pmc The high mobility group transcription factor Sox8 is a negative regulator of osteoblast differentiation
    Katy Schmidt
    Institute of Biochemistry, Friedrich Alexander University, Erlangen Nurnberg, Erlangen 91054, Germany
    J Cell Biol 168:899-910. 2005
    ..Together, these data demonstrate a novel function of Sox8, whose tightly controlled expression is critical for bone formation...
  55. ncbi request reprint Functional analysis of Sox8 and Sox9 during sex determination in the mouse
    Marie Christine Chaboissier
    INSERM U470, Centre de Biochimie, Parc Valrose, 06108 Nice Cedex 2, France
    Development 131:1891-901. 2004
    ..Finally, double knock-out analyses suggest that Sox8 reinforces Sox9 function in testis differentiation of mice...
  56. ncbi request reprint Competing waves of oligodendrocytes in the forebrain and postnatal elimination of an embryonic lineage
    Nicoletta Kessaris
    Wolfson Institute for Biomedical Research and Department of Biology, University College London, Gower Street, London WC1E 6BT, UK
    Nat Neurosci 9:173-9. 2006
    ..Notably, the embryonic MGE- and AEP-derived population is eliminated during postnatal life, raising questions about the nature and purpose of the competition...
  57. doi request reprint Quantitative assessment of glial cells in the human and guinea pig enteric nervous system with an anti-Sox8/9/10 antibody
    Sebastian Hoff
    Department of Human Biology, Technische Universitat Munchen, D 85350 Freising Weihenstephan, Germany
    J Comp Neurol 509:356-71. 2008
    ..This is a comprehensive set of quantitative EGC measures in man and guinea pig that provides a basis for pathological assessment of glial proliferation and/or degeneration in the diseased gut...
  58. ncbi request reprint Translation of SOX10 3' untranslated region causes a complex severe neurocristopathy by generation of a deleterious functional domain
    Ken Inoue
    Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo 187 8502, Japan
    Hum Mol Genet 16:3037-46. 2007
    ..Failure to properly terminate SOX10 translation causes the generation of a deleterious functional domain that occurs because of translation of the normal 3'-UTR; the mutant fusion protein causes a severe neurological disease...
  59. ncbi request reprint Oligodendroglial-specific transcriptional factor SOX10 is ubiquitously expressed in human gliomas
    Sergei I Bannykh
    Department of Pathology, Yale University School of Medicine, New Haven, CT 65210, USA
    J Neurooncol 76:115-27. 2006
    ..Our data raise a possibility that histogenesis of gliomas have more common features than previously anticipated...
  60. pmc The Runx1/AML1 transcription factor selectively regulates development and survival of TrkA nociceptive sensory neurons
    Frederic Marmigere
    Laboratory of Molecular Neurobiology, Karolinska Institute, MBB, Scheeles vag 1, Stockholm, Sweden
    Nat Neurosci 9:180-7. 2006
    ..Our data show that Runx1 directs, in a context-dependent manner, key aspects of the establishment of the TrkA(+) nociceptive subclass of neurons...
  61. ncbi request reprint Expression of Sox transcription factors in the developing mouse pancreas
    Oleg Lioubinski
    Zentrum für Molekulare Neurobiologie, Hamburg, Germany
    Dev Dyn 227:402-8. 2003
    ..Sox8 and Sox10 were detected in a thin layer of cells surrounding the islets. The expression patterns of Sox genes in the embryonic pancreas suggest that they could have important and possibly redundant functions in pancreas development...
  62. pmc Sox10 regulates ciliary neurotrophic factor gene expression in Schwann cells
    Yasuhiro Ito
    Institute for Clinical Neurobiology, University of Wuerzburg, D 97080 Wuerzburg, Germany
    Proc Natl Acad Sci U S A 103:7871-6. 2006
    ..Mice with heterozygous inactivation of the Sox10 gene show significantly reduced Cntf protein levels in sciatic nerves, indicating that Sox10 is necessary and sufficient for regulating Cntf expression in the peripheral nervous system...
  63. ncbi request reprint GCMB mutation in familial isolated hypoparathyroidism with residual secretion of parathyroid hormone
    Caroline Thomée
    Department of Internal Medicine, Children s Unit, Centre Hospitalier Etterbeek Ixelles, Brussels
    J Clin Endocrinol Metab 90:2487-92. 2005
    ..Contrary to the previously reported family, our patients displayed low but clearly detectable levels of PTH in plasma. This residual hormone secretion probably results from a very small residual activity of the G63S mutant GCMB...
  64. ncbi request reprint Molecular mechanism for distinct neurological phenotypes conveyed by allelic truncating mutations
    Ken Inoue
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Room 604B, Houston, Texas 77030, USA
    Nat Genet 36:361-9. 2004
    ..We observe similar results for truncating mutations of MPZ that convey distinct myelinopathies. Our experiments show that triggering NMD and escaping NMD may cause distinct neurological phenotypes...
  65. ncbi request reprint Induction of oligodendrocyte differentiation by Olig2 and Sox10: evidence for reciprocal interactions and dosage-dependent mechanisms
    Zijing Liu
    Department of Anatomical Sciences and Neurobiology, School of Medicine, University of Louisville, Louisville, KY 40292, USA
    Dev Biol 302:683-93. 2007
    ..In addition, we presented evidence that the control of oligodendrocyte differentiation by Olig2, Sox10 and Nkx2.2 is a dosage-dependent developmental process and can be affected by both haploinsufficiency and over-dosage...
  66. pmc Structure of the GCM domain-DNA complex: a DNA-binding domain with a novel fold and mode of target site recognition
    Serge X Cohen
    European Molecular Biology Laboratory, Grenoble Outstation, BP 181, 38042 Grenoble Cedex 9, France
    EMBO J 22:1835-45. 2003
    ..The structure combined with mutational analysis of the target site and of DNA-contacting residues provides insight into DNA recognition by this new type of Zn-containing DNA-binding domain...
  67. doi request reprint Differential expression and dynamic changes of murine NEDD9 in progenitor cells of diverse tissues
    Jorge B Aquino
    Unit of Molecular Neurobiology, Medical Biochemistry and Biophysics, Karolinska Institutet, Scheeles vag 1 A1 2, 171 77 Stockholm, Sweden
    Gene Expr Patterns 8:217-26. 2008
    ....
  68. ncbi request reprint Neural crest origin of perivascular mesenchyme in the adult thymus
    Susanna M Müller
    Institute for Immunology, University of Ulm, Ulm, Germany
    J Immunol 180:5344-51. 2008
    ....
  69. ncbi request reprint The GCM domain is a Zn-coordinating DNA-binding domain
    Serge X Cohen
    European Molecular Biology Laboratory, Grenoble Outstation, B P 181, France
    FEBS Lett 528:95-100. 2002
    ..Our results define the GCM domain as a new type of Zn-coordinating, sequence-specific DNA-binding domain...
  70. ncbi request reprint A tissue-restricted cAMP transcriptional response: SOX10 modulates alpha-melanocyte-stimulating hormone-triggered expression of microphthalmia-associated transcription factor in melanocytes
    Wade E Huber
    Division of Pediatric Hematology Oncology, Dana Farber Cancer Institute and Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 278:45224-30. 2003
    ..These observations demonstrate a means whereby the ubiquitous cAMP signaling machinery is harnessed to produce a highly tissue-restricted transcriptional response by cooperating with architectural factors, in this case SOX10...
  71. doi request reprint SOX9 is expressed in human fetal prostate epithelium and enhances prostate cancer invasion
    Hongyun Wang
    Cancer Biology Program, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Cancer Res 68:1625-30. 2008
    ..These results support important functions of SOX9 in both the development and maintenance of normal prostate, and indicate that these functions contribute to PCa tumor growth and invasion...
  72. doi request reprint Anterior segment dysgenesis in the eyes of mice deficient for the high-mobility-group transcription factor Sox11
    Antje Wurm
    Institute of Human Anatomy and Embryology, University of Regensburg, Regensburg, Germany
    Exp Eye Res 86:895-907. 2008
    ..Our findings suggest that SOX11 might similarly be involved in the pathogenesis of ASD in human patients...