Christian Weber

Summary

Affiliation: University Hospital
Country: Germany

Publications

  1. doi Chemokines in atherosclerosis, thrombosis, and vascular biology
    Christian Weber
    Institute for Molecular Cardiovascular Research, RWTH Aachen University, Germany
    Arterioscler Thromb Vasc Biol 28:1896. 2008
  2. doi Platelet microparticles enhance the vasoregenerative potential of angiogenic early outgrowth cells after vascular injury
    Sebastian F Mause
    Medical Faculty, Institute for Molecular Cardiovascular Research, RWTH Aachen University, Aachen, Germany
    Circulation 122:495-506. 2010
  3. ncbi Stabilization of atherosclerotic plaques by blockade of macrophage migration inhibitory factor after vascular injury in apolipoprotein E-deficient mice
    Andreas Schober
    Kardiovaskuläre Molekularbiologie, Universitatsklinikum Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Circulation 109:380-5. 2004
  4. ncbi Platelets and chemokines in atherosclerosis: partners in crime
    Christian Weber
    Department of Molecular Cardiovascular Research, University Hospital, Rheinisch Westfalische Technische Hochschule, Aachen, Germany
    Circ Res 96:612-6. 2005
  5. ncbi Chemokines: key regulators of mononuclear cell recruitment in atherosclerotic vascular disease
    Christian Weber
    Kardiovaskuläre Molekularbiologie, Universitatsklinikum Aachen, Rheinisch Westfälische Technische Hochschule Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Arterioscler Thromb Vasc Biol 24:1997-2008. 2004
  6. ncbi Fine-tuning leukocyte responses: towards a chemokine 'interactome'
    Christian Weber
    Institut für Kardiovaskuläre Molekularbiologie, Universitatsklinikum Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Trends Immunol 27:268-73. 2006
  7. ncbi The role of junctional adhesion molecules in vascular inflammation
    Christian Weber
    Institute for Molecular Cardiovascular Research, RWTH University Hospital, 52074 Aachen, Germany
    Nat Rev Immunol 7:467-77. 2007
  8. pmc Structural determinants of MIF functions in CXCR2-mediated inflammatory and atherogenic leukocyte recruitment
    Christian Weber
    Institute for Molecular Cardiovascular Research IMCAR, Aachen, GermanyAachen, Germany
    Proc Natl Acad Sci U S A 105:16278-83. 2008
  9. doi The multifaceted contributions of leukocyte subsets to atherosclerosis: lessons from mouse models
    Christian Weber
    Institute for Molecular Cardiovascular Research, RWTH Aachen University, 52074 Aachen, Germany
    Nat Rev Immunol 8:802-15. 2008
  10. ncbi Chemokines take centre stage in vascular biology
    Christian Weber
    Institute for Molecular Cardiovascular Research IMCAR, RWTH Aachen University, Pauwelsstr 30, 52072 Aachen, Germany
    Thromb Haemost 97:685-7. 2007

Collaborators

Detail Information

Publications114 found, 100 shown here

  1. doi Chemokines in atherosclerosis, thrombosis, and vascular biology
    Christian Weber
    Institute for Molecular Cardiovascular Research, RWTH Aachen University, Germany
    Arterioscler Thromb Vasc Biol 28:1896. 2008
  2. doi Platelet microparticles enhance the vasoregenerative potential of angiogenic early outgrowth cells after vascular injury
    Sebastian F Mause
    Medical Faculty, Institute for Molecular Cardiovascular Research, RWTH Aachen University, Aachen, Germany
    Circulation 122:495-506. 2010
    ..Vascular pathologies comprise platelet activation and concomitant generation of platelet microparticles (PMPs). We hypothesized that PMPs may interact with EOCs in the context of vascular injury and modulate their regenerative potential...
  3. ncbi Stabilization of atherosclerotic plaques by blockade of macrophage migration inhibitory factor after vascular injury in apolipoprotein E-deficient mice
    Andreas Schober
    Kardiovaskuläre Molekularbiologie, Universitatsklinikum Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Circulation 109:380-5. 2004
    ..Macrophage migration inhibitory factor (MIF), a cytokine that controls cell-mediated inflammatory responses, is upregulated in atherogenesis; however, its functional contribution to lesion development has not been evaluated...
  4. ncbi Platelets and chemokines in atherosclerosis: partners in crime
    Christian Weber
    Department of Molecular Cardiovascular Research, University Hospital, Rheinisch Westfalische Technische Hochschule, Aachen, Germany
    Circ Res 96:612-6. 2005
    ..The close linkage between platelets and chemokines as culprits in the pathogenesis of vascular diseases may provide a valuable target for selective interventions...
  5. ncbi Chemokines: key regulators of mononuclear cell recruitment in atherosclerotic vascular disease
    Christian Weber
    Kardiovaskuläre Molekularbiologie, Universitatsklinikum Aachen, Rheinisch Westfälische Technische Hochschule Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Arterioscler Thromb Vasc Biol 24:1997-2008. 2004
    ....
  6. ncbi Fine-tuning leukocyte responses: towards a chemokine 'interactome'
    Christian Weber
    Institut für Kardiovaskuläre Molekularbiologie, Universitatsklinikum Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Trends Immunol 27:268-73. 2006
    ..This model could establish how signals conferred by various chemokines are integrated for the combinatorial control of leukocyte responses...
  7. ncbi The role of junctional adhesion molecules in vascular inflammation
    Christian Weber
    Institute for Molecular Cardiovascular Research, RWTH University Hospital, 52074 Aachen, Germany
    Nat Rev Immunol 7:467-77. 2007
    ..This Review summarizes recent progress and future directions in understanding the role of JAMs as 'gate keepers' in inflammation and vascular pathology...
  8. pmc Structural determinants of MIF functions in CXCR2-mediated inflammatory and atherogenic leukocyte recruitment
    Christian Weber
    Institute for Molecular Cardiovascular Research IMCAR, Aachen, GermanyAachen, Germany
    Proc Natl Acad Sci U S A 105:16278-83. 2008
    ....
  9. doi The multifaceted contributions of leukocyte subsets to atherosclerosis: lessons from mouse models
    Christian Weber
    Institute for Molecular Cardiovascular Research, RWTH Aachen University, 52074 Aachen, Germany
    Nat Rev Immunol 8:802-15. 2008
    ..Improved understanding of the selective contributions of specific cell types to atherogenesis will pave the way for new targeted approaches to therapy...
  10. ncbi Chemokines take centre stage in vascular biology
    Christian Weber
    Institute for Molecular Cardiovascular Research IMCAR, RWTH Aachen University, Pauwelsstr 30, 52072 Aachen, Germany
    Thromb Haemost 97:685-7. 2007
  11. ncbi Novel mechanistic concepts for the control of leukocyte transmigration: specialization of integrins, chemokines, and junctional molecules
    Christian Weber
    Kardiovaskuläre Molekularbiologie, Universitatsklinikum Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    J Mol Med (Berl) 81:4-19. 2003
    ....
  12. ncbi Involvement of JAM-A in mononuclear cell recruitment on inflamed or atherosclerotic endothelium: inhibition by soluble JAM-A
    Georg Ostermann
    Department of Cardiovascular Molecular Biology, University Hospital, Aachen, Germany
    Arterioscler Thromb Vasc Biol 25:729-35. 2005
    ..It is unknown whether these functions can be inhibited by soluble forms of JAM-A, whether JAM-A is expressed on atherosclerotic endothelium, and whether it participates in atherogenic recruitment of mononuclear cells...
  13. ncbi Crucial role of the CCL2/CCR2 axis in neointimal hyperplasia after arterial injury in hyperlipidemic mice involves early monocyte recruitment and CCL2 presentation on platelets
    Andreas Schober
    Department of Molecular Cardiovascular Research, University Hospital, Rheinisch Westfalische Technische Hochschule, Aachen, Germany
    Circ Res 95:1125-33. 2004
    ..This mechanism may explain reduced neointimal macrophage infiltration and lesion formation in CCR2-deficient apoE-/- mice...
  14. doi Regulated release and functional modulation of junctional adhesion molecule A by disintegrin metalloproteinases
    Rory R Koenen
    MedicalFaculty, Institute for Molecular Cardiovascular Research, RWTH Aachen University, Aachen, Germany
    Blood 113:4799-809. 2009
    ....
  15. ncbi Importance of junctional adhesion molecule-A for neointimal lesion formation and infiltration in atherosclerosis-prone mice
    Alma Zernecke
    Department of Molecular Cardiovascular Research, RWTH University Hospital, Aachen, Germany
    Arterioscler Thromb Vasc Biol 26:e10-3. 2006
    ....
  16. ncbi Neointimal smooth muscle cells display a proinflammatory phenotype resulting in increased leukocyte recruitment mediated by P-selectin and chemokines
    Ute Zeiffer
    Department of Molecular Cardiovascular Research, University of Technology, Aachen, Germany
    Circ Res 94:776-84. 2004
    ..In conclusion, we have identified a NF-kappaB-mediated proinflammatory phenotype of niSMCs that is characterized by increased P-selectin and chemokine expression and thereby effectively supports leukocyte recruitment...
  17. ncbi Myocardial regeneration by transplantation of modified endothelial progenitor cells expressing SDF-1 in a rat model
    Alexander Schuh
    Department of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty, RWTH Aachen University, Germany
    J Cell Mol Med 16:2311-20. 2012
    ....
  18. doi Compartmentalized protective and detrimental effects of endogenous macrophage migration-inhibitory factor mediated by CXCR2 in a mouse model of myocardial ischemia/reperfusion
    Elisa A Liehn
    Institute for Molecular Cardiovascular Research, RWTH Aachen University, Aachen, Germany
    Arterioscler Thromb Vasc Biol 33:2180-6. 2013
    ..In models of myocardial infarction, MIF exerts both proinflammatory effects and protective effects in cardiomyocytes. Similarly, CXCR2 displays opposing effects in resident versus circulating cells...
  19. doi Blockade of angio-associated migratory cell protein inhibits smooth muscle cell migration and neointima formation in accelerated atherosclerosis
    Felix Vogt
    Department of Cardiology, RWTH Aachen University, Aachen, Germany
    J Am Coll Cardiol 52:302-11. 2008
    ..The aim of this study was to elucidate the role of angio-associated migratory cell protein (AAMP) for the migration of vascular smooth muscle cells (SMCs) and for the development of neointimal hyperplasia after vascular injury...
  20. ncbi Platelet microparticles: a transcellular delivery system for RANTES promoting monocyte recruitment on endothelium
    Sebastian F Mause
    Department of Molecular Cardiovascular Research, University Hospital, Aachen, Germany
    Arterioscler Thromb Vasc Biol 25:1512-8. 2005
    ..We studied the role of PMPs in delivering RANTES and promoting monocyte recruitment...
  21. ncbi A novel drug-eluting stent coated with an integrin-binding cyclic Arg-Gly-Asp peptide inhibits neointimal hyperplasia by recruiting endothelial progenitor cells
    Rüdiger Blindt
    Department of Cardiology, University Hospital Aachen, Aachen, Germany
    J Am Coll Cardiol 47:1786-95. 2006
    ..Novel stents loaded with an integrin-binding cyclic Arg-Gly-Asp peptide (cRGD) were analyzed for their potential to limit coronary neointima formation and to accelerate endothelialization by attracting endothelial progenitor cells (EPCs)...
  22. ncbi C1-esterase inhibitor protects against neointima formation after arterial injury in atherosclerosis-prone mice
    Erdenechimeg Shagdarsuren
    Institute of Molecular Cardiovascular Research, University Hospital, RWTH Aachen University, Aachen, Germany
    Circulation 117:70-8. 2008
    ..Here, we examined the contribution of the complement cascade to neointima formation in apolipoprotein E-deficient mice using a C1-esterase inhibitor (C1-inhibitor)...
  23. doi C5a receptor targeting in neointima formation after arterial injury in atherosclerosis-prone mice
    Erdenechimeg Shagdarsuren
    Institute of Molecular Cardiovascular Research, RWTH Aachen University, Aachen, Germany
    Circulation 122:1026-36. 2010
    ..In the present study, we examined the contribution of the C5a receptor (C5aR) to neointima formation in apolipoprotein E-deficient mice employing a C5aR antagonist (C5aRA) and a C5aR-blocking monoclonal antibody...
  24. doi Endothelial junctional adhesion molecule-a guides monocytes into flow-dependent predilection sites of atherosclerosis
    Martin M N Schmitt
    Institute for Cardiovascular Prevention, Ludwig Maximilians University Munich, Munich, Germany M M N S, R T A M, K B, R R K, C W the Institute for Molecular Cardiovascular Research, RWTH Aachen University, Aachen, Germany M M N S, M A v Z the Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands M M N S, R T A M, N M v d A, T R, M A v Z, T M H, R R K, C W the Division of Vascular Biology, Department of Vascular Surgery, Klinikum rechts der Isar, Technical University Munich, Germany A Z and the German Centre for Cardiovascular Research DZHK, partner site Munich Heart Alliance, Munich, Germany A Z, C W
    Circulation 129:66-76. 2014
    ..Atherosclerosis develops at sites of disturbed flow in large arteries, but the mechanisms guiding inflammatory cells into these predilection sites remain unknown...
  25. doi Improved left ventricular function after transplantation of microspheres and fibroblasts in a rat model of myocardial infarction
    Alexander Schuh
    Medizinische Klinik I, Universitätsklinikum der RWTH Aachen, Pauwelsstrasse 30, 52057, Aachen, Germany
    Basic Res Cardiol 104:403-11. 2009
    ..2 +/- 3.0 cells/mm(2), macrophages 56.02 +/- 9.93 cells/mm(2), medium 46.35 +/- 9.03 cells/mm(2), P < 0.05) suggests that the underlying mechanism of augmented left ventricular function might be based on inflammatory processes...
  26. pmc Differential roles of angiogenic chemokines in endothelial progenitor cell-induced angiogenesis
    Isabella Kanzler
    Institute of Biochemistry and Molecular Cell Biology, Rheinisch Westfälisch Technische Hochschule Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany
    Basic Res Cardiol 108:310. 2013
    ....
  27. ncbi Y-box binding protein-1 controls CC chemokine ligand-5 (CCL5) expression in smooth muscle cells and contributes to neointima formation in atherosclerosis-prone mice
    Regina Krohn
    Institute for Molecular Cardiovascular Research, University Hospital Aachen, RWTH Aachen University, Aachen, Germany
    Circulation 116:1812-20. 2007
    ..We investigated the influence of the transcriptional regulator Y-box binding protein (YB)-1 on CCL5 expression and wire-induced neointimal hyperplasia...
  28. ncbi Transplantation of endothelial progenitor cells improves neovascularization and left ventricular function after myocardial infarction in a rat model
    Alexander Schuh
    IZKF BIOMAT, Aachen, Germany
    Basic Res Cardiol 103:69-77. 2008
    ..These results imply a combined benefit of EPCs+SDF-1alpha in the treatment of myocardial infarction...
  29. doi Importance of junctional adhesion molecule-C for neointimal hyperplasia and monocyte recruitment in atherosclerosis-prone mice-brief report
    Erdenechimeg Shagdarsuren
    Institut für Molekulare Herz Kreislaufforschung, Universitätsklinikum der RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Arterioscler Thromb Vasc Biol 29:1161-3. 2009
    ..Although junctional adhesion molecule (JAM)-C has been implicated in the control of inflammatory leukocyte recruitment, its role in neointima formation after arterial injury has not been elucidated...
  30. doi Regulation of nerve growth factor in the heart: the role of the calcineurin-NFAT pathway
    Obaida R Rana
    Department of Cardiology, Angiology and Pulmonology, Medical Faculty, RWTH Aachen University, Pauwelsstr 30, D 52074 Aachen, Germany
    J Mol Cell Cardiol 46:568-78. 2009
    ..Nevertheless, the calcineurin-NFAT pathway may provide promising starting points for new pharmacological strategies to prevent SNS in the heart...
  31. doi Sympathetic neurons express and secrete MMP-2 and MT1-MMP to control nerve sprouting via pro-NGF conversion
    Erol Saygili
    Department of Cardiology, Medical Clinic I, RWTH Aachen University, Germany
    Cell Mol Neurobiol 31:17-25. 2011
    ..In summary, specific MMP-2 blockade prevents sympathetic nerve sprouting (SNS) by inhibition of pro-NGF conversion while losartan abolishes HFES-induced SNS by reducing total NGF, MMP-2 and MT1-MMP expression...
  32. ncbi SDF-1alpha/CXCR4 axis is instrumental in neointimal hyperplasia and recruitment of smooth muscle progenitor cells
    Alma Zernecke
    Department of Molecular Cardiovascular Research, University Hospital, Rheinisch Westfalische Technische Hochschule, Aachen, Germany
    Circ Res 96:784-91. 2005
    ....
  33. ncbi Transplantation of human umbilical vein endothelial cells improves left ventricular function in a rat model of myocardial infarction
    Marc W Merx
    Medizinische Klinik I, Universitatsklinikum Aachen, Pauwelsstr 30, 52057 Aachen, Germany
    Basic Res Cardiol 100:208-16. 2005
    ..Since human umbilical vein endothelial cells (HUVEC) harbor the potential for transdifferentiation, we studied the functional effects of HUVEC transplantation in a rat model of MI...
  34. doi Hyperlipidemia-triggered neutrophilia promotes early atherosclerosis
    Maik Drechsler
    Institute for Molecular Cardiovascular Research, Pauwelsstrasse 30, 52074 Aachen, Germany
    Circulation 122:1837-45. 2010
    ..Here, we investigate the effect of hypercholesterolemia on peripheral neutrophil counts, neutrophil recruitment to atherosclerotic lesions, and the importance of neutrophils in atherosclerotic lesion formation in Apoe(-/-) mice...
  35. doi The CXCR4 antagonist POL5551 is equally effective as sirolimus in reducing neointima formation without impairing re-endothelialisation
    Karim Hamesch
    Institute for Molecular Cardiovascular Research, RWTH Aachen University, Aachen, Germany
    Thromb Haemost 107:356-68. 2012
    ....
  36. ncbi Intravascular ultrasonic comparative analysis of degree of intimal hyperplasia produced by four different stents in the coronary arteries
    Rainer Hoffmann
    Medical Clinic I, University RWTH Aachen, Aachen, Germany
    Am J Cardiol 94:1548-50. 2004
    ..048 and p <0.001), respectively, whereas mean intimal hyperplasia thickness treated with dexamethasone-eluting stents was similar to those lesions treated with bare metal stents...
  37. doi Disrupting functional interactions between platelet chemokines inhibits atherosclerosis in hyperlipidemic mice
    Rory R Koenen
    Institute for Cardiovascular Molecular Research, Medical Faculty, RWTH Aachen University, Aachen, Germany
    Nat Med 15:97-103. 2009
    ..These results establish the in vivo relevance of chemokine heteromers and show the potential of targeting heteromer formation to achieve therapeutic effects...
  38. ncbi Mechanisms of monocyte recruitment in vascular repair after injury
    Andreas Schober
    Division of Cardiology, Medizinische Poliklinik, University Hospital, Munich, Germany
    Antioxid Redox Signal 7:1249-57. 2005
    ..Understanding the complex molecular interactions of the injured vessel wall with circulating monocytes may enable therapeutic targeting to prevent the development of restenosis...
  39. ncbi Differential and additive effects of platelet-derived chemokines on monocyte arrest on inflamed endothelium under flow conditions
    Thomas Baltus
    Department of Molecular Cardiovascular Research, Universitatsklinikum Aachen, Pauwelstrasse 30, 52074 Aachen, Germany
    J Leukoc Biol 78:435-41. 2005
    ..Thus, multiple platelet-derived chemokines and processable precursors, which can be presented by specific endothelial proteoglycans, may contribute and cooperate differentially to induce monocyte recruitment...
  40. ncbi Protective role of CXC receptor 4/CXC ligand 12 unveils the importance of neutrophils in atherosclerosis
    Alma Zernecke
    Institute for Molecular Cardiovascular Research, Rheinisch Westfalische Technische Hochschule, Aachen University, Germany
    Circ Res 102:209-17. 2008
    ..Disrupting Cxcl12/Cxcr4 thus promotes lesion formation through deranged neutrophil homeostasis, indicating that Cxcl12/Cxcr4 controls the important contribution of neutrophils to atherogenesis in mice...
  41. ncbi Relationship of five inflammatory gene polymorphisms with morbidity and mortality in 533 patients admitted to an ICU
    Jan R Ortlepp
    Interdisciplinary Intermediate Care, University Hospital of Aachen RTWTH, Pauwelsstrasse 30, 52057 Aachen, Germany
    Inflammation 29:65-71. 2005
    ..The aim of this study was to analyze the association of polymorphisms of five candidate genes with the outcome of consecutive patients admitted to a medical ICU...
  42. pmc A functional heteromeric MIF receptor formed by CD74 and CXCR4
    Verena Schwartz
    Department of Biochemistry and Molecular Cell Biology, RWTH Aachen University, Aachen, Germany
    FEBS Lett 583:2749-57. 2009
    ..Thus, CD74 forms functional complexes with CXCR4 that mediate MIF-specific signaling...
  43. doi MIF-chemokine receptor interactions in atherogenesis are dependent on an N-loop-based 2-site binding mechanism
    Sandra Kraemer
    Institute of Biochemistry and Molecular Cell Biology, Rheinisch Westfälische Technische Hochschule Aachen University, Pauwelsstrasse 30, D 52074 Aachen, Germany
    FASEB J 25:894-906. 2011
    ..Thus, the N-like loop in MIF is critical for MIF's noncognate interaction with CXCR2 and proatherogenic functions. The 2-site binding model that explains chemokine receptor activation also applies to MIF...
  44. ncbi Electrical stimulation of sympathetic neurons induces autocrine/paracrine effects of NGF mediated by TrkA
    Erol Saygili
    Department of Cardiology, University RWTH Aachen, Aachen, Germany
    J Mol Cell Cardiol 49:79-87. 2010
    ..In summary, this study provides evidence that high-rate electrical stimulation of sympathetic neurons mediates nerve sprouting by an increase in NGF expression that targets the TrkA receptor in an autocrine/paracrine manner...
  45. doi Delivery of microRNA-126 by apoptotic bodies induces CXCL12-dependent vascular protection
    Alma Zernecke
    Institute of Molecular Cardiovascular Research IMCAR, RWTH Aachen University, 52074 Aachen, Germany
    Sci Signal 2:ra81. 2009
    ..This study highlights functions of microRNAs in health and disease that may extend to the recruitment of progenitor cells during other forms of tissue repair or homeostasis...
  46. ncbi Heterophilic interactions of platelet factor 4 and RANTES promote monocyte arrest on endothelium
    Philipp von Hundelshausen
    Department of Molecular Cardiovascular Research, University Hospital Aachen, Germany
    Blood 105:924-30. 2005
    ..This may have implications for the modulation of inflammatory recruitment by platelet-derived chemokines...
  47. doi Differential regulation of chemokine CCL5 expression in monocytes/macrophages and renal cells by Y-box protein-1
    Ute Raffetseder
    Department of Nephrology and Clinical Immunology, University Hospital RWTH Aachen, Aachen, Germany
    Kidney Int 75:185-96. 2009
    ..We show that YB-1 is a cell-type specific regulator of CCL5 expression in infiltrating T-cells and monocytes/macrophages and acts as an adaptive controller of inflammation during kidney allograft rejection...
  48. pmc Macrophage migration inhibitory factor (MIF) exerts antifibrotic effects in experimental liver fibrosis via CD74
    Daniel Heinrichs
    Medical Department III, Rheinisch Westfälische Technische Hochschule Aachen University, 52074 Aachen, Germany
    Proc Natl Acad Sci U S A 108:17444-9. 2011
    ..In conclusion, we describe a previously unexplored antifibrotic function of MIF that is mediated by the CD74/AMPK signaling pathway in HSCs. The results imply MIF and CD74 as targets for treatment of liver diseases...
  49. ncbi Importance of CXC chemokine receptor 2 in the homing of human peripheral blood endothelial progenitor cells to sites of arterial injury
    Mihail Hristov
    Institut für Kardiovaskuläre Molekularbiologie, Universitatsklinikum Aachen, Pauwelsstr 30, 52074 Aachen, Germany
    Circ Res 100:590-7. 2007
    ..In conclusion, our data clearly demonstrate the importance of CXCR2 for the homing of circulating EPCs to sites of arterial injury and for endothelial recovery in vivo...
  50. pmc Antagonism of the chemokine Ccl5 ameliorates experimental liver fibrosis in mice
    Marie Luise Berres
    Medical Department III, University Hospital Aachen, Aachen, Germany
    J Clin Invest 120:4129-40. 2010
    ..Our results define a successful therapeutic approach to reduce experimental liver fibrosis by antagonizing Ccl5 receptors...
  51. ncbi Reduced numbers of circulating endothelial progenitor cells in patients with coronary artery disease associated with long-term statin treatment
    Mihail Hristov
    Institute for Molecular Cardiovascular Research, RWTH Aachen University, University Hospital Aachen, Aachen, Germany
    Atherosclerosis 192:413-20. 2007
    ..Thus, the statin dose during chronic and continuous treatment independently predicts reduced numbers of circulating as well as isolated EPCs in patients with CAD...
  52. doi CXC chemokine KC fails to induce neutrophil infiltration and neoangiogenesis in a mouse model of myocardial infarction
    Hasan Oral
    Institute for Molecular Cardiovascular Research, RWTH Aachen University, Aachen, Germany
    J Mol Cell Cardiol 60:1-7. 2013
    ..The objective of this study was to determine the importance of ELR-containing CXC chemokine KC in neutrophil infiltration and neoangiogenesis, in a mouse model of chronic MI...
  53. doi Double-edged role of the CXCL12/CXCR4 axis in experimental myocardial infarction
    Elisa A Liehn
    Institute for Molecular Cardiovascular Research, RWTH Aachen University, Aachen, Germany
    J Am Coll Cardiol 58:2415-23. 2011
    ..Here we assess the intrinsic functions of the chemokine receptor CXCR4 in remodeling after myocardial infarction (MI) using Cxcr4 heterozygous (Cxcr4(+/-)) mice...
  54. doi Predictors of low circulating endothelial progenitor cell numbers in haemodialysis patients
    Georg Schlieper
    Department of Nephrology and Clinical Immunology, RWTH University Hospital Aachen, Pauwelsstr 30, 52074 Aachen, Germany
    Nephrol Dial Transplant 23:2611-8. 2008
    ....
  55. doi Chemokines in atherosclerosis: an update
    Alma Zernecke
    Institute for Molecular Cardiovascular Research, University Hospital, RWTH Aachen University, Germany
    Arterioscler Thromb Vasc Biol 28:1897-908. 2008
    ..The considerable leap in insight over recent years leads us to anticipate further advances in comprehending the role of chemokines in atherosclerosis, allowing targeted interventions for its prevention and therapy...
  56. doi Soluble CD40 ligand impairs the function of peripheral blood angiogenic outgrowth cells and increases neointimal formation after arterial injury
    Mihail Hristov
    Institute for Molecular Cardiovascular Research, RWTH Aachen University, Aachen, Germany
    Circulation 121:315-24. 2010
    ..We investigated whether sCD40L functionally affects peripheral blood-derived angiogenic early outgrowth cells (EOCs) and neointimal remodeling after arterial injury...
  57. doi Requirements for leukocyte transmigration via the transmembrane chemokine CX3CL1
    Nicole Schwarz
    Institute of Pharmacology and Toxicology, RWTH Aachen University, Pauwelsstr 30, 52074, Aachen, Germany
    Cell Mol Life Sci 67:4233-48. 2010
    ..Thus, transmembrane CX3CL1 mediates leukocyte transmigration via the DRY motif and C-terminus of CX3CR1 and the activity of ADAM10...
  58. doi Chronic electrical neuronal stimulation increases cardiac parasympathetic tone by eliciting neurotrophic effects
    Obaida R Rana
    Department of Cardiology, RWTH Aachen University, Pauwelsstr 30, D 52074 Aachen, Germany
    Circ Res 108:1209-19. 2011
    ..In these experiments, we observed a decrease of the intrinsic ventricular rate during the first 4 to 5 months when HFES was intermittently shut off...
  59. doi Hypoxia-induced endothelial secretion of macrophage migration inhibitory factor and role in endothelial progenitor cell recruitment
    David Simons
    Department of Biochemistry and Molecular Cell Biology, University Hospital, RWTH Aachen University, Aachen, Germany
    J Cell Mol Med 15:668-78. 2011
    ..Thus, hypoxia-induced MIF secretion from ECs might play an important role in the recruitment and migration of EPCs to hypoxic tissues such as after ischemia-induced myocardial damage...
  60. ncbi Long-term assessment of a novel biodegradable paclitaxel-eluting coronary polylactide stent
    Felix Vogt
    Medical Clinic I, University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Eur Heart J 25:1330-40. 2004
    ..Paclitaxel was shown to inhibit vascular smooth muscle cell proliferation and migration...
  61. ncbi Blockade of keratinocyte-derived chemokine inhibits endothelial recovery and enhances plaque formation after arterial injury in ApoE-deficient mice
    Elisa A Liehn
    Department of Molecular Cardiovascular Research, University Hospital, Rheinisch Westfalische Technische Hochschule, Aachen, Germany
    Arterioscler Thromb Vasc Biol 24:1891-6. 2004
    ..We evaluated the involvement of keratinocyte-derived chemokine (KC) in neointimal hyperplasia and endothelial repair after arterial injury...
  62. ncbi Deposition of platelet RANTES triggering monocyte recruitment requires P-selectin and is involved in neointima formation after arterial injury
    Andreas Schober
    Department of Molecular Cardiovascular Research and Cardiology, Rheinisch Westfälische Technische Hochschule Aachen, Germany
    Circulation 106:1523-9. 2002
    ....
  63. doi Repetitive transplantation of different cell types sequentially improves heart function after infarction
    Schuh Alexander
    Department of Cardiology, Pulmonology, Angiology and Internal Medicine Intensive Care, Medical Faculty, RWTH Aachen University, Aachen, Germany
    J Cell Mol Med 16:1640-7. 2012
    ..In conclusion, repetitive Tx of different cell types after myocardial infarction in rat hearts significantly improved left ventricular function and could represent a feasible option to enhance the benefit of cell therapy...
  64. ncbi Administration of vascular endothelial growth factor adjunctive to fetal cardiomyocyte transplantation and improvement of cardiac function in the rat model
    Alexander Schuh
    Medical Clinic, Department of Molecular Cardiovascular Research, RWTH University Hospital, Aachen, Germany
    J Cardiovasc Pharmacol Ther 10:55-66. 2005
    ..The functional impact of cellular transplantation and the potential role of the addition of angiogenic factors for survival of engrafts remain controversial...
  65. doi Neutrophil granule proteins tune monocytic cell function
    Oliver Soehnlein
    Institute of Molecular Cardiovascular Research, University Hospital, RWTH Aachen University, Aachen, Germany
    Trends Immunol 30:538-46. 2009
    ..Efforts in this field might lead to the development of drugs for specific modulation of innate immune functions...
  66. ncbi CD73/ecto-5'-nucleotidase protects against vascular inflammation and neointima formation
    Alma Zernecke
    Institute of Molecular Cardiovascular Research, Rheinisch Westfälische Technisch Hochschule, Aachen, Germany
    Circulation 113:2120-7. 2006
    ..Although CD73/ecto-5'-nucleotidase has been implicated in maintaining vasoprotection, its role in regulating endothelial adhesion molecule or inflammatory monocyte recruitment (eg, in the context of vascular injury) remains to be defined...
  67. doi An optimized flow cytometry protocol for analysis of angiogenic monocytes and endothelial progenitor cells in peripheral blood
    Mihail Hristov
    Institute for Molecular Cardiovascular Research IMCAR, RWTH Aachen University, 52074 Aachen, Germany
    Cytometry A 75:848-53. 2009
    ..This protocol may represent a basis for standardized analysis and monitoring of these cell subsets to define their normal range and prognostic/diagnostic value in clinical use...
  68. doi Chemokines in the vascular inflammatory response of atherosclerosis
    Alma Zernecke
    Institute for Molecular Cardiovascular Research, University Hospital Aachen, RWTH Aachen University, Pauwelsstr 30, 52074 Aachen, Germany
    Cardiovasc Res 86:192-201. 2010
    ..In addition, we will discuss recent developments scrutinizing heterophilic interactions of chemokines that have advanced our understanding of how chemokines control vascular inflammatory responses...
  69. ncbi Neutrophils launch monocyte extravasation by release of granule proteins
    Oliver Soehnlein
    RWTH University Aachen, Pauwelsstr 30, 52074 Aachen, Germany
    Thromb Haemost 102:198-205. 2009
    ..Hence, granule proteins modify the monocyte extravasation cascade in a multifaceted manner ensuring the efficiency of these mechanisms...
  70. ncbi Crucial role of stromal cell-derived factor-1alpha in neointima formation after vascular injury in apolipoprotein E-deficient mice
    Andreas Schober
    Department of Molecular Cardiovascular Research, University Hospital, Rheinisch Westfalische Technische Hochschule, Aachen, Germany
    Circulation 108:2491-7. 2003
    ..Herein, we investigate the involvement of SDF-1alpha in neointimal formation after vascular injury...
  71. doi Lysophosphatidic acid receptors LPA1 and LPA3 promote CXCL12-mediated smooth muscle progenitor cell recruitment in neointima formation
    Pallavi Subramanian
    Institute for Molecular Cardiovascular Research, RWTH Aachen University, Pauwelsstr 30 52074 Aachen, Germany
    Circ Res 107:96-105. 2010
    ..Lysophosphatidic acid (LPA) induces CXCL12 and neointimal accumulation of smooth muscle cells (SMCs) in uninjured arteries. Thus, we hypothesize that LPA may regulate CXCL12-mediated vascular remodelling...
  72. doi Macrophage migration inhibitory factor in cardiovascular disease
    Alma Zernecke
    Institute for Molecular Cardiovascular Research, Molekulare Herz Kreislaufforschung, RWTH Aachen University, Aachen, Germany
    Circulation 117:1594-602. 2008
    ..The potential of targeting or exploiting MIF for therapeutic strategies or as a diagnostic marker in the management of cardiovascular diseases or disorders is scrutinized...
  73. ncbi Myocardial stiffness, cardiac remodeling, and diastolic dysfunction in calcification-prone fetuin-A-deficient mice
    Marc W Merx
    Medical Clinic I, RWTH University Hospital, Aachen, Germany
    J Am Soc Nephrol 16:3357-64. 2005
    ....
  74. ncbi Statin treatment after onset of sepsis in a murine model improves survival
    Marc W Merx
    Medizinische Klinik I, RWTH Aachen, 52057 Aachen, Germany
    Circulation 112:117-24. 2005
    ..Here, we studied whether treatment with simvastatin after onset of sepsis-induced hemodynamic alterations is beneficial and whether prolonged survival can also be achieved with other statins...
  75. doi Functional alterations of myeloid cell subsets in hyperlipidaemia: relevance for atherosclerosis
    Oliver Soehnlein
    Institute for Molecular Cardiovascular Research, RWTH Aachen, Germany
    J Cell Mol Med 13:4293-303. 2009
    ..We here review the role of myeloid cells in atherosclerosis as well as the effects of hyperlipidaemia on these cells...
  76. doi CXC chemokine ligand 4 (Cxcl4) is a platelet-derived mediator of experimental liver fibrosis
    Mirko Moreno Zaldivar
    Department of Medicine III, University Hospital Aachen, Aachen, Germany
    Hepatology 51:1345-53. 2010
    ..Conclusion: The results underscore an important role of platelets in chronic liver damage and imply a new target for antifibrotic therapies...
  77. ncbi Chemokine receptor (CCR2) genotype is associated with myocardial infarction and heart failure in patients under 65 years of age
    Jan R Ortlepp
    Medical Clinic I, University Hospital of Aachen University of Technology, Pauwelsstrasse 30, 52057 Aachen, Germany
    J Mol Med (Berl) 81:363-7. 2003
    ..If the CCR2 genotype is associated with higher mortality in the general population must be investigated in further studies...
  78. ncbi Regulation of endothelial progenitor cell homing after arterial injury
    Mihail Hristov
    Institute for Molecular Cardiovascular Research IMCAR, Aachen, Germany
    Thromb Haemost 98:274-7. 2007
    ....
  79. ncbi Transmembrane chemokines: versatile 'special agents' in vascular inflammation
    Andreas Ludwig
    Institute of Molecular Cardiovascular Research IMCAR, University Hospital, RWTH Aachen, Pauwelsstr 30, 52074 Aachen, Germany
    Thromb Haemost 97:694-703. 2007
    ..Small molecules that block either the receptors or the shedding enzymes of transmembrane chemokines need to be tested in animal models of vascular inflammation...
  80. ncbi Endothelial progenitor cells: characterization, pathophysiology, and possible clinical relevance
    Mihail Hristov
    Department for Molecular Cardiovascular Research, University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    J Cell Mol Med 8:498-508. 2004
    ..However, the specificity of the observed positive clinical effects, the mechanisms regulating the differentiation of EPCs and their homing to sites of injured tissue remain partially unknown at present...
  81. doi Platelet-mediated enhancement of leukocyte adhesion
    Philipp von Hundelshausen
    Department of Medicine, Division of Cardiology, Pulmonology and Vascular Medicine, University Hospital, Rheinisch Westfälische Technische Hochschule Aachen, Aachen, Germany
    Microcirculation 16:84-96. 2009
    ....
  82. ncbi Dexamethasone and restenosis after coronary stent implantation: new indication for an old drug?
    Peter W Radke
    Medical Clinic I and Department of Molecular Cardiovascular Research, RWTH University Hospital, Aachen, Germany
    Curr Pharm Des 10:349-55. 2004
    ....
  83. doi Ambivalence of progenitor cells in vascular repair and plaque stability
    Mihail Hristov
    Institut für Molekulare Herz Kreislaufforschung IMCAR, Universitätsklinikum der RWTH, Aachen, Germany
    Curr Opin Lipidol 19:491-7. 2008
    ..To discuss crucial cues (chemokines, adhesion molecules and pharmacological means) that guide and control the context-specific mobilization, recruitment and fate of circulating progenitor cells in arterial repair and plaque stability...
  84. ncbi Platelets as immune cells: bridging inflammation and cardiovascular disease
    Philipp von Hundelshausen
    Institute of Cardiovascular Molecular Research, University Hospital of the Rheinisch Westfälische Technische Hochschule, Aachen, Germany
    Circ Res 100:27-40. 2007
    ....
  85. ncbi Evaluation of a high-dose dexamethasone-eluting stent
    Rainer Hoffmann
    Medical Clinic I, University Hospital Aachen, Germany
    Am J Cardiol 94:193-5. 2004
    ..96 +/- 0.63 mm due to an average intimal hyperplasia area obstruction of 32 +/- 21%, indicating that high-dose dexamethasone-loaded stents do not significantly reduce neointimal proliferation...
  86. ncbi Downregulation of N-cadherin in the neointima stimulates migration of smooth muscle cells by RhoA deactivation
    Rüdiger Blindt
    Medical Clinic I, University Hospital Aachen, Pauwelsstr 30, 52074 Aachen, Germany
    Cardiovasc Res 62:212-22. 2004
    ..The aim of the study was to analyze whether cadherin- and Rho-family GTPases-mediated dynamic rearrangement of cell-cell adhesion play an important role during human arterial smooth muscle cell (haSMC) migration...
  87. ncbi Chemokines: inflammatory mediators of atherosclerosis
    Elisa A Liehn
    Institute of Molecular Cardiovascular Research IMCAR, University Hospital, RWTH Aachen, Germany
    Arch Physiol Biochem 112:229-38. 2006
    ..This diversity of chemokine expression and function might lead to the identification of selective therapeutic targets for the prevention and treatment of atherosclerosis...
  88. ncbi Association of C-reactive protein and myocardial perfusion in patients with ST-elevation acute myocardial infarction
    Rainer Hoffmann
    Medical Clinic I, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52057 Aachen, Germany
    Atherosclerosis 186:177-83. 2006
    ..The combination of clinical data, myocardial reperfusion levels after primary angioplasty for AMI and admission CRP increases the predictive value for subsequent survival...
  89. ncbi The amount of calcium-deficient hexagonal hydroxyapatite in aortic valves is influenced by gender and associated with genetic polymorphisms in patients with severe calcific aortic stenosis
    Jan R Ortlepp
    Medical Clinic I, University Hospital of Aachen, Aachen University of Technology, Pauwelsstrasse 30, 52152 Aachen, Germany
    Eur Heart J 25:514-22. 2004
    ..The study evaluated the relationship between cardiovascular risk factors (CRF), gene polymorphism, calcification and fibrosis of stenotic aortic valves...
  90. ncbi HMG-CoA reductase inhibitor simvastatin profoundly improves survival in a murine model of sepsis
    Marc W Merx
    Medizinische Klinik I, RWTH Aachen, Germany
    Circulation 109:2560-5. 2004
    ..We thus approached the question of whether treatment with simvastatin might improve cardiovascular function and survival in sepsis...
  91. ncbi Platelets and platelet-derived microparticles in vascular inflammatory disease
    Elena Vasina
    Institute for Molecular Cardiovascular Research IMCAR, University Hospital Aachen, Medical Faculty, Rheinisch Westfälische Technische Hochschule RWTH Aachen, Germany
    Inflamm Allergy Drug Targets 9:346-54. 2010
    ..The possible significance of these interactions is discussed within the context of vascular inflammation...
  92. doi The angiotensin-calcineurin-NFAT pathway mediates stretch-induced up-regulation of matrix metalloproteinases-2/-9 in atrial myocytes
    Erol Saygili
    Dept of Cardiology, Medical Clinic I, University Hospital Rheinisch Westfälische Technische Hochschule Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany
    Basic Res Cardiol 104:435-48. 2009
    ....
  93. doi Myeloid cells in atherosclerosis: initiators and decision shapers
    Oliver Soehnlein
    Institute for Molecular Cardiovascular Research, RWTH University Aachen, Pauwelsstr 30, 52074, Aachen, Germany
    Semin Immunopathol 31:35-47. 2009
    ..To stimulate further investigations about the contribution of these myeloid cells, we highlight the current mechanistic understanding by which these cells tune atherosclerosis...
  94. doi Acetylcholine as an age-dependent non-neuronal source in the heart
    Obaida R Rana
    Department of Cardiology, RWTH Aachen University, Aachen, 52074, Germany
    Auton Neurosci 156:82-9. 2010
    ..This finding may provide new physiological/pathological aspects in the communication between cardiomyocytes and other cell types in the myocardium, e.g. fibrocytes, neurocytes or endothelial cells...
  95. doi Platelet-derived chemokines in vascular remodeling and atherosclerosis
    Rory R Koenen
    Institute for Molecular Cardiovascular Research, University Hospital Aachen, Medical Faculty, Rheinisch Westfalische Technische Hochschule, Aachen, Germany
    Semin Thromb Hemost 36:163-9. 2010
    ....
  96. ncbi Statins: a preventive strike against sepsis in patients with cardiovascular disease?
    Marc W Merx
    Medizinische Klinik I, Universitätsklinikum der Rheinisch Westfälischen Technischen Hochschule Aachen, 52057 Aachen, Germany
    Lancet 367:372-3. 2006
  97. doi Alteration of matrix metalloproteinases in selective left ventricular adriamycin-induced cardiomyopathy in the pig
    Andreas Goetzenich
    Department of Cardiothoracic Surgery, University of Aachen, Aachen, Germany
    J Heart Lung Transplant 28:1087-93. 2009
    ....
  98. doi Mechanisms underlying neutrophil-mediated monocyte recruitment
    Oliver Soehnlein
    Institute for Molecular Cardiovascular Research IMCAR, RWTH University Aachen, Aachen, Germany
    Blood 114:4613-23. 2009
    ..As targeting PMNs without causing serious side effects seems futile, it may be more promising to aim at interfering with subsequent PMN-driven proinflammatory events...
  99. ncbi Effect of catheter-based transendocardial delivery of stromal cell-derived factor 1alpha on left ventricular function and perfusion in a porcine model of myocardial infarction
    Karl Christian Koch
    Department of Cardiology, RWTH Aachen University, Pauwelstrasse 30, 52074 Aachen, Germany
    Basic Res Cardiol 101:69-77. 2006
    ..Myocardial regeneration after myocardial infarction can occur via stem cell recruitment. Stromal cell-derived factor 1alpha (SDF-1alpha) has been shown to be critical for stem cell homing to injured tissue...
  100. ncbi Manipulating the chemokine system: therapeutic perspectives for atherosclerosis
    Rory R Koenen
    University Hospital Aachen, Institute for Molecular Cardiovascular Research Medical Faculty, Rheinisch Westfälische Technische Hochschule Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Curr Opin Investig Drugs 11:265-72. 2010
    ..This review discusses recent advances in the field, highlights novel opportunities for therapeutic intervention, and considers both the advantages and disadvantages of intervening in the chemokine system...
  101. ncbi Targeted disruption of cd73/ecto-5'-nucleotidase alters thromboregulation and augments vascular inflammatory response
    Patrycja Koszalka
    Department of Cardiovascular Physiology, Heinrich Heine University Duesseldorf, Duesseldorf, Germany
    Circ Res 95:814-21. 2004
    ....