F Wappler

Summary

Affiliation: University of Hamburg
Country: Germany

Publications

  1. ncbi Cardiac and thoracic vascular surgery
    F Wappler
    Department of Anaesthesiology, University Hospital Hamburg Eppendorf, Martinistrasse 52, Hamburg D 20246, Germany
    Best Pract Res Clin Anaesthesiol 17:219-33. 2003
  2. ncbi [Level concept of analgesic dosing in intensive care medicine with sufentanil]
    F Wappler
    Abteilung für Anästhesiologie, Universitats Krankenhaus Eppendorf, Hamburg
    Anasthesiol Intensivmed Notfallmed Schmerzther 33:8-26. 1998
  3. ncbi 4-chloro-m-cresol is a trigger of malignant hyperthermia in susceptible swine
    F Wappler
    Department of Anesthesiology, University Hospital Eppendorf, Hamburg, Germany
    Anesthesiology 90:1733-40. 1999
  4. ncbi [Current aspects of anesthesia in neuromuscular diseases]
    F Wappler
    , , Hamburg
    Anasthesiol Intensivmed Notfallmed Schmerzther 38:495-9. 2003
  5. ncbi 5-HT2 receptor antagonist-mediated inhibition of halothane-induced contractures in skeletal muscle specimens from malignant hyperthermia susceptible patients
    F Wappler
    Department of Anaesthesiology, University Hospital Eppendorf, Hamburg, Germany
    Naunyn Schmiedebergs Arch Pharmacol 360:376-81. 1999
  6. ncbi Multicentre evaluation of in vitro contracture testing with bolus administration of 4-chloro-m-cresol for diagnosis of malignant hyperthermia susceptibility
    F Wappler
    University Hospital Hamburg Eppendorf, Department of Anaesthesiology, Hamburg, Germany
    Eur J Anaesthesiol 20:528-36. 2003
  7. ncbi Inhalational induction of anaesthesia with 8% sevoflurane in children: conditions for endotracheal intubation and side-effects
    F Wappler
    University Hospital Hamburg Eppendorf, Department of Anaesthesiology, Hamburg, Germany
    Eur J Anaesthesiol 20:548-54. 2003
  8. ncbi Evidence for susceptibility to malignant hyperthermia in patients with exercise-induced rhabdomyolysis
    F Wappler
    Department of Anesthesiology, University Hospital Eppendorf, Hamburg, Germany
    Anesthesiology 94:95-100. 2001
  9. ncbi Effects of a 5HT(2) receptor agonist on anaesthetized pigs susceptible to malignant hyperthermia
    M U Gerbershagen
    Department of Anaesthesiology, University Hospital Hamburg Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    Br J Anaesth 91:281-4. 2003
  10. ncbi Respiratory depression under long-term sedation with sufentanil, midazolam and clonidine has no clinical significance
    A Prause
    Abt f Anästhesiologie und operative Intensivmedizin, Allgemeines Krankenhaus Altona, Hamburg, Germany
    Intensive Care Med 26:1454-61. 2000

Detail Information

Publications40

  1. ncbi Cardiac and thoracic vascular surgery
    F Wappler
    Department of Anaesthesiology, University Hospital Hamburg Eppendorf, Martinistrasse 52, Hamburg D 20246, Germany
    Best Pract Res Clin Anaesthesiol 17:219-33. 2003
    ..However, elderly patients without significant co-morbidity have a mortality rate comparable to that of younger patients...
  2. ncbi [Level concept of analgesic dosing in intensive care medicine with sufentanil]
    F Wappler
    Abteilung für Anästhesiologie, Universitats Krankenhaus Eppendorf, Hamburg
    Anasthesiol Intensivmed Notfallmed Schmerzther 33:8-26. 1998
    ..Level 1 consisted of continuous administration of sufentanil, in level 2 continuous administration of midazolam and level 3 continuous administration of midazolam and clonidine was added according to patients' needs...
  3. ncbi 4-chloro-m-cresol is a trigger of malignant hyperthermia in susceptible swine
    F Wappler
    Department of Anesthesiology, University Hospital Eppendorf, Hamburg, Germany
    Anesthesiology 90:1733-40. 1999
    ..g., insulin, heparin, succinylcholine), and it has been suggested that 4-CmC might trigger malignant hyperthermia. This study was designed to investigate the effects of 4-CmC in vivo and in vitro in the same animals...
  4. ncbi [Current aspects of anesthesia in neuromuscular diseases]
    F Wappler
    , , Hamburg
    Anasthesiol Intensivmed Notfallmed Schmerzther 38:495-9. 2003
  5. ncbi 5-HT2 receptor antagonist-mediated inhibition of halothane-induced contractures in skeletal muscle specimens from malignant hyperthermia susceptible patients
    F Wappler
    Department of Anaesthesiology, University Hospital Eppendorf, Hamburg, Germany
    Naunyn Schmiedebergs Arch Pharmacol 360:376-81. 1999
    ..Further studies have to determine the pathophysiological role of the 5-HT system in MH, and whether ritanserin could be an alternative for treatment or prevention of halothane-induced MH...
  6. ncbi Multicentre evaluation of in vitro contracture testing with bolus administration of 4-chloro-m-cresol for diagnosis of malignant hyperthermia susceptibility
    F Wappler
    University Hospital Hamburg Eppendorf, Department of Anaesthesiology, Hamburg, Germany
    Eur J Anaesthesiol 20:528-36. 2003
    ..This multicentre study was designed to investigate whether an in vitro contracture test with bolus administration of 4-chloro-m-cresol can improve the accuracy of the diagnosis of susceptibility to MH...
  7. ncbi Inhalational induction of anaesthesia with 8% sevoflurane in children: conditions for endotracheal intubation and side-effects
    F Wappler
    University Hospital Hamburg Eppendorf, Department of Anaesthesiology, Hamburg, Germany
    Eur J Anaesthesiol 20:548-54. 2003
    ..This study was designed to assess the conditions for endotracheal intubation or insertion of a laryngeal mask airway following an inhalational induction using 8% sevoflurane and nitrous oxide without the use of muscle relaxants or opioids...
  8. ncbi Evidence for susceptibility to malignant hyperthermia in patients with exercise-induced rhabdomyolysis
    F Wappler
    Department of Anesthesiology, University Hospital Eppendorf, Hamburg, Germany
    Anesthesiology 94:95-100. 2001
    ..To establish an association between ER and susceptibility to MH, the authors determined the MH status in patients with a history of MH-like episodes induced by physical stress...
  9. ncbi Effects of a 5HT(2) receptor agonist on anaesthetized pigs susceptible to malignant hyperthermia
    M U Gerbershagen
    Department of Anaesthesiology, University Hospital Hamburg Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    Br J Anaesth 91:281-4. 2003
    ..In this study the in vivo effects of DOI on anaesthetized (and thus stress-protected) MHS and MH-normal (MHN) pigs were investigated...
  10. ncbi Respiratory depression under long-term sedation with sufentanil, midazolam and clonidine has no clinical significance
    A Prause
    Abt f Anästhesiologie und operative Intensivmedizin, Allgemeines Krankenhaus Altona, Hamburg, Germany
    Intensive Care Med 26:1454-61. 2000
    ..Assessment of respiratory depression caused by long-term sedation with sufentanil, midazolam and clonidine...
  11. ncbi Effects of the phosphodiesterase-III inhibitor enoximone on skeletal muscle specimens from malignant hyperthermia susceptible patients
    M Fiege
    Department of Anesthesiology, University Hospital Eppendorf, Hamburg, Germany
    J Clin Anesth 12:123-8. 2000
    ..To study the in vitro effects of the phosphodiesterase-III inhibitor enoximone on skeletal muscle specimens from malignant hyperthermia susceptible (MHS) and normal (MHN) patients...
  12. ncbi Phosphodiesterase-III-inhibition with amrinone leads to contracture development in skeletal muscle preparations of malignant hyperthermia susceptible swine
    M Fiege
    University Hospital Hamburg Eppendorf, Department of Anaesthesiology, Hamburg, Germany
    Eur J Anaesthesiol 22:283-8. 2005
    ..Whether this is a substance specific effect of enoximone or caused by inhibition of PDE-III remained unclear. Therefore, the effects of the PDE-III inhibitor amrinone in porcine MH normal (MHN) and MHS skeletal muscles were investigated...
  13. ncbi [Interactions of intravenous anesthetics with cerebral alpha-2-adrenoceptors]
    J Scholz
    Klinik fur Anasthesiologie, Universitats Krankenhaus Eppendorf, Hamburg
    Anasthesiol Intensivmed Notfallmed Schmerzther 34:642-7. 1999
    ..Thus, the aim of this study was to study the effect of the intravenous anaesthetic agents propofol and ketamine on the binding of the specific alpha 2-adrenoceptor agonist paraiodoclonidine at cerebral alpha 2 adrenoceptors...
  14. ncbi Fulminant malignant hyperthermia associated with ketoacidotic diabetic coma
    F Wappler
    Abteilung für Anästhesiologie, Universitats Krankenhaus Eppendorf, Hamburg, Germany
    Intensive Care Med 22:809-12. 1996
    ..Furthermore, therapy with dantrolene has been demonstrated to be beneficial in the treatment of MH associated with diabetic coma...
  15. ncbi In vitro effects of 4-chloro-3-ethylphenol in skeletal muscle preparations from malignant hyperthermia susceptible and normal swine
    M U Gerbershagen
    University Hospital Hamburg Eppendorf, Department of Anaesthesiology, Hamburg, Germany
    Eur J Anaesthesiol 19:135-40. 2002
    ..0% but a specificity of only 93.6%. Therefore, an alternative drug is desirable which distinguishes between malignant hyperthermia-susceptible and malignant hyperthermia-normal subjects with a higher specificity and sensitivity...
  16. ncbi Dantrolene--a review of its pharmacology, therapeutic use and new developments
    T Krause
    Department of Anaesthesiology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Anaesthesia 59:364-73. 2004
    ..Due to economic considerations, no other similar drugs have been introduced into routine clinical practice...
  17. ncbi [Comparison of premedication with clonidine and midazolam combined with TCI for orthopaedic shoulder surgery]
    O Grottke
    ,
    Anasthesiol Intensivmed Notfallmed Schmerzther 38:772-80. 2003
    ..Because of the lower incidence of PONV and the need of piritramid in the postoperative period patients premedicated with 5 microg x kg(-1) clonidine may benefit from this premedication...
  18. ncbi [Malignant hyperthermia--update 2002]
    M Fiege
    , , Hamburg
    Anasthesiol Intensivmed Notfallmed Schmerzther 38:478-82. 2003
  19. ncbi [Dantrolene. Pharmacological and therapeutic aspects]
    M U Gerbershagen
    Klinik und Poliklinik für Anästhesiologie, Universitatsklinikum Hamburg Eppendorf, Hamburg
    Anaesthesist 52:238-45. 2003
    ..Since dantrolene is weakly water soluble, the clinical preparation is time and manpower consuming. New agents have been synthesized, but because of economic considerations no registration for clinical usage has been realised...
  20. ncbi [Theophylline induces contractures in porcine skeletal muscle preparations with the disposition to malignant hyperthermia]
    M U Gerbershagen
    Klinik und Poliklinik für Anästhesiologie Universitätsklinikum Hamburg Eppendorf
    Anasthesiol Intensivmed Notfallmed Schmerzther 39:147-52. 2004
    ....
  21. ncbi [In-vitro-effects of cocaine in skeletal muscle specimens of patients susceptible to malignant hyperthermia]
    R Weisshorn
    Klinik und Poliklinik für Anästhesiologie, Universitatsklinikum Hamburg Eppendorf
    Anasthesiol Intensivmed Notfallmed Schmerzther 37:138-43. 2002
    ..Therefore, aim of this study was to investigate the in-vitro effects of cocaine in skeletal muscle specimens of MH susceptible (MHS) and normal (MHN) patients...
  22. ncbi Sevoflurane anaesthesia does not induce the formation of sister chromatid exchanges in peripheral blood lymphocytes of children
    T Krause
    Christian Albrechts University Kiel, Brunswiker Strasse 10, D 24105 Kiel, Germany
    Br J Anaesth 90:233-5. 2003
    ..We investigated the formation of SCE in mitogen-stimulated T-lymphocytes of 40 children undergoing sevoflurane anaesthesia for minor surgical procedures...
  23. ncbi [Is a presymptomatic malignant hyperthermia in-vitro diagnosis with 4-chloro-3-ethyl phenol possible? A study using porcine skeletal preparations]
    M U Gerbershagen
    Klinik und Poliklinik für Anästhesiologie, Universitatsklinikum Hamburg Eppendorf
    Anasthesiol Intensivmed Notfallmed Schmerzther 39:81-6. 2004
    ..The pur-pose of this study was to investigate the ability of bolus CEP-applications to distinguish between porcine MHS- and MHN-muscle specimens using the IVCT...
  24. ncbi [Malignant neuroleptic syndrome after haloperidol administration]
    M U Gerbershagen
    Klinik fur Anasthesiologie, Universitatsklinikum Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg
    Anaesthesist 50:329-32. 2001
    ..blockade of central receptors, 2. a skeletal muscle target model and 3. sympathoadrenal hyperactivity. The differential diagnosis includes among others malignant hyperthermia and serotonin syndrome...
  25. ncbi The implementation of a perioperative checklist increases patients' perioperative safety and staff satisfaction
    A B Böhmer
    Department of Anaesthesiology, Hospital Cologne Merheim, University Hospital of the Witten Herdecke University, Cologne, Germany
    Acta Anaesthesiol Scand 56:332-8. 2012
    ..The aim of the present study was to evaluate perioperative safety standards and the quality of interprofessional cooperation before and after the introduction of a safety checklist from staff members' point of view...
  26. ncbi [Postoperative nausea and vomiting--pathophysiology, prophylaxis and treatment]
    F Lipka
    , , Germany
    Laryngorhinootologie 81:725-31. 2002
    ..5-HT 3 receptor antagonists are highly effective in prevention and management of PONV. This review will discuss pathophysiology, prophylaxis and treatment of postoperative nausea and vomiting after E.N.T. surgery...
  27. ncbi Malignant hyperthermia
    F Wappler
    Department of Anaesthesiology, University Hospital Hamburg-Eppendorf, Martinistr. 52, D-20246 Hamburg, Germany
    Eur J Anaesthesiol 18:632-52. 2001
    ..This review gives an overview of the main features of this disease and recent advances in research including pathophysiology, treatment, diagnosis and genetics as well as association with other disorders...
  28. ncbi Wound infiltration and drain lavage with ropivacaine after major shoulder surgery
    E P Horn
    Department of Anesthesiology, University Hospital Eppendorf, Hamburg, Germany
    Anesth Analg 89:1461-6. 1999
    ..IMPLICATIONS: Wound infiltration and lavage with 30 mL ropivacaine 7.5 mg/mL after major shoulder surgery resulted in very low pain scores and opioid requirement...
  29. ncbi Acute heart failure during spinal surgery in a boy with Duchenne muscular dystrophy
    G N Schmidt
    Department of Anaesthesiology, University Hospital Eppendorf, Hamburg, Germany
    Br J Anaesth 90:800-4. 2003
    ..This case demonstrates that a normal preoperative ECG and echocardiograph cannot exclude the development of heart failure during anaesthesia in DMD patients undergoing major surgery...
  30. ncbi [Anesthesiological management in patients with sickle cell disease]
    C Ritterbach
    ,
    Anasthesiol Intensivmed Notfallmed Schmerzther 37:104-8. 2002
    ..The case reports are intended to show up the pathogenesis of patient-relevant sickle cell crises and critically evaluate central points of anesthesiological management, especially the choice of preoperative transfusion...
  31. ncbi [Pre-operative measurement of heart rate variability in diabetics: a method to estimate blood pressure stability during anaesthesia induction]
    D Knüttgen
    Klinik fur Anasthesiologie, Universitat Witten Herdecke, Lehrstuhl für Anästhesiologie II, Krankenhaus Köln Merheim
    Anaesthesist 54:442-9. 2005
    ..The aim of this study was to determine the relationship between pre-operatively measured HRV and blood pressure stability during induction phase of anaesthesia...
  32. ncbi [Respiratory sinus arrhythmia as predictor of blood pressure stability during anaesthetic induction in diabetics]
    D Knüttgen
    Lehrstuhl für Anästhesiologie II der Universität Witten Herdecke, Klinik fur Anasthesiologie und Operative Intensivmedizin, Kliniken der Stadt Köln gGmbH, Krankenhaus Merheim, Koln
    Anasthesiol Intensivmed Notfallmed Schmerzther 41:233-40. 2006
    ..The aim of this study was to evaluate whether patients at risk could be reliably identified with less diagnostic effort...
  33. ncbi Validity and new malignant hyperthermia diagnostic procedures
    M U Gerbershagen
    Acta Anaesthesiol Scand 50:127; author reply 127-8. 2006
  34. ncbi [Safety in anaesthesia--are there new concepts for patients with neuromuscular diseases?]
    F Wappler
    Anasthesiol Intensivmed Notfallmed Schmerzther 37:123-4. 2002
  35. ncbi [Intra-articular ketamine after arthroscopic knee surgery. Optimisation of postoperative analgesia]
    M Borner
    Klinik fur Anasthesiologie und Operative Intensivmedizin, Kliniken der Stadt Köln gGmbH, Krankenhaus Köln Merheim, Universitat Witten Herdecke, 51109 Köln Frank
    Anaesthesist 56:1120-7. 2007
    ..In the present study it was investigated whether intra-articular administration of ketamine reduces the level of pain after arthroscopic knee surgery...
  36. ncbi [Which monitoring, when and to which use?]
    K Bangert
    Abteilung für Anästhesiologie, Israelitisches Krankenhaus Hamburg
    Anasthesiol Intensivmed Notfallmed Schmerzther 40:291-4. 2005
  37. ncbi [Preoperative management of patients with increased cardiac risk]
    F Wappler
    ,
    Anasthesiol Intensivmed Notfallmed Schmerzther 40:284-91. 2005
  38. ncbi [The patient at increased cardiac risk -- are there new aspects?]
    F Wappler
    Universitat Witten Herdecke, Klinik für AnästhesiologieKrankenhaus Köln Merheim, Ostmerheimerstrasse 200, 51109 Köln
    Anasthesiol Intensivmed Notfallmed Schmerzther 40:277-9. 2005
  39. ncbi Anaesthesia in patients with neuromuscular diseases--new concepts for old problems?
    F Wappler
    Anasthesiol Intensivmed Notfallmed Schmerzther 38:470-1. 2003
  40. ncbi [Malignant hyperthermia. General, clinical and experimental aspects]
    M Steinfath
    , , Schwanenweg 21, 24105 Kiel
    Anaesthesist 51:328-45; quiz 346-7. 2002