Research Topics
| Uwe WalterSummaryAffiliation: University of Rostock Country: Germany Publications
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Detail Information
Publications
Transcranial brain sonography findings in Parkinson's disease: implications for pathogenesis, early diagnosis and therapyUwe Walter
Department of Neurology, University of Rostock, Gehlsheimer Strasse 20, D 18147 Rostock, Germany
Expert Rev Neurother 9:835-46. 2009..This review summarizes TCS findings, shedding light on the pathophysiology of PD, and discusses their potential therapeutic relevance...- Insular stroke is associated with acute sympathetic hyperactivation and immunodepressionU Walter
Department of Neurology, University of Rostock, Rostock, Germany
Eur J Neurol 20:153-9. 2013..Here, we studied the influence of lesion location within middle cerebral artery (MCA) territory on parameters related to activation of sympathetic adrenomedullar pathway, immunodepression, and associated infection... - Sonographic alteration of lenticular nucleus in focal task-specific dystonia of musiciansUwe Walter
Department of Neurology, University of Rostock, Rostock, Germany
Neurodegener Dis 9:99-103. 2012..Here, we wanted to find out whether deep brain structures are altered in task-specific dystonia... - Value of combined midbrain sonography, olfactory and motor function assessment in the differential diagnosis of early Parkinson's diseaseKnut Busse
Parkinson Clinic WaldklinikBernburg GmbH, Bernburg, Germany
J Neurol Neurosurg Psychiatry 83:441-7. 2012..Here, the diagnostic sensitivity and specificity of combined assessment of these three features are evaluated... 
Predictors of pneumonia in acute stroke patients admitted to a neurological intensive care unitUwe Walter
Dept of Neurology, University of Rostock, Gehlsheimer Str 20, 18147, Rostock, Germany
J Neurol 254:1323-9. 2007..To determine independent clinical predictors of stroke-associated pneumonia (SAP) that are available in all patients on day of hospital admission...- Relationship of brainstem raphe echogenicity and clinical findings in depressive statesUwe Walter
Department of Neurology, University of Rostock, Gehlsheimer Str 20, D 18147 Rostock, Germany
Psychiatry Res 155:67-73. 2007..Reduced BR echogenicity might reflect a pathology predisposing to a certain subtype of depression characterized by less psychomotor retardation and better responsivity to SRI... - Transcranial brain sonography findings related to neuropsychological impairment in multiple sclerosisUwe Walter
Department of Neurology, University of Rostock, Gehlsheimer Str 20, 18147, Rostock, Germany
J Neurol 254:II49-52. 2007..The use of third-ventricle and basalganglia TCS for predicting and monitoring neuropsychological impairment in MS patients, however, needs to be elucidated in further studies... - Transcranial sonography findings in welding-related Parkinsonism in comparison to Parkinson's diseaseUwe Walter
Department of Neurology, University of Rostock, Rostock, Germany
Mov Disord 23:141-5. 2008..In contrast, lenticular nucleus was hyperechogenic in both WP patients but only in one of the PD patients. TCS findings suggest a different pathophysiology of Parkinsonism in WP and PD patients... - Brain parenchyma sonography detects preclinical parkinsonismUwe Walter
Department of Neurology, University of Rostock, Rostock, Germany
Mov Disord 19:1445-9. 2004..In 2 asymptomatic PMC, PET and BPS were normal. However, in another 2 asymptomatic PET-normal PMC, SN hyperechogenicity could be detected. Data suggest SN hyperechogenicity as an early marker to detect preclinical parkinsonism... - Transcranial brain sonography findings in discriminating between parkinsonism and idiopathic Parkinson diseaseUwe Walter
Department of Neurology, University of Rostock, Gehlsheimer Str 20, D 18147 Rostock, Germany
Arch Neurol 64:1635-40. 2007..In several pilot studies, transcranial brain sonography findings of substantia nigra and lenticular nucleus discriminated between idiopathic Parkinson disease (PD) and atypical parkinsonian disorders... - Contemporary ultrasound systems allow high-resolution transcranial imaging of small echogenic deep intracranial structures similarly as MRI: a phantom studyUwe Walter
Department of Neurology, University of Rostock, Gehlsheimer Str 20, D 18147 Rostock, Germany
Neuroimage 40:551-8. 2008.... - Transcranial sonography findings related to non-motor features of Parkinson's diseaseUwe Walter
Department of Neurology, University of Rostock, Rostock, Germany
J Neurol Sci 289:123-7. 2010..Further studies are warranted to find out whether TCS is useful for detecting increased risk for non-motor complications, such as depression, psychosis, or urinary incontinence, already before they become clinically obvious... - Transcranial brain sonography findings predict disease progression in multiple sclerosisU Walter
Department of Neurology, University of Rostock, Rostock, Germany
Neurology 73:1010-7. 2009..The present study deals with the question of whether TCS can also display deep gray matter lesions in patients with MS and whether sonographic findings relate to severity and progression of MS... - Deep brain stimulation in dystonia: sonographic monitoring of electrode placement into the globus pallidus internusUwe Walter
Department of Neurology, University of Rostock, Rostock, Germany
Mov Disord 24:1538-41. 2009..Simultaneous color-coded sonographic imaging of arteries near the anatomical target allows further intraoperative refinement of DBS lead positioning, simultaneously preventing hemorrhages... - Parkinson's disease-like midbrain sonography abnormalities are frequent in depressive disordersUwe Walter
Department of Neurology, University of Rostock, Gehlsheimer Strasse 20, D 18147 Rostock, Germany
Brain 130:1799-807. 2007..Data suggest that in subjects with depression nigrostriatal vulnerability is frequent, and that TCS might be useful to detect individuals at risk for developing Parkinson's disease... - Transcranial brain parenchyma sonography in movement disorders: state of the artUwe Walter
Department of Neurology, University of Rostock, Rostock, Germany
Ultrasound Med Biol 33:15-25. 2007..As TCS is a quick and noninvasive method, using the same duplex-ultrasound machines as for investigation of intracranial vessels, applicable even in agitated patients, this method has a great potential to be more widely used... - Overactive bladder in Parkinson's disease: alteration of brainstem raphe detected by transcranial sonographyU Walter
Department of Neurology, University of Rostock, Rostock, Germany
Eur J Neurol 13:1291-7. 2006..TCS findings suggest a pathogenetic role of BR in OAB related to PD. Alterations may reflect disturbance of its central serotonergic system... - Brain parenchyma sonography discriminates Parkinson's disease and atypical parkinsonian syndromesU Walter
Department of Neurology, Rostock University, Germany
Neurology 60:74-7. 2003..To study the use of brain parenchyma sonography (BPS) in discriminating between patients with idiopathic PD (IPD) and atypical parkinsonian syndromes (APS)... - [Anticoagulation in stroke. Evidence-based and empirical indications]U Walter
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Dtsch Med Wochenschr 128:2200-5. 2003 - Sonographic discrimination of corticobasal degeneration vs progressive supranuclear palsyU Walter
Department of Neurology, University of Rostock, Gehlsheimer Str 20, D 18147 Rostock, Germany
Neurology 63:504-9. 2004..To study the use of brain parenchyma sonography (BPS) in discriminating between patients with corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP)... - Substantia nigra echogenicity in Parkinson's disease: relation to serum iron and C-reactive proteinUwe Walter
Department of Neurology, University of Rostock, Gehlsheimer Str 20, 18147 Rostock, Germany
J Neural Transm 119:53-7. 2012..Microglia activation, if reflected by SN-h, may be therefore unrelated to serum CRP. Findings support the idea that SN-h indicates inherited alteration of iron metabolism... - Sonographic detection of basal ganglia lesions in asymptomatic and symptomatic Wilson diseaseU Walter
Department of Neurology, University of Rostock, Rostock, Germany
Neurology 64:1726-32. 2005..To investigate whether transcranial brain parenchyma sonography (TCS) detects basal ganglia abnormalities in asymptomatic and symptomatic patients with Wilson disease (WD) and whether findings correlate with disease severity... - Sonographic discrimination of dementia with Lewy bodies and Parkinson's disease with dementiaUwe Walter
Dept of Neurology, University of Rostock, Gehlsheimer Str 20, 18147, Rostock, Germany
J Neurol 253:448-54. 2006..To study the use of transcranial sonography (TCS) in discriminating between patients with dementia with Lewy bodies (DLB) and Parkinson's disease with dementia (PDD)... - Transcranial sonographic localization of deep brain stimulation electrodes is safe, reliable and predicts clinical outcomeUwe Walter
Department of Neurology, University of Rostock, Rostock, Germany
Ultrasound Med Biol 37:1382-91. 2011..TCS may therefore become a first-choice modality to monitor lead location... - Substantia nigra hyperechogenicity is a risk marker of Parkinson's disease: noUwe Walter
Department of Neurology, University of Rostock, Gehlsheimer Str 20, 18147, Rostock, Germany
J Neural Transm 118:607-12. 2011.... - Transcranial brain sonography findings in clinical subgroups of idiopathic Parkinson's diseaseUwe Walter
Department of Neurology, University of Rostock, Rostock, Germany
Mov Disord 22:48-54. 2007..4 mm (mean of bilateral measurements) indicated increased risk of dementia (RR = 4.11; CI = 1.51-11.2; P = 0.001). We conclude that TCS displays characteristic changes of deep brain structures in different clinical manifestations of PD... - Sonographic basal ganglia alterations are related to non-motor symptoms in multiple sclerosisSebastian Horowski
Department of Neurology, University of Rostock, Gehlsheimer Str 20, 18147, Rostock, Germany
J Neurol 258:195-202. 2011..No relation was found between depression and any of the TCS findings. These findings suggest that neurodegenerative processes affecting deep brain structures contribute to cognitive and autonomic dysfunction in MS... - Substantia nigra hyperechogenicity in depressive subjects relates to motor asymmetry and impaired word fluencyJacqueline Hoeppner
Dept of Psychiatry and Psychotherapy, University of Rostock, Rostock, Germany
Eur Arch Psychiatry Clin Neurosci 259:92-7. 2009..Both, liability for developing PD and frequency of SNH were found to be increased in depressed subjects. Here, we investigated whether SNH in depression is related to motor or cognitive abnormalities resembling early PD... - Reproducibility and diagnostic accuracy of substantia nigra sonography for the diagnosis of Parkinson's diseaseSimone van de Loo
Department of Neurology, University Hospital, Goethe University, Frankfurt am Main, Germany
J Neurol Neurosurg Psychiatry 81:1087-92. 2010..Although this feature is well established, sufficient observer reliability and diagnostic accuracy are prerequisites for advancements of this method... - Transcranial sonography in brain disorders with trace metal accumulationUwe Walter
Department of Neurology, University of Rostock, Rostock, Germany
Int Rev Neurobiol 90:166-78. 2010..The exact mechanism of how an elevated trace metal content leads to an increased echogenicity needs to be further elucidated... - Mirror movements in amyotrophic lateral sclerosisMathias Wittstock
Department of Neurology, University of Rostock, Rostock, Germany
Amyotroph Lateral Scler 12:393-7. 2011.... - Altered callosal function in cerebral microangiopathyMatthias Wittstock
Human Cortical Physiology Laboratory, Department of Neurology, University of Rostock, Gehlsheimer Str 20, 18147, Rostock, Germany
J Neurol 257:590-7. 2010..As the extent of CMA and atrophy of the corpus callosum is correlated to callosal dysfunction, analysis of the iSP can be used to assess the clinical impact of CMA detected by cMRI... - Assessment of idiopathic rapid-eye-movement sleep behavior disorder by transcranial sonography, olfactory function test, and FP-CIT-SPECTMarcus M Unger
Department of Neurology, Philipps Universitat Marburg, Germany
Mov Disord 23:596-9. 2008..Large-size longitudinal studies in iRBD patients are required to evaluate the usefulness of diagnostic tests to identify the subgroup of iRBD patients that is prone to develop PD... - Substantia nigra echogenicity is normal in non-extrapyramidal cerebral disorders but increased in Parkinson's diseaseU Walter
Department of Neurology, Rostock University, Federal Republic of Germany
J Neural Transm 109:191-6. 2002..In 30% of patients TCS does not distinguish between IPD and NED. Data further support the assumption that bilateral SN hyperechogenicity is specific for IPD... - Assessment of substantia nigra echogenicity in German and Filipino populations using a portable ultrasound systemCriscely L Go
Department of Neurology, University of Rostock, Gehlsheimer Strasse 20, D 18147 Rostock, Germany
J Ultrasound Med 31:191-6. 2012..It is unknown whether a portable ultrasound system can be appropriately used and how the Filipino population would compare with the well-studied white population... - Structural changes associated with progression of motor deficits in spinocerebellar ataxia 17Kathrin Reetz
Department of Neurology, RWTH Aachen University, Germany
Cerebellum 9:210-7. 2010.... - Swallowing disturbance pattern relates to brain lesion location in acute stroke patientsVolker Steinhagen
Department of Neurology, University of Rostock, Rostock, Germany
Stroke 40:1903-6. 2009..The relationship of brain lesion location and swallowing disturbance pattern has been poorly studied in acute stroke patients... - Prevalence of Fabry disease in patients with cryptogenic stroke: a prospective studyArndt Rolfs
Department of Neurology, University of Rostock, Rostock, Germany
Lancet 366:1794-6. 2005..To determine the importance of Fabry disease in young people with stroke, we measured the frequency of unrecognised Fabry disease in a cohort of acute stroke patients... - [Imaging of the brain: where is transcranial sonography superior to magnet resonance imaging?]U Walter
Klinik und Poliklinik fur Neurologie, Universitat Rostock, Gehlsheimer Strasse 20, Rostock
Fortschr Neurol Psychiatr 77:S39-41. 2009..There TCS supports the correct positioning of electrodes while preventing haemorrhages by simultaneous depiction of brain arteries at the target region... - Recurrent aphasic status epilepticus after prolonged generalized tonic-clonic seizures versus a special feature of Todd's paralysisJ Rösche
Klinik und Poliklinik fur Neurologie, Universitat Rostock, Rostock, Germany
Epilepsy Behav 20:132-7. 2011..Once diagnosed it has to be treated carefully, because in the elderly, aggressive treatment strategies may be associated with a high risk of adverse events... - Efficacy of intravenous lacosamide in refractory nonconvulsive status epilepticus and simple partial status epilepticusKristin Rantsch
Klinik und Poliklinik fur Neurologie, Universitat Rostock, Gehlsheimer Strasse 20, Rostock, Germany
Seizure 20:529-32. 2011..Nevertheless it seemed to be effective for termination of status epilepticus in 20% of the episodes. But the outcome at discharge seemed considerably to depend on age of patients (r=0.94, explaining 89% of variance)... - Influence of repetitive transcranial magnetic stimulation on special symptoms in depressed patientsJacqueline Höppner
Department of Psychiatry and Psychotherapy, Centre of Nervous Disease, University of Rostock, Rostock, Germany
Restor Neurol Neurosci 28:577-86. 2010..This short review summarizes important preliminary data, which focus on the symptom-oriented effects of rTMS in depression... - Transcranial sonography-assisted stereotaxy and follow-up of deep brain implants in patients with movement disordersUwe Walter
Department of Neurology, University of Rostock, Rostock, Germany
Int Rev Neurobiol 90:274-85. 2010..Dislocation of a DBS electrode can be easily detected. It is likely that the obvious advantages of TCS will promote its increasing use for the intra- and postoperative monitoring of deep brain implants... - Functional relevance of ceruloplasmin mutations in Parkinson's diseaseHelmine Hochstrasser
Department of Medical Genetics, University of Tuebingen, Tuebingen, Germany
FASEB J 19:1851-3. 2005..Our studies indicate that altered activity of ceruloplasmin may present a vulnerability factor for iron induced oxidative stress in PD... - Substantia nigra hyperechogenicity as a marker of predisposition and slower progression in Parkinson's diseaseKatherine J Schweitzer
Hertie Institute of Clinical Brain Research, , , and Department of Neurology, University Hospital, Cologne, Germany
Mov Disord 21:94-8. 2006..It may therefore be hypothesized that a differing influence of factors determining SN echogenicity early in life and impairing forces occurring later in life may account for different pathogenetic subgroups of idiopathic PD... - Screening for mutations of the ferritin light and heavy genes in Parkinson's disease patients with hyperechogenicity of the substantia nigraBettina Felletschin
Institute for Human Genetics, University of Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany
Neurosci Lett 352:53-6. 2003.... - Screening for mutations of the HFE gene in Parkinson's disease patients with hyperechogenicity of the substantia nigraNilgün Akbas
Institute of Medical Genetics, University of Tuebingen, Tuebingen, Germany
Neurosci Lett 407:16-9. 2006..Future studies are necessary to reveal a possible functional relevance of these mutations for PD. Our results indicate that mutations in the HFE gene are not a common cause for PD with increased iron levels of the SN...