Uwe Walter

Summary

Affiliation: University of Rostock
Country: Germany

Publications

  1. doi request reprint Transcranial brain sonography findings in Parkinson's disease: implications for pathogenesis, early diagnosis and therapy
    Uwe Walter
    Department of Neurology, University of Rostock, Gehlsheimer Strasse 20, D 18147 Rostock, Germany
    Expert Rev Neurother 9:835-46. 2009
  2. doi request reprint Potential impact of self-perceived prodromal symptoms on the early diagnosis of Parkinson's disease
    Uwe Walter
    Department of Neurology, University of Rostock, Gehlsheimer Str 20, 18147, Rostock, Germany
    J Neurol 260:3077-85. 2013
  3. doi request reprint How to measure substantia nigra hyperechogenicity in Parkinson disease: detailed guide with video
    Uwe Walter
    Department of Neurology, University of Rostock, Gehlsheimer Strasse 20, D 18147 Rostock, Germany E email
    J Ultrasound Med 32:1837-43. 2013
  4. doi request reprint Insular stroke is associated with acute sympathetic hyperactivation and immunodepression
    U Walter
    Department of Neurology, University of Rostock, Rostock, Germany
    Eur J Neurol 20:153-9. 2013
  5. doi request reprint Sonographic alteration of lenticular nucleus in focal task-specific dystonia of musicians
    Uwe Walter
    Department of Neurology, University of Rostock, Rostock, Germany
    Neurodegener Dis 9:99-103. 2012
  6. doi request reprint Value of combined midbrain sonography, olfactory and motor function assessment in the differential diagnosis of early Parkinson's disease
    Knut Busse
    Parkinson Clinic WaldklinikBernburg GmbH, Bernburg, Germany
    J Neurol Neurosurg Psychiatry 83:441-7. 2012
  7. doi request reprint Contemporary ultrasound systems allow high-resolution transcranial imaging of small echogenic deep intracranial structures similarly as MRI: a phantom study
    Uwe Walter
    Department of Neurology, University of Rostock, Gehlsheimer Str 20, D 18147 Rostock, Germany
    Neuroimage 40:551-8. 2008
  8. ncbi request reprint Transcranial brain sonography findings in discriminating between parkinsonism and idiopathic Parkinson disease
    Uwe Walter
    Department of Neurology, University of Rostock, Gehlsheimer Str 20, D 18147 Rostock, Germany
    Arch Neurol 64:1635-40. 2007
  9. ncbi request reprint Transcranial sonography findings in welding-related Parkinsonism in comparison to Parkinson's disease
    Uwe Walter
    Department of Neurology, University of Rostock, Rostock, Germany
    Mov Disord 23:141-5. 2008
  10. ncbi request reprint Transcranial brain sonography findings related to neuropsychological impairment in multiple sclerosis
    Uwe Walter
    Department of Neurology, University of Rostock, Gehlsheimer Str 20, 18147, Rostock, Germany
    J Neurol 254:II49-52. 2007

Detail Information

Publications52

  1. doi request reprint Transcranial brain sonography findings in Parkinson's disease: implications for pathogenesis, early diagnosis and therapy
    Uwe Walter
    Department of Neurology, University of Rostock, Gehlsheimer Strasse 20, D 18147 Rostock, Germany
    Expert Rev Neurother 9:835-46. 2009
    ..This review summarizes TCS findings, shedding light on the pathophysiology of PD, and discusses their potential therapeutic relevance...
  2. doi request reprint Potential impact of self-perceived prodromal symptoms on the early diagnosis of Parkinson's disease
    Uwe Walter
    Department of Neurology, University of Rostock, Gehlsheimer Str 20, 18147, Rostock, Germany
    J Neurol 260:3077-85. 2013
    ..We conclude that educating the general population and physicians on the importance of distinct prodromal features and applying symptom-specific diagnostic programs can improve the early detection of PD...
  3. doi request reprint How to measure substantia nigra hyperechogenicity in Parkinson disease: detailed guide with video
    Uwe Walter
    Department of Neurology, University of Rostock, Gehlsheimer Strasse 20, D 18147 Rostock, Germany E email
    J Ultrasound Med 32:1837-43. 2013
    ..Published cutoff values for grading substantia nigra hyperechogenicity with different ultrasound systems and novel technologies are reviewed. ..
  4. doi request reprint Insular stroke is associated with acute sympathetic hyperactivation and immunodepression
    U Walter
    Department of Neurology, University of Rostock, Rostock, Germany
    Eur J Neurol 20:153-9. 2013
    ..Here, we studied the influence of lesion location within middle cerebral artery (MCA) territory on parameters related to activation of sympathetic adrenomedullar pathway, immunodepression, and associated infection...
  5. doi request reprint Sonographic alteration of lenticular nucleus in focal task-specific dystonia of musicians
    Uwe Walter
    Department of Neurology, University of Rostock, Rostock, Germany
    Neurodegener Dis 9:99-103. 2012
    ..Here, we wanted to find out whether deep brain structures are altered in task-specific dystonia...
  6. doi request reprint Value of combined midbrain sonography, olfactory and motor function assessment in the differential diagnosis of early Parkinson's disease
    Knut Busse
    Parkinson Clinic WaldklinikBernburg GmbH, Bernburg, Germany
    J Neurol Neurosurg Psychiatry 83:441-7. 2012
    ..Here, the diagnostic sensitivity and specificity of combined assessment of these three features are evaluated...
  7. doi request reprint Contemporary ultrasound systems allow high-resolution transcranial imaging of small echogenic deep intracranial structures similarly as MRI: a phantom study
    Uwe Walter
    Department of Neurology, University of Rostock, Gehlsheimer Str 20, D 18147 Rostock, Germany
    Neuroimage 40:551-8. 2008
    ....
  8. ncbi request reprint Transcranial brain sonography findings in discriminating between parkinsonism and idiopathic Parkinson disease
    Uwe Walter
    Department of Neurology, University of Rostock, Gehlsheimer Str 20, D 18147 Rostock, Germany
    Arch Neurol 64:1635-40. 2007
    ..In several pilot studies, transcranial brain sonography findings of substantia nigra and lenticular nucleus discriminated between idiopathic Parkinson disease (PD) and atypical parkinsonian disorders...
  9. ncbi request reprint Transcranial sonography findings in welding-related Parkinsonism in comparison to Parkinson's disease
    Uwe Walter
    Department of Neurology, University of Rostock, Rostock, Germany
    Mov Disord 23:141-5. 2008
    ..In contrast, lenticular nucleus was hyperechogenic in both WP patients but only in one of the PD patients. TCS findings suggest a different pathophysiology of Parkinsonism in WP and PD patients...
  10. ncbi request reprint Transcranial brain sonography findings related to neuropsychological impairment in multiple sclerosis
    Uwe Walter
    Department of Neurology, University of Rostock, Gehlsheimer Str 20, 18147, Rostock, Germany
    J Neurol 254:II49-52. 2007
    ..The use of third-ventricle and basalganglia TCS for predicting and monitoring neuropsychological impairment in MS patients, however, needs to be elucidated in further studies...
  11. doi request reprint Deep brain stimulation in dystonia: sonographic monitoring of electrode placement into the globus pallidus internus
    Uwe Walter
    Department of Neurology, University of Rostock, Rostock, Germany
    Mov Disord 24:1538-41. 2009
    ..Simultaneous color-coded sonographic imaging of arteries near the anatomical target allows further intraoperative refinement of DBS lead positioning, simultaneously preventing hemorrhages...
  12. doi request reprint Transcranial brain sonography findings predict disease progression in multiple sclerosis
    U Walter
    Department of Neurology, University of Rostock, Rostock, Germany
    Neurology 73:1010-7. 2009
    ..The present study deals with the question of whether TCS can also display deep gray matter lesions in patients with MS and whether sonographic findings relate to severity and progression of MS...
  13. doi request reprint Transcranial sonography findings related to non-motor features of Parkinson's disease
    Uwe Walter
    Department of Neurology, University of Rostock, Rostock, Germany
    J Neurol Sci 289:123-7. 2010
    ..Further studies are warranted to find out whether TCS is useful for detecting increased risk for non-motor complications, such as depression, psychosis, or urinary incontinence, already before they become clinically obvious...
  14. doi request reprint Substantia nigra hyperechogenicity is a risk marker of Parkinson's disease: no
    Uwe Walter
    Department of Neurology, University of Rostock, Gehlsheimer Str 20, 18147, Rostock, Germany
    J Neural Transm 118:607-12. 2011
    ....
  15. doi request reprint Substantia nigra echogenicity in Parkinson's disease: relation to serum iron and C-reactive protein
    Uwe Walter
    Department of Neurology, University of Rostock, Gehlsheimer Str 20, 18147 Rostock, Germany
    J Neural Transm 119:53-7. 2012
    ..Microglia activation, if reflected by SN-h, may be therefore unrelated to serum CRP. Findings support the idea that SN-h indicates inherited alteration of iron metabolism...
  16. doi request reprint Transcranial sonographic localization of deep brain stimulation electrodes is safe, reliable and predicts clinical outcome
    Uwe Walter
    Department of Neurology, University of Rostock, Rostock, Germany
    Ultrasound Med Biol 37:1382-91. 2011
    ..TCS may therefore become a first-choice modality to monitor lead location...
  17. ncbi request reprint Relationship of brainstem raphe echogenicity and clinical findings in depressive states
    Uwe Walter
    Department of Neurology, University of Rostock, Gehlsheimer Str 20, D 18147 Rostock, Germany
    Psychiatry Res 155:67-73. 2007
    ..Reduced BR echogenicity might reflect a pathology predisposing to a certain subtype of depression characterized by less psychomotor retardation and better responsivity to SRI...
  18. ncbi request reprint Predictors of pneumonia in acute stroke patients admitted to a neurological intensive care unit
    Uwe Walter
    Dept of Neurology, University of Rostock, Gehlsheimer Str 20, 18147, Rostock, Germany
    J Neurol 254:1323-9. 2007
    ..To determine independent clinical predictors of stroke-associated pneumonia (SAP) that are available in all patients on day of hospital admission...
  19. ncbi request reprint [Anticoagulation in stroke. Evidence-based and empirical indications]
    U Walter
    Klinik und Poliklinik fur Neurologie, Universitat Rostock
    Dtsch Med Wochenschr 128:2200-5. 2003
  20. ncbi request reprint Sonographic detection of basal ganglia lesions in asymptomatic and symptomatic Wilson disease
    U Walter
    Department of Neurology, University of Rostock, Rostock, Germany
    Neurology 64:1726-32. 2005
    ..To investigate whether transcranial brain parenchyma sonography (TCS) detects basal ganglia abnormalities in asymptomatic and symptomatic patients with Wilson disease (WD) and whether findings correlate with disease severity...
  21. ncbi request reprint Brain parenchyma sonography discriminates Parkinson's disease and atypical parkinsonian syndromes
    U Walter
    Department of Neurology, Rostock University, Germany
    Neurology 60:74-7. 2003
    ..To study the use of brain parenchyma sonography (BPS) in discriminating between patients with idiopathic PD (IPD) and atypical parkinsonian syndromes (APS)...
  22. ncbi request reprint Sonographic discrimination of dementia with Lewy bodies and Parkinson's disease with dementia
    Uwe Walter
    Dept of Neurology, University of Rostock, Gehlsheimer Str 20, 18147, Rostock, Germany
    J Neurol 253:448-54. 2006
    ..To study the use of transcranial sonography (TCS) in discriminating between patients with dementia with Lewy bodies (DLB) and Parkinson's disease with dementia (PDD)...
  23. ncbi request reprint Brain parenchyma sonography detects preclinical parkinsonism
    Uwe Walter
    Department of Neurology, University of Rostock, Rostock, Germany
    Mov Disord 19:1445-9. 2004
    ..In 2 asymptomatic PMC, PET and BPS were normal. However, in another 2 asymptomatic PET-normal PMC, SN hyperechogenicity could be detected. Data suggest SN hyperechogenicity as an early marker to detect preclinical parkinsonism...
  24. ncbi request reprint Transcranial brain sonography findings in clinical subgroups of idiopathic Parkinson's disease
    Uwe Walter
    Department of Neurology, University of Rostock, Rostock, Germany
    Mov Disord 22:48-54. 2007
    ..4 mm (mean of bilateral measurements) indicated increased risk of dementia (RR = 4.11; CI = 1.51-11.2; P = 0.001). We conclude that TCS displays characteristic changes of deep brain structures in different clinical manifestations of PD...
  25. ncbi request reprint Sonographic discrimination of corticobasal degeneration vs progressive supranuclear palsy
    U Walter
    Department of Neurology, University of Rostock, Gehlsheimer Str 20, D 18147 Rostock, Germany
    Neurology 63:504-9. 2004
    ..To study the use of brain parenchyma sonography (BPS) in discriminating between patients with corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP)...
  26. ncbi request reprint Transcranial brain parenchyma sonography in movement disorders: state of the art
    Uwe Walter
    Department of Neurology, University of Rostock, Rostock, Germany
    Ultrasound Med Biol 33:15-25. 2007
    ..As TCS is a quick and noninvasive method, using the same duplex-ultrasound machines as for investigation of intracranial vessels, applicable even in agitated patients, this method has a great potential to be more widely used...
  27. ncbi request reprint Parkinson's disease-like midbrain sonography abnormalities are frequent in depressive disorders
    Uwe Walter
    Department of Neurology, University of Rostock, Gehlsheimer Strasse 20, D 18147 Rostock, Germany
    Brain 130:1799-807. 2007
    ..Data suggest that in subjects with depression nigrostriatal vulnerability is frequent, and that TCS might be useful to detect individuals at risk for developing Parkinson's disease...
  28. ncbi request reprint Overactive bladder in Parkinson's disease: alteration of brainstem raphe detected by transcranial sonography
    U Walter
    Department of Neurology, University of Rostock, Rostock, Germany
    Eur J Neurol 13:1291-7. 2006
    ..TCS findings suggest a pathogenetic role of BR in OAB related to PD. Alterations may reflect disturbance of its central serotonergic system...
  29. doi request reprint Substantia nigra hyperechogenicity in depressive subjects relates to motor asymmetry and impaired word fluency
    Jacqueline Hoeppner
    Dept of Psychiatry and Psychotherapy, University of Rostock, Rostock, Germany
    Eur Arch Psychiatry Clin Neurosci 259:92-7. 2009
    ..Both, liability for developing PD and frequency of SNH were found to be increased in depressed subjects. Here, we investigated whether SNH in depression is related to motor or cognitive abnormalities resembling early PD...
  30. doi request reprint Sonographic basal ganglia alterations are related to non-motor symptoms in multiple sclerosis
    Sebastian Horowski
    Department of Neurology, University of Rostock, Gehlsheimer Str 20, 18147, Rostock, Germany
    J Neurol 258:195-202. 2011
    ..No relation was found between depression and any of the TCS findings. These findings suggest that neurodegenerative processes affecting deep brain structures contribute to cognitive and autonomic dysfunction in MS...
  31. doi request reprint Reproducibility and diagnostic accuracy of substantia nigra sonography for the diagnosis of Parkinson's disease
    Simone van de Loo
    Department of Neurology, University Hospital, Goethe University, Frankfurt am Main, Germany
    J Neurol Neurosurg Psychiatry 81:1087-92. 2010
    ..Although this feature is well established, sufficient observer reliability and diagnostic accuracy are prerequisites for advancements of this method...
  32. doi request reprint Transcranial sonography in brain disorders with trace metal accumulation
    Uwe Walter
    Department of Neurology, University of Rostock, Rostock, Germany
    Int Rev Neurobiol 90:166-78. 2010
    ..The exact mechanism of how an elevated trace metal content leads to an increased echogenicity needs to be further elucidated...
  33. doi request reprint Mirror movements in amyotrophic lateral sclerosis
    Mathias Wittstock
    Department of Neurology, University of Rostock, Rostock, Germany
    Amyotroph Lateral Scler 12:393-7. 2011
    ....
  34. doi request reprint Altered callosal function in cerebral microangiopathy
    Matthias Wittstock
    Human Cortical Physiology Laboratory, Department of Neurology, University of Rostock, Gehlsheimer Str 20, 18147, Rostock, Germany
    J Neurol 257:590-7. 2010
    ..As the extent of CMA and atrophy of the corpus callosum is correlated to callosal dysfunction, analysis of the iSP can be used to assess the clinical impact of CMA detected by cMRI...
  35. doi request reprint Assessment of idiopathic rapid-eye-movement sleep behavior disorder by transcranial sonography, olfactory function test, and FP-CIT-SPECT
    Marcus M Unger
    Department of Neurology, Philipps Universitat Marburg, Germany
    Mov Disord 23:596-9. 2008
    ..Large-size longitudinal studies in iRBD patients are required to evaluate the usefulness of diagnostic tests to identify the subgroup of iRBD patients that is prone to develop PD...
  36. ncbi request reprint Substantia nigra echogenicity is normal in non-extrapyramidal cerebral disorders but increased in Parkinson's disease
    U Walter
    Department of Neurology, Rostock University, Federal Republic of Germany
    J Neural Transm 109:191-6. 2002
    ..In 30% of patients TCS does not distinguish between IPD and NED. Data further support the assumption that bilateral SN hyperechogenicity is specific for IPD...
  37. doi request reprint Treatment and course of different subtypes of status epilepticus
    Kristin Rantsch
    Klinik und Poliklinik fur Neurologie, Universitätsmedizin Rostock, Gehlsheimer Str 20, 18147 Rostock, Germany Electronic address
    Epilepsy Res 107:156-62. 2013
    ..However the frequency of refractory courses differed between the types of SE. At the time of SE termination without the administration of anaesthesia a combination therapy using 2 or more AEDs was established in most episodes. ..
  38. ncbi request reprint Assessment of substantia nigra echogenicity in German and Filipino populations using a portable ultrasound system
    Criscely L Go
    Department of Neurology, University of Rostock, Gehlsheimer Strasse 20, D 18147 Rostock, Germany
    J Ultrasound Med 31:191-6. 2012
    ..It is unknown whether a portable ultrasound system can be appropriately used and how the Filipino population would compare with the well-studied white population...
  39. doi request reprint Swallowing disturbance pattern relates to brain lesion location in acute stroke patients
    Volker Steinhagen
    Department of Neurology, University of Rostock, Rostock, Germany
    Stroke 40:1903-6. 2009
    ..The relationship of brain lesion location and swallowing disturbance pattern has been poorly studied in acute stroke patients...
  40. doi request reprint Structural changes associated with progression of motor deficits in spinocerebellar ataxia 17
    Kathrin Reetz
    Department of Neurology, RWTH Aachen University, Germany
    Cerebellum 9:210-7. 2010
    ....
  41. ncbi request reprint Prevalence of Fabry disease in patients with cryptogenic stroke: a prospective study
    Arndt Rolfs
    Department of Neurology, University of Rostock, Rostock, Germany
    Lancet 366:1794-6. 2005
    ..To determine the importance of Fabry disease in young people with stroke, we measured the frequency of unrecognised Fabry disease in a cohort of acute stroke patients...
  42. doi request reprint [Imaging of the brain: where is transcranial sonography superior to magnet resonance imaging?]
    U Walter
    Klinik und Poliklinik fur Neurologie, Universitat Rostock, Gehlsheimer Strasse 20, Rostock
    Fortschr Neurol Psychiatr 77:S39-41. 2009
    ..There TCS supports the correct positioning of electrodes while preventing haemorrhages by simultaneous depiction of brain arteries at the target region...
  43. doi request reprint Recurrent aphasic status epilepticus after prolonged generalized tonic-clonic seizures versus a special feature of Todd's paralysis
    J Rösche
    Klinik und Poliklinik fur Neurologie, Universitat Rostock, Rostock, Germany
    Epilepsy Behav 20:132-7. 2011
    ..Once diagnosed it has to be treated carefully, because in the elderly, aggressive treatment strategies may be associated with a high risk of adverse events...
  44. doi request reprint Asymmetric Postural Tremor Preceding DOPA-Responsive Parkinsonism - the Transition Disease
    Alexander Wolters
    Department of Neurology, University of Rostock, Rostock, Germany
    J Parkinsons Dis 4:45-55. 2014
    ..It is postulated that the described group of patients may represent a separate disease entity with a hereditary background. ..
  45. doi request reprint Clinical, genetic, and brain sonographic features related to Parkinson's disease in Gaucher disease
    Tobias Böttcher
    Albrecht Kossel Institute for Neuroregeneration, University of Rostock, Rostock, Germany
    J Neurol 260:2523-31. 2013
    ..We conclude that the combined clinical, genetic, and transcranial sonographic assessment may improve the PD risk evaluation in Gaucher disease...
  46. doi request reprint Efficacy of intravenous lacosamide in refractory nonconvulsive status epilepticus and simple partial status epilepticus
    Kristin Rantsch
    Klinik und Poliklinik fur Neurologie, Universitat Rostock, Gehlsheimer Strasse 20, Rostock, Germany
    Seizure 20:529-32. 2011
    ..Nevertheless it seemed to be effective for termination of status epilepticus in 20% of the episodes. But the outcome at discharge seemed considerably to depend on age of patients (r=0.94, explaining 89% of variance)...
  47. doi request reprint Influence of repetitive transcranial magnetic stimulation on special symptoms in depressed patients
    Jacqueline Höppner
    Department of Psychiatry and Psychotherapy, Centre of Nervous Disease, University of Rostock, Rostock, Germany
    Restor Neurol Neurosci 28:577-86. 2010
    ..This short review summarizes important preliminary data, which focus on the symptom-oriented effects of rTMS in depression...
  48. doi request reprint Transcranial sonography-assisted stereotaxy and follow-up of deep brain implants in patients with movement disorders
    Uwe Walter
    Department of Neurology, University of Rostock, Rostock, Germany
    Int Rev Neurobiol 90:274-85. 2010
    ..Dislocation of a DBS electrode can be easily detected. It is likely that the obvious advantages of TCS will promote its increasing use for the intra- and postoperative monitoring of deep brain implants...
  49. ncbi request reprint Screening for mutations of the ferritin light and heavy genes in Parkinson's disease patients with hyperechogenicity of the substantia nigra
    Bettina Felletschin
    Institute for Human Genetics, University of Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany
    Neurosci Lett 352:53-6. 2003
    ....
  50. ncbi request reprint Substantia nigra hyperechogenicity as a marker of predisposition and slower progression in Parkinson's disease
    Katherine J Schweitzer
    Hertie Institute of Clinical Brain Research, University of Tubingen, Tubingen, and Department of Neurology, University Hospital, Cologne, Germany
    Mov Disord 21:94-8. 2006
    ..It may therefore be hypothesized that a differing influence of factors determining SN echogenicity early in life and impairing forces occurring later in life may account for different pathogenetic subgroups of idiopathic PD...
  51. ncbi request reprint Functional relevance of ceruloplasmin mutations in Parkinson's disease
    Helmine Hochstrasser
    Department of Medical Genetics, University of Tuebingen, Tuebingen, Germany
    FASEB J 19:1851-3. 2005
    ..Our studies indicate that altered activity of ceruloplasmin may present a vulnerability factor for iron induced oxidative stress in PD...
  52. ncbi request reprint Screening for mutations of the HFE gene in Parkinson's disease patients with hyperechogenicity of the substantia nigra
    Nilgün Akbas
    Institute of Medical Genetics, University of Tuebingen, Tuebingen, Germany
    Neurosci Lett 407:16-9. 2006
    ..Future studies are necessary to reveal a possible functional relevance of these mutations for PD. Our results indicate that mutations in the HFE gene are not a common cause for PD with increased iron levels of the SN...