H Wajant

Summary

Affiliation: University of Stuttgart
Country: Germany

Publications

  1. ncbi request reprint The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators
    H Wajant
    Institute of Cell Biology and Immunology, University of Stuttgart, Allmandring 31, 70569, Stuttgart, Germany
    Cell Signal 13:389-400. 2001
  2. ncbi request reprint Inhibition of death receptor-mediated gene induction by a cycloheximide-sensitive factor occurs at the level of or upstream of Fas-associated death domain protein (FADD)
    H Wajant
    Institute of Cell Biology and Immunology, University of Stuttgart, Allmandring 31, 70569 Stuttgart, Germany
    J Biol Chem 275:24357-66. 2000
  3. ncbi request reprint p53 upregulates cFLIP, inhibits transcription of NF-kappaB-regulated genes and induces caspase-8-independent cell death in DLD-1 cells
    T Bartke
    Institute of Cell Biology and Immunology, University of Stuttgart, Allmandring 31, 70569 Stuttgart, Germany
    Oncogene 20:571-80. 2001
  4. ncbi request reprint Fas-associated death domain protein (FADD) and caspase-8 mediate up-regulation of c-Fos by Fas ligand and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) via a FLICE inhibitory protein (FLIP)-regulated pathway
    D Siegmund
    Institute of Cell Biology and Immunology, University of Stuttgart, Allmandring 31, 70569 Stuttgart, Germany
    J Biol Chem 276:32585-90. 2001
  5. pmc NF-kappaB inducers upregulate cFLIP, a cycloheximide-sensitive inhibitor of death receptor signaling
    S Kreuz
    Institute of Cell Biology and Immunology, University of Stuttgart, 70569 Stuttgart, Germany
    Mol Cell Biol 21:3964-73. 2001
  6. ncbi request reprint Protein kinase Cmu downregulation of tumor-necrosis-factor-induced apoptosis correlates with enhanced expression of nuclear-factor-kappaB-dependent protective genes
    F J Johannes
    Institute of Cell Biology and Immunology, University of Stuttgart, Germany
    Eur J Biochem 257:47-54. 1998
  7. ncbi request reprint Differential activation of TRAIL-R1 and -2 by soluble and membrane TRAIL allows selective surface antigen-directed activation of TRAIL-R2 by a soluble TRAIL derivative
    H Wajant
    Institute of Cell Biology and Immunology, University of Stuttgart, Allmandring 31, 70569 Stuttgart, Germany
    Oncogene 20:4101-6. 2001
  8. ncbi request reprint Tumor necrosis factor signaling
    H Wajant
    Institute of Cell Biology and Immunology, University of Stuttgart, Allmandring, Germany
    Cell Death Differ 10:45-65. 2003
  9. ncbi request reprint TRAIL/Apo2L activates c-Jun NH2-terminal kinase (JNK) via caspase-dependent and caspase-independent pathways
    F Muhlenbeck
    Institute of Cell Biology and Immunology, University of Stuttgart, Allmandring 31, 70569 Stuttgart, Germany
    J Biol Chem 273:33091-8. 1998
  10. pmc Potent antitumoral activity of TRAIL through generation of tumor-targeted single-chain fusion proteins
    B Schneider
    Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany
    Cell Death Dis 1:e68. 2010

Collaborators

Detail Information

Publications23

  1. ncbi request reprint The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators
    H Wajant
    Institute of Cell Biology and Immunology, University of Stuttgart, Allmandring 31, 70569, Stuttgart, Germany
    Cell Signal 13:389-400. 2001
    ..In this review, we address the structural and molecular basis of TRAF protein functions and highlight their role in cytokine signalling...
  2. ncbi request reprint Inhibition of death receptor-mediated gene induction by a cycloheximide-sensitive factor occurs at the level of or upstream of Fas-associated death domain protein (FADD)
    H Wajant
    Institute of Cell Biology and Immunology, University of Stuttgart, Allmandring 31, 70569 Stuttgart, Germany
    J Biol Chem 275:24357-66. 2000
    ..Thus, a novel functional role of cFLIP as a negative regulator of gene induction by death receptors became apparent...
  3. ncbi request reprint p53 upregulates cFLIP, inhibits transcription of NF-kappaB-regulated genes and induces caspase-8-independent cell death in DLD-1 cells
    T Bartke
    Institute of Cell Biology and Immunology, University of Stuttgart, Allmandring 31, 70569 Stuttgart, Germany
    Oncogene 20:571-80. 2001
    ..Moreover, induction of p53 interfered with TNF-induced NF-kappaB activation independently from apoptosis-induction...
  4. ncbi request reprint Fas-associated death domain protein (FADD) and caspase-8 mediate up-regulation of c-Fos by Fas ligand and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) via a FLICE inhibitory protein (FLIP)-regulated pathway
    D Siegmund
    Institute of Cell Biology and Immunology, University of Stuttgart, Allmandring 31, 70569 Stuttgart, Germany
    J Biol Chem 276:32585-90. 2001
    ..Together these data demonstrate the existence of a death receptor-induced, FADD- and caspase-8-dependent pathway leading to c-Fos induction that is inhibited by the long splice form FLIP-L...
  5. pmc NF-kappaB inducers upregulate cFLIP, a cycloheximide-sensitive inhibitor of death receptor signaling
    S Kreuz
    Institute of Cell Biology and Immunology, University of Stuttgart, 70569 Stuttgart, Germany
    Mol Cell Biol 21:3964-73. 2001
    ..In conclusion, these data suggest a key role for cFLIP in the antiapoptotic response of NF-kappaB activation...
  6. ncbi request reprint Protein kinase Cmu downregulation of tumor-necrosis-factor-induced apoptosis correlates with enhanced expression of nuclear-factor-kappaB-dependent protective genes
    F J Johannes
    Institute of Cell Biology and Immunology, University of Stuttgart, Germany
    Eur J Biochem 257:47-54. 1998
    ..The dominant negative action of the kinase-negative mutant further suggest a regulatory role of PKCmu for NF-kappaB-dependent gene expression...
  7. ncbi request reprint Differential activation of TRAIL-R1 and -2 by soluble and membrane TRAIL allows selective surface antigen-directed activation of TRAIL-R2 by a soluble TRAIL derivative
    H Wajant
    Institute of Cell Biology and Immunology, University of Stuttgart, Allmandring 31, 70569 Stuttgart, Germany
    Oncogene 20:4101-6. 2001
    ..We conclude that antibody targeting-dependent activation can be used to design selective therapeutics derived of those ligands of the TNF family that are biologically inactive in their soluble form...
  8. ncbi request reprint Tumor necrosis factor signaling
    H Wajant
    Institute of Cell Biology and Immunology, University of Stuttgart, Allmandring, Germany
    Cell Death Differ 10:45-65. 2003
    ..In particular, the multiple facets of crosstalk between the various signalling pathways engaged by TNF will be addressed...
  9. ncbi request reprint TRAIL/Apo2L activates c-Jun NH2-terminal kinase (JNK) via caspase-dependent and caspase-independent pathways
    F Muhlenbeck
    Institute of Cell Biology and Immunology, University of Stuttgart, Allmandring 31, 70569 Stuttgart, Germany
    J Biol Chem 273:33091-8. 1998
    ....
  10. pmc Potent antitumoral activity of TRAIL through generation of tumor-targeted single-chain fusion proteins
    B Schneider
    Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany
    Cell Death Dis 1:e68. 2010
    ..Cell Death and Disease (2010) 1, e68; doi:10.1038/cddis.2010.45; published online 26 August 2010...
  11. ncbi request reprint Tumor necrosis factor receptor-associated factor (TRAF) 2 and its role in TNF signaling
    H Wajant
    Institute of Cell Biology and Immunology, University of Stuttgart, Allmandring 31, Stuttgart 70569, Germany
    Int J Biochem Cell Biol 33:19-32. 2001
    ....
  12. ncbi request reprint Activation of CD95L fusion protein prodrugs by tumor-associated proteases
    I Watermann
    Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany
    Cell Death Differ 14:765-74. 2007
    ..In a xenotransplantation tumor model, local application of the prodrug reduced the growth of target antigen-expressing, but not antigen-negative tumor cells, verifying targeted CD95L prodrug activation in vivo...
  13. ncbi request reprint Tumor necrosis factor (TNF) and phorbol ester induce TNF-related apoptosis-inducing ligand (TRAIL) under critical involvement of NF-kappa B essential modulator (NEMO)/IKKgamma
    D Siegmund
    Institute of Cell Biology and Immunology, University of Stuttgart, Allmandring 31, 70569 Stuttgart, Germany
    J Biol Chem 276:43708-12. 2001
    ..The capability of the NF-kappaB pathway to induce the potent death ligand TRAIL may explain the reported proapoptotic features of this typically antiapoptotic pathway...
  14. pmc The type 1 receptor (CD120a) is the high-affinity receptor for soluble tumor necrosis factor
    M Grell
    Institute of Cell Biology and Immunology, University of Stuttgart, Germany
    Proc Natl Acad Sci U S A 95:570-5. 1998
    ..In accordance with this reasoning, the lower signaling capability of homotrimeric lymphotoxin, compared with TNF, correlates with a lower stability of the lymphotoxin-TNF-R1 complex at 37 degrees C...
  15. ncbi request reprint TNF-related apoptosis inducing ligand (TRAIL) and its receptors in tumor surveillance and cancer therapy
    H Wajant
    Institute of Cell Biology and Immunology, University of Stuttgart, Allmandring 31, 70569 Stuttgart, Germany
    Apoptosis 7:449-59. 2002
    ..In particular, we debate controversial data in the literature concerning the cytotoxicity of different TRAIL derivatives on primary human cells...
  16. ncbi request reprint TNF receptor type 2 mediates thymocyte proliferation independently of TNF receptor type 1
    M Grell
    Institute of Cell Biology and Immunology, University of Stuttgart, Germany
    Eur J Immunol 28:257-63. 1998
    ....
  17. ncbi request reprint TNF receptor associated factors in cytokine signaling
    H Wajant
    Institute of Cell Biology and Immunology, University of Stuttgart, Germany
    Cytokine Growth Factor Rev 10:15-26. 1999
    ..Some of the activities of the individual TRAF family members may be redundant although transgenic knockout animal models have already shown that crucial signaling pathways for single TRAF molecules in vivo can be defined...
  18. ncbi request reprint Dominant-negative FADD inhibits TNFR60-, Fas/Apo1- and TRAIL-R/Apo2-mediated cell death but not gene induction
    H Wajant
    Institute of Cell Biology and Immunology, University of Stuttgart, Allmandring 31, 70569 Stuttgart, Germany
    Curr Biol 8:113-6. 1998
    ....
  19. ncbi request reprint Restoration of membrane TNF-like activity by cell surface targeting and matrix metalloproteinase-mediated processing of a TNF prodrug
    J Gerspach
    1Institute of Cell Biology and Immunology, University of Stuttgart, Germany
    Cell Death Differ 13:273-84. 2006
    ..MMP-2-sensitive TNF prodrugs represent novel cytokine-based reagents for targeted cancer therapy, which should be exploitable for MMP-overexpressing tumors...
  20. ncbi request reprint Organization of the human tumour necrosis factor receptor-associated factor 1 (TRAF1) gene and mapping to chromosome 9q33-34
    K Siemienski
    Institute of Cell Biology and Immunology, Stuttgart, Germany
    Gene 195:35-9. 1997
    ..The putative promotor region of the TRAFI gene was isolated by use of a PCR-based genomic walking approach. Fluorescence in situ hybridization was used to map this gene to chromosome 9q33-34...
  21. ncbi request reprint Analogies between Drosophila and mammalian TRAF pathways
    H Wajant
    Department of Molecular Internal Medicine, Medical Polyclinic, University Wurzburg, Rontgenring 11, 97070 Wurzburg, Germany
    Prog Mol Subcell Biol 34:47-72. 2004
    ..In this review, we will focus on the similarities but also the differences in TRAF-dependent signaling pathways of mammals and insects...
  22. ncbi request reprint Dynamic expression of Drosophila TRAF1 during embryogenesis and larval development
    A Preiss
    Universitat Hohenheim, Institut für Genetik 240, Garbenstrasse 30, D 70599 Stuttgart, Germany
    Mech Dev 100:109-13. 2001
    ..In order to gain insight into possible roles of DTRAF1 during development, we have performed a detailed transcriptional analysis of the gene at various embryonic and larval stages...
  23. ncbi request reprint Enforced covalent trimerization increases the activity of the TNF ligand family members TRAIL and CD95L
    D Berg
    Department of Molecular Internal Medicine, Medical Clinic and Polyclinic II, University of Wuerzburg, Wuerzburg 97070, Germany
    Cell Death Differ 14:2021-34. 2007
    ....