Michael Wagner

Summary

Affiliation: University of Bonn
Country: Germany

Publications

  1. ncbi request reprint Cognitive improvement in schizophrenic patients does not require a serotonergic mechanism: randomized controlled trial of olanzapine vs amisulpride
    Michael Wagner
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Neuropsychopharmacology 30:381-90. 2005
  2. doi request reprint Neurocognitive impairments in non-deprived smokers--results from a population-based multi-center study on smoking-related behavior
    Michael Wagner
    Department of Psychiatry, University of Bonn, Germany
    Addict Biol 18:752-61. 2013
  3. pmc Cognitive behavioural therapy versus supportive therapy for persistent positive symptoms in psychotic disorders: the POSITIVE Study, a multicenter, prospective, single-blind, randomised controlled clinical trial
    Stefan Klingberg
    Department of Psychiatry and Psychotherapy, University of Tuebingen, Germany
    Trials 11:123. 2010
  4. pmc Search for copy number variants in chromosomes 15q11-q13 and 22q11.2 in obsessive compulsive disorder
    Richard Delorme
    INSERM, U955, Institut Mondor de Recherche Biomedicale, PsychiatricGenetics, Creteil, France
    BMC Med Genet 11:100. 2010
  5. doi request reprint The His452Tyr variant of the gene encoding the 5-HT2A receptor is specifically associated with consolidation of episodic memory in humans
    Michael Wagner
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Int J Neuropsychopharmacol 11:1163-7. 2008
  6. pmc Sensorimotor gating is associated with CHRNA3 polymorphisms in schizophrenia and healthy volunteers
    Nadine Petrovsky
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    Neuropsychopharmacology 35:1429-39. 2010
  7. doi request reprint The functional coding variant Asn107Ile of the neuropeptide S receptor gene (NPSR1) is associated with schizophrenia and modulates verbal memory and the acoustic startle response
    Leonhard Lennertz
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    Int J Neuropsychopharmacol 15:1205-15. 2012
  8. doi request reprint Antisaccade performance in patients with obsessive-compulsive disorder and unaffected relatives: further evidence for impaired response inhibition as a candidate endophenotype
    Leonhard Lennertz
    Department of Psychiatry and Psychotherapy, University of Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 262:625-34. 2012
  9. pmc DAOA/G72 predicts the progression of prodromal syndromes to first episode psychosis
    Rainald Mossner
    Department of Psychiatry and Psychotherapy, University of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 260:209-15. 2010
  10. doi request reprint Influence of 5-HT3 receptor subunit genes HTR3A, HTR3B, HTR3C, HTR3D and HTR3E on treatment response to antipsychotics in schizophrenia
    Anna Schuhmacher
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    Pharmacogenet Genomics 19:843-51. 2009

Collaborators

Detail Information

Publications94

  1. ncbi request reprint Cognitive improvement in schizophrenic patients does not require a serotonergic mechanism: randomized controlled trial of olanzapine vs amisulpride
    Michael Wagner
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Neuropsychopharmacology 30:381-90. 2005
    ..Importantly, amisulpride was not inferior to olanzapine for any cognitive domain. Combined 5-HT(2A)/D2 receptor blockade is probably not necessary for cognitive improvement by SGAs...
  2. doi request reprint Neurocognitive impairments in non-deprived smokers--results from a population-based multi-center study on smoking-related behavior
    Michael Wagner
    Department of Psychiatry, University of Bonn, Germany
    Addict Biol 18:752-61. 2013
    ..The independence of these deficits from consumption intensity may argue for an a priori deficit of some cognitive abilities in smokers. These specific deficits may constitute intermediate phenotypes for genetic research on nicotine use...
  3. pmc Cognitive behavioural therapy versus supportive therapy for persistent positive symptoms in psychotic disorders: the POSITIVE Study, a multicenter, prospective, single-blind, randomised controlled clinical trial
    Stefan Klingberg
    Department of Psychiatry and Psychotherapy, University of Tuebingen, Germany
    Trials 11:123. 2010
    ....
  4. pmc Search for copy number variants in chromosomes 15q11-q13 and 22q11.2 in obsessive compulsive disorder
    Richard Delorme
    INSERM, U955, Institut Mondor de Recherche Biomedicale, PsychiatricGenetics, Creteil, France
    BMC Med Genet 11:100. 2010
    ..Therefore, the aim of this study was to search for microrearrangements in these two regions in OCD patients...
  5. doi request reprint The His452Tyr variant of the gene encoding the 5-HT2A receptor is specifically associated with consolidation of episodic memory in humans
    Michael Wagner
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Int J Neuropsychopharmacol 11:1163-7. 2008
    ..Results suggest a possible role of 5-HT2A receptors in memory consolidation. Serotonergic drugs may have the potential to improve memory...
  6. pmc Sensorimotor gating is associated with CHRNA3 polymorphisms in schizophrenia and healthy volunteers
    Nadine Petrovsky
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    Neuropsychopharmacology 35:1429-39. 2010
    ..These results suggest that sensorimotor gating is influenced by variations of the CHRNA3 gene, which might also have an impact on the course and severity of schizophrenia...
  7. doi request reprint The functional coding variant Asn107Ile of the neuropeptide S receptor gene (NPSR1) is associated with schizophrenia and modulates verbal memory and the acoustic startle response
    Leonhard Lennertz
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    Int J Neuropsychopharmacol 15:1205-15. 2012
    ..Based on these findings, we consider NPS as a promising target for antipsychotic drug development...
  8. doi request reprint Antisaccade performance in patients with obsessive-compulsive disorder and unaffected relatives: further evidence for impaired response inhibition as a candidate endophenotype
    Leonhard Lennertz
    Department of Psychiatry and Psychotherapy, University of Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 262:625-34. 2012
    ..In agreement with previous findings from imaging studies, our data suggest that functional abnormalities in frontostriatal and parietal cortical regions form part of the vulnerability for OCD...
  9. pmc DAOA/G72 predicts the progression of prodromal syndromes to first episode psychosis
    Rainald Mossner
    Department of Psychiatry and Psychotherapy, University of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 260:209-15. 2010
    ..This is one of the first studies to identify a specific genetic factor for the progression of prodromal syndromes to schizophrenia, and further underscores the importance of the DAOA/G72 gene for schizophrenia...
  10. doi request reprint Influence of 5-HT3 receptor subunit genes HTR3A, HTR3B, HTR3C, HTR3D and HTR3E on treatment response to antipsychotics in schizophrenia
    Anna Schuhmacher
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    Pharmacogenet Genomics 19:843-51. 2009
    ..Moreover, many antipsychotic drugs are antagonists at 5-HT3 receptors. However, the role of 5-HT3 receptor variants on response to antipsychotic drugs in schizophrenic patients is still unclear...
  11. doi request reprint Executive performance of depressed suicide attempters: the role of suicidal ideation
    Jens Westheide
    Department of Psychiatry, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 258:414-21. 2008
    ..Yet it remains unclear if a distinct cognitive suicidal phenotype does exist. The aim of the present study was to further investigate the role of suicidal thinking for the neuropsychological performance in depressive suicide attempters...
  12. doi request reprint Investigation of tryptophan hydroxylase 2 (TPH2) in schizophrenia and in the response to antipsychotics
    Anna Schuhmacher
    Department of Psychiatry and Psychotherapy, University of Bonn, Sigmund Freud Strasse 25, Bonn, Germany
    J Psychiatr Res 46:1073-80. 2012
    ..We also investigated the association of the SNPs to treatment response, but did not get significant results. In sum, our results argue for only a minor role of TPH2 in schizophrenia...
  13. doi request reprint A coding variant of the novel serotonin receptor subunit 5-HT3E influences sustained attention in schizophrenia patients
    Leonhard Lennertz
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    Eur Neuropsychopharmacol 20:414-20. 2010
    ..This study provides additional evidence for a role of the serotonergic system and the 5-HT3 receptor in schizophrenia...
  14. doi request reprint Novel schizophrenia risk gene TCF4 influences verbal learning and memory functioning in schizophrenia patients
    Leonhard Lennertz
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    Neuropsychobiology 63:131-6. 2011
    ..Thus, we hypothesized that the disease-associated C allele of the rs9960767 polymorphism of the TCF4 gene led to impaired VDM functioning in schizophrenia patients...
  15. doi request reprint Further evidence for a functional role of the glutamate receptor gene GRM3 in schizophrenia
    Rainald Mossner
    Department of Psychiatry and Psychotherapy, University of Bonn, Sigmund Freud Strasse 25, Germany
    Eur Neuropsychopharmacol 18:768-72. 2008
    ..008). Our results provide further evidence for the potential importance of the glutamate receptor GRM3 in schizophrenia, and indicate that the novel antipsychotic LY2140023 may actually be targeting a pathogenic pathway of schizophrenia...
  16. doi request reprint Sensorimotor gating of schizophrenia patients is influenced by 5-HT2A receptor polymorphisms
    Boris B Quednow
    Department of Psychiatry, University of Bonn, Germany
    Biol Psychiatry 64:434-7. 2008
    ..Moreover, both schizophrenia and PPI are thought to be inheritable. We investigated the impact of three 5-HT(2A)R polymorphisms (A-1438G, T102C, H452Y) on PPI in schizophrenia patients...
  17. ncbi request reprint Sensorimotor gating and habituation of the startle response in schizophrenic patients randomly treated with amisulpride or olanzapine
    Boris B Quednow
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Biol Psychiatry 59:536-45. 2006
    ..Thus, we compared the effects of a combined 5-HT2A/D2 and a pure D2/D3 antagonist on PPI and habituation of ASR in patients with schizophrenia...
  18. doi request reprint Association of amygdala volumes with cortisol secretion in unipolar depressed patients
    Anna Schuhmacher
    Department of Psychiatry and Psychotherapy, University of Bonn, Germany
    Psychiatry Res 202:96-103. 2012
    ....
  19. doi request reprint Prediction of dementia by subjective memory impairment: effects of severity and temporal association with cognitive impairment
    Frank Jessen
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Arch Gen Psychiatry 67:414-22. 2010
    ..Subjective memory impairment (SMI) is receiving increasing attention as a pre-mild cognitive impairment (MCI) condition in the course of the clinical manifestation of Alzheimer disease (AD)...
  20. pmc Neuropsychological profiles in different at-risk states of psychosis: executive control impairment in the early--and additional memory dysfunction in the late--prodromal state
    Ingo Frommann
    Department of Psychiatry, University Hospital of Bonn, Sigmund Freud Street 25, Bonn, Germany
    Schizophr Bull 37:861-73. 2011
    ..Memory deficits were associated with the onset of psychotic symptoms indicating further disease progression in the trajectory to psychosis and, thus, may be useful in predicting psychosis and targeting early intervention...
  21. doi request reprint Impaired sensorimotor gating of the acoustic startle response in the prodrome of schizophrenia
    Boris B Quednow
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Biol Psychiatry 64:766-73. 2008
    ..To test this assumption, we investigated PPI of ASR in individuals with prodromal symptoms of schizophrenia and patients with first-episode schizophrenia...
  22. pmc N-acetylaspartylglutamate (NAAG) and N-acetylaspartate (NAA) in patients with schizophrenia
    Frank Jessen
    Department of Psychiatry and Psychotherapy, University of Bonn, Germany
    Schizophr Bull 39:197-205. 2013
    ..The signal of NAAG, however, largely overlaps with its precursor and degrading product N-acetylaspartate (NAA) that by itself does not act in glutamatergic neurotransmission...
  23. doi request reprint The schizophrenia risk gene ZNF804A influences the antipsychotic response of positive schizophrenia symptoms
    Rainald Mossner
    Department of Psychiatry and Psychotherapy, University of Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 262:193-7. 2012
    ..41 ± 0.71, P = 0.022). This provides further evidence that ZNF804A is of functional relevance to schizophrenia and indicates that ZNF804A may be a novel target for pharmacological interventions...
  24. doi request reprint A promoter variant of SHANK1 affects auditory working memory in schizophrenia patients and in subjects clinically at risk for psychosis
    Leonhard Lennertz
    Department of Psychiatry and Psychotherapy, University of Bonn, Sigmund Freud Strase 25, 53105, Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 262:117-24. 2012
    ..Our findings suggest a role of SHANK1 in working memory deficits in schizophrenia, which may arise from neurodevelopmental changes to prefrontal cortical areas...
  25. doi request reprint Impact of TCF4 on the genetics of schizophrenia
    Leonhard Lennertz
    Department of Psychiatry and Psychotherapy, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 261:S161-5. 2011
    ..This indicates that TCF4 influences key mechanisms of information processing, which may contribute to the pathogenesis of schizophrenia...
  26. doi request reprint The German multi-centre study on smoking-related behavior-description of a population-based case-control study
    Annette Lindenberg
    Department of Psychiatry, Heinrich Heine University Dusseldorf, Germany
    Addict Biol 16:638-53. 2011
    ..Study design and major population characteristics with emphasis on risk prediction of smoking status were presented in this paper...
  27. doi request reprint A variant of the neuronal amino acid transporter SLC6A15 is associated with ACTH and cortisol responses and cognitive performance in unipolar depression
    Anna Schuhmacher
    Department of Psychiatry and Psychotherapy, University of Bonn, Germany
    Int J Neuropsychopharmacol 16:83-90. 2013
    ..Our findings argue for a role of the SLC6A15 gene in ACTH and cortisol secretion during the Dex/CRH test and furthermore in the occurrence of cognitive impairments in unipolar depression...
  28. pmc Prediction of dementia in primary care patients
    Frank Jessen
    Department of Psychiatry, University of Bonn, Bonn, Germany
    PLoS ONE 6:e16852. 2011
    ..AD prediction tools for primary care are therefore needed. We present a prediction score based on information that can be obtained in the primary care setting...
  29. doi request reprint Auditory P300 in individuals clinically at risk for psychosis
    Ingo Frommann
    Department of Psychiatry and Psychotherapy, Rheinische Friedrich Wilhelms University of Bonn, Bonn, Germany
    Int J Psychophysiol 70:192-205. 2008
    ..The aim of this study was to assess the amplitude, latency, and topography of the P300 in individuals at clinical high risk for psychosis...
  30. doi request reprint Functional serotonin 1A receptor variant influences treatment response to atypical antipsychotics in schizophrenia
    Rainald Mossner
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    Pharmacogenet Genomics 19:91-4. 2009
    ..003). The functional variant of the 5-HT1A receptor thus influences the response of schizophrenia patients to atypical antipsychotics and may be useful in the future to predict the pharmacogenetics of negative symptoms...
  31. doi request reprint Nicotine differentially modulates antisaccade performance in healthy male non-smoking volunteers stratified for low and high accuracy
    Nadine Petrovsky
    Department of Psychiatry and Psychotherapy, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Psychopharmacology (Berl) 221:27-38. 2012
    ..The response to acute nicotine is heterogeneous across subjects and samples; however, only a few reliable predictors of response have been identified...
  32. doi request reprint Startle cue-reactivity differentiates between light and heavy smokers
    Anne K Rehme
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Addiction 104:1757-64. 2009
    ..The goal of the present study was to investigate (i) whether smoking scenes induce appetitive cue effects in smokers, and (ii) whether smoking intensity is related to cue-reactivity...
  33. doi request reprint P50 sensory gating and smoking in the general population
    Jürgen Brinkmeyer
    Department of Psychiatry, Heinrich Heine University Dusseldorf, Bergische Landstrasse 2, Dusseldorf, Germany
    Addict Biol 16:485-98. 2011
    ..The suitability and application of sensory P50 gating as functional biomarker with regard to genetic and pharmacological studies is discussed...
  34. doi request reprint From genes to psychoses and back: the role of the 5HT2alpha-receptor and prepulse inhibition in schizophrenia
    Wolfgang Maier
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, der Universität Bonn, Sigmund Freud Strasse 25, Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 258:40-3. 2008
    ....
  35. doi request reprint Evidence for specific cognitive deficits in visual information processing in patients with OCD compared to patients with unipolar depression
    Friederike Rampacher
    Department of Psychiatry and Psychotherapy, University of Bonn, Sigmund Freud Strasse 25, DE 53105 Bonn, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 34:984-91. 2010
    ..As yet, it has not been substantiated whether deficits in visual organization and complex visual memory are also specific to OCD and are not shared by MDD...
  36. ncbi request reprint Familiality of obsessive-compulsive disorder in nonclinical and clinical subjects
    Hans Joergen Grabe
    Department of Psychiatry, Ernst Moritz Arndt University of Greifswald, Klinikum der Hansestadt Stralsund, Rostocker Chaussee 70, 18437 Stralsund, Germany
    Am J Psychiatry 163:1986-92. 2006
    ..This study compared the familial aggregation of OCD in first-degree relatives of community subjects with never-treated OCD, outpatients with OCD, and comparison subjects...
  37. doi request reprint AD dementia risk in late MCI, in early MCI, and in subjective memory impairment
    Frank Jessen
    Department of Psychiatry, University of Bonn, Bonn, Germany German Center for Neurodegenerative Diseases DZNE, Bonn, Germany Electronic address
    Alzheimers Dement 10:76-83. 2014
    ..To compare the risk of developing Alzheimer's disease (AD) dementia in late mild cognitive impairment (LMCI), early MCI (EMCI), and subjective memory impairment (SMI) with normal test performance...
  38. ncbi request reprint Effects of serotonergic and noradrenergic antidepressants on auditory startle response in patients with major depression
    Boris B Quednow
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Psychopharmacology (Berl) 175:399-406. 2004
    ..Studies with rodents suggest that an increase or decrease in serotonin level in the brain alters several modalities of the ASR. So far, little is known about serotonergic and noradrenergic startle modulation in humans...
  39. doi request reprint Volume loss of the medial temporal lobe structures in subjective memory impairment
    Nadine Striepens
    Department of Psychiatry, University of Bonn, Germany
    Dement Geriatr Cogn Disord 29:75-81. 2010
    ..In this study, we determined the volumes of the hippocampus, the entorhinal cortex (EC) and the amygdala to provide biological evidence for AD in SMI...
  40. doi request reprint Anticholinergic drug use and risk for dementia: target for dementia prevention
    Frank Jessen
    Department of Psychiatry and Psychotherapy, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 260:S111-5. 2010
    ..In terms of dementia prevention, centrally acting anticholinergic drugs should be strictly avoided, because of long-term dementia risk increase in addition to acute negative effects on cognition...
  41. doi request reprint Cognitive trajectory after transcatheter aortic valve implantation
    Alexander Ghanem
    From the Department of Medicine Cardiology A G, J K, J M S, B V B, M V, T S, M V N, C H, J O S, N W, E G, G N, Department of Psychiatry and Psychotherapy M W, S W, and Department of Radiology D T, A M, University of Bonn, Bonn, Germany and German Center for Neurodegenerative Diseases DZNE, Bonn, Germany M W, S W
    Circ Cardiovasc Interv 6:615-24. 2013
    ..Considering its increasing use, thorough longitudinal investigation of cognitive trajectory after TAVI is pivotal...
  42. ncbi request reprint Normal prepulse inhibition and habituation of acoustic startle response in suicidal depressive patients without psychotic symptoms
    Boris B Quednow
    Department of Psychiatry, University of Bonn, Germany
    J Affect Disord 92:299-303. 2006
    ..Thus, we investigated PPI and habituation of ASR in suicidal patients with depressive disorders as potential biological markers for suicidal behavior...
  43. ncbi request reprint Glucose metabolism, gray matter structure, and memory decline in subjective memory impairment
    Lukas Scheef
    Department of Radiology, University of Bonn, Bonn, Germany
    Neurology 79:1332-9. 2012
    ..To identify biological evidence for Alzheimer disease (AD) in individuals with subjective memory impairment (SMI) and unimpaired cognitive performance and to investigate the longitudinal cognitive course in these subjects...
  44. doi request reprint PCLO rs2522833 modulates HPA system response to antidepressant treatment in major depressive disorder
    Anna Schuhmacher
    Department of Psychiatry and Psychotherapy, University of Bonn, Germany
    Int J Neuropsychopharmacol 14:237-45. 2011
    ..Our results point to a moderating role of PCLO SNP rs2522833 on HPA regulation during antidepressant treatment, which may represent a neurobiological feature of stability of clinical response...
  45. doi request reprint CHRFAM7A copy number and 2-bp deletion polymorphisms and antisaccade performance
    Nadine Petrovsky
    Department of Psychiatry and Psychotherapy, University of Bonn, Germany
    Int J Neuropsychopharmacol 12:267-73. 2009
    ..The failure to observe an association between antisaccade performance and polymorphisms in CHRFAM7A gene is consistent with specificity of the gene effects on hippocampal and memory functions as previously demonstrated...
  46. ncbi request reprint Amygdala control of emotion-induced forgetting and remembering: evidence from Urbach-Wiethe disease
    Rene Hurlemann
    Department of Psychiatry, University of Bonn, 53105 Bonn, Germany
    Neuropsychologia 45:877-84. 2007
    ..Our findings implicate the amygdala in a neural circuitry that orchestrates rapid retrograde and anterograde regulation of episodic memory access upon criteria of behavioral significance...
  47. doi request reprint Gene polymorphisms in prodynorphin (PDYN) are associated with episodic memory in the elderly
    Heike Kolsch
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, Bonn 53105, Germany
    J Neural Transm 116:897-903. 2009
    ..Verbal fluency scores were non-significantly better in carriers of these respective alleles. Thus, our results suggest a role of PDYN gene variations in determining memory function also in elderly humans...
  48. doi request reprint The functional coding variant Asn107Ile of the neuropeptide S receptor gene (NPSR1) influences age at onset of obsessive-compulsive disorder
    Leonhard Lennertz
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    Int J Neuropsychopharmacol 16:1951-8. 2013
    ..In agreement with preclinical research, we suggest that NPS may be a promising pharmacological candidate with anti-obsessional properties...
  49. ncbi request reprint Proton magnetic resonance spectroscopy in subjects at risk for schizophrenia
    Frank Jessen
    Department of Psychiatry, University of Bonn Sigmund Freud Str 25 53105 Bonn, Germany
    Schizophr Res 87:81-8. 2006
    ....
  50. ncbi request reprint Attenuation of the prepulse inhibition of the acoustic startle response within and between sessions
    Boris B Quednow
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
    Biol Psychol 71:256-63. 2006
    ..Nevertheless, PPI was reliable across three test sessions, indicating that the significant attenuation of PPI over time was a consistent phenomenon. These results suggest that PPI exhibits short- and long-term attenuation...
  51. pmc Sensorimotor gating depends on polymorphisms of the serotonin-2A receptor and catechol-O-methyltransferase, but not on neuregulin-1 Arg38Gln genotype: a replication study
    Boris B Quednow
    Department of Psychiatry, University of Bonn, Germany
    Biol Psychiatry 66:614-20. 2009
    ..Therefore, we aimed to replicate these results and investigated the impact of the related polymorphisms on PPI in healthy human volunteers...
  52. doi request reprint The effect of nicotine on sensorimotor gating is modulated by a CHRNA3 polymorphism
    Nadine Petrovsky
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    Psychopharmacology (Berl) 229:31-40. 2013
    ..Moreover, the TT genotype of the nicotinic acetylcholine receptor (nAChR) α3-subunit (CHRNA3) rs1051730 polymorphism has previously been associated with diminished PPI and nicotine dependence...
  53. doi request reprint Nicotine enhances antisaccade performance in schizophrenia patients and healthy controls
    Nadine Petrovsky
    Department of Psychiatry and Psychotherapy, University of Bonn, Germany
    Int J Neuropsychopharmacol 16:1473-81. 2013
    ..Instead, the findings likely represent genuine nicotine-induced enhancement of cognitive performance. ..
  54. ncbi request reprint Memory deficits in abstinent MDMA (ecstasy) users: neuropsychological evidence of frontal dysfunction
    Boris B Quednow
    Department of Psychiatry, University of Bonn, Bonn, Germany
    J Psychopharmacol 20:373-84. 2006
    ..These results suggest that the memory deficits of MDMA users are not only the result of a temporal or hippocampal dysfunction, but also of a dysfunction of regions within the frontal cortex...
  55. ncbi request reprint Neuropsychological performance in partly remitted unipolar depressive patients: focus on executive functioning
    Jens Westheide
    Department of Psychiatry, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 257:389-95. 2007
    ..The role of impulsivity/orbitofrontal associated executive functioning in remitted depression has not yet been examined...
  56. doi request reprint The hippocampus in families with schizophrenia in relation to obstetric complications
    Florian Ebner
    Department of Psychiatry, University of Bonn, Germany
    Schizophr Res 104:71-8. 2008
    ..The aim of this study was to compare hippocampal volume of schizophrenic patients as well as and their relatives with control subjects and to quantify the additional contribution of obstetric complications...
  57. doi request reprint Is the clock drawing test appropriate for screening for mild cognitive impairment?--Results of the German study on Ageing, Cognition and Dementia in Primary Care Patients (AgeCoDe)
    Lena Ehreke
    Department of Psychiatry, University of Leipzig, Leipzig, Germany
    Dement Geriatr Cogn Disord 28:365-72. 2009
    ..Due to the fact that the Clock Drawing Test (CDT) is widely used to screen for dementia, it is questionable whether it is suited to screen for MCI...
  58. ncbi request reprint Impaired prepulse inhibition of acoustic startle in obsessive-compulsive disorder
    Klaus Hoenig
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Biol Psychiatry 57:1153-8. 2005
    ..However, there is only preliminary evidence about impaired PPI in OCD so far...
  59. doi request reprint Prognostic value of cerebral injury following transfemoral aortic valve implantation
    Alexander Ghanem
    Department of Medicine Cardiology, University of Bonn, Bonn, Germany
    EuroIntervention 8:1296-306. 2013
    ..To evaluate the impact of serological, imaging and clinical measures of cerebral injury on patient self-sufficiency and survival after transcatheter aortic valve implantation (TAVI)...
  60. doi request reprint Novel approaches for prevention of stroke related to transcatheter aortic valve implantation
    Alexander Ghanem
    Department of Medicine Cardiology, University of Bonn, Bonn, Germany
    Expert Rev Cardiovasc Ther 11:1311-20. 2013
    ....
  61. ncbi request reprint Schizophrenia and bipolar disorder: differences and overlaps
    Wolfgang Maier
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Curr Opin Psychiatry 19:165-70. 2006
    ..Following the recent progress mainly in the fields of genetics and neurobiology, the validity of the diagnostic distinction between schizophrenia and bipolar disorder is increasingly challenged...
  62. doi request reprint Oxytocin enhances amygdala-dependent, socially reinforced learning and emotional empathy in humans
    Rene Hurlemann
    Department of Psychiatry, University of Bonn, 53105 Bonn, Germany
    J Neurosci 30:4999-5007. 2010
    ..Overall these findings provide the first demonstration that OT can facilitate amygdala-dependent, socially reinforced learning and emotional empathy in men...
  63. ncbi request reprint Alexithymia in obsessive-compulsive disorder - results from a family study
    Hans Joergen Grabe
    Department of Psychiatry, University of Greifswald, Greifswald, Germany
    Psychother Psychosom 75:312-8. 2006
    ..This study investigates the hypotheses of an elevated level of alexithymia in subjects with OCD and their first-degree relatives compared to controls and their first-degree relatives...
  64. ncbi request reprint Decreased prefrontal 5-HT2A receptor binding in subjects at enhanced risk for schizophrenia
    Rene Hurlemann
    Department of Psychiatry, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Anat Embryol (Berl) 210:519-23. 2005
    ....
  65. ncbi request reprint Distinctive neurocognitive effects of repetitive transcranial magnetic stimulation and electroconvulsive therapy in major depression
    Svenja C Schulze-Rauschenbach
    Department of Psychiatry, University of Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    Br J Psychiatry 186:410-6. 2005
    ....
  66. ncbi request reprint Improvement of working but not declarative memory is correlated with HPA normalization during antidepressant treatment
    Astrid W Zobel
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Universitatsklinikum Bonn, Sigmund Freud Strasse 25, Bonn 53105, Germany
    J Psychiatr Res 38:377-83. 2004
    ..We suggest that improvement of working memory is more sensitive to the changes of hormones of the HPA system (e.g. cortisol) than other cognitive functions and the global severity of depression...
  67. doi request reprint Antisaccade performance is related to genetic loading for schizophrenia
    Nadine Petrovsky
    Department of Psychiatry and Psychotherapy, Rheinische Friedrich Wilhelms University of Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    J Psychiatr Res 43:291-7. 2009
    ..018). No group differences were found for prosaccade parameters. These results support the hypothesis that antisaccade impairment is associated with genetic loading for schizophrenia...
  68. ncbi request reprint Prepulse inhibition and habituation of acoustic startle response in male MDMA ('ecstasy') users, cannabis users, and healthy controls
    Boris B Quednow
    Department of Psychiatry, University of Bonn, Germany
    Neuropsychopharmacology 29:982-90. 2004
    ..Use of cannabis does not lead to alterations of amplitude, habituation, or PPI of ASR...
  69. doi request reprint An fMRI study on the acute effects of exercise on pain processing in trained athletes
    Lukas Scheef
    Functional Neuroimaging Group, Department of Radiology, University of Bonn, Germany
    Pain 153:1702-14. 2012
    ..Our findings provide the first evidence using functional imaging to support the role of endurance exercise in pain modulation...
  70. ncbi request reprint Executive and visuospatial deficits in patients with chronic progressive external ophthalmoplegia and Kearns-Sayre syndrome
    Simone Bosbach
    Department of Psychiatry and Department of Neurology, University of Bonn, Germany
    Brain 126:1231-40. 2003
    ....
  71. ncbi request reprint Reduction of the internal capsule in families affected with schizophrenia
    Thomas Wobrock
    Department of Psychiatry and Psychotherapy, University of the Saarland, Germany
    Biol Psychiatry 63:65-71. 2008
    ..To detect volumetric changes in ALIC, including the influence of genetic factors, a magnetic resonance imaging (MRI) study of families affected with schizophrenia was performed...
  72. ncbi request reprint Relation between cerebrospinal fluid, gray matter and white matter changes in families with schizophrenia
    Thomas Schneider-Axmann
    Department of Psychiatry and Psychotherapy, University of Saarland, D 66421 Homburg Saar, Germany
    J Psychiatr Res 40:646-55. 2006
    ..The intention of this study was to examine whether non-psychotic first-degree relatives reveal similar morphologic changes as schizophrenic patients and how state of genetic loading contribute to these abnormalities...
  73. ncbi request reprint Repetitive transcranial magnetic stimulation of the dorsolateral prefrontal cortex affects divided attention immediately after cessation of stimulation
    Michael Wagner
    Psychiatric Neuroimaging Group, Department of Psychiatry, University Hospital Bern, Switzerland
    J Psychiatr Res 40:315-21. 2006
    ..Sensitive cognitive measures may be useful to trace those short-term effects of rTMS non-invasively in humans...
  74. ncbi request reprint Elevated impulsivity and impaired decision-making cognition in heavy users of MDMA ("Ecstasy")
    Boris B Quednow
    Department of Psychiatry, University of Zurich, Lenggstrasse 31, CH 8008, Zurich, Switzerland
    Psychopharmacology (Berl) 189:517-30. 2007
    ..In fact, MDMA users have shown elevated impulsivity in two studies, but little is known about decision making in drug-free MDMA consumers...
  75. ncbi request reprint 5-HT2A receptor density is decreased in the at-risk mental state
    Rene Hurlemann
    Brain Imaging Center West, Research Center Juelich, 52425, Juelich, Germany
    Psychopharmacology (Berl) 195:579-90. 2008
    ..Current perspectives on the pathophysiology of schizophrenia direct attention to serotonergic (serotonin, 5-HT) dysregulation in the prodrome or at-risk mental state (ARMS)...
  76. ncbi request reprint Disturbed frontal gyrification within families affected with schizophrenia
    Peter Falkai
    Department of Psychiatry and Psychotherapy, University of Gottingen, Von Siebold Str 5, 37075 Gottingen, Germany
    J Psychiatr Res 41:805-13. 2007
    ....
  77. ncbi request reprint Neural correlates of working memory dysfunction in first-episode schizophrenia patients: an fMRI multi-center study
    Frank Schneider
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Pauwelsstr 30, 52074 Aachen, Germany
    Schizophr Res 89:198-210. 2007
    ....
  78. ncbi request reprint Psychoeducation and compliance in the treatment of schizophrenia: results of the Munich Psychosis Information Project Study
    Gabriele Pitschel-Walz
    Department of Psychiatry and Psychotherapy, Technical University of Munich, Munich, Germany
    J Clin Psychiatry 67:443-52. 2006
    ..The present study examined whether psychoeducational groups for patients with schizophrenic disorders and for their families can reduce rehospitalization rates and improve compliance...
  79. ncbi request reprint Development of volume conductor and source models to localize epileptic foci
    Manfred Fuchs
    Compumedics Neuroscan Germany GmbH, Hamburg, Germany
    J Clin Neurophysiol 24:101-19. 2007
    ....
  80. ncbi request reprint Foley balloon to tamponade bleeding in the retropubic space
    Matthew Aungst
    Department of Obstetrics and Gynecology, Kaiser Vallejo Medical Center, Vallejo, California, USA
    Obstet Gynecol 102:1037-8. 2003
    ..Hemorrhage from the retropubic space is a well-described complication of the tension-free vaginal tape procedure that can be difficult to control with conservative measures...
  81. ncbi request reprint Structure and activity of multiple nitrifying bacterial populations co-existing in a biofilm
    Armin Gieseke
    Department of Molecular Ecology, Max Planck Institute for Marine Microbiology, Celsiusstrasse 1, D 28359 Bremen, Germany
    Environ Microbiol 5:355-69. 2003
    ..Results of functional and structural analyses are discussed with respect to specific niches of individual populations in this system...
  82. ncbi request reprint The (2-phenyl-2-trimethylsilyl)ethyl-(PTMSEL)-linker in the synthesis of glycopeptide partial structures of complex cell surface glycoproteins
    Michael Wagner
    Institut für Organische Chemie der Universität Mainz, Duesbergweg 10 14, 55128 Mainz, Germany
    Chemistry 9:6018-30. 2003
    ..Using the PTMSEL linker these molecules are accessible by automated synthesis according to the Fmoc strategy without frequently observed side reactions such as aspartimide or diketopiperazine formation...
  83. ncbi request reprint Quantification of uncultured microorganisms by fluorescence microscopy and digital image analysis
    Holger Daims
    Department für Mikrobielle Okologie, Universitat Wien, Althanstrasse 14, 1090, Vienna, Austria
    Appl Microbiol Biotechnol 75:237-48. 2007
    ..This article provides an overview of these methods and some of their applications with emphasis on (semi-)automated image analysis solutions...
  84. ncbi request reprint Harm avoidance in subjects with obsessive-compulsive disorder and their families
    Susan Ettelt
    Department of Psychiatry and Psychotherapy, University of Greifswald, Germany
    J Affect Disord 107:265-9. 2008
    ..HA is considered to be a genetically influenced personality trait with an increasingly understood neuroanatomical basis...
  85. ncbi request reprint Confidence limits of dipole source reconstruction results
    Manfred Fuchs
    Compumedics Neuroscan Germany GmbH, Lutterothstrasse 28e, D 20255 Hamburg, Germany
    Clin Neurophysiol 115:1442-51. 2004
    ..In order to avoid the misleading impression of exact localization results, a measure of the SD of the dipole localization is desirable...
  86. pmc Generators of the intracranial P50 response in auditory sensory gating
    Oleg Korzyukov
    Department of Psychiatry, Wayne State University, 2751 E Jefferson, Suite 304, Detroit, MI 48207, USA
    Neuroimage 35:814-26. 2007
    ..Present findings suggest that while the temporal lobe is the main generator of the P50 component, the frontal lobe seems to be a substantial contributor to the process of sensory gating as observed from scalp recordings...
  87. ncbi request reprint Early detection and secondary prevention of psychosis: facts and visions
    Heinz Hafner
    Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    Eur Arch Psychiatry Clin Neurosci 254:117-28. 2004
    ....
  88. ncbi request reprint A standardized boundary element method volume conductor model
    Manfred Fuchs
    Neuroscan Laboratories, Lutterothstrasse 28e, D 20255 Hamburg, Germany
    Clin Neurophysiol 113:702-12. 2002
    ..The localization accuracy of the new approach was tested in a comparison with simulated data and with individual BEM models of epileptic spike data from several patients...
  89. ncbi request reprint Evaluation of sLORETA in the presence of noise and multiple sources
    Michael Wagner
    Compumedics Neuroscan, Hamburg, Germany
    Brain Topogr 16:277-80. 2004
    ..In the context of a strong or superficial source, weak or deep sources remain invisible, and nearby sources of similar orientation tend not to be separated but interpreted as one source located roughly in between...
  90. pmc Spatiotemporal dynamics of audiovisual speech processing
    Lynne E Bernstein
    Communication Neuroscience Department, House Ear Institute, 2100 W Third St, Los Angeles, CA 90057, USA
    Neuroimage 39:423-35. 2008
    ..As discussed here, the relatively late activity of the SMG/AG solely under audiovisual conditions is a possible candidate audiovisual speech integration response...
  91. ncbi request reprint Is the movement-evoked potential mandatory for movement execution? A high-resolution EEG study in a deafferented patient
    Rumyana Kristeva
    Neurological Clinic, Albert Ludwigs University, Breisacher Strasse 64, 79106 Freiburg, Germany
    Neuroimage 31:677-85. 2006
    ..The role of the sensory feedback in updating the internal models and of the movement-evoked potential as a possible cortical correlate of motor awareness is discussed...
  92. ncbi request reprint Interventions in the initial prodromal states of psychosis in Germany: concept and recruitment
    Andreas Bechdolf
    Early Recognition and Intervention Centre for Mental Crisis FETZ, Department of Psychiatry and Psychotherapy, University of Cologne, Kerpenerstrasse 62, 50924 Cologne, Germany
    Br J Psychiatry Suppl 48:s45-8. 2005
    ..Two intervention strategies are being studied by two large-scale multicentre projects...
  93. ncbi request reprint Cognitive-behavioral therapy in the pre-psychotic phase: an exploratory study
    Andreas Bechdolf
    Cologne Early Recognition and Intervention Centre for Mental Crisis FETZ, Department of Psychiatry and Psychotherapy, University of Cologne, Kerpener Str 62, 50924 Cologne, Germany
    Psychiatry Res 136:251-5. 2005
    ..The specificity of these effects needs to be explored in a controlled trial...
  94. ncbi request reprint Obsessive-compulsive disorder and posttraumatic stress disorder
    Hans Joergen Grabe
    Department of Psychiatry and Psychotherapy, University of Greifswald, Stralsund, Germany
    Psychopathology 41:129-34. 2008
    ..This study investigates the hypothesis that traumatic events and posttraumatic stress disorders (PTSD) precede the onset of OCD...