Charlotte Wagner

Summary

Affiliation: University of Regensburg
Country: Germany

Publications

  1. doi request reprint Connexin 37 is dispensable for the control of the renin system and for positioning of renin-producing cells in the kidney
    Charlotte Wagner
    Physiologisches Institut, Universitat Regensburg, 93040, Regensburg, Germany
    Pflugers Arch 459:151-8. 2009
  2. doi request reprint Distribution and functional relevance of connexins in renin-producing cells
    Charlotte Wagner
    Institute of Physiology, University of Regensburg, 93053, Regensburg, Germany
    Pflugers Arch 465:71-7. 2013
  3. ncbi request reprint Function of connexins in the renal circulation
    C Wagner
    Physiologisches Institut der Universität Regensburg, Regensburg, Germany
    Kidney Int 73:547-55. 2008
  4. ncbi request reprint Increased expression of cyclooxygenase 2 contributes to aberrant renin production in connexin 40-deficient kidneys
    Charlotte Wagner
    Institute of Physiology, University of Regensburg, Regensburg, Germany
    Am J Physiol Regul Integr Comp Physiol 293:R1781-6. 2007
  5. ncbi request reprint Connexin40 is essential for the pressure control of renin synthesis and secretion
    Charlotte Wagner
    Physiologisches Institut der Universität Regensburg, Regensburg, Germany
    Circ Res 100:556-63. 2007
  6. ncbi request reprint Differential regulation of renin and Cox-2 expression in the renal cortex of C57Bl/6 mice
    Charlotte Wagner
    Department of Physiology, University of Regensburg, 93040 Regensburg, Germany
    Pflugers Arch 447:214-22. 2003
  7. pmc Role of cGMP-kinase II in the control of renin secretion and renin expression
    C Wagner
    Institut fur Physiologie I, Universitat Regensburg, D 93040 Regensburg, Germany
    J Clin Invest 102:1576-82. 1998
  8. pmc Connexin expression in renin-producing cells
    Lisa Kurtz
    Institute of Physiology, University of Regensburg, Regensburg, Germany
    J Am Soc Nephrol 20:506-12. 2009
  9. doi request reprint Replacement of connexin 40 by connexin 45 causes ectopic localization of renin-producing cells in the kidney but maintains in vivo control of renin gene expression
    Lisa Kurtz
    Klinik und Poliklinik fur Innere Medizin II, Universitat Regensburg, D 93042 Regensburg, Germany
    Am J Physiol Renal Physiol 297:F403-9. 2009
  10. pmc Selective deletion of Connexin 40 in renin-producing cells impairs renal baroreceptor function and is associated with arterial hypertension
    Charlotte Wagner
    Physiologisches Institut der Universität Regensburg, Regensburg, Germany
    Kidney Int 78:762-8. 2010

Collaborators

Detail Information

Publications33

  1. doi request reprint Connexin 37 is dispensable for the control of the renin system and for positioning of renin-producing cells in the kidney
    Charlotte Wagner
    Physiologisches Institut, Universitat Regensburg, 93040, Regensburg, Germany
    Pflugers Arch 459:151-8. 2009
    ..As a consequence, it appears unlikely that Cx40 exerts its important function in renin-producing cells via Cx37/Cx40 heteromeric gap junctions...
  2. doi request reprint Distribution and functional relevance of connexins in renin-producing cells
    Charlotte Wagner
    Institute of Physiology, University of Regensburg, 93053, Regensburg, Germany
    Pflugers Arch 465:71-7. 2013
    ..This short review aims to summarize these findings and tries to set them into a functional context...
  3. ncbi request reprint Function of connexins in the renal circulation
    C Wagner
    Physiologisches Institut der Universität Regensburg, Regensburg, Germany
    Kidney Int 73:547-55. 2008
    ..In addition, this review discusses the role of renal connexin expression in the pathogenesis of hypertension or diabetes...
  4. ncbi request reprint Increased expression of cyclooxygenase 2 contributes to aberrant renin production in connexin 40-deficient kidneys
    Charlotte Wagner
    Institute of Physiology, University of Regensburg, Regensburg, Germany
    Am J Physiol Regul Integr Comp Physiol 293:R1781-6. 2007
    ..Apparently, these disseminated cells do not contribute to the enhanced renin secretion rates of Cx40-deficient kidneys...
  5. ncbi request reprint Connexin40 is essential for the pressure control of renin synthesis and secretion
    Charlotte Wagner
    Physiologisches Institut der Universität Regensburg, Regensburg, Germany
    Circ Res 100:556-63. 2007
    ..Because Cx40 gap junctions are also formed between renin producing cells and endothelial cells our finding could provide additional information to suggest that the endothelium may be strongly involved in the control of the renin system...
  6. ncbi request reprint Differential regulation of renin and Cox-2 expression in the renal cortex of C57Bl/6 mice
    Charlotte Wagner
    Department of Physiology, University of Regensburg, 93040 Regensburg, Germany
    Pflugers Arch 447:214-22. 2003
    ..Our data suggest a marked divergence of renin and Cox-2 expression in the kidney cortex of C57Bl/6 mice with no clear evidence for a role of Cox-2-derived prostanoids from the macula densa in the regulation of renin expression...
  7. pmc Role of cGMP-kinase II in the control of renin secretion and renin expression
    C Wagner
    Institut fur Physiologie I, Universitat Regensburg, D 93040 Regensburg, Germany
    J Clin Invest 102:1576-82. 1998
    ..Taken together, these findings suggest that activation of cGKII has a general inhibitory effect on renin secretion from renal JG cells...
  8. pmc Connexin expression in renin-producing cells
    Lisa Kurtz
    Institute of Physiology, University of Regensburg, Regensburg, Germany
    J Am Soc Nephrol 20:506-12. 2009
    ..These findings suggest that Cx40 expression is a characteristic of renin-producing cells in the kidney, and it seems to be essential in the recruitment of renin-producing cells in the adult but not the fetal kidney...
  9. doi request reprint Replacement of connexin 40 by connexin 45 causes ectopic localization of renin-producing cells in the kidney but maintains in vivo control of renin gene expression
    Lisa Kurtz
    Klinik und Poliklinik fur Innere Medizin II, Universitat Regensburg, D 93042 Regensburg, Germany
    Am J Physiol Renal Physiol 297:F403-9. 2009
    ..In summary, we infer from our findings that the function of Cx40 for the localization of potential renin-producing cells cannot be substituted by that of Cx45, although the regulability of renin gene expression can...
  10. pmc Selective deletion of Connexin 40 in renin-producing cells impairs renal baroreceptor function and is associated with arterial hypertension
    Charlotte Wagner
    Physiologisches Institut der Universität Regensburg, Regensburg, Germany
    Kidney Int 78:762-8. 2010
    ..Cx40 in renin-producing cells is required for their correct positioning in the juxtaglomerular area and the control of renin secretion by pressure...
  11. doi request reprint Substitution of connexin40 with connexin45 prevents hyperreninemia and attenuates hypertension
    Frank Schweda
    Institute of Physiology, University of Regensburg, Regensburg, Germany
    Kidney Int 75:482-9. 2009
    ..Since Cx40 can be replaced by Cx45, a connexin with a significantly lower conductivity, we suggest that the regulation of renin release is not dependent on the unique electrical properties of these channel proteins...
  12. doi request reprint Developmental renin expression in mice with a defective renin-angiotensin system
    Katharina Machura
    Institute of Physiology, University of Regensburg, Regensburg, Germany
    Am J Physiol Renal Physiol 297:F1371-80. 2009
    ....
  13. pmc Reciprocal expression of connexin 40 and 45 during phenotypical changes in renin-secreting cells
    Birguel Kurt
    Institute of Physiology, University of Regensburg, Regensburg, Germany
    Am J Physiol Renal Physiol 300:F743-8. 2011
    ....
  14. doi request reprint Renin expression in large renal vessels during fetal development depends on functional beta1/beta2-adrenergic receptors
    Björn Neubauer
    Physiologisches Institut, Universitat Regensburg, D 93040 Regensburg, Germany
    Am J Physiol Renal Physiol 301:F71-7. 2011
    ..Furthermore, β-adrenergic receptor input is critical for the expression of renin in large renal vessels during early fetal development...
  15. doi request reprint Development of vascular renin expression in the kidney critically depends on the cyclic AMP pathway
    Björn Neubauer
    Department of Physiology, Universitat Regensburg, Regensburg, Germany
    Am J Physiol Renal Physiol 296:F1006-12. 2009
    ....
  16. doi request reprint High-level connexin expression in the human juxtaglomerular apparatus
    Lisa Kurtz
    Department of Internal Medicine II, University of Regensburg, Regensburg, Germany
    Nephron Physiol 116:p1-8. 2010
    ....
  17. ncbi request reprint Regulation of renin gene expression in kidneys of eNOS- and nNOS-deficient mice
    C Wagner
    Institut fur Physiologie I, Universitat Regensburg, Germany
    Pflugers Arch 439:567-72. 2000
    ..These observations suggest that neither eNOS nor nNOS is essential for up- or downregulation of renin expression. eNOS-derived NO appears to enhance renin expression, whereas nNOS-derived NO does not...
  18. ncbi request reprint Lack of connexin 40 causes displacement of renin-producing cells from afferent arterioles to the extraglomerular mesangium
    Lisa Kurtz
    Physiologisches Institut der Universität Regensburg, D 93040 Regensburg, Germany
    J Am Soc Nephrol 18:1103-11. 2007
    ..Moreover, these findings support the notion that gap junctions are relevant for the macula densa signaling to renin-producing cells...
  19. ncbi request reprint Upregulation of macula densa cyclooxygenase-2 expression is not dependent on glomerular filtration
    Frank Schweda
    Institut fur Physiologie, Universitat Regensburg, 93042 Regensburg, Germany
    Am J Physiol Renal Physiol 287:F95-101. 2004
    ....
  20. ncbi request reprint Preserved macula densa-dependent renin secretion in A1 adenosine receptor knockout mice
    Frank Schweda
    Institut für Physiologie and Klinik und Poliklinik für Innere Medizin, Universitat Regensburg, 93040 Regensburg, Germany
    Am J Physiol Renal Physiol 284:F770-7. 2003
    ..Taken together, our data are consistent with the concept of a tonic inhibitory role of the A(1)AR in the renin system, whereas they indicate that the A(1)AR is not indispensable in macula densa control of the renin system...
  21. doi request reprint Physiology of kidney renin
    Hayo Castrop
    Institute of Physiology, University of Regensburg, Regensburg, Germany
    Physiol Rev 90:607-73. 2010
    ..The broad spectrum of biological actions of (pro)renin is mediated by receptors for (pro)renin, angiotensin II and angiotensin-(1-7)...
  22. ncbi request reprint Renin release
    Frank Schweda
    Institute of Physiology, University of Regensburg, Germany
    Physiology (Bethesda) 22:310-9. 2007
    ..The unravelling of these mysteries has led to new and interesting insights into the process of renin release...
  23. pmc The connexin 40 A96S mutation causes renin-dependent hypertension
    Indra Lübkemeier
    Institute of Genetics, University of Bonn, Bonn, Germany
    J Am Soc Nephrol 22:1031-40. 2011
    ....
  24. ncbi request reprint Cellular control of renin secretion
    A Kurtz
    Institut für Physiologie der Universität Regensburg, D 93040 Regensburg, Germany
    J Exp Biol 202:219-25. 1999
    ..This review summarizes our present knowledge about the possible actions of these kinases in renal juxtaglomerular cells and considers pathways in the organ control of renin secretion...
  25. ncbi request reprint Endogenous nitric oxide attenuates erythropoietin gene expression in vivo
    V Todorov
    Department of Physiology, Medical University Sofia, Bulgaria
    Pflugers Arch 439:445-8. 2000
    ..EPO mRNA levels in eNOS-/- mirrored those of wt+L-NAME, but the effects were less prominent. Our data suggest that endogenous NO attenuates EPO gene expression in mice. This effect is dependent on the rate of EPO gene induction...
  26. ncbi request reprint Regulation of renin secretion by angiotensin II-AT1 receptors
    A Kurtz
    Physiologisches Institut der Universität Regensburg, Germany
    J Am Soc Nephrol 10:S162-8. 1999
    ..These reactions may comprise activation of protein kinase C and activation of chloride channels...
  27. ncbi request reprint Role of renal nerves in the stimulation of the renin system by reduced renal arterial pressure
    C Wagner
    Institut fur Physiologie, Universitat Regensburg, Germany
    Hypertension 34:1101-5. 1999
    ..Renal nerve activity is therefore an important determinant of the gain of renin stimulation during reduced renal arterial pressure...
  28. pmc Stimulation of renin secretion by nitric oxide is mediated by phosphodiesterase 3
    A Kurtz
    Institut für Physiologie der Universität Regensburg, D 93040 Regensburg, Germany
    Proc Natl Acad Sci U S A 95:4743-7. 1998
    ..Our findings are compatible with the idea that the stimulatory effects of endogenous and exogenous NO on renin secretion are mediated by a cGMP-induced inhibition of cAMP degradation...
  29. ncbi request reprint Development of renin expression in the mouse kidney
    A Sauter
    Institut für Physiologie der Universität Regensburg, D 93040 Regensburg, Germany
    Kidney Int 73:43-51. 2008
    ..At all stages of kidney development, renin expression among comparable vessel segments was heterogeneous. Renin expression remained stable after it reached the terminal parts of afferent arterioles...
  30. ncbi request reprint Dominant role of prostaglandin E2 EP4 receptor in furosemide-induced salt-losing tubulopathy: a model for hyperprostaglandin E syndrome/antenatal Bartter syndrome
    Rolf M Nusing
    Institute of Clinical Pharmacology, Johann Wolfgang Goethe University, Theodor Stern Kai 7, Frankfurt 60590, Germany
    J Am Soc Nephrol 16:2354-62. 2005
    ..In summary, these findings demonstrate that the EP4 receptor mediates PGE2-induced renin secretion and that EP1, EP3, and EP4 receptors all contribute to enhanced PGE2-mediated salt and water excretion in the HPS/aBS model...
  31. ncbi request reprint Chronic cyclooxygenase-2 inhibition does not alter blood pressure and kidney function in renovascular hypertensive rats
    Claus M Richter
    Center for Cardiovascular Research, Charite, Humboldt University of Berlin, Germany
    J Hypertens 22:191-8. 2004
    ..We tested the effect of chronic COX-2 inhibition on blood pressure, urinary aldosterone excretion and kidney morphology, as well as kidney function...
  32. ncbi request reprint General inhibition of renocortical cyclooxygenase-2 expression by the renin-angiotensin system
    Hayo Castrop
    Institut für Physiologie und Pharmakologie der Universität Regensburg, D 93040 Regensburg, Germany
    Am J Physiol Renal Physiol 284:F518-24. 2003
    ..Thus our data suggest a general inhibitory effect of the renin-angiotensin system on renocortical COX-2 expression...
  33. ncbi request reprint Temporal-spatial co-localisation of tissue transglutaminase (Tgase2) and matrix metalloproteinase-9 (MMP-9) with SBA-positive micro-fibres in the embryonic kidney cortex
    Karl Schumacher
    Institute of Bioengineering and Nanotechnology, A STAR, 04 01, 31 Biopolis Way, The Nanos, 138669, Singapore
    Cell Tissue Res 319:491-500. 2005
    ..Thus, the micro-fibres are developmentally modulated by enzymes of the ECM in embryonic kidney cortex. These findings illustrate the importance of micro-fibres in directing CD ampulla growth...