Affiliation: University of Regensburg
Wagner C, Kurtz L, Schweda F, Simon A, Kurtz A. Connexin 37 is dispensable for the control of the renin system and for positioning of renin-producing cells in the kidney. Pflugers Arch. 2009;459:151-8 pubmed publisher
..As a consequence, it appears unlikely that Cx40 exerts its important function in renin-producing cells via Cx37/Cx40 heteromeric gap junctions. ..
Wagner C. Function of connexins in the renal circulation. Kidney Int. 2008;73:547-55 pubmed
..In addition, this review discusses the role of renal connexin expression in the pathogenesis of hypertension or diabetes. ..
Wagner C, Kurtz A. Distribution and functional relevance of connexins in renin-producing cells. Pflugers Arch. 2013;465:71-7 pubmed publisher
..This short review aims to summarize these findings and tries to set them into a functional context. ..
Wagner C, Pfeifer A, Ruth P, Hofmann F, Kurtz A. Role of cGMP-kinase II in the control of renin secretion and renin expression. J Clin Invest. 1998;102:1576-82 pubmed
..Taken together, these findings suggest that activation of cGKII has a general inhibitory effect on renin secretion from renal JG cells. ..
Wagner C, de Wit C, Kurtz L, Grünberger C, Kurtz A, Schweda F. Connexin40 is essential for the pressure control of renin synthesis and secretion. Circ Res. 2007;100:556-63 pubmed
..Because Cx40 gap junctions are also formed between renin producing cells and endothelial cells our finding could provide additional information to suggest that the endothelium may be strongly involved in the control of the renin system. ..
Wagner C, de Wit C, Gerl M, Kurtz A, Hocherl K. Increased expression of cyclooxygenase 2 contributes to aberrant renin production in connexin 40-deficient kidneys. Am J Physiol Regul Integr Comp Physiol. 2007;293:R1781-6 pubmed
..Apparently, these disseminated cells do not contribute to the enhanced renin secretion rates of Cx40-deficient kidneys. ..