M von Knebel Doeberitz

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. pmc Phase I/IIa study of intratumoral/intracerebral or intravenous/intracerebral administration of Parvovirus H-1 (ParvOryx) in patients with progressive primary or recurrent glioblastoma multiforme: ParvOryx01 protocol
    Karsten Geletneky
    Department of Neurosurgery, University Hospital Heidelberg, Germany
    BMC Cancer 12:99. 2012
  2. doi request reprint Towards a vaccine to prevent cancer in Lynch syndrome patients
    Magnus von Knebel Doeberitz
    Department of Applied Tumor Biology, Institute of Pathology, University Hospital Heidelberg, Im Neuenheimer Feld 224, Heidelberg, Germany
    Fam Cancer 12:307-12. 2013
  3. doi request reprint Biomarkers for cervical cancer screening: the role of p16(INK4a) to highlight transforming HPV infections
    Magnus von Knebel Doeberitz
    Department of Applied Tumor Biology, Clinical Cooperation Unit, German Cancer Research Center and Institute of Pathology, University of Heidelberg, Im Neuenheimer Feld 220, Heidelberg, Germany
    Expert Rev Proteomics 9:149-63. 2012
  4. pmc Frameshift mutations in coding repeats of protein tyrosine phosphatase genes in colorectal tumors with microsatellite instability
    Sebastian Korff
    Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany
    BMC Cancer 8:329. 2008
  5. doi request reprint [Human papillomaviruses in the pathogenesis of intraepithelial neoplasia (AIN) and carcinoma of the anus]
    M von Knebel Doeberitz
    Abteilung für Angewandte Tumorbiologie, Institut fur Pathologie, Universitat Heidelberg, Heidelberg, Deutschland
    Hautarzt 61:13-20. 2010
  6. pmc Microsatellite instability in colorectal cancer is associated with local lymphocyte infiltration and low frequency of distant metastases
    A Buckowitz
    Department of Surgery, University Hospital of Heidelberg, Heidelberg, Germany
    Br J Cancer 92:1746-53. 2005
  7. ncbi request reprint New markers for cervical dysplasia to visualise the genomic chaos created by aberrant oncogenic papillomavirus infections
    M von Knebel Doeberitz
    Division of Molecular Pathology, Department of Pathology, School of Medicine, University of Heidelberg, Im Neuenheimer Feld 220, D 69120, Heidelberg, Germany
    Eur J Cancer 38:2229-42. 2002
  8. pmc New molecular tools for efficient screening of cervical cancer
    M von Knebel Doeberitz
    Division of Molecular Diagnostics and Therapy, Department of Surgery, University of Heidelberg, Im Neuenheimer 110, D 69120 Heidelberg, Germany
    Dis Markers 17:123-8. 2001
  9. ncbi request reprint [Aspects of molecular pathogenesis of cervical cancer in establishing new tumor markers for early detection and diagnosis]
    M von Knebel Doeberitz
    Sektion für Molekulare Diagnostik und Therapie, Chirurgische Universitatsklinik Heidelberg
    Zentralbl Gynakol 123:186-91. 2001
  10. ncbi request reprint Nucleic acid based techniques for the detection of rare cancer cells in clinical samples
    M von Knebel Doeberitz
    Department of Surgery, University of Heidelberg, Germany
    Cancer Metastasis Rev 18:43-64. 1999

Collaborators

Detail Information

Publications37

  1. pmc Phase I/IIa study of intratumoral/intracerebral or intravenous/intracerebral administration of Parvovirus H-1 (ParvOryx) in patients with progressive primary or recurrent glioblastoma multiforme: ParvOryx01 protocol
    Karsten Geletneky
    Department of Neurosurgery, University Hospital Heidelberg, Germany
    BMC Cancer 12:99. 2012
    ..ParvOryx01 is the first trial with a replication competent oncolytic virus in Germany...
  2. doi request reprint Towards a vaccine to prevent cancer in Lynch syndrome patients
    Magnus von Knebel Doeberitz
    Department of Applied Tumor Biology, Institute of Pathology, University Hospital Heidelberg, Im Neuenheimer Feld 224, Heidelberg, Germany
    Fam Cancer 12:307-12. 2013
    ..In addition, clinical perspectives will be discussed, focusing on MSI-H cancer-associated FSP antigens as potential targets for immune therapy approaches. ..
  3. doi request reprint Biomarkers for cervical cancer screening: the role of p16(INK4a) to highlight transforming HPV infections
    Magnus von Knebel Doeberitz
    Department of Applied Tumor Biology, Clinical Cooperation Unit, German Cancer Research Center and Institute of Pathology, University of Heidelberg, Im Neuenheimer Feld 220, Heidelberg, Germany
    Expert Rev Proteomics 9:149-63. 2012
    ..Here, we review the molecular background and the current evidence for the clinical utility of the p16(INK4a) biomarker for HPV-related cancers, and cervical cancer prevention in particular...
  4. pmc Frameshift mutations in coding repeats of protein tyrosine phosphatase genes in colorectal tumors with microsatellite instability
    Sebastian Korff
    Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany
    BMC Cancer 8:329. 2008
    ....
  5. doi request reprint [Human papillomaviruses in the pathogenesis of intraepithelial neoplasia (AIN) and carcinoma of the anus]
    M von Knebel Doeberitz
    Abteilung für Angewandte Tumorbiologie, Institut fur Pathologie, Universitat Heidelberg, Heidelberg, Deutschland
    Hautarzt 61:13-20. 2010
    ..We here briefly review the basic concepts and some clinical applications of this recent research...
  6. pmc Microsatellite instability in colorectal cancer is associated with local lymphocyte infiltration and low frequency of distant metastases
    A Buckowitz
    Department of Surgery, University Hospital of Heidelberg, Heidelberg, Germany
    Br J Cancer 92:1746-53. 2005
    ..04, respectively). These data, together with the recent definition of highly immunogenic neo-antigens expressed in MSI-H tumour cells, suggest that MSI-H CRCs elicit a protective host response that may prevent metastasis formation...
  7. ncbi request reprint New markers for cervical dysplasia to visualise the genomic chaos created by aberrant oncogenic papillomavirus infections
    M von Knebel Doeberitz
    Division of Molecular Pathology, Department of Pathology, School of Medicine, University of Heidelberg, Im Neuenheimer Feld 220, D 69120, Heidelberg, Germany
    Eur J Cancer 38:2229-42. 2002
    ..These new markers will result in a modified classification of cervical precancers and improved screening assays. Here, we review the basic concept and potential clinical applications of these new developments...
  8. pmc New molecular tools for efficient screening of cervical cancer
    M von Knebel Doeberitz
    Division of Molecular Diagnostics and Therapy, Department of Surgery, University of Heidelberg, Im Neuenheimer 110, D 69120 Heidelberg, Germany
    Dis Markers 17:123-8. 2001
    ..These new assays discussed here will help to improve current limitations in cervical cancer screening, diagnosis, and therapy control...
  9. ncbi request reprint [Aspects of molecular pathogenesis of cervical cancer in establishing new tumor markers for early detection and diagnosis]
    M von Knebel Doeberitz
    Sektion für Molekulare Diagnostik und Therapie, Chirurgische Universitatsklinik Heidelberg
    Zentralbl Gynakol 123:186-91. 2001
    ..These findings will allow to establish highly sensitive, but specific and cost efficient new cancer early detection assays...
  10. ncbi request reprint Nucleic acid based techniques for the detection of rare cancer cells in clinical samples
    M von Knebel Doeberitz
    Department of Surgery, University of Heidelberg, Germany
    Cancer Metastasis Rev 18:43-64. 1999
    ..Here, the theoretical background, basic principles and some diagnostic applications of these new tests are reviewed...
  11. ncbi request reprint Systematic identification of genes with coding microsatellites mutated in DNA mismatch repair-deficient cancer cells
    S M Woerner
    Division of Molecular Diagnostics and Therapy, Department of Surgery, University of Heidelberg, Heidelberg, Germany
    Int J Cancer 93:12-9. 2001
    ..The approach outlined here identified a new set of genes frequently affected by mutations in MSI-positive tumor cells. It will lead to novel and highly specific diagnostic and therapeutic targets for microsatellite unstable cancers...
  12. ncbi request reprint Comparative analysis of tumor cell dissemination in mesenteric, central, and peripheral venous blood in patients with colorectal cancer
    M Koch
    Division for Molecular Diagnostics and Therapy, Department of Surgery, University of Heidelberg, INF 110, D-69120 Heidelberg, Germany
    Arch Surg 136:85-9. 2001
    ..Tumor cell detection in central and peripheral venous blood, however, shows that this filtering process is limited and indicates early systemic hematogenic tumor cell dissemination in colorectal cancer...
  13. ncbi request reprint Analysis of FUS-CHOP fusion transcripts in different types of soft tissue liposarcoma and their diagnostic implications
    F Willeke
    Department of Surgery, University of Heidelberg, Germany
    Clin Cancer Res 4:1779-84. 1998
    ..Furthermore, using FUS-CHOP fusion transcripts as targets in reverse transcription-PCR assays, we detected disseminated tumor cells in peripheral blood or bone marrow in 3 of 5 patients undergoing surgery for soft tissue liposarcoma...
  14. ncbi request reprint Detection of disseminated tumour cells as a potential surrogate-marker for monitoring palliative chemotherapy in colorectal cancer patients
    P Staritz
    Dept of Medicine, University of Heidelberg, Germany
    J Exp Clin Cancer Res 23:633-9. 2004
    ..Further investigations are needed to clarify the potential role of circulating tumour cells for monitoring chemotherapy in these patients...
  15. ncbi request reprint [Detection of isolated disseminated tumor cells of colorectal carcinomas in lymph nodes]
    J Weitz
    Sektion für Molekulare Diagnostik und Therapie, Chirurgische Universitatsklinik, Heidelberg
    Chirurg 71:410-6. 2000
    ..Although these observations appear to confirm the therapeutic importance of meticulous lymph node dissection, their prognostic relevance has yet to be determined in prospective studies...
  16. ncbi request reprint Detection of isolated disseminated tumor cells in bone marrow and blood samples of patients with hepatocellular carcinoma
    P Kienle
    Department of Surgery, University of Heidelberg, Germany
    Arch Surg 135:213-8. 2000
    ..Reverse transcription-polymerase chain reaction (RT-PCR) for alpha-fetoprotein (AFP) has been used to detect circulating liver cancer cells, but results in blood samples have been contradictory...
  17. pmc Expression of cytokeratin 20 in thyroid carcinomas and peripheral blood detected by reverse transcription polymerase chain reaction
    T Weber
    Division of Molecular Diagnostics and Therapy, University of Heidelberg, Germany
    Br J Cancer 82:157-60. 2000
    ..Our results therefore strongly suggest that CK20 RT-PCR assays may improve the diagnosis of thyroid carcinoma and is able to detect circulating tumour cells in peripheral blood of thyroid carcinoma patients...
  18. ncbi request reprint Overexpression of p16(INK4A) as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri
    R Klaes
    Division of Molecular Diagnostics and Therapy, Department of Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    Int J Cancer 92:276-84. 2001
    ..These data demonstrate that p16(INK4a) is a specific biomarker to identify dysplastic cervical epithelia in sections of cervical biopsy samples or cervical smears...
  19. ncbi request reprint Frameshift peptide-derived T-cell epitopes: a source of novel tumor-specific antigens
    M Linnebacher
    , , Heidelberg, Germany
    Int J Cancer 93:6-11. 2001
    ....
  20. doi request reprint [HPV-associated carcinomas of the female genital tract. Molecular mechanisms of development]
    M Reuschenbach
    Abteilung für Angewandte Tumorbiologie, Institut fur Pathologie, Universitatsklinikum Heidelberg, Im Neuenheimer Feld 220, 69120, Heidelberg, Deutschland
    Pathologe 32:451-60. 2011
    ..The transforming stage is seen as the actual carcinogenic event and can be immunohistochemically detected by the biomarker p16(INK4a)...
  21. ncbi request reprint Sensitive detection of rare cancer cells in sputum and peripheral blood samples of patients with lung cancer by preproGRP-specific RT-PCR
    J Lacroix
    Division of Molecular Diagnostics and Therapy, Department of Surgery, University of Heidelberg, Heidelberg, Germany
    Int J Cancer 92:1-8. 2001
    ..Amplification of preproGRP transcripts from clinical samples is a sensitive and specific assay to detect disseminated or exfoliated lung cancer cells either in peripheral blood or sputum samples...
  22. ncbi request reprint [Diagnosis and significance of minimal residual disease in patients with colorectal carcinoma]
    M von Knebel Doeberitz
    Sektion für Molekulare Diagnostik und Therapie, Chirurgische Universitatsklinik, Heidelberg
    Zentralbl Chir 125:15-9. 2000
    ..It is one of our primary aims to test, whether the detection of disseminated cancer cells might guide the indication for adjuvant therapies and might predict the efficacy of therapies in patients with solid cancers...
  23. ncbi request reprint Evaluation of Bethesda guidelines in relation to microsatellite instability
    H P Wüllenweber
    Department of General Surgery, University of Heidelberg, Germany
    Dis Colon Rectum 44:1281-9. 2001
    ..This study examined the validity of the different Bethesda criteria in relation to microsatellite instability status to simplify their use in clinical practice...
  24. ncbi request reprint Hematogenous tumor cell dissemination during colonoscopy for colorectal cancer
    M Koch
    Division for Molecular Diagnostics and Therapy, Department of Surgery, University of Heidelberg, INF 110, D 69120 Heidelberg, Germany
    Surg Endosc 18:587-91. 2004
    ..The objective of this study was to determine the extent of hematogenous tumor cell spread in colorectal cancer patients during colonoscopy...
  25. pmc Microsatellite instability and Beta2-Microglobulin mutations as prognostic markers in colon cancer: results of the FOGT-4 trial
    A Tikidzhieva
    Department of Applied Tumor Biology, Institute of Pathology, University Hospital Heidelberg, Im Neuenheimer Feld 220 221, Heidelberg 69120, Germany
    Br J Cancer 106:1239-45. 2012
    ....
  26. ncbi request reprint Detection of integrated papillomavirus sequences by ligation-mediated PCR (DIPS-PCR) and molecular characterization in cervical cancer cells
    F Luft
    Division of Molecular Diagnostics and Therapy, Department of Surgery, University of Heidelberg, Germany
    Int J Cancer 92:9-17. 2001
    ..Therefore, DIPS-PCR might allow efficient therapy control and prediction of relapse in patients with HPV-associated anogenital cancers...
  27. doi request reprint [Molecular pathogenesis. Its importance in targeted therapy in colorectal cancer]
    M Kloor
    Abteilung für Angewandte Tumorbiologie, Institut fur Pathologie, Universitatsklinikum Heidelberg, Im Neuenheimer Feld 220, 69120 Heidelberg
    Pathologe 29:196-9. 2008
    ..Interventions specifically targeting these antigens may be the basis for novel therapeutic strategies in MSI colorectal cancer and will be evaluated in clinical trials...
  28. ncbi request reprint Mutational activation of the beta-catenin proto-oncogene is a common event in the development of Wilms' tumors
    R Koesters
    Department of Surgery, University of Heidelberg, Germany
    Cancer Res 59:3880-2. 1999
    ....
  29. ncbi request reprint The nonsteroidal anti-inflammatory drugs aspirin and indomethacin attenuate beta-catenin/TCF-4 signaling
    S Dihlmann
    Division of Molecular Diagnostics and Therapy, Department of Surgery, University of Heidelberg, D-69120 Heidelberg, Germany
    Oncogene 20:645-53. 2001
    ..These results strongly suggest that aspirin and indomethacin attenuate the transcription of beta-catenin/TCF-responsive genes, by modulating TCF activity without disrupting beta-catenin/TCF complex formation...
  30. pmc High density of FOXP3-positive T cells infiltrating colorectal cancers with microsatellite instability
    S Michel
    Molecular Medicine Partnership Unit MMPU, Department of Applied Tumour Biology, Institute of Pathology, University of Heidelberg, Im Neuenheimer Feld 220 221, Heidelberg 69120, Germany
    Br J Cancer 99:1867-73. 2008
    ..These data suggest that FOXP3-positive cells may play a role in the regulation of the immune response directed against MSI-H colorectal cancers at the primary tumour site...
  31. ncbi request reprint Significant increase of a specific variant TSG101 transcript during the progression of cervical neoplasia
    R Klaes
    Department of Surgery, University of Heidelberg, Germany
    Eur J Cancer 35:733-7. 1999
    ..The relative amounts of variant transcripts do not support a major functional role of TSG101 variants in cervical carcinogenesis...
  32. pmc High-risk human papillomavirus in non-melanoma skin lesions from renal allograft recipients and immunocompetent patients
    M Reuschenbach
    Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Im Neuenheimer Feld 220, Heidelberg 69120, Germany
    Br J Cancer 104:1334-41. 2011
    ..Data on prevalence are inconclusive, but are essential to estimate the relevance of HR-HPV, particularly with regard to prophylactic HPV vaccines for skin cancer prevention...
  33. ncbi request reprint Overexpression of a member of the pentraxin family (PTX3) in human soft tissue liposarcoma
    F Willeke
    Department of Surgery, Mannheim University Clinic, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68135 Mannheim, Germany
    Eur J Cancer 42:2639-46. 2006
    ..This finding mandates further research efforts to clarify the exact role of PTX3 in liposarcoma oncogenesis...
  34. pmc Transmission risk of Borrelia burgdorferi sensu lato from Ixodes ricinus ticks to humans in southwest Germany
    M Maiwald
    Hygiene Institut der Universität, Abt Hygiene und Med Mikrobiologie, Heidelberg, Germany
    Epidemiol Infect 121:103-8. 1998
    ..These results indicate that the transmission rate from infected ticks in Europe is higher than previously assumed. Examination of ticks and antibiotic prophylaxis in the case of positivity appears to be indicated...
  35. ncbi request reprint [Viral carcinogenesis of head and neck tumors]
    N Wentzensen
    Abteilung für Molekulare Pathologie, Pathologisches Institut der Universität Heidelberg
    Pathologe 25:21-30. 2004
    ..NPC has a high incidence in some East Asian countries. In this review, the molecular pathogenesis of HPV- and EBV-associated malignancies are described and the clinical relevance of the presented findings is discussed...
  36. ncbi request reprint [Molecular pathogenesis of cervical cancer and its first steps]
    M J Trunk
    mtm laboratories AG, Heidelberg
    Pathologe 26:283-90. 2005
    ..This review summarizes the basic molecular mechanisms of how papillomaviruses contribute to cellular transformation and how this can influence future diagnostic applications...
  37. pmc The p53 codon 72 variation is associated with the age of onset of hereditary non-polyposis colorectal cancer (HNPCC)
    S Kruger
    Department of Surgical Research, Dresden University of Technology, Germany
    J Med Genet 42:769-73. 2005
    ..These findings may be relevant for preventive strategies in HNPCC...