Ivar von Kügelgen

Summary

Affiliation: University of Bonn
Country: Germany

Publications

  1. ncbi request reprint Pharmacological profiles of cloned mammalian P2Y-receptor subtypes
    Ivar von Kügelgen
    Department of Pharmacology, University of Bonn, Reuterstrasse 2b, D 53113 Bonn, Germany
    Pharmacol Ther 110:415-32. 2006
  2. ncbi request reprint Molecular pharmacology of P2Y-receptors
    I von Kugelgen
    Department of Pharmacology, University of Bonn, Germany
    Naunyn Schmiedebergs Arch Pharmacol 362:310-23. 2000
  3. pmc Excitatory P2-receptors at sympathetic axon terminals: role in temperature control of cutaneous blood flow
    Ivar von Kügelgen
    Department of Pharmacology, University of Bonn, Reuterstrasse 2b, Bonn D 53113, Germany
    Br J Pharmacol 148:561-2. 2006
  4. ncbi request reprint Cloning and functional expression of a novel Gi protein-coupled receptor for adenine from mouse brain
    Ivar von Kügelgen
    Department of Pharmacology and Toxicology, University of Bonn, D 53113 Bonn, Germany
    Mol Pharmacol 73:469-77. 2008
  5. ncbi request reprint Interaction of new, very potent non-nucleotide antagonists with Arg256 of the human platelet P2Y12 receptor
    Kristina Hoffmann
    Department of Pharmacology and Toxicology, University of Bonn, Bonn, Germany
    J Pharmacol Exp Ther 331:648-55. 2009
  6. ncbi request reprint Characterization of an antiproliferative effect of imidazoline receptor ligands on PC12 cells
    Gerhard J Molderings
    Institute of Pharmacology and Toxicology, University of Bonn, Reuterstrasse 2b, D 53113 Bonn, Germany
    Pharmacol Rep 59:789-94. 2007
  7. pmc Characterization of new G protein-coupled adenine receptors in mouse and hamster
    Dominik Thimm
    PharmaCenter Bonn, Pharmaceutical Institute, Pharmaceutical Chemistry I, University of Bonn, An der Immenburg 4, 53121, Bonn, Germany
    Purinergic Signal 9:415-26. 2013
  8. ncbi request reprint Inhibitory effects of benzodiazepines on the adenosine A(2B) receptor mediated secretion of interleukin-8 in human mast cells
    Kristina Hoffmann
    Pharma Center Bonn, Department of Pharmacology and Toxicology, Biomedical Research Center, University of Bonn, Sigmund Freud Strasse 25, 53127 Bonn, Germany
    Eur J Pharmacol 700:152-8. 2013
  9. ncbi request reprint P2Y-receptors mediating an inhibition of the evoked entry of calcium through N-type calcium channels at neuronal processes
    Melanie B Kulick
    Department of Pharmacology, University of Bonn, Reuterstrasse 2b, D 53113 Bonn, Germany
    J Pharmacol Exp Ther 303:520-6. 2002
  10. doi request reprint In vitro analysis of LIPH mutations causing hypotrichosis simplex: evidence confirming the role of lipase H and lysophosphatidic acid in hair growth
    Sandra M Pasternack
    Institute of Human Genetics, University of Bonn, Bonn D 53111, Germany
    J Invest Dermatol 129:2772-6. 2009

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Pharmacological profiles of cloned mammalian P2Y-receptor subtypes
    Ivar von Kügelgen
    Department of Pharmacology, University of Bonn, Reuterstrasse 2b, D 53113 Bonn, Germany
    Pharmacol Ther 110:415-32. 2006
    ..Finally, UDP has been reported to act on receptors for cysteinyl leukotrienes as an additional agonist--indicating a dual agonist specificity of these receptors...
  2. ncbi request reprint Molecular pharmacology of P2Y-receptors
    I von Kugelgen
    Department of Pharmacology, University of Bonn, Germany
    Naunyn Schmiedebergs Arch Pharmacol 362:310-23. 2000
    ..The P2Y4-receptor is highly expressed in the placenta. The distribution of the P2Y6-receptor is widespread including heart, blood vessels and brain. The P2Y11-receptor may play a role in the differentiation of immunocytes...
  3. pmc Excitatory P2-receptors at sympathetic axon terminals: role in temperature control of cutaneous blood flow
    Ivar von Kügelgen
    Department of Pharmacology, University of Bonn, Reuterstrasse 2b, Bonn D 53113, Germany
    Br J Pharmacol 148:561-2. 2006
    ..The commentary discusses the implication of the results and remaining questions...
  4. ncbi request reprint Cloning and functional expression of a novel Gi protein-coupled receptor for adenine from mouse brain
    Ivar von Kügelgen
    Department of Pharmacology and Toxicology, University of Bonn, D 53113 Bonn, Germany
    Mol Pharmacol 73:469-77. 2008
    ..In summary, our data show that a second mammalian DNA sequence encodes for a G(i)-coupled GPCR activated by low, nanomolar concentrations of adenine...
  5. ncbi request reprint Interaction of new, very potent non-nucleotide antagonists with Arg256 of the human platelet P2Y12 receptor
    Kristina Hoffmann
    Department of Pharmacology and Toxicology, University of Bonn, Bonn, Germany
    J Pharmacol Exp Ther 331:648-55. 2009
    ..The results also indicate that the sulfonic acid residue at ring D is involved in the interaction of antagonists derived from reactive blue 2 with the residue Arg256 of the human P2Y(12) receptor...
  6. ncbi request reprint Characterization of an antiproliferative effect of imidazoline receptor ligands on PC12 cells
    Gerhard J Molderings
    Institute of Pharmacology and Toxicology, University of Bonn, Reuterstrasse 2b, D 53113 Bonn, Germany
    Pharmacol Rep 59:789-94. 2007
    ..In conclusion, the present data add further evidence to the recent finding that effects of imidazoline receptor ligands in PC12 cells are mediated by homo- and heterodimers of members of the S1P receptor family...
  7. pmc Characterization of new G protein-coupled adenine receptors in mouse and hamster
    Dominik Thimm
    PharmaCenter Bonn, Pharmaceutical Institute, Pharmaceutical Chemistry I, University of Bonn, An der Immenburg 4, 53121, Bonn, Germany
    Purinergic Signal 9:415-26. 2013
    ..In addition, the cAdeR from hamster expressed in CHO cells produced an increase in intracellular calcium concentrations (EC50 6.24 nM) and was found to be additionally coupled to Gq proteins...
  8. ncbi request reprint Inhibitory effects of benzodiazepines on the adenosine A(2B) receptor mediated secretion of interleukin-8 in human mast cells
    Kristina Hoffmann
    Pharma Center Bonn, Department of Pharmacology and Toxicology, Biomedical Research Center, University of Bonn, Sigmund Freud Strasse 25, 53127 Bonn, Germany
    Eur J Pharmacol 700:152-8. 2013
    ..The rank order of potency indicates the involvement of an atypical benzodiazepine binding site...
  9. ncbi request reprint P2Y-receptors mediating an inhibition of the evoked entry of calcium through N-type calcium channels at neuronal processes
    Melanie B Kulick
    Department of Pharmacology, University of Bonn, Reuterstrasse 2b, D 53113 Bonn, Germany
    J Pharmacol Exp Ther 303:520-6. 2002
    ..This suggests a role of P2Y12-receptors in neuromodulation in addition to their involvement in platelet aggregation...
  10. doi request reprint In vitro analysis of LIPH mutations causing hypotrichosis simplex: evidence confirming the role of lipase H and lysophosphatidic acid in hair growth
    Sandra M Pasternack
    Institute of Human Genetics, University of Bonn, Bonn D 53111, Germany
    J Invest Dermatol 129:2772-6. 2009
    ..Our study increases the spectrum of known LIPH mutations and provides biochemical evidence for the important role of lipase H and its product LPA in human hair growth...
  11. ncbi request reprint Involvement of basic amino acid residues in transmembrane regions 6 and 7 in agonist and antagonist recognition of the human platelet P2Y(12)-receptor
    Kristina Hoffmann
    Department of Pharmacology, University of Bonn, Reuterstrasse 2b, D 53113 Bonn, Germany
    Biochem Pharmacol 76:1201-13. 2008
    ..Arg256 appears to play a role in the recognition of nucleotide agonists and the non-nucleotide antagonist reactive blue-2, but no role in the recognition of the nucleotide antagonist cangrelor...
  12. pmc The rat adenine receptor: pharmacological characterization and mutagenesis studies to investigate its putative ligand binding site
    Melanie Knospe
    PharmaCenter Bonn, Pharmaceutical Institute, Pharmaceutical Chemistry I, University of Bonn, An der Immenburg 4, 53121, Bonn, Germany
    Purinergic Signal 9:367-81. 2013
    ..Our results provide important insights into this new, poorly investigated family of purinergic receptors...
  13. doi request reprint New aspects of liver abnormalities as part of the systemic mast cell activation syndrome
    Kirsten Alfter
    Evangelische Kliniken, Waldkrankenhaus, Department for Internal Medicine, Bonn, Germany
    Liver Int 29:181-6. 2009
    ..An attempt was made to shed light on potential mechanisms responsible for mast cell mediator-related liver abnormalities...
  14. doi request reprint A₂B receptors mediate the induction of early genes and inhibition of arterial smooth muscle cell proliferation via Epac
    Peter Mayer
    Federal Institute for Drugs and Medical Devices, Bonn, Germany
    Cardiovasc Res 90:148-56. 2011
    ..In the present study, we therefore searched for adenosine-induced changes in the expression of early genes in cultured human coronary artery smooth muscle cells (HCASMCs)...
  15. ncbi request reprint G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth
    Sandra M Pasternack
    Institute of Human Genetics, University of Bonn, Bonn 53111, Germany
    Nat Genet 40:329-34. 2008
    ..This finding may provide opportunities for new therapeutic approaches to the treatment of hair loss in humans...
  16. ncbi request reprint Evidence for the functional expression and pharmacological characterization of adenine receptors in native cells and tissues
    Simone Gorzalka
    Pharmaceutical Institute, Pharmaceutical Chemistry Poppelsdorf, University of Bonn, Bonn, Germany
    Mol Pharmacol 67:955-64. 2005
    ..Moreover, preliminary radioligand binding studies with [3H]adenine at membranes of human astrocytoma 1321N1 cells suggest that a human ortholog of the rat adenine receptor exists...
  17. ncbi request reprint Multiple novel alterations in Kit tyrosine kinase in patients with gastrointestinally pronounced systemic mast cell activation disorder
    Gerhard J Molderings
    Institut fur Pharmakologie und Toxikologie, Universitatsklinikum Bonn, Germany
    Scand J Gastroenterol 42:1045-53. 2007
    ....
  18. pmc P2X1 receptor-mediated inhibition of the proliferation of human coronary smooth muscle cells involving the transcription factor NR4A1
    Annette Viktoria Hinze
    Federal Institute for Drugs and Medical Devices, Kurt Georg Kiesinger Allee 3, 53175, Bonn, Germany
    Purinergic Signal 9:677-86. 2013
    ..In conclusion, our results demonstrate for the first time that adenine nucleotides acting at P2X1 receptors inhibit the proliferation of human coronary smooth muscle cells via the induction of the early gene NR4A1. ..
  19. doi request reprint Key determinants of nucleotide-activated G protein-coupled P2Y(2) receptor function revealed by chemical and pharmacological experiments, mutagenesis and homology modeling
    Petra Hillmann
    PharmaCenter Bonn, Pharmaceutical Chemistry I, University of Bonn, An der Immenburg 4, 53121 Bonn, Germany
    J Med Chem 52:2762-75. 2009
    ..The disulfide bridge Cys25-Cys278 was found to be important for agonist potency but neither for agonist efficacy nor for antagonist potency...
  20. ncbi request reprint S1P-receptors in PC12 and transfected HEK293 cells: molecular targets of hypotensive imidazoline I(1) receptor ligands
    Gerhard J Molderings
    University of Bonn, Institute of Pharmacology and Toxicology, Reuterstr 2b, D 53113 Bonn, Germany
    Neurochem Int 51:476-85. 2007
    ....
  21. ncbi request reprint Ureteral stones due to systemic mastocytosis: diagnostic and therapeutic characteristics
    Gerhard J Molderings
    Institute of Human Genetics, University Hospital of Bonn, Bonn, Germany
    Urol Res 37:227-9. 2009
    ..Opioids should be used cautiously for analgesia in patients with systemic mastocytosis...
  22. doi request reprint Molecular pharmacology, physiology, and structure of the P2Y receptors
    Ivar von Kügelgen
    Department of Pharmacology and Toxicology, University of Bonn, Germany
    Adv Pharmacol 61:373-415. 2011
    ..The widely prescribed drug, clopidogrel, which results in irreversible blockade of the platelet P2Y(12) receptor, is the most important therapeutic agent that targets a P2Y receptor...