Research Topics
Genomes and Genes | Ivar von KügelgenSummaryAffiliation: University of Bonn Country: Germany Publications
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Detail Information
Publications
Pharmacological profiles of cloned mammalian P2Y-receptor subtypesIvar von Kügelgen
Department of Pharmacology, University of Bonn, Reuterstrasse 2b, D 53113 Bonn, Germany
Pharmacol Ther 110:415-32. 2006..Finally, UDP has been reported to act on receptors for cysteinyl leukotrienes as an additional agonist--indicating a dual agonist specificity of these receptors...- Molecular pharmacology of P2Y-receptorsI von Kugelgen
Department of Pharmacology, University of Bonn, Germany
Naunyn Schmiedebergs Arch Pharmacol 362:310-23. 2000..The P2Y4-receptor is highly expressed in the placenta. The distribution of the P2Y6-receptor is widespread including heart, blood vessels and brain. The P2Y11-receptor may play a role in the differentiation of immunocytes... 
Interaction of new, very potent non-nucleotide antagonists with Arg256 of the human platelet P2Y12 receptorKristina Hoffmann
Department of Pharmacology and Toxicology, University of Bonn, Bonn, Germany
J Pharmacol Exp Ther 331:648-55. 2009..The results also indicate that the sulfonic acid residue at ring D is involved in the interaction of antagonists derived from reactive blue 2 with the residue Arg256 of the human P2Y(12) receptor...
Excitatory P2-receptors at sympathetic axon terminals: role in temperature control of cutaneous blood flowIvar von Kügelgen
Department of Pharmacology, University of Bonn, Reuterstrasse 2b, Bonn D 53113, Germany
Br J Pharmacol 148:561-2. 2006..The commentary discusses the implication of the results and remaining questions...- Cloning and functional expression of a novel Gi protein-coupled receptor for adenine from mouse brainIvar von Kügelgen
Department of Pharmacology and Toxicology, University of Bonn, D 53113 Bonn, Germany
Mol Pharmacol 73:469-77. 2008..In summary, our data show that a second mammalian DNA sequence encodes for a G(i)-coupled GPCR activated by low, nanomolar concentrations of adenine... - Characterization of an antiproliferative effect of imidazoline receptor ligands on PC12 cellsGerhard J Molderings
Institute of Pharmacology and Toxicology, University of Bonn, Reuterstrasse 2b, D 53113 Bonn, Germany
Pharmacol Rep 59:789-94. 2007..In conclusion, the present data add further evidence to the recent finding that effects of imidazoline receptor ligands in PC12 cells are mediated by homo- and heterodimers of members of the S1P receptor family... - Involvement of basic amino acid residues in transmembrane regions 6 and 7 in agonist and antagonist recognition of the human platelet P2Y(12)-receptorKristina Hoffmann
Department of Pharmacology, University of Bonn, Reuterstrasse 2b, D 53113 Bonn, Germany
Biochem Pharmacol 76:1201-13. 2008..Arg256 appears to play a role in the recognition of nucleotide agonists and the non-nucleotide antagonist reactive blue-2, but no role in the recognition of the nucleotide antagonist cangrelor... - In vitro analysis of LIPH mutations causing hypotrichosis simplex: evidence confirming the role of lipase H and lysophosphatidic acid in hair growthSandra M Pasternack
Institute of Human Genetics, University of Bonn, Bonn D 53111, Germany
J Invest Dermatol 129:2772-6. 2009..Our study increases the spectrum of known LIPH mutations and provides biochemical evidence for the important role of lipase H and its product LPA in human hair growth... - A₂B receptors mediate the induction of early genes and inhibition of arterial smooth muscle cell proliferation via EpacPeter Mayer
Federal Institute for Drugs and Medical Devices, Bonn, Germany
Cardiovasc Res 90:148-56. 2011..In the present study, we therefore searched for adenosine-induced changes in the expression of early genes in cultured human coronary artery smooth muscle cells (HCASMCs)... - New aspects of liver abnormalities as part of the systemic mast cell activation syndromeKirsten Alfter
Evangelische Kliniken, Waldkrankenhaus, Department for Internal Medicine, Bonn, Germany
Liver Int 29:181-6. 2009..An attempt was made to shed light on potential mechanisms responsible for mast cell mediator-related liver abnormalities... - G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growthSandra M Pasternack
Institute of Human Genetics, University of Bonn, Bonn 53111, Germany
Nat Genet 40:329-34. 2008..This finding may provide opportunities for new therapeutic approaches to the treatment of hair loss in humans... - Evidence for the functional expression and pharmacological characterization of adenine receptors in native cells and tissuesSimone Gorzalka
Pharmaceutical Institute, Pharmaceutical Chemistry Poppelsdorf, University of Bonn, Bonn, Germany
Mol Pharmacol 67:955-64. 2005..Moreover, preliminary radioligand binding studies with [3H]adenine at membranes of human astrocytoma 1321N1 cells suggest that a human ortholog of the rat adenine receptor exists... - Multiple novel alterations in Kit tyrosine kinase in patients with gastrointestinally pronounced systemic mast cell activation disorderGerhard J Molderings
Institut fur Pharmakologie und Toxikologie, Universitatsklinikum Bonn, Germany
Scand J Gastroenterol 42:1045-53. 2007.... - Key determinants of nucleotide-activated G protein-coupled P2Y(2) receptor function revealed by chemical and pharmacological experiments, mutagenesis and homology modelingPetra Hillmann
PharmaCenter Bonn, Pharmaceutical Chemistry I, University of Bonn, An der Immenburg 4, 53121 Bonn, Germany
J Med Chem 52:2762-75. 2009..The disulfide bridge Cys25-Cys278 was found to be important for agonist potency but neither for agonist efficacy nor for antagonist potency... - P2Y-receptors mediating an inhibition of the evoked entry of calcium through N-type calcium channels at neuronal processesMelanie B Kulick
Department of Pharmacology, University of Bonn, Reuterstrasse 2b, D-53113 Bonn, Germany
J Pharmacol Exp Ther 303:520-6. 2002..This suggests a role of P2Y12-receptors in neuromodulation in addition to their involvement in platelet aggregation... - Inhibitory effects of benzodiazepines on the adenosine A(2B) receptor mediated secretion of interleukin-8 in human mast cellsKristina Hoffmann
Pharma Center Bonn, Department of Pharmacology and Toxicology, Biomedical Research Center, University of Bonn, Sigmund Freud Strasse 25, 53127 Bonn, Germany
Eur J Pharmacol 700:152-8. 2013..The rank order of potency indicates the involvement of an atypical benzodiazepine binding site... - S1P-receptors in PC12 and transfected HEK293 cells: molecular targets of hypotensive imidazoline I(1) receptor ligandsGerhard J Molderings
University of Bonn, Institute of Pharmacology and Toxicology, Reuterstr 2b, D 53113 Bonn, Germany
Neurochem Int 51:476-85. 2007.... - Ureteral stones due to systemic mastocytosis: diagnostic and therapeutic characteristicsGerhard J Molderings
Institute of Human Genetics, University Hospital of Bonn, Bonn, Germany
Urol Res 37:227-9. 2009..Opioids should be used cautiously for analgesia in patients with systemic mastocytosis... - Molecular pharmacology, physiology, and structure of the P2Y receptorsIvar von Kügelgen
Department of Pharmacology and Toxicology, University of Bonn, Germany
Adv Pharmacol 61:373-415. 2011..The widely prescribed drug, clopidogrel, which results in irreversible blockade of the platelet P2Y(12) receptor, is the most important therapeutic agent that targets a P2Y receptor...