Esther von Stebut

Summary

Affiliation: University of Mainz
Country: Germany

Publications

  1. ncbi request reprint Skin-derived macrophages from Leishmania major-susceptible mice exhibit interleukin-12- and interferon-gamma-independent nitric oxide production and parasite killing after treatment with immunostimulatory DNA
    Esther von Stebut
    Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
    J Invest Dermatol 119:621-8. 2002
  2. doi request reprint [Significance of topical therapy in clinical situations : Location-dependent principles]
    E von Stebut
    Hautklinik, Universitatsmedizin, Johannes Gutenberg Universitat, Langenbeckstr 1, 55131, Mainz, Deutschland
    Hautarzt 65:186-91. 2014
  3. doi request reprint [Cutaneous leishmaniasis as travelers' disease. Clinical presentation, diagnostics and therapy]
    E von Stebut
    Hautklinik, Universitätsmedizin Mainz, Johannes Gutenberg Universitat, Langenbeckstr 1, 55131, Mainz, Deutschland
    Hautarzt 63:233-46; quiz 247-8. 2012
  4. doi request reprint Successful treatment of adult multisystemic Langerhans cell histiocytosis with psoralen-UV-A, prednisolone, mercaptopurine, and vinblastine
    Esther von Stebut
    Department of Dermatology, University of Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany
    Arch Dermatol 144:649-53. 2008
  5. ncbi request reprint Cutaneous Leishmania infection: progress in pathogenesis research and experimental therapy
    Esther von Stebut
    Department of Dermatology, Johannes Gutenberg University Mainz, Mainz, Germany
    Exp Dermatol 16:340-6. 2007
  6. ncbi request reprint Immunology of cutaneous leishmaniasis: the role of mast cells, phagocytes and dendritic cells for protective immunity
    Esther von Stebut
    Department of Dermatology, Johannes Gutenberg University, Langenbeckstrasse 1, 55131 Mainz
    Eur J Dermatol 17:115-22. 2007
  7. doi request reprint Research in practice: Different dendritic cell types in skin with various functions - important implications for intradermal vaccines
    Esther von Stebut
    Department of Dermatology, University of Mainz, Germany
    J Dtsch Dermatol Ges 9:506-9. 2011
  8. ncbi request reprint Requirements for Th1-dependent immunity against infection with Leishmania major
    Esther von Stebut
    Department of Dermatology, Johannes Gutenberg University, Langenbeckstrasse 1, D 55101 Mainz, Germany
    Microbes Infect 6:1102-9. 2004
  9. pmc Interleukin 1alpha promotes Th1 differentiation and inhibits disease progression in Leishmania major-susceptible BALB/c mice
    Esther von Stebut
    Department of Dermatology, University of Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany
    J Exp Med 198:191-9. 2003
  10. pmc IL-17 promotes progression of cutaneous leishmaniasis in susceptible mice
    Susanna Lopez Kostka
    Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
    J Immunol 182:3039-46. 2009

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Skin-derived macrophages from Leishmania major-susceptible mice exhibit interleukin-12- and interferon-gamma-independent nitric oxide production and parasite killing after treatment with immunostimulatory DNA
    Esther von Stebut
    Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
    J Invest Dermatol 119:621-8. 2002
    ..In addition, CpG-containing immunostimulatory oligodeoxynucleotides may also act locally on skin macrophages to facilitate Leishmania clearance by inducing nitric oxide production...
  2. doi request reprint [Significance of topical therapy in clinical situations : Location-dependent principles]
    E von Stebut
    Hautklinik, Universitatsmedizin, Johannes Gutenberg Universitat, Langenbeckstr 1, 55131, Mainz, Deutschland
    Hautarzt 65:186-91. 2014
    ..These location-specific differences and potential therapeutic principles will be discussed in greater detail. ..
  3. doi request reprint [Cutaneous leishmaniasis as travelers' disease. Clinical presentation, diagnostics and therapy]
    E von Stebut
    Hautklinik, Universitätsmedizin Mainz, Johannes Gutenberg Universitat, Langenbeckstr 1, 55131, Mainz, Deutschland
    Hautarzt 63:233-46; quiz 247-8. 2012
    ..Therapy can consist of a variety of topical measures or systemic drug treatment. A modern and safe vaccine does not yet exist...
  4. doi request reprint Successful treatment of adult multisystemic Langerhans cell histiocytosis with psoralen-UV-A, prednisolone, mercaptopurine, and vinblastine
    Esther von Stebut
    Department of Dermatology, University of Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany
    Arch Dermatol 144:649-53. 2008
    ..We report successful treatment of a 70-year-old woman with adult onset of LCH and multisystem disease (diabetes insipidus centralis, bone marrow infiltration, and lung and skin involvement)...
  5. ncbi request reprint Cutaneous Leishmania infection: progress in pathogenesis research and experimental therapy
    Esther von Stebut
    Department of Dermatology, Johannes Gutenberg University Mainz, Mainz, Germany
    Exp Dermatol 16:340-6. 2007
    ..This review highlights recent advances in the understanding of the role of DC for the induction of Th1/Tc1-predominant immunity against L. major and how this knowledge may translate into clinical approaches...
  6. ncbi request reprint Immunology of cutaneous leishmaniasis: the role of mast cells, phagocytes and dendritic cells for protective immunity
    Esther von Stebut
    Department of Dermatology, Johannes Gutenberg University, Langenbeckstrasse 1, 55131 Mainz
    Eur J Dermatol 17:115-22. 2007
    ..This review highlights the importance of the various phagocytes for the development of anti-Leishmania immunity...
  7. doi request reprint Research in practice: Different dendritic cell types in skin with various functions - important implications for intradermal vaccines
    Esther von Stebut
    Department of Dermatology, University of Mainz, Germany
    J Dtsch Dermatol Ges 9:506-9. 2011
    ..Thus, when producing vaccines designed for intradermal use, it would seem advisable to attempt to activate dermal DC subtypes while avoiding activation of epidermal LC...
  8. ncbi request reprint Requirements for Th1-dependent immunity against infection with Leishmania major
    Esther von Stebut
    Department of Dermatology, Johannes Gutenberg University, Langenbeckstrasse 1, D 55101 Mainz, Germany
    Microbes Infect 6:1102-9. 2004
    ..Murine strain-dependent differences between DC derived from Leishmania-susceptible as compared to resistant mice are highlighted...
  9. pmc Interleukin 1alpha promotes Th1 differentiation and inhibits disease progression in Leishmania major-susceptible BALB/c mice
    Esther von Stebut
    Department of Dermatology, University of Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany
    J Exp Med 198:191-9. 2003
    ..Differential production of IL-1 by C57BL/6 and BALB/c mice may provide a partial explanation for the disparate outcomes of infection in these mouse strains...
  10. pmc IL-17 promotes progression of cutaneous leishmaniasis in susceptible mice
    Susanna Lopez Kostka
    Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
    J Immunol 182:3039-46. 2009
    ..major-infected BALB/c mice, and suggests that IL-23 production by L. major-infected DC maintains IL-17(+) cells that influence disease progression via regulation of neutrophil recruitment...
  11. ncbi request reprint Distinct roles for IL-1 receptor type I signaling in early versus established Leishmania major infections
    Susanna Lopez Kostka
    Department of Dermatology, Johannes Gutenberg University Mainz, Mainz, Germany
    J Invest Dermatol 126:1582-9. 2006
    ..Effects of IL-1 on disease outcome may be related to levels of IL-1RI on Th subpopulations...
  12. ncbi request reprint Dendritic cell-derived IL-12p40 homodimer contributes to susceptibility in cutaneous leishmaniasis in BALB/c mice
    Axel P Nigg
    Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
    J Immunol 178:7251-8. 2007
    ..Thus, in addition to IL-1alphabeta, strain-dependent differences in the release of other DC-derived factors such as IL-12p80 may influence genetically determined disease outcome...
  13. doi request reprint A role for leukocyte-derived IL-1RA in DC homeostasis revealed by increased susceptibility of IL-1RA-deficient mice to cutaneous leishmaniasis
    Kordula Kautz-Neu
    Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
    J Invest Dermatol 131:1650-9. 2011
    ..Thus, the complex regulation of various members of the IL-1 cytokine family mediated through effects on both DCs and T cells critically contributes to disease outcome against this important human pathogen...
  14. pmc Uptake of Leishmania major by dendritic cells is mediated by Fcgamma receptors and facilitates acquisition of protective immunity
    Florian Woelbing
    Department of Dermatology and 2Section for Pathophysiology, First Department of Internal Medicine, Johannes Gutenberg University, Mainz 55131, Germany
    J Exp Med 203:177-88. 2006
    ..major with different outcomes, and indicate that B cell-derived, parasite-reactive IgG and DC FcgammaRI and FcgammaRIII are essential for optimal development of protective immunity...
  15. ncbi request reprint Skin mast cells control T cell-dependent host defense in Leishmania major infections
    Marcus Maurer
    Department of Dermatology, University Hospital Mainz, Mainz, Germany
    FASEB J 20:2460-7. 2006
    ..These findings extend the view of MCs as salient sentinels of innate immunity to complex host defense reactions against intracellular pathogens...
  16. doi request reprint Animal model for cutaneous leishmaniasis
    Michael R Fischer
    Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz, Germany
    Methods Mol Biol 961:389-402. 2013
    ....
  17. doi request reprint Dendritic cells in Leishmania major infections: mechanisms of parasite uptake, cell activation and evidence for physiological relevance
    Kordula Kautz-Neu
    Department of Dermatology, University Medicine, Johannes Gutenberg University Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany
    Med Microbiol Immunol 201:581-92. 2012
    ..A detailed understanding of the role of DC for the development of efficient anti-Leishmania immunity will aid the development of potent anti-parasite drugs and/or vaccines...
  18. doi request reprint Vaccination with TAT-antigen fusion protein induces protective, CD8(+) T cell-mediated immunity against Leishmania major
    Katharina Kronenberg
    Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
    J Invest Dermatol 130:2602-10. 2010
    ....
  19. doi request reprint Model for generation of large numbers of primary, inflammatory skin-derived neutrophils, and macrophages
    Dominik John
    Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz, Germany
    Methods Mol Biol 961:403-10. 2013
    ..Within this protocol, we present a strategy for isolation of large numbers of inflammatory neutrophils and macrophages from murine skin that allows for follow-up in vivo or in vitro studies...
  20. pmc Langerhans cells are negative regulators of the anti-Leishmania response
    Kordula Kautz-Neu
    Department of Dermatology, Johannes Gutenberg University, 55131 Mainz, Germany
    J Exp Med 208:885-91. 2011
    ..major infection by driving the expansion of T reg cells. A better understanding of the various roles of different DC subsets in cutaneous leishmaniasis will improve the development of a potent therapeutic/prophylactic vaccine...
  21. pmc Miltefosine efficiently eliminates Leishmania major amastigotes from infected murine dendritic cells without altering their immune functions
    Klaus Griewank
    Department of Dermatology, Universitatsmedizin, Johannes Gutenberg University Mainz, Langenbeckstr 1, 55131 Mainz, Germany
    Antimicrob Agents Chemother 54:652-9. 2010
    ..Our data confirm prior studies indicating that in contrast to, e.g., pentavalent antimonials, miltefosine functions independently of the immune system, mostly through direct toxicity against the Leishmania parasite...
  22. doi request reprint Dual role of interleukin-1alpha in delayed-type hypersensitivity and airway hyperresponsiveness
    Peri Caucig
    Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
    Int Arch Allergy Immunol 152:303-12. 2010
    ..In the present study, we determined the role of IL-1alpha in other Th2-mediated diseases...
  23. doi request reprint Dendritic cells ameliorate autoimmunity in the CNS by controlling the homeostasis of PD-1 receptor(+) regulatory T cells
    Nir Yogev
    Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, Germany
    Immunity 37:264-75. 2012
    ..Our results show that a reduction of DCs interferes with tolerance, resulting in a stronger inflammatory response, and that other APC populations could compensate for the loss of immunogenic APC function in DC-depleted mice...
  24. doi request reprint Human epidermal Langerhans cells replenish skin xenografts and are depleted by alloreactive T cells in vivo
    Julia Hemmerling
    Department of Hematology, Oncology, and Pneumology, University Medical Center, Johannes Gutenberg University Mainz, 55131 Mainz, Germany
    J Immunol 187:1142-9. 2011
    ..Our data also propose xeno-transplantation of human skin as a model system for studying the role of skin dendritic cells in the efferent arm of GVHD...
  25. doi request reprint Leishmaniasis, contact hypersensitivity and graft-versus-host disease: understanding the role of dendritic cell subsets in balancing skin immunity and tolerance
    Kordula Kautz-Neu
    Department of Dermatology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany
    Exp Dermatol 19:760-71. 2010
    ..A detailed knowledge about the immune modulatory capacity of different cutaneous DC subsets might be helpful to specifically target these cells through the skin during therapeutic interventions...
  26. ncbi request reprint Impaired Th1 responses in mice deficient in Epstein-Barr virus-induced gene 3 and challenged with physiological doses of Leishmania major
    Sabine Zahn
    Department of Dermatology, Johannes Gutenberg University of Mainz, Mainz, Germany
    Eur J Immunol 35:1106-12. 2005
    ..In conclusion, our data show that DC-derived IL-27 is critical for the timely initiation of efficient anti-parasite Th1 immunity early in infections...
  27. ncbi request reprint Congenital dermatofibrosarcoma protuberans: 30 years of follow-up
    Esther von Stebut
    Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
    J Dtsch Dermatol Ges 5:223-5. 2007
    ..In line with a few additional reports, we suggest that congenital dermatofibrosarcoma protuberans is a tumor with a low malignant potential...
  28. doi request reprint Blue light irradiation suppresses dendritic cells activation in vitro
    Michael R Fischer
    Department of Dermatology, University Medical Centre, Johannes Gutenberg University, Mainz, Germany
    Exp Dermatol 22:558-60. 2013
    ....
  29. doi request reprint An alternative pathway of imiquimod-induced psoriasis-like skin inflammation in the absence of interleukin-17 receptor a signaling
    Khalifa El Malki
    Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany
    J Invest Dermatol 133:441-51. 2013
    ..Hence, our findings have major implications in the potential long-term treatment of psoriasis by IL-17-targeting drugs...
  30. doi request reprint IL-1 signalling is dispensable for protective immunity in Leishmania-resistant mice
    Kordula Kautz-Neu
    Exp Dermatol 20:76-8. 2011
    ..In addition, DC-based vaccination against leishmaniasis in C57BL/6 mice was independent of IL-1. Thus, in Leishmania-resistant C57BL/6 mice, IL-1 signalling is dispensable for protection...
  31. pmc Platelet, not endothelial, P-selectin expression contributes to generation of immunity in cutaneous contact hypersensitivity
    Ralf J Ludwig
    Department of Dermatology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Am J Pathol 176:1339-45. 2010
    ..Our observations indicate that platelet, not endothelial, P-selectin contributes to generation of immunity in DNFB-induced contact hypersensitivity...
  32. ncbi request reprint Early macrophage influx to sites of cutaneous granuloma formation is dependent on MIP-1alpha /beta released from neutrophils recruited by mast cell-derived TNFalpha
    Esther von Stebut
    Department of Dermatology, University Hospital Mainz, Germany
    Blood 101:210-5. 2003
    ..These findings indicate that MPhi recruitment to cutaneous PAG- induced granulomas is the result of a sequence of inflammatory processes initiated by MC-derived TNFalpha followed by PMN influx and MIP-1a/beta release...
  33. doi request reprint Interleukin-2 immediate type hypersensitivity?
    Peri Caucig
    Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
    J Dtsch Dermatol Ges 6:956-8. 2008
    ....
  34. pmc Clinical efficacy of blue light full body irradiation as treatment option for severe atopic dermatitis
    Detlef Becker
    Department of Dermatology, University Medicine, Johannes Gutenberg University, Mainz, Germany
    PLoS ONE 6:e20566. 2011
    ..Here, we assessed clinical efficacy and histopathological alterations induced by blue light-treatment of AD within an observational, non-interventional study...
  35. ncbi request reprint Chronic infiltrates and persisting ulcerations on the arms and legs
    Esther von Stebut
    Johannes Gutenberg University, Mainz, Germany
    Arch Dermatol 141:897-902. 2005
  36. doi request reprint Clinical features and epidemiology of cutaneous leishmaniasis and Leishmania major/HIV co-infection in Cameroon: results of a large cross-sectional study
    Omer Bébe Ngouateu
    Department of Animal Biology and Physiology, University of Yaounde I, Yaounde, Cameroon
    Trans R Soc Trop Med Hyg 106:137-42. 2012
    ..These findings provide important data necessary for the development and implementation of successful control programmes against CL and HIV in this geographical area...
  37. ncbi request reprint CD8+ T cells are required for primary immunity in C57BL/6 mice following low-dose, intradermal challenge with Leishmania major
    Yasmine Belkaid
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, and Dermatology Branch, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 168:3992-4000. 2002
    ..The low dose, intradermal challenge model reveals that CD8(+) T cells play an essential role in both pathogenesis of and immunity to primary infection with L. major in the skin...