Research Topics
Genomes and Genes | Esther von StebutSummaryAffiliation: University of Mainz Country: Germany Publications
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Publications
[Cutaneous leishmaniasis as travelers' disease. Clinical presentation, diagnostics and therapy]E von Stebut
Hautklinik, Universitätsmedizin Mainz, Johannes Gutenberg Universitat, Langenbeckstr 1, 55131, Mainz, Deutschland
Hautarzt 63:233-46; quiz 247-8. 2012..Therapy can consist of a variety of topical measures or systemic drug treatment. A modern and safe vaccine does not yet exist...- Research in practice: Different dendritic cell types in skin with various functions - important implications for intradermal vaccinesEsther von Stebut
Department of Dermatology, University of Mainz, Germany
J Dtsch Dermatol Ges 9:506-9. 2011..Thus, when producing vaccines designed for intradermal use, it would seem advisable to attempt to activate dermal DC subtypes while avoiding activation of epidermal LC... - Successful treatment of adult multisystemic Langerhans cell histiocytosis with psoralen-UV-A, prednisolone, mercaptopurine, and vinblastineEsther von Stebut
Department of Dermatology, University of Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany
Arch Dermatol 144:649-53. 2008..We report successful treatment of a 70-year-old woman with adult onset of LCH and multisystem disease (diabetes insipidus centralis, bone marrow infiltration, and lung and skin involvement)... 
Cutaneous Leishmania infection: progress in pathogenesis research and experimental therapyEsther von Stebut
Department of Dermatology, Johannes Gutenberg University Mainz, Mainz, Germany
Exp Dermatol 16:340-6. 2007..This review highlights recent advances in the understanding of the role of DC for the induction of Th1/Tc1-predominant immunity against L. major and how this knowledge may translate into clinical approaches...- Immunology of cutaneous leishmaniasis: the role of mast cells, phagocytes and dendritic cells for protective immunityEsther von Stebut
Department of Dermatology, Johannes Gutenberg University, Langenbeckstrasse 1, 55131 Mainz
Eur J Dermatol 17:115-22. 2007..This review highlights the importance of the various phagocytes for the development of anti-Leishmania immunity... - Skin-derived macrophages from Leishmania major-susceptible mice exhibit interleukin-12- and interferon-gamma-independent nitric oxide production and parasite killing after treatment with immunostimulatory DNAEsther von Stebut
Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
J Invest Dermatol 119:621-8. 2002..In addition, CpG-containing immunostimulatory oligodeoxynucleotides may also act locally on skin macrophages to facilitate Leishmania clearance by inducing nitric oxide production... 
Interleukin 1alpha promotes Th1 differentiation and inhibits disease progression in Leishmania major-susceptible BALB/c miceEsther von Stebut
Department of Dermatology, University of Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany
J Exp Med 198:191-9. 2003..Differential production of IL-1 by C57BL/6 and BALB/c mice may provide a partial explanation for the disparate outcomes of infection in these mouse strains...- Requirements for Th1-dependent immunity against infection with Leishmania majorEsther von Stebut
Department of Dermatology, Johannes Gutenberg University, Langenbeckstrasse 1, D 55101 Mainz, Germany
Microbes Infect 6:1102-9. 2004..Murine strain-dependent differences between DC derived from Leishmania-susceptible as compared to resistant mice are highlighted... - IL-17 promotes progression of cutaneous leishmaniasis in susceptible miceSusanna Lopez Kostka
Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
J Immunol 182:3039-46. 2009..major-infected BALB/c mice, and suggests that IL-23 production by L. major-infected DC maintains IL-17(+) cells that influence disease progression via regulation of neutrophil recruitment... - Distinct roles for IL-1 receptor type I signaling in early versus established Leishmania major infectionsSusanna Lopez Kostka
Department of Dermatology, Johannes Gutenberg University Mainz, Mainz, Germany
J Invest Dermatol 126:1582-9. 2006..Effects of IL-1 on disease outcome may be related to levels of IL-1RI on Th subpopulations... - Dendritic cell-derived IL-12p40 homodimer contributes to susceptibility in cutaneous leishmaniasis in BALB/c miceAxel P Nigg
Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
J Immunol 178:7251-8. 2007..Thus, in addition to IL-1alphabeta, strain-dependent differences in the release of other DC-derived factors such as IL-12p80 may influence genetically determined disease outcome... - A role for leukocyte-derived IL-1RA in DC homeostasis revealed by increased susceptibility of IL-1RA-deficient mice to cutaneous leishmaniasisKordula Kautz-Neu
Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
J Invest Dermatol 131:1650-9. 2011..Thus, the complex regulation of various members of the IL-1 cytokine family mediated through effects on both DCs and T cells critically contributes to disease outcome against this important human pathogen... - Skin mast cells control T cell-dependent host defense in Leishmania major infectionsMarcus Maurer
Department of Dermatology, University Hospital Mainz, Mainz, Germany
FASEB J 20:2460-7. 2006..These findings extend the view of MCs as salient sentinels of innate immunity to complex host defense reactions against intracellular pathogens... - Uptake of Leishmania major by dendritic cells is mediated by Fcgamma receptors and facilitates acquisition of protective immunityFlorian Woelbing
Department of Dermatology and 2Section for Pathophysiology, First Department of Internal Medicine, Johannes Gutenberg University, Mainz 55131, Germany
J Exp Med 203:177-88. 2006..major with different outcomes, and indicate that B cell-derived, parasite-reactive IgG and DC FcgammaRI and FcgammaRIII are essential for optimal development of protective immunity... - Dendritic cells in Leishmania major infections: mechanisms of parasite uptake, cell activation and evidence for physiological relevanceKordula Kautz-Neu
Department of Dermatology, University Medicine, Johannes Gutenberg University Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany
Med Microbiol Immunol 201:581-92. 2012..A detailed understanding of the role of DC for the development of efficient anti-Leishmania immunity will aid the development of potent anti-parasite drugs and/or vaccines... - Vaccination with TAT-antigen fusion protein induces protective, CD8(+) T cell-mediated immunity against Leishmania majorKatharina Kronenberg
Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
J Invest Dermatol 130:2602-10. 2010.... - Langerhans cells are negative regulators of the anti-Leishmania responseKordula Kautz-Neu
Department of Dermatology, Johannes Gutenberg University, 55131 Mainz, Germany
J Exp Med 208:885-91. 2011..major infection by driving the expansion of T reg cells. A better understanding of the various roles of different DC subsets in cutaneous leishmaniasis will improve the development of a potent therapeutic/prophylactic vaccine... - Miltefosine efficiently eliminates Leishmania major amastigotes from infected murine dendritic cells without altering their immune functionsKlaus Griewank
Department of Dermatology, Universitatsmedizin, Johannes Gutenberg University Mainz, Langenbeckstr 1, 55131 Mainz, Germany
Antimicrob Agents Chemother 54:652-9. 2010..Our data confirm prior studies indicating that in contrast to, e.g., pentavalent antimonials, miltefosine functions independently of the immune system, mostly through direct toxicity against the Leishmania parasite... - Dual role of interleukin-1alpha in delayed-type hypersensitivity and airway hyperresponsivenessPeri Caucig
Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
Int Arch Allergy Immunol 152:303-12. 2010..In the present study, we determined the role of IL-1alpha in other Th2-mediated diseases... - Animal model for cutaneous leishmaniasisMichael R Fischer
Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz, Germany
Methods Mol Biol 961:389-402. 2013.... - Dendritic cells ameliorate autoimmunity in the CNS by controlling the homeostasis of PD-1 receptor(+) regulatory T cellsNir Yogev
Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, Germany
Immunity 37:264-75. 2012..Our results show that a reduction of DCs interferes with tolerance, resulting in a stronger inflammatory response, and that other APC populations could compensate for the loss of immunogenic APC function in DC-depleted mice... - Human epidermal Langerhans cells replenish skin xenografts and are depleted by alloreactive T cells in vivoJulia Hemmerling
Department of Hematology, Oncology, and Pneumology, University Medical Center, Johannes Gutenberg University Mainz, 55131 Mainz, Germany
J Immunol 187:1142-9. 2011..Our data also propose xeno-transplantation of human skin as a model system for studying the role of skin dendritic cells in the efferent arm of GVHD... - Leishmaniasis, contact hypersensitivity and graft-versus-host disease: understanding the role of dendritic cell subsets in balancing skin immunity and toleranceKordula Kautz-Neu
Department of Dermatology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany
Exp Dermatol 19:760-71. 2010..A detailed knowledge about the immune modulatory capacity of different cutaneous DC subsets might be helpful to specifically target these cells through the skin during therapeutic interventions... - Impaired Th1 responses in mice deficient in Epstein-Barr virus-induced gene 3 and challenged with physiological doses of Leishmania majorSabine Zahn
Department of Dermatology, Johannes Gutenberg University of Mainz, Mainz, Germany
Eur J Immunol 35:1106-12. 2005..In conclusion, our data show that DC-derived IL-27 is critical for the timely initiation of efficient anti-parasite Th1 immunity early in infections... - Congenital dermatofibrosarcoma protuberans: 30 years of follow-upEsther von Stebut
Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
J Dtsch Dermatol Ges 5:223-5. 2007..In line with a few additional reports, we suggest that congenital dermatofibrosarcoma protuberans is a tumor with a low malignant potential... - IL-1 signalling is dispensable for protective immunity in Leishmania-resistant miceKordula Kautz-Neu
Exp Dermatol 20:76-8. 2011..In addition, DC-based vaccination against leishmaniasis in C57BL/6 mice was independent of IL-1. Thus, in Leishmania-resistant C57BL/6 mice, IL-1 signalling is dispensable for protection... - Platelet, not endothelial, P-selectin expression contributes to generation of immunity in cutaneous contact hypersensitivityRalf J Ludwig
Department of Dermatology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
Am J Pathol 176:1339-45. 2010..Our observations indicate that platelet, not endothelial, P-selectin contributes to generation of immunity in DNFB-induced contact hypersensitivity... - Early macrophage influx to sites of cutaneous granuloma formation is dependent on MIP-1alpha /beta released from neutrophils recruited by mast cell-derived TNFalphaEsther von Stebut
Department of Dermatology, University Hospital Mainz, Germany
Blood 101:210-5. 2003..These findings indicate that MPhi recruitment to cutaneous PAG- induced granulomas is the result of a sequence of inflammatory processes initiated by MC-derived TNFalpha followed by PMN influx and MIP-1a/beta release... - An alternative pathway of imiquimod-induced psoriasis-like skin inflammation in the absence of interleukin-17 receptor a signalingKhalifa El Malki
Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany
J Invest Dermatol 133:441-51. 2013..Hence, our findings have major implications in the potential long-term treatment of psoriasis by IL-17-targeting drugs... - Model for generation of large numbers of primary, inflammatory skin-derived neutrophils, and macrophagesDominik John
Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz, Germany
Methods Mol Biol 961:403-10. 2013..Within this protocol, we present a strategy for isolation of large numbers of inflammatory neutrophils and macrophages from murine skin that allows for follow-up in vivo or in vitro studies... - Interleukin-2 immediate type hypersensitivity?Peri Caucig
Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
J Dtsch Dermatol Ges 6:956-8. 2008.... - Clinical efficacy of blue light full body irradiation as treatment option for severe atopic dermatitisDetlef Becker
Department of Dermatology, University Medicine, Johannes Gutenberg University, Mainz, Germany
PLoS ONE 6:e20566. 2011..Here, we assessed clinical efficacy and histopathological alterations induced by blue light-treatment of AD within an observational, non-interventional study... - Chronic infiltrates and persisting ulcerations on the arms and legsEsther von Stebut
Johannes Gutenberg-University, Mainz, Germany
Arch Dermatol 141:897-902. 2005 - Clinical features and epidemiology of cutaneous leishmaniasis and Leishmania major/HIV co-infection in Cameroon: results of a large cross-sectional studyOmer Bébe Ngouateu
Department of Animal Biology and Physiology, University of Yaounde I, Yaounde, Cameroon
Trans R Soc Trop Med Hyg 106:137-42. 2012..These findings provide important data necessary for the development and implementation of successful control programmes against CL and HIV in this geographical area... - CD8+ T cells are required for primary immunity in C57BL/6 mice following low-dose, intradermal challenge with Leishmania majorYasmine Belkaid
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, and Dermatology Branch, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 168:3992-4000. 2002..The low dose, intradermal challenge model reveals that CD8(+) T cells play an essential role in both pathogenesis of and immunity to primary infection with L. major in the skin...