Clemens von Schacky

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. ncbi request reprint The effect of dietary omega-3 fatty acids on coronary atherosclerosis. A randomized, double-blind, placebo-controlled trial
    C von Schacky
    University of Munich, Germany
    Ann Intern Med 130:554-62. 1999
  2. ncbi request reprint [Omega-3-fatty acids, Mediterranean cooking, low-fat diet. What really prevents myocardial infarct?]
    C von Schacky
    Medizinische Klinik Innenstadt Klinikum der Universität München
    MMW Fortschr Med 144:37-9. 2002
  3. ncbi request reprint The role of omega-3 fatty acids in cardiovascular disease
    Clemens von Schacky
    Medizinische Klinik Innenstadt, Klinikum der Universitat, Ziemssenstr 1, 80336 Munich, Germany
    Curr Atheroscler Rep 5:139-45. 2003
  4. ncbi request reprint [Secondary prevention of coronary heart disease]
    C von Schacky
    Medizinische Klinik und Poliklinik Innenstadt, Munchen
    MMW Fortschr Med 145:28, 30, 32-3. 2003
  5. ncbi request reprint n-3 fatty acids and the prevention of coronary atherosclerosis
    C von Schacky
    Medizinische Klinik, Klinikum Innenstadt, University of Munich, Germany
    Am J Clin Nutr 71:224S-7S. 2000
  6. ncbi request reprint The effect of n-3 fatty acids on coronary atherosclerosis: results from SCIMO, an angiographic study, background and implications
    C von Schacky
    Medizinische Klinik Innenstadt, Klinikum der Universitat Munchen, Germany
    Lipids 36:S99-102. 2001
  7. doi request reprint Cardiovascular disease prevention and treatment
    Clemens von Schacky
    Preventive Cardiology, Medizinische Clinic and Policlinic Innenstadt, University of Munich, Ziemssensstr 1, D 80336 Munich, Germany
    Prostaglandins Leukot Essent Fatty Acids 81:193-8. 2009
  8. ncbi request reprint Omega-3 fatty acids and cardiovascular disease
    Clemens von Schacky
    Preventive Cardiology, Medizinische Klinik und Poliklinik Innenstadt, Ludwig Maximilians Universitat Munchen, Munich, Germany
    Curr Opin Clin Nutr Metab Care 10:129-35. 2007
  9. doi request reprint Omega-3 fatty acids: antiarrhythmic, proarrhythmic or both?
    Clemens von Schacky
    Preventive Cardiology, University of Munich, and Omegametrix, Martinsried, Germany
    Curr Opin Clin Nutr Metab Care 11:94-9. 2008
  10. ncbi request reprint Effect of oral postmenopausal hormone replacement on progression of atherosclerosis : a randomized, controlled trial
    P Angerer
    Medizinische Klinik, , , Germany
    Arterioscler Thromb Vasc Biol 21:262-8. 2001

Detail Information

Publications37

  1. ncbi request reprint The effect of dietary omega-3 fatty acids on coronary atherosclerosis. A randomized, double-blind, placebo-controlled trial
    C von Schacky
    University of Munich, Germany
    Ann Intern Med 130:554-62. 1999
    ..Epidemiologic studies, studies of mechanisms of action, and many animal studies indicate that dietary intake of omega-3 fatty acids has antiatherosclerotic potential. Few trials in humans have examined this potential...
  2. ncbi request reprint [Omega-3-fatty acids, Mediterranean cooking, low-fat diet. What really prevents myocardial infarct?]
    C von Schacky
    Medizinische Klinik Innenstadt Klinikum der Universität München
    MMW Fortschr Med 144:37-9. 2002
    ..The results of ongoing studies on the use of vitamin supplements are as yet unavailable...
  3. ncbi request reprint The role of omega-3 fatty acids in cardiovascular disease
    Clemens von Schacky
    Medizinische Klinik Innenstadt, Klinikum der Universitat, Ziemssenstr 1, 80336 Munich, Germany
    Curr Atheroscler Rep 5:139-45. 2003
    ..Unfortunately, this complicates efficient implementation of an effective means of prophylaxis of atherosclerosis...
  4. ncbi request reprint [Secondary prevention of coronary heart disease]
    C von Schacky
    Medizinische Klinik und Poliklinik Innenstadt, Munchen
    MMW Fortschr Med 145:28, 30, 32-3. 2003
    ..Quality-controlled close cooperation by the family doctor and cardiologist arguably provides the best long-term care in the area of secondary prevention, but still remains utopian...
  5. ncbi request reprint n-3 fatty acids and the prevention of coronary atherosclerosis
    C von Schacky
    Medizinische Klinik, Klinikum Innenstadt, University of Munich, Germany
    Am J Clin Nutr 71:224S-7S. 2000
    ..Large-scale clinical studies with endpoints such as morbidity and mortality are needed to more precisely define the role of n-3 fatty acids in primary and secondary prophylaxis of coronary atherosclerosis...
  6. ncbi request reprint The effect of n-3 fatty acids on coronary atherosclerosis: results from SCIMO, an angiographic study, background and implications
    C von Schacky
    Medizinische Klinik Innenstadt, Klinikum der Universitat Munchen, Germany
    Lipids 36:S99-102. 2001
    ..Together, our investigations lend support to the importance of PDGF-A, PDGF-B, and MCP-1 in the pathogenesis of atherosclerosis, and the beneficial role of n-3 fatty acids therein...
  7. doi request reprint Cardiovascular disease prevention and treatment
    Clemens von Schacky
    Preventive Cardiology, Medizinische Clinic and Policlinic Innenstadt, University of Munich, Ziemssensstr 1, D 80336 Munich, Germany
    Prostaglandins Leukot Essent Fatty Acids 81:193-8. 2009
    ..EPA and DHA prevent fatal and non-fatal cardiovascular disease and complications of congestive heart failure...
  8. ncbi request reprint Omega-3 fatty acids and cardiovascular disease
    Clemens von Schacky
    Preventive Cardiology, Medizinische Klinik und Poliklinik Innenstadt, Ludwig Maximilians Universitat Munchen, Munich, Germany
    Curr Opin Clin Nutr Metab Care 10:129-35. 2007
    ..EPA and DHA have advanced from scientific research into everyday practice, a development reviewed here...
  9. doi request reprint Omega-3 fatty acids: antiarrhythmic, proarrhythmic or both?
    Clemens von Schacky
    Preventive Cardiology, University of Munich, and Omegametrix, Martinsried, Germany
    Curr Opin Clin Nutr Metab Care 11:94-9. 2008
    ..Recent publications seem to indicate no or an untoward effect of the marine omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid on cardiac rhythm. This review puts these developments into perspective...
  10. ncbi request reprint Effect of oral postmenopausal hormone replacement on progression of atherosclerosis : a randomized, controlled trial
    P Angerer
    Medizinische Klinik, , , Germany
    Arterioscler Thromb Vasc Biol 21:262-8. 2001
    ..2). HRT significantly decreased LDL cholesterol, fibrinogen, and follicle-stimulating hormone. In conclusion, 1 year of HRT was not effective in slowing progression of subclinical atherosclerosis in postmenopausal women at increased risk...
  11. doi request reprint The Omega-3 Index as a risk factor for cardiovascular diseases
    Clemens von Schacky
    Preventive Cardiology, Medizinische Klinik and Poliklinik Innenstadt, Ludwig Maximilians University Munich, Ziemssenstr 1, 80336 Munich, Germany
    Prostaglandins Other Lipid Mediat 96:94-8. 2011
    ..Future results will add precision to the value of the Omega-3 Index in cardiology, and probably expand its application to other areas, like psychiatry and pregnancy...
  12. ncbi request reprint Effect of dietary supplementation with omega-3 fatty acids on progression of atherosclerosis in carotid arteries
    Peter Angerer
    Klinikum der Universitat Munchen, Institut und Poliklinik für Arbeits und Umweltmedizin Innenstadt, Ziemssenstrasse 1, Germany
    Cardiovasc Res 54:183-90. 2002
    ..Embedded in this trial, the present study examined the influence of 2 years of dietary supplementation with 1.65 g omega-3 PUFA per day on progression of carotid atherosclerosis in 223 patients with coronary artery disease...
  13. pmc A review of omega-3 ethyl esters for cardiovascular prevention and treatment of increased blood triglyceride levels
    Clemens von Schacky
    Medizinische Klinik and Poliklinik Innenstadt, University of Munich, Munich, Germany
    Vasc Health Risk Manag 2:251-62. 2006
    ..As a consequence, relevant cardiac societies recommend using 1 g/day of EPA and DHA for cardiovascular prevention, after a myocardial infarction and for prevention of sudden cardiac death...
  14. ncbi request reprint Cardiovascular benefits of omega-3 fatty acids
    Clemens von Schacky
    Medizinische Klinik und Poliklinik Innenstadt, Ludwig Maximilians Universitat Munchen, Ziemssenstrasse 1, D 80336 Munich, Germany
    Cardiovasc Res 73:310-5. 2007
    ..As is the case now for LDL, in the future, the cardiac societies might very well recommend treatment with EPA and DHA to become goal oriented (e.g. an omega-3 index>8%)...
  15. ncbi request reprint Use of red blood cell fatty-acid profiles as biomarkers in cardiac disease
    Clemens von Schacky
    Preventive Cardiology, Medizinische Klinik and Poliklinik Innenstadt, Ziemssenstr 1, , Germany and, Omegametrix, Am Klopferspitz19, D 82152 Martinsried, Germany
    Biomark Med 3:25-32. 2009
    ..Ongoing research will define the value of the Omega-3 Index as a risk factor and treatment parameter more precisely...
  16. ncbi request reprint [Omega-3 fatty acids in cardiology. Latest developments]
    Clemens von Schacky
    Medizinische Klinik und Poliklinik der Ludwig Maximilians Universität München und Omegametrix, Martinsried
    MMW Fortschr Med 149:97-101. 2007
    ..Due to methodological considerations and analytical problems, it is advisable to have the omega-3 index determined in certified laboratories...
  17. ncbi request reprint Effect of postmenopausal hormone replacement on atherosclerosis in femoral arteries
    Peter Angerer
    Klinikum der Universitat Munchen, Institut und Poliklinik für Arbeits und Umweltmedizin, Medizinische Klinik Innenstadt, Ziemssenstrasse 1, 80336 Munchen, Germany
    Maturitas 41:51-60. 2002
    ..025 mg gestodene in every month (HRT 1), or in every third month (HRT 2) slows the increase of intima-media thickness in femoral arteries compared with no HRT...
  18. ncbi request reprint Endothelial function of the popliteal artery in patients with coronary artery disease
    P Angerer
    Medizinische Klinik, Klinikum der Universitat Munchen Innenstadt, Ziemssenstrasse 1, 80336, Munich, Germany
    Atherosclerosis 155:187-93. 2001
    ..We conclude that maximum vasomotion may be more sensitive for detection of endothelial dysfunction than FMD. Endothelial dysfunction in patients with CAD is more pronounced in the popliteal artery than in the brachial artery...
  19. ncbi request reprint Omega-3 fatty acids vs. cardiac disease--the contribution of the omega-3 index
    C von Schacky
    Preventive Cardiology, Medizinische Klinik und Poliklinik Innenstadt, Ziemssenstrasse 1, Munich, Germany
    Cell Mol Biol (Noisy-le-grand) 56:93-101. 2010
    ..Currently ongoing and future scientific work on the basis of the Omega-3 Index will further define its value...
  20. ncbi request reprint n-3 polyunsaturated fatty acids and the cardiovascular system
    P Angerer
    Medizinische Klinik Innenstadt, Klinikum der Ludwig Maximilians Universität München, Munich, Germany
    Curr Opin Lipidol 11:57-63. 2000
    ..Marine n-3 polyunsaturated fatty acids retard coronary atherosclerosis and appear to prevent fatal arrhythmias; and they decrease mortality subsequent to myocardial infarction...
  21. ncbi request reprint n-3 polyunsaturated fatty acids and the cardiovascular system
    P Angerer
    Medizinische Klinik Innenstadt, Klinikum der Ludwig Maximilians Universität München, Munich, Germany
    Curr Opin Clin Nutr Metab Care 3:439-45. 2000
    ..Marine n-3 polyunsaturated fatty acids retard coronary atherosclerosis and appear to prevent fatal arrhythmias; and they decrease mortality subsequent to myocardial infarction...
  22. ncbi request reprint Influence of 17beta-oestradiol on blood pressure of postmenopausal women at high vascular risk
    P Angerer
    Klinikum der Universitat Munchen, Medizinische Klinik, Innenstadt, Munchen, Germany
    J Hypertens 19:2135-42. 2001
    ..All subjects had an increased risk for adverse vascular events as indicated by intima-media thickness of carotid arteries and standard risk factors...
  23. ncbi request reprint n-3 PUFA in CVD: influence of cytokine polymorphism
    C von Schacky
    Preventive Cardiology, Medizinische Klinik und Poliklinik Innenstadt, University of Munich, Ziemssenstrasse 1, D 80336 MUnchen, Germany
    Proc Nutr Soc 66:166-70. 2007
    ..The precise underlying mechanism, however, remains to be clarified, but might involve PPAR, NF-kappaB and/or the eicosanoid system. The same holds true for the mechanisms by which levels of other cytokines are altered by EPA and DHA...
  24. ncbi request reprint [Cardiovascular prevention and rehabilitation]
    C von Schacky
    Medizinische Klinik und Poliklinik Innenstadt, Klinikum der Ludwig Maximilians Universität München
    Internist (Berl) 45:182-8. 2004
    ..A number of structural problems add to individual factors impeding optimal implementation of cardiovascular prevention in Germany...
  25. ncbi request reprint Impact of social support, cynical hostility and anger expression on progression of coronary atherosclerosis
    P Angerer
    Medizinische Klinik der Universität München Innenstadt, Munich, Germany
    J Am Coll Cardiol 36:1781-8. 2000
    ..This prospective cohort study of patients with coronary artery disease (CAD) sought to determine the impact of social support, anger expression and cynical hostility on progression of coronary atherosclerosis as shown by angiography...
  26. ncbi request reprint [Statin therapy in patients with acute coronary syndrome. "Prove-it" study]
    C von Schacky
    Abteilung fur Kardiologie, Medizinische Poliklinik Innenstadt, Munchen
    Internist (Berl) 45:1437-9. 2004
  27. ncbi request reprint Bone sialoprotein is a specific biochemical marker of bone metabolism in postmenopausal women: a randomized 1-year study
    S Stork
    Department of Medicine, Ludwig Maximilians Universitat Munchen, Munich, Germany
    Osteoporos Int 11:790-6. 2000
    ..In conclusion, serum BSP circumvents some of the limitations of urinary measurements and appears valuable for the quantitative monitoring of the skeletal response to HRT in healthy postmenopausal women...
  28. ncbi request reprint Hormone replacement therapy and distensibility of carotid arteries in postmenopausal women: a randomized, controlled trial
    P Angerer
    Medizinische Klinik, Klinikum der Universitat Munchen Innenstadt, Germany
    J Am Coll Cardiol 36:1789-96. 2000
    ....
  29. ncbi request reprint The effect of 17beta-estradiol on endothelial and inflammatory markers in postmenopausal women: a randomized, controlled trial
    Stefan Störk
    Medizinische Klinik, Klinikum der Ludwig Maximilians Universität München Innenstadt, Munchen, Germany
    Atherosclerosis 165:301-7. 2002
    ....
  30. ncbi request reprint Coronary artery disease
    Clemens von Schacky
    Medizinische Klinik Innenstadt, Klinikum der Ludwig Maximilians Universität München, Germany
    Dtsch Med Wochenschr 127:2429-31. 2002
    ..Primary and secondary prevention are already giving way to risk-adapted prevention, based on an individual assessment of a person's cardiovascular risk...
  31. ncbi request reprint Cardiovascular risk and the omega-3 index
    Clemens von Schacky
    Preventive Cardiology, Medizinische Klinik und Poliklinik Innenstadt, Ludwig Maximilians Universitat Munchen, Munich, Germany
    J Cardiovasc Med (Hagerstown) 8:S46-9. 2007
    ..Cardiac societies recommend EPA + DHA for prevention of SCD. The omega-3 index can assess risk for SCD and monitor therapy with EPA + DHA. Moreover, it compares very favourably with other risk factors for SCD...
  32. ncbi request reprint Omega-3 fatty acids and cardiovascular disease
    Clemens von Schacky
    Medical Clinic and Policlinic Innenstadt, University of Munich, Ziemssenstrasse 1, D 80336 Munich, Germany
    Curr Opin Clin Nutr Metab Care 7:131-6. 2004
    ..Omega-3 fatty acids are gaining acceptance in the cardiovascular field. The present review describes the most recent studies and developments in the field...
  33. ncbi request reprint The effect of 17 beta-estradiol on MCP-1 serum levels in postmenopausal women
    Stefan Störk
    Medizinische Klinik, Klinikum der Universitat Munchen Innenstadt, Ziemssenstr 1, D 80336 MUnchen, Germany
    Cardiovasc Res 53:642-9. 2002
    ..We aimed to assess (1) the range of circulating MCP-1 levels in postmenopausal women, (2) the correlation between MCP-1 and atherosclerotic burden, and (3) the effects of commencement and discontinuation of HRT on MCP-1 serum levels...
  34. ncbi request reprint The Omega-3 Index: a new risk factor for death from coronary heart disease?
    William S Harris
    Lipid and Diabetes Research Center, Mid America Heart Institute of Saint Luke s Hospital, University of Missouri KC School of Medicine, Kansas City, MO 64111, USA
    Prev Med 39:212-20. 2004
    ..Red blood cell (RBC) fatty acid (FA) composition reflects long-term intake of EPA + DHA. We propose that the RBC EPA + DHA (hereafter called the Omega-3 Index) be considered a new risk factor for death from CHD...
  35. ncbi request reprint Low levels of adiponectin predict worsening of arterial morphology and function
    Stefan Störk
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
    Atherosclerosis 194:e147-53. 2007
    ..We conclude that low levels of adiponectin are associated with adverse changes in morphology and function of central arteries over time independently of other cardiovascular risk factors in postmenopausal non-diabetic women...
  36. ncbi request reprint Carotid artery plaque burden, stiffness, and mortality risk in elderly men: a prospective, population-based cohort study
    Stefan Störk
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Circulation 110:344-8. 2004
    ..Carotid artery morphology (plaque burden) and function (stiffness indexes) as predictors of all-cause and cardiovascular mortality were prospectively evaluated in elderly men...
  37. ncbi request reprint C-reactive protein is associated with polymorphisms of the angiotensin-converting enzyme gene in major depressed patients
    Sibylle Häfner
    J Psychiatr Res 42:163-5. 2008