Christine A F von Arnim

Summary

Affiliation: University of Ulm
Country: Germany

Publications

  1. pmc Micronutrients supplementation and nutritional status in cognitively impaired elderly persons: a two-month open label pilot study
    Christine A F von Arnim
    Department of Neurology, Ulm University, Oberer Eselsberg 45, 89081 Ulm, Germany
    Nutr J 12:148. 2013
  2. doi request reprint More than the sum of its parts? Nutrition in Alzheimer's disease
    Christine A F von Arnim
    Department of Neurology, Ulm University, Ulm, Germany
    Nutrition 26:694-700. 2010
  3. doi request reprint Impact of cholesterol level upon APP and BACE proximity and APP cleavage
    Christine A F von Arnim
    Deparment of Neurology, Ulm University, Albert Einstein Allee 11, 89081 Ulm, Germany
    Biochem Biophys Res Commun 370:207-12. 2008
  4. doi request reprint The role of low-density receptor-related protein 1 (LRP1) as a competitive substrate of the amyloid precursor protein (APP) for BACE1
    Bjoern von Einem
    Dept of Neurology, Ulm University, Albert Einstein Allee 11, 89081 Ulm, Germany
    Exp Neurol 225:85-93. 2010
  5. doi request reprint Amyloid beta 1-42 in cerebrospinal fluid is associated with cognitive plasticity
    Ingo Uttner
    Neurologische Klinik der Universität Ulm, Oberer Eselsberg 45, 89081 Ulm, Germany
    Psychiatry Res 190:132-6. 2011
  6. pmc TDP-43 in cerebrospinal fluid of patients with frontotemporal lobar degeneration and amyotrophic lateral sclerosis
    Petra Steinacker
    Department of Neurology, University of Ulm, Ulm, Germany
    Arch Neurol 65:1481-7. 2008
  7. doi request reprint Glial fibrillary acidic protein and protein S-100B: different concentration pattern of glial proteins in cerebrospinal fluid of patients with Alzheimer's disease and Creutzfeldt-Jakob disease
    Sarah Jesse
    Department of Neurology, University of Ulm, Ulm, Germany
    J Alzheimers Dis 17:541-51. 2009
  8. pmc Engulfment adaptor phosphotyrosine-binding-domain-containing 1 (GULP1) is a nucleocytoplasmic shuttling protein and is transactivationally active together with low-density lipoprotein receptor-related protein 1 (LRP1)
    Anke Wahler
    Department of Neurology, Ulm University, 89081 Ulm, Germany
    Biochem J 450:333-43. 2013
  9. pmc Differential sialylation of serpin A1 in the early diagnosis of Parkinson's disease dementia
    Sarah Jesse
    Department of Neurology, University of Ulm, Ulm, Germany
    PLoS ONE 7:e48783. 2012
  10. doi request reprint Engulfment adapter PTB domain containing 1 interacts with and affects processing of the amyloid-β precursor protein
    Anja Silke Beyer
    Department of Neurology, Center for Clinical Research, Ulm University, Helmholtzstrasse 8 1, D 89081 Ulm, Germany
    Neurobiol Aging 33:732-43. 2012

Collaborators

Detail Information

Publications25

  1. pmc Micronutrients supplementation and nutritional status in cognitively impaired elderly persons: a two-month open label pilot study
    Christine A F von Arnim
    Department of Neurology, Ulm University, Oberer Eselsberg 45, 89081 Ulm, Germany
    Nutr J 12:148. 2013
    ..For this reason, we wanted to determine the effect of micronutrient supplementation on blood and tissue levels and on general nutritional status in persons with mild or moderate cognitive impairment...
  2. doi request reprint More than the sum of its parts? Nutrition in Alzheimer's disease
    Christine A F von Arnim
    Department of Neurology, Ulm University, Ulm, Germany
    Nutrition 26:694-700. 2010
    ..Approaches with multiple nutritional components might be promising...
  3. doi request reprint Impact of cholesterol level upon APP and BACE proximity and APP cleavage
    Christine A F von Arnim
    Deparment of Neurology, Ulm University, Albert Einstein Allee 11, 89081 Ulm, Germany
    Biochem Biophys Res Commun 370:207-12. 2008
    ..To analyze the impact of alterations in cholesterol level upon BACE-cleavage, we measured sAPP secretion. Alteration of APP processing and BACE proximity by cholesterol might be explained by alterations in cell membrane fluidity...
  4. doi request reprint The role of low-density receptor-related protein 1 (LRP1) as a competitive substrate of the amyloid precursor protein (APP) for BACE1
    Bjoern von Einem
    Dept of Neurology, Ulm University, Albert Einstein Allee 11, 89081 Ulm, Germany
    Exp Neurol 225:85-93. 2010
    ..In conclusion, our data suggest that--in addition to its role in APP trafficking--LRP1 affects APP processing by competing for cleavage by BACE1...
  5. doi request reprint Amyloid beta 1-42 in cerebrospinal fluid is associated with cognitive plasticity
    Ingo Uttner
    Neurologische Klinik der Universität Ulm, Oberer Eselsberg 45, 89081 Ulm, Germany
    Psychiatry Res 190:132-6. 2011
    ..Also, none of the standard tests correlates with Abeta 42-1 level. T-tau does not correlate with recognition performance. Our results suggest that Abeta(1-42) could be useful as a state marker for cognitive plasticity...
  6. pmc TDP-43 in cerebrospinal fluid of patients with frontotemporal lobar degeneration and amyotrophic lateral sclerosis
    Petra Steinacker
    Department of Neurology, University of Ulm, Ulm, Germany
    Arch Neurol 65:1481-7. 2008
    ..It was demonstrated that different TDP-43 profiles correspond to clinical phenotypes of FTLD or ALS subgroups, and the differential diagnostic potential of TDP-43 was suggested...
  7. doi request reprint Glial fibrillary acidic protein and protein S-100B: different concentration pattern of glial proteins in cerebrospinal fluid of patients with Alzheimer's disease and Creutzfeldt-Jakob disease
    Sarah Jesse
    Department of Neurology, University of Ulm, Ulm, Germany
    J Alzheimers Dis 17:541-51. 2009
    ....
  8. pmc Engulfment adaptor phosphotyrosine-binding-domain-containing 1 (GULP1) is a nucleocytoplasmic shuttling protein and is transactivationally active together with low-density lipoprotein receptor-related protein 1 (LRP1)
    Anke Wahler
    Department of Neurology, Ulm University, 89081 Ulm, Germany
    Biochem J 450:333-43. 2013
    ..The results from the present study indicate that Fe65 might have signalling properties together with APP and LRP1, whereas GULP1 only mediates LRP1 transactivation...
  9. pmc Differential sialylation of serpin A1 in the early diagnosis of Parkinson's disease dementia
    Sarah Jesse
    Department of Neurology, University of Ulm, Ulm, Germany
    PLoS ONE 7:e48783. 2012
    ..On the basis of these results, we conclude that differentially sialylated products of Serpin A1 are an interesting biomarker to indicate the development of a dementia during the course of PD...
  10. doi request reprint Engulfment adapter PTB domain containing 1 interacts with and affects processing of the amyloid-β precursor protein
    Anja Silke Beyer
    Department of Neurology, Center for Clinical Research, Ulm University, Helmholtzstrasse 8 1, D 89081 Ulm, Germany
    Neurobiol Aging 33:732-43. 2012
    ..Taken together, these data identify GULP1 as a novel neuronal APP interacting protein that alters trafficking and processing of APP...
  11. doi request reprint Ubiquitin as potential cerebrospinal fluid marker of Creutzfeldt-Jakob disease
    Petra Steinacker
    Department of Neurology, University of Ulm, Germany
    Proteomics 10:81-9. 2010
    ..The selective increase of ubiquitin in CSF of CJD patients might point to an involvement of ubiquitin in pathophysiological process...
  12. doi request reprint Dietary antioxidants and dementia in a population-based case-control study among older people in South Germany
    Christine A F von Arnim
    Department of Neurology, Ulm University, Ulm, Germany
    J Alzheimers Dis 31:717-24. 2012
    ..Our findings suggest an association of vitamin C and β-carotene with dementia. However this is limited to the cross-sectional character of our study and longitudinal data will give further insight into this association...
  13. doi request reprint Genetic variants in PSEN2 and correlation to CSF β-amyloid42 levels in AD
    Elena Lebedeva
    Institute of Pharmacology of Natural Products and Clinical Pharmacology, Ulm University, Ulm, Germany
    Neurobiol Aging 33:201.e9-18. 2012
    ..A better understanding of genetic influences on biomarkers like CSF Aβ42 might help to stratify patients and develop specific treatment strategies...
  14. doi request reprint The Golgi-Localized γ-Ear-Containing ARF-Binding (GGA) Proteins Alter Amyloid-β Precursor Protein (APP) Processing through Interaction of Their GAE Domain with the Beta-Site APP Cleaving Enzyme 1 (BACE1)
    Bjoern von Einem
    Institute of Neurology, Ulm University, Helmholtzstraße 8 1, 89081 Ulm, Germany
    PLoS ONE 10:e0129047. 2015
    ..Autoinhibition of the GGA1-VHS domain was irrelevant for BACE1 interaction. Our data suggest that all three GGAs affect APP processing via the GGA-GAE domain. ..
  15. doi request reprint Neurofilaments in the diagnosis of motoneuron diseases: a prospective study on 455 patients
    Petra Steinacker
    Department of Neurology, University of Ulm, Ulm, Germany
    J Neurol Neurosurg Psychiatry 87:12-20. 2016
    ....
  16. pmc Visualizing interaction of proteins relevant to Alzheimer's disease in intact cells
    Anne V Thomas
    Department of Neurology, University of Cologne, Germany
    Methods 44:299-303. 2008
    ....
  17. pmc Summary of cerebrospinal fluid routine parameters in neurodegenerative diseases
    Sarah Jesse
    Department of Neurology, University of Ulm, Steinhovelstr 1, 89075, Ulm, Germany
    J Neurol 258:1034-41. 2011
    ..Extensive elevation of routine parameters is not characteristic and should encourage a re-evaluation of the clinical diagnosis...
  18. doi request reprint Intact protein analysis of ubiquitin in cerebrospinal fluid by multiple reaction monitoring reveals differences in Alzheimer's disease and frontotemporal lobar degeneration
    Patrick Oeckl
    Department of Neurology, Ulm University Hospital, Oberer Eselsberg 45, 89081 Ulm, Germany
    J Proteome Res 13:4518-25. 2014
    ..776, and the specificity and sensitivity were 53 and 100%, respectively. In conclusion, our LC-MS/MS method may facilitate ubiquitin determination to a broader community and might help to discriminate AD, CJD, and FTLD patients. ..
  19. doi request reprint Biochemical stages of amyloid-β peptide aggregation and accumulation in the human brain and their association with symptomatic and pathologically preclinical Alzheimer's disease
    Ajeet Rijal Upadhaya
    1 Laboratory of Neuropathology, Institute of Pathology, Centre for Clinical Research at the University of Ulm, Ulm, Germany
    Brain 137:887-903. 2014
    ....
  20. doi request reprint Reduced benefit from mnemonic strategies in early-stage Alzheimer's disease: a brief testing-the-limits paradigm for clinical practice
    Ingo Uttner
    Neurologische Klinik der Universität Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany
    J Neurol 257:1718-26. 2010
    ..Our data confirm the finding of an impaired cognitive plasticity already present in very early stages of AD and illustrate the efficiency of a dynamic test approach in identifying incipient dementia...
  21. doi request reprint Efficient processing of Alzheimer's disease amyloid-Beta peptides by neuroectodermally converted mesenchymal stem cells
    Hans Jörg Habisch
    Department of Neurology, University of Ulm, Ulm, Germany
    Stem Cells Dev 19:629-33. 2010
    ..These in vitro results indicate that MSCs might be useful vehicles for delivering anti-Abeta activity depicting a causal stem cell-based therapeutic approach to treat AD...
  22. doi request reprint Frontotemporal lobar degeneration FTLD-tau: preclinical lesions, vascular, and Alzheimer-related co-pathologies
    Dietmar Rudolf Thal
    Laboratory of Neuropathology, Institute of Pathology, Center for Clinical Research, Ulm University, Ulm, Germany
    J Neural Transm (Vienna) 122:1007-18. 2015
    ..As such, our results indicate that age, together with vascular and AD-related copathology, contributes to the morphological appearance of FTLD-tau...
  23. doi request reprint Serum microRNAs in sporadic amyotrophic lateral sclerosis
    Axel Freischmidt
    Department of Neurology, Ulm University, Ulm, Germany
    Neurobiol Aging 36:2660.e15-20. 2015
    ..Moreover, our results indicate a more heterogeneous molecular etiology of sporadic ALS compared with (mono)genic cases, which should be considered for the development of disease modifying treatments. ..
  24. doi request reprint Concentrations of beta-amyloid precursor protein processing products in cerebrospinal fluid of patients with amyotrophic lateral sclerosis and frontotemporal lobar degeneration
    Petra Steinacker
    Department of Neurology, University of Ulm, Ulm, Germany
    J Neural Transm (Vienna) 116:1169-78. 2009
    ..We propose to expand this study to larger patient groups comprising followed up cases with known neuropathology...
  25. doi request reprint Spectrally resolved fluorescence lifetime imaging microscopy: Förster resonant energy transfer global analysis with a one- and two-exponential donor model
    Daniela Strat
    University of Ulm, Institut for Lasertechnologies in Medicine, Helmholtzstrasse 12, Ulm, Baden Wurttenberg 89081, Germany
    J Biomed Opt 16:026002. 2011
    ..We attempt to verify if an improvement in calculating the donor lifetimes could be achieved when time-resolved and spectrally resolved techniques are simultaneously incorporated...