P H Vogt

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. ncbi request reprint Molecular genetics of human male infertility: from genes to new therapeutic perspectives
    Peter H Vogt
    Section Molecular Genetics and Infertility, Dept Gynecol Endocrinol and Reproductive Medicine, University of Heidelberg, D 69115 Heidelberg, Germany
    Curr Pharm Des 10:471-500. 2004
  2. ncbi request reprint Azoospermia factor (AZF) in Yq11: towards a molecular understanding of its function for human male fertility and spermatogenesis
    Peter H Vogt
    Section of Molecular Genetics and Infertility, Department of Gynecological Endocrinology and Reproductive Medicine, University of Heidelberg, Heidelberg, Germany
    Reprod Biomed Online 10:81-93. 2005
  3. ncbi request reprint Introduction: basic science meets the clinic
    Peter H Vogt
    Section Molecular Genetics and Infertility, Department of Gynecology, Endocrinology and Reproductive Medicine, University of Heidelberg, D 69115 Heidelberg, Germany
    Reprod Biomed Online 10:11-3. 2005
  4. ncbi request reprint Genomic heterogeneity and instability of the AZF locus on the human Y chromosome
    Peter H Vogt
    Section of Molecular Genetics and Infertility, Department of Gynecological Endocrinology and Reproductive Medicine, University of Heidelberg, Vossstrasse 9, D 69115 Heidelberg, FRG, Heidelberg, Germany
    Mol Cell Endocrinol 224:1-9. 2004
  5. ncbi request reprint AZF deletions and Y chromosomal haplogroups: history and update based on sequence
    Peter H Vogt
    Section of Molecular Genetics and Infertility, Department of Gynecological Endocrinology and Reproductive Medicine, University of Heidelberg, Heidelberg, Germany
    Hum Reprod Update 11:319-36. 2005
  6. doi request reprint The AZF proteins
    P H Vogt
    Molecular Genetics and Infertility Unit, Department of Gynecology, Endocrinology and Infertility, University Women Hospital, Heidelberg, Germany
    Int J Androl 31:383-94. 2008
  7. ncbi request reprint Polymorphic DAZ gene family in polymorphic structure of AZFc locus: Artwork or functional for human spermatogenesis?
    Peter H Vogt
    Section Molecular Genetics and Infertility, Department Gynecol Endocrinol and Reproductive Medicine, University of Heidelberg, D 69115 Heidelberg, Germany
    APMIS 111:115-26; discussion 126-7. 2003
  8. pmc A large AZFc deletion removes DAZ3/DAZ4 and nearby genes from men in Y haplogroup N
    S Fernandes
    Section of Molecular Genetics and Infertility, Department of Gynecological Endocrinology and Reproductive Medicine, University of Heidelberg, Heidelberg, Germany
    Am J Hum Genet 74:180-7. 2004
  9. ncbi request reprint High deletion frequency of the complete AZFa sequence in men with Sertoli-cell-only syndrome
    C Kamp
    Reproduction Genetics, Institute of Human Genetics, University of Heidelberg, Im Neuenheimer Feld 328, D-69120 Heidelberg, Germany
    Mol Hum Reprod 7:987-94. 2001
  10. doi request reprint AZFa protein DDX3Y is differentially expressed in human male germ cells during development and in testicular tumours: new evidence for phenotypic plasticity of germ cells
    B Gueler
    Department of Gynaecological Endocrinology and Reproductive Medicine, University of Heidelberg, Heidelberg, Germany
    Hum Reprod 27:1547-55. 2012

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Molecular genetics of human male infertility: from genes to new therapeutic perspectives
    Peter H Vogt
    Section Molecular Genetics and Infertility, Dept Gynecol Endocrinol and Reproductive Medicine, University of Heidelberg, D 69115 Heidelberg, Germany
    Curr Pharm Des 10:471-500. 2004
    ....
  2. ncbi request reprint Azoospermia factor (AZF) in Yq11: towards a molecular understanding of its function for human male fertility and spermatogenesis
    Peter H Vogt
    Section of Molecular Genetics and Infertility, Department of Gynecological Endocrinology and Reproductive Medicine, University of Heidelberg, Heidelberg, Germany
    Reprod Biomed Online 10:81-93. 2005
    ..Genetic redundancy might exist in AZFc because a number of gene copies in the large P1 palindrome structure in distal AZFc were found to be deleted also in fertile men...
  3. ncbi request reprint Introduction: basic science meets the clinic
    Peter H Vogt
    Section Molecular Genetics and Infertility, Department of Gynecology, Endocrinology and Reproductive Medicine, University of Heidelberg, D 69115 Heidelberg, Germany
    Reprod Biomed Online 10:11-3. 2005
  4. ncbi request reprint Genomic heterogeneity and instability of the AZF locus on the human Y chromosome
    Peter H Vogt
    Section of Molecular Genetics and Infertility, Department of Gynecological Endocrinology and Reproductive Medicine, University of Heidelberg, Vossstrasse 9, D 69115 Heidelberg, FRG, Heidelberg, Germany
    Mol Cell Endocrinol 224:1-9. 2004
    ....
  5. ncbi request reprint AZF deletions and Y chromosomal haplogroups: history and update based on sequence
    Peter H Vogt
    Section of Molecular Genetics and Infertility, Department of Gynecological Endocrinology and Reproductive Medicine, University of Heidelberg, Heidelberg, Germany
    Hum Reprod Update 11:319-36. 2005
    ....
  6. doi request reprint The AZF proteins
    P H Vogt
    Molecular Genetics and Infertility Unit, Department of Gynecology, Endocrinology and Infertility, University Women Hospital, Heidelberg, Germany
    Int J Androl 31:383-94. 2008
    ....
  7. ncbi request reprint Polymorphic DAZ gene family in polymorphic structure of AZFc locus: Artwork or functional for human spermatogenesis?
    Peter H Vogt
    Section Molecular Genetics and Infertility, Department Gynecol Endocrinol and Reproductive Medicine, University of Heidelberg, D 69115 Heidelberg, Germany
    APMIS 111:115-26; discussion 126-7. 2003
    ....
  8. pmc A large AZFc deletion removes DAZ3/DAZ4 and nearby genes from men in Y haplogroup N
    S Fernandes
    Section of Molecular Genetics and Infertility, Department of Gynecological Endocrinology and Reproductive Medicine, University of Heidelberg, Heidelberg, Germany
    Am J Hum Genet 74:180-7. 2004
    ..These data confirm the expectation that the human Y chromosome sequence and gene complement may differ substantially between individuals and more variations are to be expected in different Y chromosomal haplogroups...
  9. ncbi request reprint High deletion frequency of the complete AZFa sequence in men with Sertoli-cell-only syndrome
    C Kamp
    Reproduction Genetics, Institute of Human Genetics, University of Heidelberg, Im Neuenheimer Feld 328, D-69120 Heidelberg, Germany
    Mol Hum Reprod 7:987-94. 2001
    ..This may provide a valuable prognostic tool for infertility clinics performing testicular sperm extraction, as it would enable the exclusion of AZFa patients with a complete SCO syndrome...
  10. doi request reprint AZFa protein DDX3Y is differentially expressed in human male germ cells during development and in testicular tumours: new evidence for phenotypic plasticity of germ cells
    B Gueler
    Department of Gynaecological Endocrinology and Reproductive Medicine, University of Heidelberg, Heidelberg, Germany
    Hum Reprod 27:1547-55. 2012
    ....
  11. ncbi request reprint High frequency of DAZ1/DAZ2 gene deletions in patients with severe oligozoospermia
    S Fernandes
    Reproduction Genetics, Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany
    Mol Hum Reprod 8:286-98. 2002
    ..It is most likely caused by intrachromosomal recombination events between two long repetitive sequence blocks (AZFc-Rep1) flanking the DAZ gene structures...
  12. ncbi request reprint Arylsulfatase D gene in Xp22.3 encodes two protein isoforms
    P Urbitsch
    Institute of Human Genetics, University of Heidelberg, INF 328, D 69120 Heidelberg, Germany
    DNA Cell Biol 19:765-73. 2000
    ....
  13. ncbi request reprint A SPGY copy homologous to the mouse gene Dazla and the Drosophila gene boule is autosomal and expressed only in the human male gonad
    Z Shan
    Institute of Human Genetics, University of Heidelberg, Germany
    Hum Mol Genet 5:2005-11. 1996
    ..SPGYLA encodes an RNA binding protein expressed only in the human male gonad. The data presented give strong evidence that not DAZ but SPGYLA is the functional human homologue of Dazla and boule...
  14. pmc Complex transcriptional control of the AZFa gene DDX3Y in human testis
    M A Rauschendorf
    Unit of Molecular Genetics and Infertility, Department of Gynecological Endocrinology and Reproductive Medicine, University of Heidelberg, Heidelberg, Germany
    Int J Androl 34:84-96. 2011
    ..We therefore suggest that the development of a novel distal DDX3Y promoter in primates, which is activated only in testis tissue, is probably part of the gene's germline translation control...
  15. doi request reprint Translational control of the AZFa gene DDX3Y by 5'UTR exon-T extension
    L Jaroszynski
    Unit Molecular Genetics and Fertility Disorders, Department of Gynecological Endocrinology and Fertility Disorders, University Women Hospital, Heidelberg
    Int J Androl 34:313-26. 2011
    ....
  16. ncbi request reprint Report of the Third International Workshop on Y Chromosome Mapping 1997. Heidelberg, Germany, April 13-16, 1997
    P H Vogt
    Institut fur Humangenetik, Universitat Heidelberg, Germany
    Cytogenet Cell Genet 79:1-20. 1997
  17. ncbi request reprint The AZFa gene DBY (DDX3Y) is widely transcribed but the protein is limited to the male germ cells by translation control
    H J Ditton
    Section of Molecular Genetics and Infertility, Department of Gynecological Endocrinology and Reproductive Medicine, University of Heidelberg, Heidelberg, Germany
    Hum Mol Genet 13:2333-41. 2004
    ....
  18. ncbi request reprint Human Y chromosome azoospermia factors (AZF) mapped to different subregions in Yq11
    P H Vogt
    Section Molecular Human Genetics, University of Heidelberg, Germany
    Hum Mol Genet 5:933-43. 1996
    ..As the most severe phenotype after deletion of each locus is azoospermia, we designated them as: AZFa, AZFb and AZFc. Their probable phase of function in human spermatogenesis and candidate genes involved will be discussed...
  19. ncbi request reprint Conservation of the deleted-in-azoospermia-like-1 (DAZL1) gene structure in old world monkeys points to a homologous function of DAZL1 in this primate class
    B Grossmann
    Reproduction Genetics in Institute of Human Genetics, University of Heidelberg, Germany
    J Endocrinol Invest 23:616-22. 2000
    ....
  20. doi request reprint Variable expression of the Fragile X Mental Retardation 1 (FMR1) gene in patients with premature ovarian failure syndrome is not dependent on number of (CGG)n triplets in exon 1
    J Schuettler
    Department of Gynecology Endocrinology, University Women Hospital, Heidelberg, Germany
    Hum Reprod 26:1241-51. 2011
    ..Increased CGG triplet numbers, including that of the so-called premutation range (n= 55-200), were shown to have a risk of <26% to impair ovarian reserve leading to primary ovarian insufficiency and premature ovarian failure (POF)...
  21. ncbi request reprint Polymorphisms associated with the DAZ genes on the human Y chromosome
    Yi Wen Lin
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan
    Genomics 86:431-8. 2005
    ..Additional polymorphisms identified within the DAZ repeat regions of the DAZ genes indicate that sister chromatid exchange plays a significant role in the genesis of deletions, duplications, and polymorphisms of the Y chromosome...
  22. pmc Sequence variation at the human FOXO3 locus: a study of premature ovarian failure and primary amenorrhea
    Teresa D Gallardo
    Department of Pathology, UT Southwestern Medical Center, Dallas, TX, USA
    Hum Reprod 23:216-21. 2008
    ..The forkhead transcription factor Foxo3 is a master regulator and potent suppressor of primordial follicle activation. Loss of Foxo3 function in the mouse leads to premature ovarian failure (POF) due to global follicle activation...
  23. ncbi request reprint Developmental expression of POU5F1 (OCT-3/4) in normal and dysgenetic human gonads
    Ewa Rajpert-De Meyts
    Department of Growth and Reproduction, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
    Hum Reprod 19:1338-44. 2004
    ....
  24. ncbi request reprint No AZF deletion in 160 patients with testicular germ cell neoplasia
    Lone Frydelund-Larsen
    University Department of Growth and Reproduction, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Mol Hum Reprod 9:517-21. 2003
    ..Malignant transformation of germ cells is thus caused by the dysfunction of some other genes that still need to be identified...