D Voehringer

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. pmc Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity
    Caspar Ohnmacht
    Institute for Immunology, Department of Medicine, University of Munich, 80336 Munich, Germany
    J Exp Med 206:549-59. 2009
  2. pmc Homeostasis and effector function of lymphopenia-induced "memory-like" T cells in constitutively T cell-depleted mice
    David Voehringer
    Howard Hughes Medical Institute, Department of Medicine, University of California, San Francisco, CA 94143, USA
    J Immunol 180:4742-53. 2008
  3. pmc Efficient generation of long-distance conditional alleles using recombineering and a dual selection strategy in replicate plates
    David Voehringer
    Howard Hughes Medical Institute, Department of Medicine, University of California San Francisco, San Francisco, CA 94143 0795, USA
    BMC Biotechnol 9:69. 2009
  4. doi The role of basophils in helminth infection
    David Voehringer
    Institute for Immunology, University of Munich, Goethestrasse 31, 80336 Munich, Germany
    Trends Parasitol 25:551-6. 2009
  5. ncbi [Allergies and parasites]
    D Voehringer
    Institut fur Immunologie, Ludwig Maximilians Universitat Munchen
    Dtsch Med Wochenschr 132:991-4. 2007
  6. doi Basophil effector function and homeostasis during helminth infection
    Caspar Ohnmacht
    Institute for Immunology, University of Munich, Munich, Germany
    Blood 113:2816-25. 2009
  7. doi Basophils protect against reinfection with hookworms independently of mast cells and memory Th2 cells
    Caspar Ohnmacht
    Institute for Immunology, University of Munich, Munich, Germany
    J Immunol 184:344-50. 2010
  8. pmc Type 2 immunity is controlled by IL-4/IL-13 expression in hematopoietic non-eosinophil cells of the innate immune system
    David Voehringer
    Howard Hughes Medical Institute, Departments of Medicine and Microbiology Immunology, University of California San Francisco, San Francisco, CA 94143, USA
    J Exp Med 203:1435-46. 2006
  9. ncbi Accumulation of effector CD4 T cells during type 2 immune responses is negatively regulated by Stat6
    Susan B S King
    Institute for Immunology, University of Munich, Munich, Germany
    J Immunol 180:754-63. 2008
  10. doi Basophils orchestrate chronic allergic dermatitis and protective immunity against helminths
    Caspar Ohnmacht
    Institute for Immunology, Ludwig Maximilians University, Munich, Germany
    Immunity 33:364-74. 2010

Collaborators

  • Richard Locksley
  • Reinhard Hoffmann
  • Ludger Klein
  • LEWIS LANIER
  • Daniel B Stetson
  • Andrew D Luster
  • Christian Bogdan
  • Wendy Peters
  • Caspar Ohnmacht
  • Heike Unsoeld
  • Hanspeter Pircher
  • Silke Huber
  • Susan B S King
  • Marie Koschella
  • Maria Hinterberger
  • Claudia J Wagner
  • Andrea Pullner
  • Christina C Lewis
  • Tiffany A Reese
  • Nico Van Rooijen
  • Isabel Marcolino
  • Stefan Krautwald
  • Martin Aichinger
  • Marc Panzer
  • Olivia Prazeres da Costa
  • Femke Muskens
  • Ronald Naumann
  • Christian Schwartz
  • Isabell Schiedewitz
  • Stefanie Wirth
  • Thomas Brocker
  • Stefanie Meier
  • Ingo Drexler
  • Timothy S Blackwell
  • Michael R Blackburn
  • Donald M McDonald
  • Peter Baluk
  • Xiaozhu Huang
  • David J Erle
  • Jean Yee Hwa Yang
  • Anna M Knorn
  • Vijaya Nagabhushanam
  • Suman K Banerjee
  • Ulrike Schleicher
  • Andrew M Tager
  • Hong Erh Liang
  • Katja Mueller
  • Jörg Zwirner
  • Grzegorz K Przybylski
  • Christian A Schmidt
  • Michael Schlesier
  • Ulrich Kunzendorf

Detail Information

Publications27

  1. pmc Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity
    Caspar Ohnmacht
    Institute for Immunology, Department of Medicine, University of Munich, 80336 Munich, Germany
    J Exp Med 206:549-59. 2009
    ..This demonstrates that DCs play an essential role to protect against fatal autoimmunity under steady-state conditions...
  2. pmc Homeostasis and effector function of lymphopenia-induced "memory-like" T cells in constitutively T cell-depleted mice
    David Voehringer
    Howard Hughes Medical Institute, Department of Medicine, University of California, San Francisco, CA 94143, USA
    J Immunol 180:4742-53. 2008
    ..Infection with the helminth Nippostrongylus brasiliensis resulted in diminished effector cell recruitment and impaired worm expulsion, demonstrating that T(ML) cells are not sufficient to mediate an effective immune response...
  3. pmc Efficient generation of long-distance conditional alleles using recombineering and a dual selection strategy in replicate plates
    David Voehringer
    Howard Hughes Medical Institute, Department of Medicine, University of California San Francisco, San Francisco, CA 94143 0795, USA
    BMC Biotechnol 9:69. 2009
    ..Therefore, we developed a new strategy to rapidly identify ES cells containing the desired allele...
  4. doi The role of basophils in helminth infection
    David Voehringer
    Institute for Immunology, University of Munich, Goethestrasse 31, 80336 Munich, Germany
    Trends Parasitol 25:551-6. 2009
    ..Recent work demonstrated that basophils contribute to initiation and execution of type 2 immunity. This review discusses the potential role of basophils for protective immunity against helminths...
  5. ncbi [Allergies and parasites]
    D Voehringer
    Institut fur Immunologie, Ludwig Maximilians Universitat Munchen
    Dtsch Med Wochenschr 132:991-4. 2007
  6. doi Basophil effector function and homeostasis during helminth infection
    Caspar Ohnmacht
    Institute for Immunology, University of Munich, Munich, Germany
    Blood 113:2816-25. 2009
    ....
  7. doi Basophils protect against reinfection with hookworms independently of mast cells and memory Th2 cells
    Caspar Ohnmacht
    Institute for Immunology, University of Munich, Munich, Germany
    J Immunol 184:344-50. 2010
    ..We conclude that basophils play a crucial role for worm expulsion during a memory type 2 immune response independently of mast cells and memory Th2 cells...
  8. pmc Type 2 immunity is controlled by IL-4/IL-13 expression in hematopoietic non-eosinophil cells of the innate immune system
    David Voehringer
    Howard Hughes Medical Institute, Departments of Medicine and Microbiology Immunology, University of California San Francisco, San Francisco, CA 94143, USA
    J Exp Med 203:1435-46. 2006
    ..Thus, components of type 2 immunity mediated by IL-4/IL-13 are partitioned between T cell-dependent IgE and an innate non-eosinophil tissue component, suggesting new strategies for interventions in allergic immunity...
  9. ncbi Accumulation of effector CD4 T cells during type 2 immune responses is negatively regulated by Stat6
    Susan B S King
    Institute for Immunology, University of Munich, Munich, Germany
    J Immunol 180:754-63. 2008
    ....
  10. doi Basophils orchestrate chronic allergic dermatitis and protective immunity against helminths
    Caspar Ohnmacht
    Institute for Immunology, Ludwig Maximilians University, Munich, Germany
    Immunity 33:364-74. 2010
    ....
  11. ncbi CD200 receptor family members represent novel DAP12-associated activating receptors on basophils and mast cells
    David Voehringer
    Department of Medicine, University of California San Francisco, CA 94143 0654, USA
    J Biol Chem 279:54117-23. 2004
    ....
  12. pmc Nippostrongylus brasiliensis: identification of intelectin-1 and -2 as Stat6-dependent genes expressed in lung and intestine during infection
    David Voehringer
    Department of Medicine and Microbiology, University of California San Francisco, San Francisco, CA 94143, USA
    Exp Parasitol 116:458-66. 2007
    ..Further, no significant modulation of the immune response in lung or lymph nodes was observed. Thus, under these conditions, intelectins did not enhance pathogen clearance...
  13. pmc Chitin induces accumulation in tissue of innate immune cells associated with allergy
    Tiffany A Reese
    Howard Hughes Medical Institute, Departments of Medicine and Microbiology Immunology, University of California San Francisco, San Francisco, California 94143 0795, USA
    Nature 447:92-6. 2007
    ..Chitin is a recognition element for tissue infiltration by innate cells implicated in allergic and helminth immunity and this process can be negatively regulated by a vertebrate chitinase...
  14. doi Chitin induces upregulation of B7-H1 on macrophages and inhibits T-cell proliferation
    Claudia J Wagner
    Institute for Immunology, Medical Faculty, University of Munich, Munich, Germany
    Eur J Immunol 40:2882-90. 2010
    ..Inhibition of T-cell proliferation was largely dependent on B7-H1, as the effect was not observed in cocultures with cells from B7-H1-deficient mice...
  15. ncbi Type 2 immunity reflects orchestrated recruitment of cells committed to IL-4 production
    David Voehringer
    Howard Hughes Medical Institute, Department of Medicine, University of California at San Francisco, San Francisco, CA 94143, USA
    Immunity 20:267-77. 2004
    ..Primary type 2 immune responses in the lung represent the focal recruitment and activation of discrete cell populations from the blood that have previously committed to express IL-4...
  16. doi Autonomous role of medullary thymic epithelial cells in central CD4(+) T cell tolerance
    Maria Hinterberger
    Institute for Immunology, Ludwig Maximilians Universitat, Munich, Germany
    Nat Immunol 11:512-9. 2010
    ..Our data document an autonomous contribution of mTECs to both dominant and recessive mechanisms of CD4(+) T cell tolerance and support an avidity model of T(reg) cell development versus deletion...
  17. doi Alternatively activated macrophages inhibit T-cell proliferation by Stat6-dependent expression of PD-L2
    Silke Huber
    Institute for Immunology, Ludwig Maximilians University, Munich, Germany
    Blood 116:3311-20. 2010
    ..In vivo blockade of PD-L2 during N brasiliensis infection caused an enhanced Th2 response in the lung, indicating that AAM inhibit Th2 cells by expression of PD-L2...
  18. ncbi Eosinophils develop in distinct stages and are recruited to peripheral sites by alternatively activated macrophages
    David Voehringer
    Howard Hughes Medical Institute, Department of Medicine, University of California San Francisco, San Francisco, California, USA
    J Leukoc Biol 81:1434-44. 2007
    ..Alternatively activated macrophages contributed substantially to tissue recruitment of eosinophils, providing a novel basis for development of therapeutic approaches to lower tissue eosinophilia...
  19. ncbi Analysis of eosinophil turnover in vivo reveals their active recruitment to and prolonged survival in the peritoneal cavity
    Caspar Ohnmacht
    Institute for Immunology, University of Munich, Munich, Germany
    J Immunol 179:4766-74. 2007
    ..These results demonstrate that the peritoneum serves as reservoir for eosinophils...
  20. ncbi Th2 cells: orchestrating barrier immunity
    Daniel B Stetson
    Howard Hughes Medical Institute, University of California San Francisco, 94143, USA
    Adv Immunol 83:163-89. 2004
  21. ncbi CD40 ligation in vivo induces bystander proliferation of memory phenotype CD8 T cells
    Marie Koschella
    Institute of Medical Microbiology and Hygiene, Department of Immunology, University of Freiburg, Freiburg, Germany
    J Immunol 172:4804-11. 2004
    ..In addition, we demonstrate that bona fide Ag-experienced memory CD8 T cells respond differently to anti-CD40-induced signals than memory phenotype CD8 T cells...
  22. ncbi Cutting edge: CCR7+ and CCR7- memory T cells do not differ in immediate effector cell function
    Heike Unsoeld
    Department of Immunology, Institute for Medical Microbiology and Hygiene, University of Freiburg, Freiburg, Germany
    J Immunol 169:638-41. 2002
    ..These results question the proposed concept of differential effector cell function of CCR7(+) and CCR7(-) memory T cells...
  23. pmc Disease-specific gene expression profiling in multiple models of lung disease
    Christina C Lewis
    Cincinnati Children s Hospital Medical Center Division of Immunobiology, 3333 Burnet Avenue, MLC 7038, Cincinnati, OH 45229, USA
    Am J Respir Crit Care Med 177:376-87. 2008
    ..However, analyses of individual diseases or models of diseases frequently yield extensive lists of differentially expressed genes with uncertain relationships to disease pathogenesis...
  24. ncbi Abrogation of CCL21 chemokine function by transgenic over-expression impairs T cell immunity to local infections
    Heike Unsoeld
    Department of Immunology, Institute of Medical Microbiology and Hygiene, University of Freiburg, Freiburg, Germany
    Int Immunol 19:1281-9. 2007
    ..Taken together, these data demonstrate the importance of CCR7 in mediating T cell immunity to viral and parasitic pathogens after local infection...
  25. ncbi Frequent expression of the natural killer cell receptor KLRG1 in human cord blood T cells: correlation with replicative history
    Isabel Marcolino
    Institute for Medical Microbiology and Hygiene, University of Freiburg, Freiburg, Germany
    Eur J Immunol 34:2672-80. 2004
    ..Thus, analysis of KLRG1 expression in cord blood revealed an unexpected heterogeneity of human T cells in newborns...
  26. ncbi Constitutive expression of CCR7 directs effector CD8 T cells into the splenic white pulp and impairs functional activity
    Heike Unsoeld
    Institute for Medical Microbiology and Hygiene, Department of Immunology, University of Freiburg, Freiburg, Germany
    J Immunol 173:3013-9. 2004
    ....
  27. ncbi Lack of proliferative capacity of human effector and memory T cells expressing killer cell lectinlike receptor G1 (KLRG1)
    David Voehringer
    Institute for Medical Microbiology and Hygiene, Department of Immunology, University of Freiburg, Germany
    Blood 100:3698-702. 2002
    ..Interestingly, these KLRG1(+) NK cells were found exclusively in the CD56(dim) NK-cell subset. Thus, the expression of KLRG1 identifies a subset of NK cells and antigen-experienced T cells in humans that lack proliferative capacity...