Research Topics
| Ulrich VoderholzerSummaryAffiliation: University of Freiburg Country: Germany Publications
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Detail Information
Publications
Are there gender differences in objective and subjective sleep measures? A study of insomniacs and healthy controlsUlrich Voderholzer
Department of Psychiatry and Psychotherapy, University Hospital of Freiburg, Germany
Depress Anxiety 17:162-72. 2003..Primary insomnia may be, at least in a part of the cases, a subclinical or subthreshold form of anxiety or depression...
Sleep and memory in healthy children and adolescents - a critical reviewMarta Kopasz
Department of Psychiatry and Psychotherapy, University Medical Center Freiburg, Hauptstrasse 5, 79104 Freiburg, Germany
Sleep Med Rev 14:167-77. 2010..This line of research can provide valuable input relevant to teaching, learning and public health policy...- Does REM sleep contribute to subjective wake time in primary insomnia? A comparison of polysomnographic and subjective sleep in 100 patientsBernd Feige
Department of Psychiatry and Psychotherapy, University Medical Center, Freiburg, Germany
J Sleep Res 17:180-90. 2008..This REM sleep contribution was larger for PI than for GSC subjects. The findings suggest that REM sleep-related processes might contribute to subjectively disturbed sleep and the perception of waking time in patients with PI... - Sleep-related memory consolidation in primary insomniaChristoph Nissen
Department of Psychiatry and Psychotherapy, University Medical Center Freiburg, Freiburg, Germany
J Sleep Res 20:129-36. 2011..Future work is needed to investigate the impact of treatment on improving sleep and memory... - The impact of increasing sleep restriction on cortisol and daytime sleepiness in adolescentsUlrich Voderholzer
Department of Psychiatry and Psychotherapy, University Medical Center Freiburg, Germany
Neurosci Lett 507:161-6. 2012..The lack of detrimental effects of sleep restriction on cortisol levels might be due to compensation mechanisms during sleep... - Effects of substance P on memory and mood in healthy male subjectsInga Herpfer
Department of Psychiatry and Psychotherapy, University Medical Center Freiburg, Freiburg, Germany
Hum Psychopharmacol 22:567-73. 2007..The results may be interpreted as evidence for an anxiogenic and memory-disturbing effect of SP. Further studies will focus on the effects of SP in patients with depression, anxiety and cognitive disorders... - Sleep restriction over several days does not affect long-term recall of declarative and procedural memories in adolescentsUlrich Voderholzer
Department of Psychiatry and Psychotherapy, University Medical Center Freiburg, Germany
Sleep Med 12:170-8. 2011..The current study addressed the question whether different extents of sleep restriction after learning would impair long-term memory consolidation in adolescents... - Effects of tryptophan depletion on cognitive functioning, obsessive-compulsive symptoms and mood in obsessive-compulsive disorder: preliminary resultsAnne Katrin Külz
Department of Psychiatry and Psychotherapy, University Hospital of Freiburg, Freiburg, Germany
Neuropsychobiology 56:127-31. 2007..There is also evidence for altered serotonergic transmission in OCD. The aim of this study was to evaluate the impact of rapid plasma tryptophan depletion on cognitive functioning in OCD... - Transient total sleep loss in cerebral Whipple's disease: a longitudinal studyUlrich Voderholzer
Department of Psychiatry and Psychotherapy, University of Freiburg, Freiburg, Germany
J Sleep Res 11:321-9. 2002..The extent of sleep disruption in this case of organic insomnia was similar to cases of familial fatal insomnia, but was at least partially reversible with treatment... - Impact of sleep-related complaints on depressive symptoms in patients with restless legs syndromeMagdolna Hornyak
Department of Psychiatry and Psychotherapy, University Hospital, Freiburg, Germany
J Clin Psychiatry 66:1139-45. 2005..RLS has been reported to be associated with depression and anxiety. The aim of the present study was to investigate the relationship between RLS symptom severity, sleep disturbances, and depressive symptoms... - No persisting effect of partial sleep curtailment on cognitive performance and declarative memory recall in adolescentsMarta Kopasz
Department of Psychiatry and Psychotherapy, University Medical Center, Freiburg, Germany
J Sleep Res 19:71-9. 2010..This may be explained by the high ability of adolescents to compensate for acute sleep loss. The correlation between non-REM sleep and declarative memory performance supports earlier findings... - Impact of sleep deprivation and subsequent recovery sleep on cortisol in unmedicated depressed patientsUlrich Voderholzer
Department of Psychiatry and Psychotherapy, University Hospital of Freiburg, Freiburg, Germany
Am J Psychiatry 161:1404-10. 2004..Since depression is associated with abnormalities of the hypothalamic-pituitary-adrenal (HPA) axis, the authors measured cortisol secretion before, during, and after therapeutic sleep deprivation for 1 night... - Nocturnal cortisol and melatonin secretion in primary insomniaDieter Riemann
Department of Psychiatry and Psychotherapy, University Hospital of Freiburg, Hauptstrasse 5, 79104, Freiburg, Germany
Psychiatry Res 113:17-27. 2002..The pathophysiological significance of this finding is, however, still a matter of debate... - Insomnia as a predictor of depression: a meta-analytic evaluation of longitudinal epidemiological studiesChiara Baglioni
Department of Psychiatry and Psychotherapy, University of Freiburg Medical Center, Hauptstrasse 5, 79104 Freiburg, Germany
J Affect Disord 135:10-9. 2011..This meta-analysis is aimed at evaluating quantitatively if insomnia constitutes a predictor of depression... - Heart rate and heart rate variability in subjectively reported insomniaKai Spiegelhalder
Department of Psychiatry and Psychotherapy, University of Freiburg Medical Center, Freiburg, Germany
J Sleep Res 20:137-45. 2011..A lower wake-to-sleep HR reduction and alterations in HRV variables might, at least partially, mediate the increased rates of cardiovascular morbidity and mortality observed in insomnia patients... - Relationship of periodic leg movements and severity of restless legs syndrome: a study in unmedicated and medicated patientsMagdolna Hornyak
Department of Psychiatry and Psychotherapy, University Medical Center, Freiburg, Germany
Clin Neurophysiol 118:1532-7. 2007.... - Neuropsychological impairment in obsessive-compulsive disorder--improvement over the course of cognitive behavioral treatmentAnne Katrin Kuelz
Department of Psychiatry and Psychotherapy, University Hospital of Freiburg, Germany
J Clin Exp Neuropsychol 28:1273-87. 2006..We hypothesize that particularly cognitive behavioral treatment enables OCD patients to think and act in a more flexible way that helps them to develop more effective cognitive strategies... - Effects of the neuropeptide substance P on sleep, mood, and neuroendocrine measures in healthy young menKlaus Lieb
Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Hauptstr 5, D 79104 Freiburg, Germany
Neuropsychopharmacology 27:1041-9. 2002..These effects can be interpreted as evidence for a central arousing effect of SP. Further studies should focus on the effects of substance P in patients with depressive or other psychiatric disorders... - The hyperarousal model of insomnia: a review of the concept and its evidenceDieter Riemann
Department of Psychiatry and Psychotherapy, Freiburg University Medical Center, Hauptstrasse 5, D 79104 Freiburg, Germany
Sleep Med Rev 14:19-31. 2010.... - Sleep in adults with attention-deficit/hyperactivity disorder: a controlled polysomnographic study including spectral analysis of the sleep EEGAlexandra Philipsen
Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Germany
Sleep 28:877-84. 2005..We investigated objective and subjective sleep quality in adultADHD, including an electroencephalogram spectral power analysis... - Variability of periodic leg movements in various sleep disorders: implications for clinical and pathophysiologic studiesMagdolna Hornyak
Sleep Disorders Unit, Department of Psychiatry and Psychotherapy, University Hospital, Freiburg, Germany
Sleep 28:331-5. 2005..In the present study, we investigated the intrasubject variance of PLMS from one night to the other because a fluctuation in the number of PLMS may influence the outcome of pharmacologic and pathophysiologic studies... - Increased nocturnal interleukin-6 excretion in patients with primary insomnia: a pilot studyIvonne Burgos
Department of Psychiatry and Psychotherapy, University Hospital of Leipzig, Leipzig, Germany
Brain Behav Immun 20:246-53. 2006..This might also implicate a higher risk for inflammatory and cardiovascular diseases in patients with chronic insomnia... 
The timing of learning before night-time sleep differentially affects declarative and procedural long-term memory consolidation in adolescentsJohannes Holz
Department of Psychiatry and Psychotherapy, University Medical Center Freiburg, Freiburg, Germany
PLoS ONE 7:e40963. 2012..In contrast, the higher retention of declarative memories after encoding in the afternoon is surprising, appeared to be less robust and needs further investigation...- Quetiapine addition to serotonin reuptake inhibitors in patients with severe obsessive-compulsive disorder: a double-blind, randomized, placebo-controlled studyAndreas Kordon
Department of Psychiatry and Psychotherapy, University of Luebeck, Ratzeburger Allee 160, D 23538 Luebeck, Germany
J Clin Psychopharmacol 28:550-4. 2008..The objective of the present study was to evaluate the efficacy of quetiapine added to baseline treatment with SRIs for the treatment of OCD in severely ill adult subjects... - Polysomnography findings in patients with restless legs syndrome and in healthy controls: a comparative observational studyMagdolna Hornyak
Center for Sleep Research and Sleep Medicine, Department of Psychiatry and Psychotherapy, University Medical Center Freiburg, Germany
Sleep 30:861-5. 2007..Sleep disturbances and their sequelae are the most common complaints of patients with restless legs syndrome (RLS). We compared polysomnography (PSG) findings in a large cohort of patients with idiopathic RLS and of healthy subjects... - Do periodic leg movements influence patients' perception of sleep quality?Magdolna Hornyak
Department of Psychiatry and Psychotherapy, University Hospital of Freiburg, Hauptstrasse 5, D 79104 Freiburg, Germany
Sleep Med 5:597-600. 2004..We investigated the relationship of the occurrence of PLMS to patients' perception of sleep quality during a night of polysomnography in various sleep disorders... - Impaired sleep-related memory consolidation in primary insomnia--a pilot studyChristoph Nissen
Department of Psychiatry and Psychotherapy, Albert Ludwigs University of Freiburg, Freiburg, Germany
Sleep 29:1068-73. 2006..To compare sleep-related consolidation of procedural memory in patients with primary insomnia and healthy controls... - Periodic leg movements in sleep and periodic limb movement disorder: prevalence, clinical significance and treatmentMagdolna Hornyak
Department of Psychiatry and Psychotherapy, University Hospital Freiburg, Hauptstrasse 5, D 79104 Freiburg, Germany
Sleep Med Rev 10:169-77. 2006..To date, only a few studies have evaluated the efficacy of therapeutic substances in reducing PLMS in PLMD patients. Their results need to be confirmed in controlled randomized trials... - Increased delta power and discrepancies in objective and subjective sleep measurements in borderline personality disorderAlexandra Philipsen
Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Haupt strasse 5, 79104 Freiburg, Germany
J Psychiatr Res 39:489-98. 2005..Earlier findings in sleep EEG abnormalities in BPD may have been confounded by concomitant depressive symptoms... - Spectral analysis of sleep EEG in patients with restless legs syndromeMagdolna Hornyak
Department of Psychiatry and Psychotherapy, University Hospital, Hauptstrasse 5, D 79104 Freiburg, Germany
Clin Neurophysiol 116:1265-72. 2005..Furthermore, we studied the relationship of sleep EEG spectral power to the occurrence of periodic leg movements in sleep (PLMS) and arousal events... - Neurobiological findings before and during successful lithium therapy of a patient with 48-hour rapid-cycling bipolar disorderUlrich Voderholzer
Department of Psychiatry and Psychotherapy, Albert Ludwig University, Freiburg, Germany
Neuropsychobiology 45:13-9. 2002..With plasma levels between 0.8 and 1.0 mmol, almost complete remission occurred. An overview on previous reports on the therapeutic effect of mood stabilizers in this rare form of bipolar disorder is presented... - The tryptophan depletion test: impact on sleep in primary insomnia - a pilot studyDieter Riemann
Department of Psychiatry and Psychotherapy, University of Freiburg, Hauptstrasse 5, Germany
Psychiatry Res 109:129-35. 2002..The results suggest a negative impact of tryptophan depletion on sleep continuity and a stimulating effect on phasic measures of REM sleep in patients with primary insomnia... - Dream recall and dream content in obsessive-compulsive patients: is there a change during exposure treatment?Anne K Kuelz
Department of Psychiatry and Psychotherapy, University Hospital Freiburg, Freiburg, Germany
J Nerv Ment Dis 198:593-6. 2010..The findings support the continuity hypothesis of dreaming by showing a link between day-time symptoms and OC symptoms in dreams. Contrary to expectations, however, exposure treatment does not intensify dreams... - Voxel-based morphometry in unmedicated patients with restless legs syndromeMagdolna Hornyak
Center for Sleep Research and Sleep Medicine, Department of Psychiatry and Psychotherapy, University Hospital, Freiburg, Germany
Sleep Med 9:22-6. 2007..To address this issue, we performed VBM in unmedicated RLS patients... - Periodic limb movements during sleep in alcohol dependent patientsHorst Gann
Department of Psychiatry and Psychotherapy, University of Freiburg, Hauptstr 5, 79104 Freiburg, Germany
Eur Arch Psychiatry Clin Neurosci 252:124-9. 2002.... - Object alternation test--is it sensitive enough to detect cognitive dysfunction in obsessive-compulsive disorder?Anne Katrin Kuelz
Department of Psychiatry and Psychotherapy, University Hospital of Freiburg, Freiburg, Germany
Eur Psychiatry 19:441-3. 2004..OCD patients performed normally on the OAT but scored below controls on a task assessing visuo-spatial working memory. The results challenge the concept of the OAT as a sensitive instrument for orbitofrontal dysfunction in OCD... - Sleep and sleep-wake manipulations in bipolar depressionDieter Riemann
Department of Psychiatry and Psychotherapy, University Hospital of Freiburg, Germany
Neuropsychobiology 45:7-12. 2002..For patients with mania, sleep deprivation is not an adequate treatment--in contrast, treatment strategies aiming at stabilizing a regular sleep-wake schedule are indicated... - Neuropsychological performance in obsessive-compulsive disorder: a critical reviewAnne Katrin Kuelz
Departments of Psychiatry and Psychotherapy, University Hospital of Freiburg, Albert-Ludwig University, Hauptstrasse 5, Freiburg, Germany
Biol Psychol 65:185-236. 2004..The results of our study suggest that some cognitive deficits seem to be common in OCD, but future studies should focus more on possible confounding variables such as co-morbidity or psychotropic medication... - Primary insomnia: a risk factor to develop depression?Dieter Riemann
Department of Psychiatry and Psychotherapy, University Hospital of Freiburg, Hauptstrasse 5, 79104 Freiburg, Germany
J Affect Disord 76:255-9. 2003.... - Fluoxetine and sleep EEG: effects of a single dose, subchronic treatment, and discontinuation in healthy subjectsBernd Feige
Department of Psychiatry and Psychotherapy, Albert-Ludwigs-University, Freiburg, Germany
Neuropsychopharmacology 26:246-58. 2002..Finally, the pattern of change observed for the delta sleep ratio indicates that it may be due to secondary, adaptive effects possibly linked to the antidepressant effect of fluoxetine in depressed patients... - The potential of telemental health applications for obsessive-compulsive disorderNirmal Herbst
Department of Psychiatry and Psychotherapy, University Medical Center Freiburg, Germany
Clin Psychol Rev 32:454-66. 2012..This review critically evaluates the current body of evidence on TMH applications for OCD patients. The review focuses on studies that include exposure therapy with response prevention as the best validated treatment component... - Chronic insomnia and MRI-measured hippocampal volumes: a pilot studyDieter Riemann
Department of Psychiatry and Psychotherapy, Freiburg University Medical Center, Hauptstr 5, D 79104 Germany
Sleep 30:955-8. 2007..Morphometric analysis of magnetic resonance imaging brain scans was used to investigate possible neuroanatomic differences between patients with primary insomnia compared to good sleepers... - Clinical outcome in patients with obsessive-compulsive disorder after discontinuation of SRI treatment: results from a two-year follow-upAndreas Kordon
Universitaetsklinikum Schleswig Holstein, Campus Luebeck, Klinik fuer Psychiatrie und Psychotherapie, Ratzeburger Allee 160, 23538 Luebeck, Germany
Eur Arch Psychiatry Clin Neurosci 255:48-50. 2005..However, it is a matter of debate whether discontinuation of SRI after combined treatment leads to relapse... - Transient narcolepsy-cataplexy syndrome after discontinuation of the antidepressant venlafaxineChristoph Nissen
J Sleep Res 14:207-8. 2005 - [Insomnia]John Peter Doerr
Abteilung für Psychiatrie und Psychotherapie der Universitätsklinik Freiburg, Hauptstr 5, 79104 Freiburg
Med Monatsschr Pharm 31:339-45. 2008..This paper gives an overview on current and new pharmacological treatments of insomnia. Additionally, some evidence based treatment options with regard to cognitive behavioral therapy are presented... - Sleep in obsessive compulsive disorder: polysomnographic studies under baseline conditions and after experimentally induced serotonin deficiencyUlrich Voderholzer
Dept of Psychiatry and Psychotherapy, Klinikum of the Albert Ludwigs University, Freiburg, Germany
Eur Arch Psychiatry Clin Neurosci 257:173-82. 2007..Assuming that changes of sleep architecture indicate underlying neurobiological abnormalities, this study indicates that neurobiological disturbances are different in primary OCD as compared with primary depression...