J Chr Virchow

Summary

Affiliation: University of Rostock
Country: Germany

Publications

  1. ncbi request reprint Efficacy and safety of montelukast in adults with asthma and allergic rhinitis
    J Chr Virchow
    Universitat Rostock, Ernst Heydemann Str 6, 18057 Rostock, Germany
    Respir Med 100:1952-9. 2006
  2. ncbi request reprint [Fix combinations should be first line therapy in asthma irrespective of its severity - contra]
    J Christian Virchow
    Abteilung fur Pneumologie, Universitat Rostock
    Pneumologie 57:677-80. 2003
  3. pmc Stage-dependent association of BDNF and TGF-β1 with lung function in stable COPD
    Paul Stoll
    Department of Pneumology and Critical Care Medicine, University of Rostock, Ernst Heydemann Strasse 6, 18057, Rostock, Germany
    Respir Res 13:116. 2012
  4. doi request reprint Asthma and pregnancy
    J Christian Virchow
    Abteilung fur Pneumologie, Intensive Care Medicine, Klinik I, Zentrum fur Innere Medizin, Universitat Rostock, Rostock, Germany
    Semin Respir Crit Care Med 33:630-44. 2012
  5. pmc Can asthma control be improved by understanding the patient's perspective?
    Rob Horne
    Centre for Behavioural Medicine, School of Pharmacy University of London, UK
    BMC Pulm Med 7:8. 2007
  6. doi request reprint [Prevention of respiratory tract diseases]
    J C Virchow
    Abteilung fur Pneumologie, Medizinische Klinik und Poliklinik, Universitätsklinikum Rostock, Ernst Heydemann Strasse 6, 18057 Rostock
    Internist (Berl) 49:170-7. 2008
  7. doi request reprint [Asthma--a small airway disease: concepts and evidence]
    J C Virchow
    Abteilung Pneumologie, Medizinische Kliniken der Universität Rostock
    Pneumologie 63:S96-101. 2009
  8. doi request reprint Add-on montelukast in inadequately controlled asthma patients in a 6-month open-label study: the MONtelukast In Chronic Asthma (MONICA) study
    J Christian Virchow
    Department of Pneumology, University of Rostock, Rostock, Germany
    Respir Med 104:644-51. 2010
  9. ncbi request reprint [Asthma - historical development, current status and perspectives]
    J C Virchow
    Universitätsklinikum Rostock, Klinik und Poliklinik für Innere Medizin, Rostock
    Pneumologie 64:541-9. 2010
  10. ncbi request reprint [Therapy-resistant asthma--a distinct phenotype?]
    J Christian Virchow
    Abteilung fur Pneumologie, Klinik und Poliklinik für Innere Medizin, Universitat Rostock, Rostock
    Med Klin (Munich) 101:301-7. 2006

Detail Information

Publications37

  1. ncbi request reprint Efficacy and safety of montelukast in adults with asthma and allergic rhinitis
    J Chr Virchow
    Universitat Rostock, Ernst Heydemann Str 6, 18057 Rostock, Germany
    Respir Med 100:1952-9. 2006
    ..Adverse drug reactions occurred in 14 out of 6158 patients. None of the adverse events was serious. Accordingly, montelukast 10mg is a safe and effective treatment for patients with both asthma and allergic rhinitis...
  2. ncbi request reprint [Fix combinations should be first line therapy in asthma irrespective of its severity - contra]
    J Christian Virchow
    Abteilung fur Pneumologie, Universitat Rostock
    Pneumologie 57:677-80. 2003
  3. pmc Stage-dependent association of BDNF and TGF-β1 with lung function in stable COPD
    Paul Stoll
    Department of Pneumology and Critical Care Medicine, University of Rostock, Ernst Heydemann Strasse 6, 18057, Rostock, Germany
    Respir Res 13:116. 2012
    ..In patients with asthma, it was previously shown that elevated serum BDNF concentrations correlate with disease severity, whereas TGF-β1 concentrations were normal...
  4. doi request reprint Asthma and pregnancy
    J Christian Virchow
    Abteilung fur Pneumologie, Intensive Care Medicine, Klinik I, Zentrum fur Innere Medizin, Universitat Rostock, Rostock, Germany
    Semin Respir Crit Care Med 33:630-44. 2012
    ....
  5. pmc Can asthma control be improved by understanding the patient's perspective?
    Rob Horne
    Centre for Behavioural Medicine, School of Pharmacy University of London, UK
    BMC Pulm Med 7:8. 2007
    ..An international panel of experts invited by the International Primary Care Respiratory Group considered the evidence and discussed the implications for primary care practice...
  6. doi request reprint [Prevention of respiratory tract diseases]
    J C Virchow
    Abteilung fur Pneumologie, Medizinische Klinik und Poliklinik, Universitätsklinikum Rostock, Ernst Heydemann Strasse 6, 18057 Rostock
    Internist (Berl) 49:170-7. 2008
    ..The great need for studies on the effectiveness of preventive strategies is also addressed...
  7. doi request reprint [Asthma--a small airway disease: concepts and evidence]
    J C Virchow
    Abteilung Pneumologie, Medizinische Kliniken der Universität Rostock
    Pneumologie 63:S96-101. 2009
    ..A combined therapy with ICS and LABA seem to have the capability to improve efficacy and safety, especially when very fine formulations are chosen...
  8. doi request reprint Add-on montelukast in inadequately controlled asthma patients in a 6-month open-label study: the MONtelukast In Chronic Asthma (MONICA) study
    J Christian Virchow
    Department of Pneumology, University of Rostock, Rostock, Germany
    Respir Med 104:644-51. 2010
    ..In patients insufficiently controlled with ICS or ICS+LABAs, daily add-on montelukast improved both asthma control and asthma-related quality of life. Clinicaltrials.gov registry number NCT00802789...
  9. ncbi request reprint [Asthma - historical development, current status and perspectives]
    J C Virchow
    Universitätsklinikum Rostock, Klinik und Poliklinik für Innere Medizin, Rostock
    Pneumologie 64:541-9. 2010
    ..The developments of the past 100 years as well as a careful look into the future are presented in this review...
  10. ncbi request reprint [Therapy-resistant asthma--a distinct phenotype?]
    J Christian Virchow
    Abteilung fur Pneumologie, Klinik und Poliklinik für Innere Medizin, Universitat Rostock, Rostock
    Med Klin (Munich) 101:301-7. 2006
    ..There is data that different phenotypes of therapy-resistant asthma might exist but little if any evidence to suggest a single phenotype of therapy-resistant asthma...
  11. ncbi request reprint Importance of inhaler devices in the management of airway disease
    J C Virchow
    Department of Pneumology, University Medical Clinic, University of Rostock, Rostock, Germany
    Respir Med 102:10-9. 2008
    ..New and advanced devices are considered being helpful to minimise the most important problems patients have with current DPIs...
  12. ncbi request reprint What plays a role in the choice of inhaler device for asthma therapy?
    J Christian Virchow
    Department of Pneumology, University Medical Clinic, University of Rostock, Germany
    Curr Med Res Opin 21:S19-25. 2005
    ..Among the currently available dry powder inhalers the Novolizer device fulfils several characteristics of an ideal inhaler for the treatment of asthma and chronic obstructive pulmonary disease (COPD)...
  13. doi request reprint A subgroup analysis of the MONICA study: a 12-month, open-label study of add-on montelukast treatment in asthma patients
    J Christian Virchow
    Department of Pneumology, University of Rostock, Rostock, Germany
    J Asthma 47:986-93. 2010
    ....
  14. ncbi request reprint [Asthma, allergic rhinitis, sinusitis. Concept of the "unified respiratory tracts"]
    J C Virchow
    Klinik und Poliklinik für Innere Medizin, Universitätsklinik Rostock
    HNO 53:S16-20. 2005
    ..ARC should no longer be viewed as a harmless disorder but as the early manifestation of a potentially progressive systemic disease and be treated as such...
  15. ncbi request reprint Guidelines versus clinical practice--which therapy and which device?
    J Christian Virchow
    Department of Pneumology, University Medical Clinic, 18057 Rostock, Germany
    Respir Med 98:S28-34. 2004
    ..This is important when inhalation therapy is considered not only for asthma but also for chronic obstructive pulmonary disease...
  16. ncbi request reprint [On what criteria is the choice of an inhaler made for the treatment of asthma?]
    J Christian Virchow
    Departement de Pneumologie, University Medical Clinic, University of Rostock, Allemagne
    Rev Pneumol Clin 61:3S15-9. 2005
  17. ncbi request reprint The course of allergen-induced leukocyte infiltration in human and experimental asthma
    Marek Lommatzsch
    Department of Pneumology, Clinic of Internal Medicine, University of Rostock, Ernst Heydemann Strasse 6, 18057 Rostock, Germany
    J Allergy Clin Immunol 118:91-7. 2006
    ....
  18. doi request reprint Differential development of plasmacytoid dendritic cells in Th1- and Th2-like cytokine milieus
    K Bratke
    Department of Pneumology, University of Rostock, Rostock, Germany
    Allergy 66:386-95. 2011
    ..Therefore, we investigated the impact of Th1- and Th2-like conditions during the development of pDCs on their antigen expression and function...
  19. ncbi request reprint Platelet and plasma BDNF in lower respiratory tract infections of the adult
    Marek Lommatzsch
    Department of Pneumology, University of Rostock, 18057 Rostock, Germany
    Respir Med 101:1493-9. 2007
    ..In conclusion, these data suggest that lower respiratory tract infections might be associated with an augmented release of BDNF by platelets and mononuclear cells...
  20. pmc Interleukin-4 suppresses the cytotoxic potential of in vitro generated, adaptive regulatory CD4 T cells by down-regulation of granzyme B
    Kai Bratke
    Department of Pneumology, University of Rostock, Rostock, Germany
    Immunology 127:338-44. 2009
    ..In addition, IL-4-mediated suppression of GrB led to impaired cytotoxicity of aTregs against K562 target cells. In conclusion, our data suggest that IL-4 might play a role in impaired aTreg function in allergy...
  21. ncbi request reprint Maternal serum concentrations of BDNF and depression in the perinatal period
    Marek Lommatzsch
    Department of Pneumology, University of Rostock, Ernst Heydemann Strasse 6, 18057 Rostock, Germany
    Psychoneuroendocrinology 31:388-94. 2006
    ..This phenomenon might reflect an increased risk for the development of mood disorders in the perinatal period. However, the individual serum concentration of BDNF alone did not predict maternal depression in our study...
  22. doi request reprint Extracellular adenosine triphosphate and chronic obstructive pulmonary disease
    Marek Lommatzsch
    Department of Pneumology, University of Rostock, Rostock, Germany
    Am J Respir Crit Care Med 181:928-34. 2010
    ..Extracellular ATP promotes inflammation, but its role in chronic obstructive pulmonary disease (COPD) is unknown...
  23. doi request reprint Function-associated surface molecules on airway dendritic cells in cigarette smokers
    Kai Bratke
    Department of Pneumology, University of Rostock, Rostock, Germany
    Am J Respir Cell Mol Biol 38:655-60. 2008
    ..We provide the first evidence that a reduced CCR7 expression on airway mDCs is associated with airflow limitation in smokers...
  24. pmc Expression of interleukin-13 receptor alpha 1-subunit on peripheral blood eosinophils is regulated by cytokines
    Daniel Myrtek
    Department of Pneumology, University Hospital Freiburg, Freiburg, Germany
    Immunology 112:597-604. 2004
    ..These findings suggest a regulatory cytokine network influencing the reactivity of eosinophils to IL-13...
  25. doi request reprint Chitinase-like protein and asthma
    Michael Kuepper
    N Engl J Med 358:1073-5; author reply 1075. 2008
  26. ncbi request reprint Salmeterol powder provides significantly better benefit than montelukast in asthmatic patients receiving concomitant inhaled corticosteroid therapy
    J Christian Virchow
    Chest 121:2083-4. 2002
  27. ncbi request reprint Summing up 100 years of asthma
    Zuzana Diamant
    Department of Respiratory and Allergy Research, Centre for Human Drug Research, Leiden, Zernikedreef 10, 2333 CL Leiden, The Netherlands
    Respir Med 101:378-88. 2007
    ..The recognition of its heterogeneous nature in combination with several refined and sophisticated technologies will mark a new era of phenotype-specific approach and treatment of asthma...
  28. ncbi request reprint [Anti-obstructive anti-inflammatory therapy: no problems in pneumology, problematic in cardiology?]
    Rainer W Hauck
    Medizinische Abteilung 2, Städtisches Krankenhaus Bad Reichenhall
    Med Klin (Munich) 97:350-6. 2002
    ..In addition, their influence on serum potassium levels can be problematic and have the potential to increase side effects of other drugs...
  29. ncbi request reprint Postnatal dexamethasone for lung disease of prematurity
    Marek Lommatzsch
    N Engl J Med 350:2715-8; author reply 2715-8. 2004
  30. ncbi request reprint Fluticasone reduces CRP in COPD
    J Christian Virchow
    Am J Respir Crit Care Med 171:1191; author reply 1191-2. 2005
  31. ncbi request reprint Letter regarding article by Ejiri et al, "possible role of brain-derived neurotrophic factor in the pathogenesis of coronary artery disease"
    Marek Lommatzsch
    Circulation 113:e724; author reply e724-5. 2006
  32. ncbi request reprint Granzyme B, a novel mediator of allergic inflammation: its induction and release in blood basophils and human asthma
    Cornelia M Tschopp
    Institute of Immunology, Inselspital, University Hospital Bern, Inselspital, CH 3010 Bern, Switzerland
    Blood 108:2290-9. 2006
    ..Our study demonstrates an unexpected plasticity of the granule composition of mature basophils and suggests a role of granzyme B as a novel mediator of allergic diseases...
  33. ncbi request reprint The neural underpinnings of asthma
    Marek Lommatzsch
    J Allergy Clin Immunol 119:254-5; author reply 255. 2007
  34. ncbi request reprint Maternal nerve growth factor serum levels in the perinatal period
    Olaf Schulte-Herbrüggen
    Department of Psychiatry, University Medicine Berlin, Germany
    J Reprod Immunol 74:170-3. 2007
    ..32, p<0.05). In conclusion, NGF is not altered during normal pregnancy on a systemic level. In addition, NGF displays a different regulation compared with BDNF during the menstrual cycle...
  35. ncbi request reprint Mice running late: T-cell kinetics in models of asthma
    Marek Lommatzsch
    Am J Respir Crit Care Med 175:522b-523. 2007
  36. ncbi request reprint Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells
    Marco Idzko
    Department of Pulmonary Medicine, Erasmus University Medical Center, Dr Molewaterplein 50, P O Box 1738, 3000 DR Rotterdan, The Netherlands
    Nat Med 13:913-9. 2007
    ..Together these data show that purinergic signaling has a key role in allergen-driven lung inflammation that is likely to be amenable to therapeutic intervention...
  37. ncbi request reprint Invariant natural killer T cells in obstructive pulmonary diseases
    Kai Bratke
    N Engl J Med 357:194; author reply 194-5. 2007