I Vernaleken

Summary

Affiliation: University Hospital
Country: Germany

Publications

  1. doi request reprint Vulnerability to psychotogenic effects of ketamine is associated with elevated D2/3-receptor availability
    Ingo Vernaleken
    Department of Psychiatry and Psychotherapy, Medical Faculty, RWTH Aachen University, Aachen, Germany
    Int J Neuropsychopharmacol 16:745-54. 2013
  2. doi request reprint Baseline [18F]-FDOPA kinetics are predictive of haloperidol-induced changes in dopamine turnover and cognitive performance: A positron emission tomography study in healthy subjects
    Ingo Vernaleken
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany
    Neuroimage 40:1222-31. 2008
  3. doi request reprint Striatal and extrastriatal D2/D3-receptor-binding properties of ziprasidone: a positron emission tomography study with [18F]Fallypride and [11C]raclopride (D2/D3-receptor occupancy of ziprasidone)
    Ingo Vernaleken
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, Germany
    J Clin Psychopharmacol 28:608-17. 2008
  4. ncbi request reprint Asymmetry in dopamine D(2/3) receptors of caudate nucleus is lost with age
    Ingo Vernaleken
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Germany Pauwelsstrasse 30, 52074 Aachen, Germany
    Neuroimage 34:870-8. 2007
  5. ncbi request reprint 'Prefrontal' cognitive performance of healthy subjects positively correlates with cerebral FDOPA influx: an exploratory [18F]-fluoro-L-DOPA-PET investigation
    Ingo Vernaleken
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, Germany
    Hum Brain Mapp 28:931-9. 2007
  6. ncbi request reprint Modulation of [18F]fluorodopa (FDOPA) kinetics in the brain of healthy volunteers after acute haloperidol challenge
    Ingo Vernaleken
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, Germany
    Neuroimage 30:1332-9. 2006
  7. doi request reprint Dopamine D2/3 receptor occupancy by quetiapine in striatal and extrastriatal areas
    Ingo Vernaleken
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, and JARA Translational Brain Medicine, Germany
    Int J Neuropsychopharmacol 13:951-60. 2010
  8. pmc The applicability of SRTM in [(18)F]fallypride PET investigations: impact of scan durations
    Ingo Vernaleken
    Department of Psychiatry and Psychotherapy, Medical Faculty, RWTH Aachen University, Aachen, Germany
    J Cereb Blood Flow Metab 31:1958-66. 2011
  9. doi request reprint Imaging studies - differential action of typical and atypical antipsychotics in a network perspective
    I Vernaleken
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, Germany
    Pharmacopsychiatry 41:S60-9. 2008
  10. doi request reprint [Use of PET and SPECT in psychiatry]
    G Grunder
    Klinik fur Psychiatrie und Psychotherapie, Universitatsklinikum Aachen, RWTH Aachen, Aachen
    Nervenarzt 81:97-107; quiz 108. 2010

Detail Information

Publications21

  1. doi request reprint Vulnerability to psychotogenic effects of ketamine is associated with elevated D2/3-receptor availability
    Ingo Vernaleken
    Department of Psychiatry and Psychotherapy, Medical Faculty, RWTH Aachen University, Aachen, Germany
    Int J Neuropsychopharmacol 16:745-54. 2013
    ....
  2. doi request reprint Baseline [18F]-FDOPA kinetics are predictive of haloperidol-induced changes in dopamine turnover and cognitive performance: A positron emission tomography study in healthy subjects
    Ingo Vernaleken
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany
    Neuroimage 40:1222-31. 2008
    ..We hypothesize that these effects may be driven by D(1)-receptor mediated transmission during D(2) blockade...
  3. doi request reprint Striatal and extrastriatal D2/D3-receptor-binding properties of ziprasidone: a positron emission tomography study with [18F]Fallypride and [11C]raclopride (D2/D3-receptor occupancy of ziprasidone)
    Ingo Vernaleken
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, Germany
    J Clin Psychopharmacol 28:608-17. 2008
    ..The discrepancies between single-dose and steady-state results are important for the future design of dose-finding PET occupancy studies of novel antipsychotics. Single-dose studies may not be totally relied on for final dose selection...
  4. ncbi request reprint Asymmetry in dopamine D(2/3) receptors of caudate nucleus is lost with age
    Ingo Vernaleken
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Germany Pauwelsstrasse 30, 52074 Aachen, Germany
    Neuroimage 34:870-8. 2007
    ..Because ventral striatal dopamine neurotransmission is involved in cognitive processes, this loss of physiological asymmetry in NC dopamine transmission during aging might be involved in age-related declines of cognitive performance...
  5. ncbi request reprint 'Prefrontal' cognitive performance of healthy subjects positively correlates with cerebral FDOPA influx: an exploratory [18F]-fluoro-L-DOPA-PET investigation
    Ingo Vernaleken
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, Germany
    Hum Brain Mapp 28:931-9. 2007
    ..005; putamen: -0.870, P < 0. 001). Thus, the present findings reveal a strong correlation between dopamine synthesis capacity in striatum of healthy volunteers and performance of cognitive tasks linked to the prefrontal cortex...
  6. ncbi request reprint Modulation of [18F]fluorodopa (FDOPA) kinetics in the brain of healthy volunteers after acute haloperidol challenge
    Ingo Vernaleken
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, Germany
    Neuroimage 30:1332-9. 2006
    ..The stimulation of DDC cannot be excluded due to insufficient statistical power in the estimation of k3(D) changes...
  7. doi request reprint Dopamine D2/3 receptor occupancy by quetiapine in striatal and extrastriatal areas
    Ingo Vernaleken
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, and JARA Translational Brain Medicine, Germany
    Int J Neuropsychopharmacol 13:951-60. 2010
    ..Taken together, quetiapine shows preferential extrastriatal binding at D2/3Rs; the extent of this difference is comparable to that previously described for clozapine. Both antipsychotics show very low affinity for D2/3Rs...
  8. pmc The applicability of SRTM in [(18)F]fallypride PET investigations: impact of scan durations
    Ingo Vernaleken
    Department of Psychiatry and Psychotherapy, Medical Faculty, RWTH Aachen University, Aachen, Germany
    J Cereb Blood Flow Metab 31:1958-66. 2011
    ..Apparently, the D(2/3) receptor occupancy results of APs, especially preferential extrastriatal binding observations, are not relevantly biased by inappropriate scan durations...
  9. doi request reprint Imaging studies - differential action of typical and atypical antipsychotics in a network perspective
    I Vernaleken
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, Germany
    Pharmacopsychiatry 41:S60-9. 2008
    ..Finally, hypotheses are proposed to explain differences between first- and second generation antipsychotics with respect of regional selectivity for dopamine and serotonin neurons...
  10. doi request reprint [Use of PET and SPECT in psychiatry]
    G Grunder
    Klinik fur Psychiatrie und Psychotherapie, Universitatsklinikum Aachen, RWTH Aachen, Aachen
    Nervenarzt 81:97-107; quiz 108. 2010
    ..Due to its unmatched sensitivity, molecular imaging with PET and SPECT represents an important complement to magnetic resonance imaging technology in research and clinical practice...
  11. ncbi request reprint The striatal and extrastriatal D2/D3 receptor-binding profile of clozapine in patients with schizophrenia
    Gerhard Grunder
    Department of Psychiatry, University of Mainz, Mainz, Germany
    Neuropsychopharmacology 31:1027-35. 2006
    ..Extrastriatal binding of clozapine may be more relevant to its antipsychotic actions than striatal. However, further studies with an intraindividual comparison of untreated vs treated state are desirable to confirm this finding...
  12. doi request reprint Brain and plasma pharmacokinetics of aripiprazole in patients with schizophrenia: an [18F]fallypride PET study
    Gerhard Grunder
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany
    Am J Psychiatry 165:988-95. 2008
    ....
  13. doi request reprint Therapeutic plasma concentrations of antidepressants and antipsychotics: lessons from PET imaging
    G Grunder
    Department of Psychiatry, Psychotherapy, and Psychosomatics, Medical Faculty, RWTH Aachen University, Germany
    Pharmacopsychiatry 44:236-48. 2011
    ..Associations between brain target occupancy, plasma concentrations, and clinical effects and adverse reactions will be discussed for the most commonly used antidepressant and antipsychotic drugs...
  14. ncbi request reprint Elevated [18F]fluorodopamine turnover in brain of patients with schizophrenia: an [18F]fluorodopa/positron emission tomography study
    Yoshitaka Kumakura
    Centre for Functionally Integrative Neuroscience, Aarhus University, DK 8000 Aarhus C, Denmark
    J Neurosci 27:8080-7. 2007
    ....
  15. ncbi request reprint Parametric mapping of binding in human brain of D2 receptor ligands of different affinities
    Thomas Siessmeier
    Department of Nuclear Medicine, University of Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany
    J Nucl Med 46:964-72. 2005
    ..However, the in vivo kinetics of these compounds and the quantification approaches for parametric mapping of their specific bindings have not been systematically compared...
  16. ncbi request reprint PET studies of net blood-brain clearance of FDOPA to human brain: age-dependent decline of [18F]fluorodopamine storage capacity
    Yoshitaka Kumakura
    PET Centre, Aarhus University Hospitals, Aarhus, Denmark
    J Cereb Blood Flow Metab 25:807-19. 2005
    ..The present results furthermore constitute the first demonstration of an abnormality in the cerebral utilization of FDOPA in caudate and putamen as a function of normal aging, which we attribute to loss of vesicular storage capacity...
  17. ncbi request reprint High striatal occupancy of D2-like dopamine receptors by amisulpride in the brain of patients with schizophrenia
    Ingo Vernaleken
    Department of Psychiatry, University of Mainz, Mainz, Germany
    Int J Neuropsychopharmacol 7:421-30. 2004
    ..However, our data show high striatal D2-like receptor occupancies under rising plasma concentrations. Using the full range of recommended amisulpride dosage, striatal occupancies up to 90% can be measured...
  18. ncbi request reprint Subchronic haloperidol downregulates dopamine synthesis capacity in the brain of schizophrenic patients in vivo
    Gerhard Grunder
    Department of Psychiatry, University of Mainz, Germany
    Neuropsychopharmacology 28:787-94. 2003
    ..We link an alteration in cerebral catecholamine metabolism in human brain with the therapeutic action of neuroleptic medication...
  19. ncbi request reprint Quantification of D2-like dopamine receptors in the human brain with 18F-desmethoxyfallypride
    Gerhard Grunder
    Department of Psychiatry, University of Mainz, Mainz, Germany
    J Nucl Med 44:109-16. 2003
    ..18)F-Desmethoxyfallypride ((18)F-DMFP) is a benzamide tracer with the advantage of an (18)F label. We optimized the synthesis and evaluated (18)F-DMFP in PET studies on healthy human volunteers...
  20. ncbi request reprint Therapeutic monitoring of new antipsychotic drugs
    Christoph Hiemke
    Department of Psychiatry, University of Mainz, D 55101 Mainz, Germany
    Ther Drug Monit 26:156-60. 2004
    ..The few reported investigations, however, need to be confirmed and extended...