R Veltkamp

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. ncbi request reprint Continuous stroke unit electrocardiographic monitoring versus 24-hour Holter electrocardiography for detection of paroxysmal atrial fibrillation after stroke
    Timolaos Rizos
    Department of Neurology, University Heidelberg, INF 400, 69120 Heidelberg, Germany
    Stroke 43:2689-94. 2012
  2. doi request reprint Anticoagulation with dabigatran does not increase secondary intracerebral haemorrhage after thrombolysis in experimental cerebral ischaemia
    Li Sun
    Department of Neurology, Ruprecht Karls University Heidelberg, INF 400, 69120 Heidelberg, Germany
    Thromb Haemost 110:153-61. 2013
  3. doi request reprint Hemostatic therapy in experimental intracerebral hemorrhage associated with rivaroxaban
    Wei Zhou
    Department of Neurology, University Heidelberg, Heidelberg, Germany
    Stroke 44:771-8. 2013
  4. doi request reprint [Current registry studies of acute ischemic stroke]
    R Veltkamp
    Neurologische Klinik, Universitätsklinik Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Deutschland
    Nervenarzt 83:1270-4. 2012
  5. pmc Comparison of humoral neuroinflammation and adhesion molecule expression in two models of experimental intracerebral hemorrhage
    Arthur Liesz
    Department of Neurology, University Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Exp Transl Stroke Med 3:11. 2011
  6. doi request reprint Hemostatic therapy in experimental intracerebral hemorrhage associated with the direct thrombin inhibitor dabigatran
    Wei Zhou
    Department of Neurology, University Heidelberg, INF 400, 69120 Heidelberg, Germany
    Stroke 42:3594-9. 2011
  7. doi request reprint [New oral anticoagulants in atrial fibrillation]
    R Veltkamp
    Neurologische Klinik, Ruprecht Karls Universitat Heidelberg, Heidelberg, Deutschland
    Nervenarzt 82:180, 182-4, 186-9. 2011
  8. doi request reprint Rapid reversal of anticoagulation prevents excessive secondary hemorrhage after thrombolysis in a thromboembolic model in rats
    Li Sun
    Department of Neurology, Ruprecht Karls University Heidelberg, INF 400, 69120 Heidelberg, Germany
    Stroke 42:3524-9. 2011
  9. doi request reprint Does the STAF score help detect paroxysmal atrial fibrillation in acute stroke patients?
    S Horstmann
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Eur J Neurol 20:147-52. 2013
  10. doi request reprint Paroxysmal atrial fibrillation is more prevalent than persistent atrial fibrillation in acute stroke and transient ischemic attack patients
    T Rizos
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Cerebrovasc Dis 32:276-82. 2011

Collaborators

Detail Information

Publications45

  1. ncbi request reprint Continuous stroke unit electrocardiographic monitoring versus 24-hour Holter electrocardiography for detection of paroxysmal atrial fibrillation after stroke
    Timolaos Rizos
    Department of Neurology, University Heidelberg, INF 400, 69120 Heidelberg, Germany
    Stroke 43:2689-94. 2012
    ..We compared 24-hour Holter electrocardiography (ECG) with continuous stroke unit ECG monitoring (CEM) for pxAF detection...
  2. doi request reprint Anticoagulation with dabigatran does not increase secondary intracerebral haemorrhage after thrombolysis in experimental cerebral ischaemia
    Li Sun
    Department of Neurology, Ruprecht Karls University Heidelberg, INF 400, 69120 Heidelberg, Germany
    Thromb Haemost 110:153-61. 2013
    ..The implications of this finding for stroke patients have to be determined in the clinical setting. ..
  3. doi request reprint Hemostatic therapy in experimental intracerebral hemorrhage associated with rivaroxaban
    Wei Zhou
    Department of Neurology, University Heidelberg, Heidelberg, Germany
    Stroke 44:771-8. 2013
    ..The aims of the present study were to establish a murine model of ICH associated with rivaroxaban, and to examine the effectiveness of different hemostatic factors in preventing excess hematoma expansion...
  4. doi request reprint [Current registry studies of acute ischemic stroke]
    R Veltkamp
    Neurologische Klinik, Universitätsklinik Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Deutschland
    Nervenarzt 83:1270-4. 2012
    ..Finally, the recently started RASUNOA registry examines diagnostic and therapeutic aspects of ischemic and hemorrhagic stroke occurring during therapy with new oral anticoagulants...
  5. pmc Comparison of humoral neuroinflammation and adhesion molecule expression in two models of experimental intracerebral hemorrhage
    Arthur Liesz
    Department of Neurology, University Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Exp Transl Stroke Med 3:11. 2011
    ..abstract:..
  6. doi request reprint Hemostatic therapy in experimental intracerebral hemorrhage associated with the direct thrombin inhibitor dabigatran
    Wei Zhou
    Department of Neurology, University Heidelberg, INF 400, 69120 Heidelberg, Germany
    Stroke 42:3594-9. 2011
    ..The aims of the present study were to establish a murine model of ICH associated with dabigatran, and to test the efficacy of different hemostatic factors in preventing hematoma growth...
  7. doi request reprint [New oral anticoagulants in atrial fibrillation]
    R Veltkamp
    Neurologische Klinik, Ruprecht Karls Universitat Heidelberg, Heidelberg, Deutschland
    Nervenarzt 82:180, 182-4, 186-9. 2011
    ..Currently unresolved issues relate to the verification of patient adherence by suitable coagulation tests and to the emergency coagulation diagnostics and therapy in acute ischemic or hemorrhagic strokes under the new OAC...
  8. doi request reprint Rapid reversal of anticoagulation prevents excessive secondary hemorrhage after thrombolysis in a thromboembolic model in rats
    Li Sun
    Department of Neurology, Ruprecht Karls University Heidelberg, INF 400, 69120 Heidelberg, Germany
    Stroke 42:3524-9. 2011
    ....
  9. doi request reprint Does the STAF score help detect paroxysmal atrial fibrillation in acute stroke patients?
    S Horstmann
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Eur J Neurol 20:147-52. 2013
    ..Recently, the STAF score, a composite of clinical and instrumental findings, was introduced to identify stroke patients at risk of pAF. We aimed to validate this score in an independent study population...
  10. doi request reprint Paroxysmal atrial fibrillation is more prevalent than persistent atrial fibrillation in acute stroke and transient ischemic attack patients
    T Rizos
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Cerebrovasc Dis 32:276-82. 2011
    ..More extensive diagnostic effort is required to detect paroxysmal AF (pxAF) than persistent AF (pAF); the prevalence of pxAF in stroke patients is unknown. We evaluated the prevalence of pAF and pxAF in ischemic stroke and TIA patients...
  11. ncbi request reprint Delayed hyperbaric oxygenation is more effective than early prolonged normobaric hyperoxia in experimental focal cerebral ischemia
    Christopher Beynon
    Department of Neurology, University of Heidelberg, Germany
    Neurosci Lett 425:141-5. 2007
    ..8+/-1.1). In conclusion, HBO is a more effective therapy than NBO in transient experimental ischemia even when accounting for delayed treatment-onset of HBO. The combination of NBO and HBO results in no additional benefit...
  12. pmc Oxygen therapy reduces secondary hemorrhage after thrombolysis in thromboembolic cerebral ischemia
    Li Sun
    Department of Neurology, Ruprecht Karls University Heidelberg, Heidelberg, Germany
    J Cereb Blood Flow Metab 30:1651-60. 2010
    ..As NBO and HBO also reduce postthrombolytic intracerebral hemorrhage, combining the two with thrombolysis seems promising...
  13. doi request reprint Hyperbaric oxygen reduces tissue hypoxia and hypoxia-inducible factor-1 alpha expression in focal cerebral ischemia
    Li Sun
    Department of Neurology, Ruprecht Karls University Heidelberg, Heidelberg, Germany
    Stroke 39:1000-6. 2008
    ..However, even the basic mechanisms underlying oxygen therapy are poorly understood. We investigated the effect of both oxygen therapies on tissue hypoxia and on the transcription factor hypoxia-inducible factor-1 alpha...
  14. doi request reprint Intracerebral hemorrhage during anticoagulation with vitamin K antagonists: a consecutive observational study
    S Horstmann
    Department of Neurology, University of Heidelberg, INF 400, 69120, Heidelberg, Germany
    J Neurol 260:2046-51. 2013
    ..08). One-fourth of all ICH are related to OAC. Initial extension of ICH into the ventricles and primary IVH are more frequent in OAC-ICH. The rate of hematoma expansion in OAC-ICH patients is similar to non-anticoagulated ICH patients. ..
  15. doi request reprint Continuous monitoring versus HOLTER ECG for detection of atrial fibrillation in patients with stroke
    C Gumbinger
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Eur J Neurol 19:253-7. 2012
    ..Furthermore, we investigate how many additional patients with paroxysmal atrial fibrillation can be identified as a result of a longer duration of continuous monitoring...
  16. ncbi request reprint Regulatory CD4+ CD25+ T cells prevent thymic dysfunction in experimental chronic colitis
    C Veltkamp
    Department of Gastroenterology, Ruprecht Karls University, Heidelberg, Germany
    Scand J Immunol 66:636-44. 2007
    ..In conclusion, early CD4+ CD25+ cotransfer prevents thymic dysfunction which underlies immune-mediated bowel inflammation in BM-->Tg epsilon26 mice...
  17. ncbi request reprint Influence of positive end-expiratory pressure on intracranial pressure and cerebral perfusion pressure in patients with acute stroke
    D Georgiadis
    Department of Neurology, University of Heidelberg, Germany
    Stroke 32:2088-92. 2001
    ..We undertook this study to evaluate the influence of positive end-expiratory pressure (PEEP) on intracranial pressure (ICP) and cerebral perfusion pressure (CPP) in patients with acute stroke...
  18. pmc Regulatory CD4+CD25+ cells reverse imbalances in the T cell pool of bone marrow transplanted TGepsilon26 mice leading to the prevention of colitis
    C Veltkamp
    Department of Gastroenterology, University of Heidelberg, INF 410, 69120 Heidelberg, Germany
    Gut 54:207-14. 2005
    ..Colitis in bone marrow (BM) transplanted Tgepsilon26 mice is induced by abnormally activated T cells developing in an aberrant thymic microenvironment. We investigated the protective role of regulatory CD4+CD25+ T cells in this model...
  19. ncbi request reprint [Symptomatic dissection of the internal carotid artery. A rare manifestation of autosome dominant polycystic kidney disease?]
    R Veltkamp
    Neurologische Klinik, Ruprecht Karls Universitat Heidelberg
    Nervenarzt 75:149-52. 2004
    ..Finally, special aspects of the diagnostic evaluation and therapeutic management in patients with ADPKD and cervicocephalic dissection are discussed...
  20. ncbi request reprint Progressive arm weakness and tonic hand spasm from multifocal motor neuropathy in the brachial plexus
    R Veltkamp
    Department of Neurology, Ruprecht Karls University Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Muscle Nerve 28:242-5. 2003
    ..Strength recovered and cramps disappeared after intravenous immunoglobulins. Motor neuropathies may thus manifest with features of central motor disorders...
  21. doi request reprint Autonomic shift and increased susceptibility to infections after acute intracerebral hemorrhage
    Marek Sykora
    Department of Neurology, University Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Stroke 42:1218-23. 2011
    ..However, the underlying pathophysiology remains unclear. The aim of the current study was to investigate the role of autonomic shift in increased susceptibility to infection after acute intracerebral hemorrhage (ICH)...
  22. doi request reprint Quantitative EEG correlates of low cerebral perfusion in severe stroke
    Jennifer Diedler
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Neurocrit Care 11:210-6. 2009
    ..We aimed to identify parameters that may be used for continuous monitoring even in patients with a burst-suppression baseline EEG pattern...
  23. ncbi request reprint Hyperbaric oxygen induces rapid protection against focal cerebral ischemia
    Roland Veltkamp
    Department of Neurology, Ruprecht Karls University Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Brain Res 1037:134-8. 2005
    ..The timing and mechanisms of protection by hyperbaric oxygen (HBO) in cerebral ischemia have only been partially elucidated. We monitored the early in vivo effects of HBO after 2 h transient focal ischemia using repetitive MRI...
  24. doi request reprint Infarct volume is a major determiner of post-stroke immune cell function and susceptibility to infection
    Andreas Hug
    Department of Neurology, University of Heidelberg, University Hospital Heidelberg, Germany
    Stroke 40:3226-32. 2009
    ..Hallmarks of this stroke-induced immunodepression syndrome are: lymphocytopenia, impairment of T helper cell and monocyte function. We studied which stroke-specific factors predict these immunologic alterations and subsequent infections...
  25. doi request reprint Intrapulmonary right-left shunts in Guillain-Barré syndrome with severe dysautonomia
    Marek Sykora
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany
    Neurocrit Care 9:374-7. 2008
    ..To our knowledge, increased intrapulmonary shunts in association with GBS have not yet been reported...
  26. doi request reprint Autonomic impairment in tetanus: delayed baroreflex involvement
    Marek Sykora
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany
    J Neurol Sci 270:201-4. 2008
    ..Blood pressure instability could not be explained by baroreflex dynamics. We suggest that a shift towards sympathetic activity possibly overruled the effects of decreased baroreflex sensitivity on blood pressure regulation...
  27. ncbi request reprint Endovascular cooling in a patient with neuroleptic malignant syndrome
    Jennifer Diedler
    Department of Neurology, University of Heidelberg, Germany
    J Neurol Sci 264:163-5. 2008
    ..However, upon withdrawl of endovascular temperature control there was a relapse. This is the first case where endovascular cooling was applied successfully in neuroleptic malignant syndrome...
  28. ncbi request reprint Oxygen therapy in permanent brain ischemia: potential and limitations
    Roland Veltkamp
    Department of Neurology, Ruprecht Karls University Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Brain Res 1107:185-91. 2006
    ..The goals of the present study were to compare both oxygen therapies in 2 models of permanent ischemia, to study the effect of time window, and to evaluate the combination of both oxygen therapies...
  29. ncbi request reprint CD4+CD25+ cell depletion from the normal CD4+ T cell pool prevents tolerance toward the intestinal flora and leads to chronic colitis in immunodeficient mice
    Claudia Veltkamp
    Department of Gastroenterology, Ruprecht Karls University, Heidelberg, Germany
    Inflamm Bowel Dis 12:437-46. 2006
    ....
  30. ncbi request reprint Hyperbaric oxygen reduces basal lamina degradation after transient focal cerebral ischemia in rats
    Roland Veltkamp
    Department of Neurology, Ruprecht Karls University Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Brain Res 1076:231-7. 2006
    ..In conclusion, HBO therapy attenuates ischemic degradation of cerebral microvascular laminin-5 and blocks postischemic plasma MMP-9 upregulation...
  31. ncbi request reprint Prolonged low-dose intravenous thrombolysis in a stroke patient with distal basilar thrombus
    Roland Veltkamp
    Department of Neurology, Ruprecht Karls University Heidelberg, Germany
    Stroke 37:e9-11. 2006
    ..Patients with high-grade basilar artery stenosis secondary to thromboembolism are at high risk of developing subsequent vessel occlusion. Optimal medical management of this condition is unclear...
  32. ncbi request reprint Hyperbaric oxygen reduces blood-brain barrier damage and edema after transient focal cerebral ischemia
    Roland Veltkamp
    Department of Neurology, Ruprecht Karls University Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Stroke 36:1679-83. 2005
    ..We examined the potential of HBO to reduce postischemic blood-brain barrier (BBB) damage and edema...
  33. doi request reprint Autoregulation and brain metabolism in the perihematomal region of spontaneous intracerebral hemorrhage: an observational pilot study
    Jennifer Diedler
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    J Neurol Sci 295:16-22. 2010
    ..A study in a larger population is needed to clarify the relationship between PRx and ORx in ICH patients, the local metabolic effects of autoregulatory failure and its relation to brain edema formation and clinical outcome...
  34. ncbi request reprint Transient focal ischemia increases endothelial nitric oxide synthase in cerebral blood vessels
    Roland Veltkamp
    Department of Physiology and Pharmacology and Center for Investigative Neuroscience, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Stroke 33:2704-10. 2002
    ..Production of NO by endothelial NO synthase (eNOS) plays a protective role in cerebral ischemia. We studied the effects of transient focal ischemia on eNOS expression...
  35. doi request reprint The spectrum of systemic immune alterations after murine focal ischemia: immunodepression versus immunomodulation
    Arthur Liesz
    Department of Neurology, University Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Stroke 40:2849-58. 2009
    ..Herein, we characterize the impact of 3 ischemia models on systemic immunological and microbiological parameters...
  36. doi request reprint Kinetics of hematoma expansion in murine warfarin-associated intracerebral hemorrhage
    Sergio Illanes
    Department of Neurology, University Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Brain Res 1320:135-42. 2010
    ..Herein, we refine a mouse model of OAC-ICH using repetitive T2* MRI to describe kinetics of hematoma enlargement, and establish a benchside point of care INR assay (PoC) for assessment of anticoagulation...
  37. doi request reprint Detection of paroxysmal atrial fibrillation in acute stroke patients
    T Rizos
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Cerebrovasc Dis 30:410-7. 2010
    ....
  38. doi request reprint Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke
    Arthur Liesz
    Department of Neurology, University Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Nat Med 15:192-9. 2009
    ..In conclusion, T(reg) cells are major cerebroprotective modulators of postischemic inflammatory brain damage targeting multiple inflammatory pathways. IL-10 signaling is essential for their immunomodulatory effect...
  39. doi request reprint Point-of-care international normalized ratio testing accelerates thrombolysis in patients with acute ischemic stroke using oral anticoagulants
    Timolaos Rizos
    Department of Neurology, University Heidelberg, 69120 Heidelberg Germany
    Stroke 40:3547-51. 2009
    ..The accuracy and effectiveness of POC devices for emergency management in acute ischemic stroke has not been tested...
  40. doi request reprint AXIS: a trial of intravenous granulocyte colony-stimulating factor in acute ischemic stroke
    Wolf R Schabitz
    Department of Neurology, University of Munster, Munster, Germany
    Stroke 41:2545-51. 2010
    ..The present phase IIa study assessed safety and tolerability over a broad dose range of G-CSF doses in acute ischemic stroke patients and explored outcome data...
  41. ncbi request reprint Oxygen therapy in acute ischemic stroke - experimental efficacy and molecular mechanisms
    Sven Poli
    Department of Neurology, University Heidelberg, Germany
    Curr Mol Med 9:227-41. 2009
    ..Finally, its beneficial effects on the ischemic microcirculation suggest an important modification of various cell types within the neurovascular unit...
  42. doi request reprint Comparative effectiveness of hemostatic therapy in experimental warfarin-associated intracerebral hemorrhage
    Sergio Illanes
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, Heidelberg 69120, Germany
    Stroke 42:191-5. 2011
    ..We compared the effectiveness of diverse hemostatic approaches in a mouse model of warfarin-associated intracerebral hemorrhage...
  43. doi request reprint Inhibition of lymphocyte trafficking shields the brain against deleterious neuroinflammation after stroke
    Arthur Liesz
    Department of Neurology, University Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Brain 134:704-20. 2011
    ..Thus, targeting T lymphocyte-migration represents a promising therapeutic approach for ischaemic stroke...
  44. doi request reprint Point-of-care reversal treatment in phenprocoumon-related intracerebral hemorrhage
    Timolaos Rizos
    Department of Neurology, University Heidelberg, Heidelberg, Germany
    Ann Neurol 67:788-93. 2010
    ..Accuracy and effectiveness of point-of-care INR coagulometers (POCs) for INR reversal in OAC-ICH have not been evaluated...
  45. ncbi request reprint Correlation of soluble gp130 serum concentrations with arterial blood pressure
    Ioana Inta
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    J Hypertens 27:527-34. 2009
    ....