P Vaupel

Summary

Affiliation: University of Mainz
Country: Germany

Publications

  1. ncbi request reprint The role of hypoxia-induced factors in tumor progression
    Peter Vaupel
    Institute of Physiology and Pathophysiology, University of Mainz, Duesbergweg 6, 55099 Mainz, Germany
    Oncologist 9:10-7. 2004
  2. doi request reprint Lack of hypoxic response in uterine leiomyomas despite severe tissue hypoxia
    Arnulf Mayer
    Institute of Physiology and Pathophysiology, Johannes Gutenberg University, Mainz, Germany
    Cancer Res 68:4719-26. 2008
  3. doi request reprint Hypoxia in tumors: pathogenesis-related classification, characterization of hypoxia subtypes, and associated biological and clinical implications
    Peter Vaupel
    Department of Radiooncology and Radiotherapy, University Medical Center, Langenbeckstrasse 1, 55131, Mainz, Germany
    Adv Exp Med Biol 812:19-24. 2014
  4. doi request reprint Tumor oxygenation: an appraisal of past and present concepts and a look into the future : Arisztid G. B. Kovách Lecture
    Peter Vaupel
    Department of Radiotherapy and Radiooncology, Klinikum rechts der Isar, Technical University, Ismaninger Strasse 22, 81675, Munich, Germany
    Adv Exp Med Biol 789:229-36. 2013
  5. doi request reprint Availability, not respiratory capacity governs oxygen consumption of solid tumors
    Peter Vaupel
    Department of Radiooncology and Radiotherapy, Tumor Pathophysiology Division, University Medical Center, Mainz, Germany
    Int J Biochem Cell Biol 44:1477-81. 2012
  6. doi request reprint Blood flow and oxygenation status of prostate cancers
    Peter Vaupel
    Department of Radiotherapy and Radiooncology, Technische Universitat Munchen, Munich, Germany
    Adv Exp Med Biol 765:299-305. 2013
  7. ncbi request reprint Oxygenation gain factor: a novel parameter characterizing the association between hemoglobin level and the oxygenation status of breast cancers
    Peter Vaupel
    Institute of Physiology and Pathophysiology, University of Mainz, Duesbergweg 6, 55099 Mainz, Germany
    Cancer Res 63:7634-7. 2003
  8. ncbi request reprint Tumor hypoxia: causative factors, compensatory mechanisms, and cellular response
    Peter Vaupel
    Institute of Physiology and Pathophysiology, University of Mainz, Duesbergweg 6, 55099 Mainz, Germany
    Oncologist 9:4-9. 2004
  9. ncbi request reprint Hypoxia and anemia: effects on tumor biology and treatment resistance
    Peter Vaupel
    Institute of Physiology and Pathophysiology, University of Mainz, Duesbergweg 6, 55099 Mainz, Germany
    Transfus Clin Biol 12:5-10. 2005
  10. ncbi request reprint Effects of recombinant human erythropoietin (rHuEPO) on tumor control in patients with cancer-induced anemia
    Peter Vaupel
    Institut fur Physiologie und Pathophysiologie, Universitat Mainz, Germany
    Onkologie 28:216-21. 2005

Detail Information

Publications93

  1. ncbi request reprint The role of hypoxia-induced factors in tumor progression
    Peter Vaupel
    Institute of Physiology and Pathophysiology, University of Mainz, Duesbergweg 6, 55099 Mainz, Germany
    Oncologist 9:10-7. 2004
    ..The selection and expansion of new (and more aggressive) clones, which eventually become the dominant tumor cell type, lead to the establishment of a vicious circle of hypoxia and malignant progression...
  2. doi request reprint Lack of hypoxic response in uterine leiomyomas despite severe tissue hypoxia
    Arnulf Mayer
    Institute of Physiology and Pathophysiology, Johannes Gutenberg University, Mainz, Germany
    Cancer Res 68:4719-26. 2008
    ..Malignancy in the same organ system is associated with growth and metabolism beyond tissue-inherent limitations leading to the induction of hypoxia-related markers, thereby contributing to a self-perpetuating aggressive phenotype...
  3. doi request reprint Hypoxia in tumors: pathogenesis-related classification, characterization of hypoxia subtypes, and associated biological and clinical implications
    Peter Vaupel
    Department of Radiooncology and Radiotherapy, University Medical Center, Langenbeckstrasse 1, 55131, Mainz, Germany
    Adv Exp Med Biol 812:19-24. 2014
    ....
  4. doi request reprint Tumor oxygenation: an appraisal of past and present concepts and a look into the future : Arisztid G. B. Kovách Lecture
    Peter Vaupel
    Department of Radiotherapy and Radiooncology, Klinikum rechts der Isar, Technical University, Ismaninger Strasse 22, 81675, Munich, Germany
    Adv Exp Med Biol 789:229-36. 2013
    ..In multivariate analysis, hypoxia was found to be an independent, adverse prognostic factor for patient survival due to hypoxia-driven malignant progression and hypoxia-associated resistance to anticancer therapy. ..
  5. doi request reprint Availability, not respiratory capacity governs oxygen consumption of solid tumors
    Peter Vaupel
    Department of Radiooncology and Radiotherapy, Tumor Pathophysiology Division, University Medical Center, Mainz, Germany
    Int J Biochem Cell Biol 44:1477-81. 2012
    ..Instead, due to a "reprogrammed" cancer cell metabolism, glycolysis is used to produce intermediates as building blocks for various biosynthetic pathways of cancer cells...
  6. doi request reprint Blood flow and oxygenation status of prostate cancers
    Peter Vaupel
    Department of Radiotherapy and Radiooncology, Technische Universitat Munchen, Munich, Germany
    Adv Exp Med Biol 765:299-305. 2013
    ..As was the case with blood flow, tissue oxygenation was extremely heterogeneous with no clear dependency on a series of tumor (Gleason score, clinical size, androgen deprivation) and patient characteristics (serum PSA levels, age)...
  7. ncbi request reprint Oxygenation gain factor: a novel parameter characterizing the association between hemoglobin level and the oxygenation status of breast cancers
    Peter Vaupel
    Institute of Physiology and Pathophysiology, University of Mainz, Duesbergweg 6, 55099 Mainz, Germany
    Cancer Res 63:7634-7. 2003
    ..Conversely, in breast cancers, even mild anemia (grade I anemia) is a major causative factor for the development of hypoxia or anoxia...
  8. ncbi request reprint Tumor hypoxia: causative factors, compensatory mechanisms, and cellular response
    Peter Vaupel
    Institute of Physiology and Pathophysiology, University of Mainz, Duesbergweg 6, 55099 Mainz, Germany
    Oncologist 9:4-9. 2004
    ....
  9. ncbi request reprint Hypoxia and anemia: effects on tumor biology and treatment resistance
    Peter Vaupel
    Institute of Physiology and Pathophysiology, University of Mainz, Duesbergweg 6, 55099 Mainz, Germany
    Transfus Clin Biol 12:5-10. 2005
    ....
  10. ncbi request reprint Effects of recombinant human erythropoietin (rHuEPO) on tumor control in patients with cancer-induced anemia
    Peter Vaupel
    Institut fur Physiologie und Pathophysiologie, Universitat Mainz, Germany
    Onkologie 28:216-21. 2005
    ..However, one of the most essential prerequisites for achieving this benefit is the use of rHuEPO in agreement with the evidence-based ASCO/ASH-guidelines recommending a target Hb concentration of 12 g/dl (7.44 mmol/l)...
  11. ncbi request reprint Impact of hemoglobin levels on tumor oxygenation: the higher, the better?
    Peter Vaupel
    Institute of Physiology and Pathophysiology, University of Mainz, Duesbergweg 6, 55099 Mainz, Germany
    Strahlenther Onkol 182:63-71. 2006
    ..Since anemia is a major factor causing tumor hypoxia, the association between blood hemoglobin concentration (cHb) and tumor oxygenation status has been examined...
  12. ncbi request reprint Hypoxia in cancer: significance and impact on clinical outcome
    Peter Vaupel
    Institute of Physiology and Pathophysiology, University of Mainz, Duesbergweg 6, 55099 Mainz, Germany
    Cancer Metastasis Rev 26:225-39. 2007
    ..g., different immunohistochemical staining procedures) may compromise the power of the prognostic parameter used...
  13. ncbi request reprint Detection and characterization of tumor hypoxia using pO2 histography
    Peter Vaupel
    Institute of Physiology and Pathophysiology, University of Mainz, Mainz, Germany
    Antioxid Redox Signal 9:1221-35. 2007
    ..Detection of hypoxia in the clinical setting may therefore be helpful in selecting high-risk patients for individual and/or more intensive treatment schedules...
  14. doi request reprint Hypoxia and aggressive tumor phenotype: implications for therapy and prognosis
    Peter Vaupel
    Institute of Physiology and Pathophysiology, University of Mainz, Duesbergweg 6, 55099 Mainz, Germany
    Oncologist 13:21-6. 2008
    ..In the current situation, it remains important to use ESAs within the approved indications and according to treatment guidelines such as those developed by the European Organization for Research and Treatment of Cancer...
  15. doi request reprint Prognostic potential of the pre-therapeutic tumor oxygenation status
    Peter Vaupel
    Institute of Physiology and Pathophysiology, University of Mainz, Duesbergweg 6, 55099 Mainz, Germany
    Adv Exp Med Biol 645:241-6. 2009
    ..In head & neck cancers, the studies suggest that pretherapeutic hypoxia is prognostic for survival and local control...
  16. doi request reprint Oxygenation status of urogenital tumors
    Peter Vaupel
    Department of Radiooncology and Radiotherapy, University Medical Center, Langenbeckstrasse 1, 55131 Mainz, Germany
    Adv Exp Med Biol 701:101-6. 2011
    ..In these benign tumors, the median pO(2) is 1 mmHg and signs of hypoxia-driven processes are missing...
  17. ncbi request reprint O(2) extraction is a key parameter determining the oxygenation status of malignant tumors and normal tissues
    Peter Vaupel
    Institute of Physiology and Pathophysiology, University of Mainz, D 55099 Mainz, Germany
    Int J Oncol 22:795-8. 2003
    ....
  18. ncbi request reprint Oxygenation status of gynecologic tumors: what is the optimal hemoglobin level?
    Peter Vaupel
    Institute of Physiology and Pathophysiology, University of Mainz, Germany
    Strahlenther Onkol 178:727-31. 2002
    ..Since anemia is a major causative factor for the development of hypoxia, the association between blood hemoglobin concentration (cHb) and tumor oxygenation was examined in this study...
  19. ncbi request reprint Metabolic microenvironment of tumor cells: a key factor in malignant progression
    P Vaupel
    Department of Radiotherapy and Radiooncology, Klinikum rechts der Isar, Munich Technical University, Ismaninger Strasse 22, Munich 81675, Germany
    Exp Oncol 32:125-7. 2010
    ..The interpretation of the role of tumor pH in tumor progression is complicated by the frequently occurring coexistence of tumor hypoxia and acidosis...
  20. ncbi request reprint Blood supply, oxygenation status and metabolic micromilieu of breast cancers: characterization and therapeutic relevance
    P Vaupel
    Institute of Physiology and Pathophysiology, University of Mainz, D 55099 Mainz, Germany
    Int J Oncol 17:869-79. 2000
    ..The <physiological barriers> to treatment are also considered...
  21. ncbi request reprint Tumor oxygenation in anemic rats: effects of erythropoietin treatment versus red blood cell transfusion
    D K Kelleher
    Institute of Physiology and Pathophysiology, University of Mainz, Germany
    Acta Oncol 34:379-84. 1995
    ..4 ml). In larger tumors (> or = 1.4 ml), neither method of anemia correction resulted in significant changes in tumor oxygenation...
  22. ncbi request reprint Treatment resistance of solid tumors: role of hypoxia and anemia
    P Vaupel
    Institute of Physiology and Pathophysiology, University of Mainz, Germany
    Med Oncol 18:243-59. 2001
    ..Treatment resistance in anemic patients can be, at least partially, prevented or overcome by anemia correction, resulting in better locoregional tumor control and overall survival of patients...
  23. ncbi request reprint Erythropoietin restores the anemia-induced reduction in cyclophosphamide cytotoxicity in rat tumors
    O Thews
    Institute of Physiology and Pathophysiology, University of Mainz, Germany
    Cancer Res 61:1358-61. 2001
    ....
  24. ncbi request reprint Can erythropoietin improve tumor oxygenation?
    D K Kelleher
    Institute of Physiology and Pathophysiology, University of Mainz
    Strahlenther Onkol 174:20-3. 1998
    ....
  25. ncbi request reprint Water-filtered infrared-A radiation: a novel technique for localized hyperthermia in combination with bacteriochlorophyll-based photodynamic therapy
    D K Kelleher
    Institute of Physiology and Pathophysiology, University of Mainz, Germany
    Int J Hyperthermia 15:467-74. 1999
    ..This novel technique has proved to be well-tolerated, easy to apply and should be suitable for treatment of superficial malignancies, especially where hypoxic tumour areas are present...
  26. pmc Enhanced radiosensitivity in experimental tumours following erythropoietin treatment of chemotherapy-induced anaemia
    O Thews
    Institute of Physiology and Pathophysiology, Johannes Gutenberg University, Mainz, Germany
    Br J Cancer 78:752-6. 1998
    ..These data suggest that the correction of chemotherapy-induced anaemia by rhEPO (epoetin beta) treatment increases tumour radiosensitivity, presumably as a result of an improved oxygen supply to tumour tissue...
  27. pmc Combined hyperthermia and chlorophyll-based photodynamic therapy: tumour growth and metabolic microenvironment
    D K Kelleher
    Institute of Physiology and Pathophysiology, Johannes Gutenberg University Mainz, Duesbergweg 6 D 55099 Mainz, Germany
    Br J Cancer 89:2333-9. 2003
    ....
  28. ncbi request reprint No improvement in perfusion and oxygenation of experimental tumors upon application of vasodilator drugs
    O Thews
    Institute of Physiology and Pathophysiology, University of Mainz, 55099 Mainz, Germany
    Int J Oncol 19:1243-7. 2001
    ..The vasodilator drugs studied are not suitable for dilation of tumor vessels either because the tumor vasculature lacks contractile wall elements or because the vessels are already maximally dilated...
  29. pmc Stable bioenergetic status despite substantial changes in blood flow and tissue oxygenation in a rat tumour
    P Vaupel
    Institute of Physiology and Pathophysiology, University of Mainz, Germany
    Br J Cancer 69:46-9. 1994
    ..Perfusion rate seems to play a paramount role in determining energy status only in low-flow tumours or low-flow tissue areas...
  30. doi request reprint Endogenous hypoxia markers: case not proven!
    Arnulf Mayer
    Institute of Physiology and Pathophysiology, University of Mainz, 55099 Mainz, Germany
    Adv Exp Med Biol 614:127-36. 2008
    ..The term "endogenous hypoxia markers" should therefore be avoided, at least in the clinical oncology setting...
  31. ncbi request reprint Oxygenation status of primary and recurrent squamous cell carcinomas of the vulva
    P Vaupel
    Institute of Physiology and Pathophysiology, University of Mainz, Germany
    Eur J Gynaecol Oncol 27:142-6. 2006
    ..Cancers of the vulva are relatively rare and, therefore, little is known about the pathophysiological role of tumor oxygenation in this entity...
  32. ncbi request reprint Oxygenation of human tumors: the Mainz experience
    P Vaupel
    Institute of Physiology and Pathophysiology, University of Mainz, Germany
    Strahlenther Onkol 174:6-12. 1998
    ..e., tumor cells are more likely to be more metastatic and/or invasive. In addition, clonal heterogeneity is more pronounced in hypoxic tumors...
  33. pmc Microenvironmental adaptation of experimental tumours to chronic vs acute hypoxia
    O Thews
    Institute of Physiology and Pathophysiology, University of Mainz, Duesbergweg 6, 55099 Mainz, Germany
    Br J Cancer 91:1181-9. 2004
    ..These results suggest that long-term adaptation of tumours to chronic hypoxia in vivo, while not affecting vascularity, does influence the functional status of the microvessels in favour of a more homogeneous perfusion...
  34. pmc Disparate responses of tumour vessels to angiotensin II: tumour volume-dependent effects on perfusion and oxygenation
    O Thews
    Institute of Physiology and Pathophysiology, University of Mainz, Germany
    Br J Cancer 83:225-31. 2000
    ....
  35. ncbi request reprint Hypoxia-stimulated expression of angiogenic growth factors in cervical cancer cells and cervical cancer-derived fibroblasts
    H Pilch
    Department of Obstetrics and Gynecology, University of Mainz, Medical Center, Germany
    Int J Gynecol Cancer 11:137-42. 2001
    ..05). The presented data support the concept that in cervical cancer non-neoplastic fibroblasts could play a pivotal role in the complex process of tumor angiogenesis...
  36. pmc Localized hypothermia: impact on oxygenation, microregional perfusion, metabolic and bioenergetic status of subcutaneous rat tumours
    D K Kelleher
    Institute of Physiology and Pathophysiology, University of Mainz, Germany
    Br J Cancer 78:56-61. 1998
    ..No changes in lactate or adenylate phosphate levels were observed. As a way of improving tumour oxygenation, localized hypothermia may therefore be a useful means of radiosensitization...
  37. ncbi request reprint Tumor hypoxia in pelvic recurrences of cervical cancer
    M Hockel
    Department of Obstetrics and Gynecology, University of Mainz, Germany
    Int J Cancer 79:365-9. 1998
    ..Our results further support our thesis that in cervical cancer, tumor hypoxia and clinical aggressiveness in terms of resistance to therapy and tumor dissemination, are interrelated...
  38. ncbi request reprint Oxygen status of malignant tumors: pathogenesis of hypoxia and significance for tumor therapy
    P Vaupel
    Institute of Physiology and Pathophysiology, University of Mainz, Germany
    Semin Oncol 28:29-35. 2001
    ..Hypoxia is a powerful, independent prognostic factor in cervix cancers, carcinomas of the head and neck, and in soft-tissue sarcomas...
  39. doi request reprint Intra- and intertumor heterogeneities in total, chronic, and acute hypoxia in xenografted squamous cell carcinomas. Detection and quantification using (immuno-)fluorescence techniques
    C A Maftei
    Department of Radiotherapy and Radiation Oncology, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Str 22, 81675, Munich, Germany
    Strahlenther Onkol 188:606-15. 2012
    ....
  40. doi request reprint Acute versus chronic hypoxia in tumors: Controversial data concerning time frames and biological consequences
    C Bayer
    Department of Radiotherapy and Radiation Oncology, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str 22, 81675, Munich, Germany
    Strahlenther Onkol 188:616-27. 2012
    ..In order to accurately assess the specific biological consequences, it is important to understand which time frames best define acute and chronic hypoxia...
  41. ncbi request reprint Quantitative changes of metabolic and bioenergetic parameters in experimental tumors during fractionated irradiation
    O Thews
    Institute of Physiology and Pathophysiology, University of Mainz, Germany
    Int J Radiat Oncol Biol Phys 45:1281-8. 1999
    ....
  42. ncbi request reprint Hypoxia in breast cancer: pathogenesis, characterization and biological/therapeutic implications
    P Vaupel
    Institute of Physiology and Pathophysiology, University of Mainz, Duesbergweg 6, D 55099 Mainz, Germany
    Wien Med Wochenschr 152:334-42. 2002
    ..Anaemia in cancer patients should be prevented/corrected in order to improve radio-/chemosensitivity and thus to increase cancer cure rates...
  43. pmc Lacking hypoxia-mediated downregulation of E-cadherin in cancers of the uterine cervix
    A Mayer
    Department of Radiooncology and Radiotherapy, University Medical Center, Mainz, Germany
    Br J Cancer 108:402-8. 2013
    ..Our study aimed at elucidating the interrelationship of these processes in cancers of the uterine cervix in vivo...
  44. doi request reprint Basal HIF-1α expression levels are not predictive for radiosensitivity of human cancer cell lines
    D Schilling
    Department of Radiation Oncology, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Str 22, 81675, Munich, Germany
    Strahlenther Onkol 188:353-8. 2012
    ..To examine the impact of HIF-1α on radioresistance under normoxia, the sensitivity towards irradiation was measured in human tumor cell lines that differ significantly in their basal HIF-1α levels...
  45. ncbi request reprint [Hypoxia in cervical cancer: pathogenesis, characterization, and biological/clinical consequences]
    P Vaupel
    Institut fur Physiologie und Pathophysiologie, Universitat Mainz
    Zentralbl Gynakol 123:192-7. 2001
    ..In addition, the routine evaluation of the pretherapeutic oxygenation status may enable individual therapeutic strategies, independent of other oncologic parameters...
  46. ncbi request reprint Endogenous hypoxia markers in locally advanced cancers of the uterine cervix: reality or wishful thinking?
    Arnulf Mayer
    Institute of Physiology and Pathophysiology, University of Mainz, Mainz, Germany
    Strahlenther Onkol 182:501-10. 2006
    ..g., hypoxia-inducible factor-1alpha (HIF-1alpha), glucose transporter-1 (GLUT-1) and carbonic anhydrase IX (CA IX) are currently being discussed as "endogenous hypoxia markers"...
  47. ncbi request reprint Impact of therapeutically induced reactive oxygen species and radical scavenging by alpha-tocopherol on tumor cell adhesion
    Oliver Thews
    Institute of Physiology and Pathophysiology, University of Mainz, 55099 Mainz, Germany
    Oncol Rep 18:965-71. 2007
    ..Depending on the individual tumor entity ROS may therefore influence the mechanical stability of solid tumors and by this affect metastatic behavior...
  48. doi request reprint Strikingly high respiratory quotients: a further characteristic of the tumor pathophysiome
    Peter Vaupel
    Institute of Physiology and Pathophysiology, University of Mainz, Duesbergweg 6, 55099 Mainz, Germany
    Adv Exp Med Biol 614:121-5. 2008
    ..Strikingly high (RQs) may thus be a further characteristic of the tumor microenvironment and of the tumor (patho-)physiome, the latter quantitatively describing the pathophysiologic characteristics of tumor cells and solid tumors...
  49. doi request reprint Evidence against a major role for TKTL-1 in hypoxic and normoxic cancer cells
    Arnulf Mayer
    Department of Radiooncology and Radiotherapy, University Medical Center, Langenbeckstrasse 1, 55131 Mainz, Germany
    Adv Exp Med Biol 701:123-8. 2011
    ..Our data argue against a major role of TKTL-1 for the metabolism of cancer cells...
  50. ncbi request reprint GLUT-1 staining of squamous cell carcinomas of the uterine cervix identifies a novel element of invasion
    Arnulf Mayer
    Department of Radiooncology and Radiotherapy, University Medical Center, Johannes Gutenberg University, Langenbeckstrasse 1, 55131 Mainz, Germany
    Int J Oncol 38:145-50. 2011
    ....
  51. ncbi request reprint Glucose metabolism of malignant cells is not regulated by transketolase-like (TKTL)-1
    Arnulf Mayer
    Department of Radiooncology and Radiotherapy, University Medical Center, Johannes Gutenberg University, 55131 Mainz, Germany
    Int J Oncol 37:265-71. 2010
    ..On the basis of these data, nutritional recommendations based on a hypothetically TKTL-1 controlled metabolism of tumor cells must be regarded as lacking scientific evidence...
  52. doi request reprint HIF-mediated hypoxic response is missing in severely hypoxic uterine leiomyomas
    Arnulf Mayer
    Institute of Physiology and Pathophysiology, University Medical Center, Mainz, Germany
    Adv Exp Med Biol 662:399-405. 2010
    ....
  53. doi request reprint Solid tumours arising from differently pre-oxygenated cells: comparable growth rates despite dissimilar tissue oxygenation
    Arnulf Mayer
    Department of Radiooncology and Radiotherapy, University Medical Center, Mainz, Germany
    Int J Radiat Biol 85:981-8. 2009
    ..Here, the influence of the microenvironment of tumour-initiating cells as a factor determining intertumoural variations in the relative contributions of both processes has been examined...
  54. doi request reprint No sustained improvement in tumor oxygenation after localized mild hyperthermia
    Debra K Kelleher
    Institute of Physiology and Pathophysiology, University of Mainz, 55099 Mainz, Germany
    Adv Exp Med Biol 662:393-8. 2010
    ....
  55. ncbi request reprint Carbonic anhydrase IX expression and tumor oxygenation status do not correlate at the microregional level in locally advanced cancers of the uterine cervix
    Arnulf Mayer
    Institute of Physiology and Pathophysiology, University of Mainz, Mainz, Germany
    Clin Cancer Res 11:7220-5. 2005
    ..CA IX might therefore serve as an endogenous marker of tumor hypoxia, although comparisons of CA IX immunostaining with direct oxygenation measurements using pO2 microsensors have thus far yielded contradictory results...
  56. ncbi request reprint The physician-patient relationship before cancer treatment: a prospective longitudinal study
    Sabine Hawighorst
    Department of Obstetrics and Gynecology, University of Mainz, 55101, Mainz, Germany
    Gynecol Oncol 94:93-7. 2004
    ..To evaluate quality of life before surgery for genital cancer to determine risk factors that might influence the physician-patient relationship...
  57. ncbi request reprint Lack of correlation between expression of HIF-1alpha protein and oxygenation status in identical tissue areas of squamous cell carcinomas of the uterine cervix
    Arnulf Mayer
    Institute of Physiology and Pathophysiology, University of Mainz, Mainz, Germany
    Cancer Res 64:5876-81. 2004
    ..Additionally, no significant prognostic impact of HIF-1alpha expression was found in this group of patients...
  58. ncbi request reprint The impact of treatment for genital cancer on quality of life and body image--results of a prospective longitudinal 10-year study
    Sabine Hawighorst-Knapstein
    Department of Obstetrics and Gynecology, University of Mainz, 55101 Mainz, Germany
    Gynecol Oncol 94:398-403. 2004
    ..To evaluate the impact of treatment for genital cancer on quality of life and body image to determine patients' therapy-related needs for quality improvement of medical care before and after surgery...
  59. ncbi request reprint Lack of association between tumor oxygenation and cell cycle distribution or proliferation kinetics in experimental sarcomas
    Oliver Thews
    Institute of Physiology and Pathophysiology, University of Mainz, 55099 Mainz, Germany
    Adv Exp Med Biol 540:245-50. 2003
  60. ncbi request reprint Perfusion, oxygenation status and growth of experimental tumors upon photodynamic therapy with Pd-bacteriopheophorbide
    Debra K Kelleher
    Institute of Physiology and Pathophysiology, Johannes Gutenberg University, 55099 Mainz, Germany
    Int J Oncol 24:1505-11. 2004
    ....
  61. ncbi request reprint Tumor hypoxia and malignant progression
    Peter Vaupel
    Institute of Physiology and Pathophysiology, University of Mainz, Germany
    Methods Enzymol 381:335-54. 2004
  62. ncbi request reprint Impact of oxygenation status and patient age on DNA content in cancers of the uterine cervix
    Arnulf Mayer
    Institute of Physiology and Pathophysiology, University of Mainz, Mainz, Germany
    Int J Radiat Oncol Biol Phys 56:929-36. 2003
    ..This study analyzed whether hypoxia alters net DNA content in uterine cervix cancer cells to the extent that it is identifiable by DNA image cytometry...
  63. ncbi request reprint Lack of association between tumor hypoxia, GLUT-1 expression and glucose uptake in experimental sarcomas
    Oliver Thews
    Inst of Physiology and Pathophysiology, University of Mainz, 55099 Mainz, Germany
    Adv Exp Med Biol 510:57-61. 2003
  64. ncbi request reprint Microregional expression of glucose transporter-1 and oxygenation status: lack of correlation in locally advanced cervical cancers
    Arnulf Mayer
    Institute of Physiology and Pathophysiology, University of Mainz, Germany
    Clin Cancer Res 11:2768-73. 2005
    ..Overexpression of GLUT-1 has been shown to correlate with poor prognosis in several tumor entities, among them cancers of the uterine cervix. The validity of these hypotheses is investigated...
  65. pmc Enhanced effects of aminolaevulinic acid-based photodynamic therapy through local hyperthermia in rat tumours
    D K Kelleher
    Institute of Physiology and Pathophysiology, Johannes Gutenberg University Mainz, 55099 Mainz, Germany
    Br J Cancer 89:405-11. 2003
    ..These results demonstrate an enhanced antitumour effect upon ALA+HT, which appears to involve direct cell toxicity rather than solely vascular damage...
  66. pmc Nifedipine improves blood flow and oxygen supply, but not steady-state oxygenation of tumours in perfusion pressure-controlled isolated limb perfusion
    O Thews
    Institute of Physiology and Pathophysiology, University of Mainz, Duesbergweg 6, 55099 Mainz, Germany
    Br J Cancer 87:1462-9. 2002
    ....
  67. ncbi request reprint Dynamics of tumor oxygenation and red blood cell flux in response to inspiratory hyperoxia combined with different levels of inspiratory hypercapnia
    Oliver Thews
    Institute of Physiology and Pathophysiology, University of Mainz, 55099 Mainz, Germany
    Radiother Oncol 62:77-85. 2002
    ..This study aimed at analyzing the impact of different inspiratory CO2 fractions on the time course of oxygenation and perfusion changes in experimental tumors during and after inspiratory hyperoxia...
  68. ncbi request reprint Tumor microenvironmental physiology and its implications for radiation oncology
    Peter Vaupel
    Institute of Physiology and Pathophysiology, Johannes Gutenberg University, Mainz, Germany
    Semin Radiat Oncol 14:198-206. 2004
    ..Because of a relatively high risk of local relapse or distant metastasis, patients with hypoxic and/or "high-lactate" tumors should undergo close surveillance...
  69. ncbi request reprint Tumor oxygenation and its relevance to tumor physiology and treatment
    Peter Vaupel
    Inst Physiology and Pathophysiology, University of Mainz, 55099 Mainz, Germany
    Adv Exp Med Biol 510:45-9. 2003
  70. pmc Expression pattern of the urokinase-plasminogen activator system in rat DS-sarcoma: role of oxygenation status and tumour size
    M Weinmann
    Institute of Physiology and Pathophysiology, University of Mainz, 55099 Mainz, Germany
    Br J Cancer 86:1355-61. 2002
    ..This may indicate that the serum level of plasminogen activator inhibitor type 1 is not a reliable surrogate marker of tumour hypoxia...
  71. ncbi request reprint Microcirculatory function, tissue oxygenation, microregional redox status and ATP distribution in tumors upon localized infrared-A-hyperthermia at 42 degrees C
    Oliver Thews
    Institute of Physiology and Pathophysiology, University of Mainz, Duesbrgweg 6, 55099 Mainz, Germany
    Adv Exp Med Biol 530:237-47. 2003
    ..The latter finding can be explained by an equivalent increase in the oxygen consumption rate of the cells which increases by approx. 58% at 42 degrees C compared to normothermia...
  72. ncbi request reprint Imaging of tumor physiology: impacts on clinical radiation oncology
    S T Astner
    Klinik für Strahlentherapie und Radiologische Onkologie, Klinikum rechts der Isar, Technische Universitat Munchen, 81675 Munich, Germany
    Exp Oncol 32:149-52. 2010
    ..Co-investigation of tumor oxygenation and perfusion should be performed in order to investigate their interaction and consequences for radiooncology...
  73. ncbi request reprint An in vivo tumor model expressing green fluorescent protein for the investigation of metastasis
    Oliver Thews
    Institute of Physiology and Pathophysiology, University of Mainz, D 55099 Mainz, Germany
    Int J Oncol 27:705-12. 2005
    ..This in vivo model showing stable expression of GFP could be useful for analyzing the mechanisms of metastasis, particularly where micrometastases or circulating tumor cells are to be identified...
  74. ncbi request reprint [Influence of hemoglobin value on hematogenous tumor cell dissemination at the time of primary breast carcinoma diagnosis]
    Peter Vaupel
    Institut fur Physiologie und Pathophysiologie, Fachbereich Medizin, Germany
    Dtsch Med Wochenschr 127:1277-8. 2002
  75. ncbi request reprint Role of the tumor microenvironment in the activity and expression of the p-glycoprotein in human colon carcinoma cells
    Christopher Lotz
    Institute of Physiology and Pathophysiology, University of Mainz, Duesbergweg 6, 55099 Mainz, Germany
    Oncol Rep 17:239-44. 2007
    ....
  76. doi request reprint Quantitative assessment of hypoxia kinetic models by a cross-study of dynamic 18F-FAZA and 15O-H2O in patients with head and neck tumors
    Kuangyu Shi
    Department of Radiotherapy and Radiooncology, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    J Nucl Med 51:1386-94. 2010
    ..We performed a feasibility study to assess hypoxia kinetic models using voxelwise cross-analysis between the uptake of the perfusion tracer (15)O-H(2)O and the hypoxia tracer (18)F-fluoroazomycin arabinoside ((18)F-FAZA)...
  77. doi request reprint Impact of reactive oxygen species on the expression of adhesion molecules in vivo
    Oliver Thews
    Institute of Physiology and Pathophysiology, University of Mainz, 55099 Mainz, Germany
    Adv Exp Med Biol 645:95-100. 2009
    ..Further studies are needed to clarify the impact of ROS induction on the metastatic behavior of tumors...
  78. ncbi request reprint Erythropoietin restores the anemia-induced reduction in radiosensitivity of experimental human tumors in nude mice
    Georg Stüben
    Department of Radiotherapy, West German Tumor Centre, Universitatsklinikum, Essen, Germany
    Int J Radiat Oncol Biol Phys 55:1358-62. 2003
    ..The effect of recombinant human erythropoietin (rhEPO) on the radiosensitivity of human tumor xenografts growing in anemic and nonanemic nude mice was studied...
  79. ncbi request reprint Oxygenation of cervix cancers: impact of clinical and pathological parameters
    Michael Hockel
    Dept Obstetrics and Gynecology, University of Leipzig, 04103 Leipzig, Germany
    Adv Exp Med Biol 510:31-5. 2003
  80. ncbi request reprint Evidence for and against hypoxia as the primary cause of tumor aggressiveness
    Paul Okunieff
    University of Rochester, Rochester, New York 14642, USA
    Adv Exp Med Biol 510:69-75. 2003
  81. ncbi request reprint Beyond anaemia management: evolving role of erythropoietin therapy in neurological disorders, multiple myeloma and tumour hypoxia models
    Marc Boogaerts
    University Hospital Gasthuisberg, Leuven, Belgium
    Oncology 69:22-30. 2005
    ..Therefore, the role of epoetin may go well beyond that of increasing haemoglobin levels in anaemic patients, although additional studies are required to confirm these promising results...
  82. ncbi request reprint Intensified oxidative and nitrosative stress following combined ALA-based photodynamic therapy and local hyperthermia in rat tumors
    Juergen Frank
    Institute of Biological Chemistry and Nutrition, University of Hohenheim, Fruwirthstrasse 12, D 70593 Stuttgart, Germany
    Int J Cancer 107:941-8. 2003
    ....
  83. ncbi request reprint Hyperoxia-induced improvement of the in vitro response to gemcitabine in transitional cell carcinoma
    Guido Fechner
    Department of Urology, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Anticancer Res 25:3413-8. 2005
    ..Tumor cell survival, invasion and angiogenesis thereby compromise treatment...
  84. ncbi request reprint Hypoxia in breast cancer: role of blood flow, oxygen diffusion distances, and anemia in the development of oxygen depletion
    Peter Vaupel
    Adv Exp Med Biol 566:333-42. 2005
    ..These in turn can drive subsequent events that are known to further increase resistance to therapy in addition to critically affecting long-term prognosis...
  85. ncbi request reprint Possible protective effects of alpha-tocopherol on enhanced induction of reactive oxygen species by 2-methoxyestradiol in tumors
    Oliver Thews
    Adv Exp Med Biol 566:349-55. 2005
    ..Inhibition of SOD during ROS-generating hyperthermia results in pronounced cell injury and an improved local tumor control whereas exogenously applied vitamin E seems not to have an impact on oxidative stress...
  86. ncbi request reprint Changes in perfusion pattern of experimental tumors due to reduction in arterial oxygen partial pressure
    Oliver Thews
    Institute of Physiology, University of Wurzburg, 97070 Wüzburg, Germany
    Adv Exp Med Biol 578:363-8. 2006
  87. ncbi request reprint Cancer-related anemia: biological findings, clinical implications and impact on quality of life
    Jens Uwe Blohmer
    Sankt Gertrauden Krankenhaus, Berlin Wilmersdorf, Germany
    Oncology 68:12-21. 2005
    ..Systematic correction of anemia with appropriate supportive therapies prior to or during chemotherapy or radiotherapy may enhance patients' QOL...
  88. ncbi request reprint Hypoxia: importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy
    James L Tatum
    National Cancer Institute, Executive Plaza North, Room 6000, 6130 Executive Boulevard, Rockville, MD 20852 7440, USA
    Int J Radiat Biol 82:699-757. 2006
    ....
  89. ncbi request reprint Evaluation of hypoxia-mediated growth factors in a novel bladder cancer animal model
    Guido Fechner
    Department of Urology, University of Bonn, D 53105 Bonn, Germany
    Anticancer Res 27:4225-31. 2007
    ..g. vascular endothelial growth factor (VEGF), epidermal growth factor (EGF)). The aim of our study was to establish an animal model with modulatable tumor hypoxia. Resulting tumor growth and growth factors were assessed...
  90. ncbi request reprint Erythropoietin to treat anaemia in patients with head and neck cancer
    Peter Vaupel
    Lancet 363:992; author reply 993. 2004
  91. ncbi request reprint Impact of anemia prevention by recombinant human erythropoietin on the sensitivity of xenografted glioblastomas to fractionated irradiation
    Georg Stüben
    West German Tumor Center, Department of Radiotherapy, University Hospital Essen, Germany
    Strahlenther Onkol 179:620-5. 2003
    ..The aim of this study was to analyze whether anemia prevention by recombinant human erythropoietin (rHuEPO) affects the radiosensitivity of human glioblastoma xenografts during fractionated irradiation...
  92. doi request reprint Erythropoiesis-stimulating agents: favorable safety profile when used as indicated
    Mohammad R Nowrousian
    Department of Internal Medicine Cancer Research, West German Cancer Center, University Hospital Essen, Germany
    Strahlenther Onkol 184:121-36. 2008
    ..Several studies with erythropoiesis-stimulating agents (ESAs) have raised a number of safety issues. Therefore, a discussion of available data in light of the current EORTC guidelines 2006 on the use of ESAs in anemic patients is warranted...
  93. ncbi request reprint Oxygenation status of cervical carcinomas before and during spinal anesthesia for application of brachytherapy
    Hajo Dirk Weitmann
    Department of Radiotherapy and Radiobiology, University of Vienna, General Hospital of Vienna, Austria
    Strahlenther Onkol 179:633-40. 2003
    ..The aim of this study was therefore to determine the influence of spinal anesthesia on the oxygenation status of cervical carcinomas...