Research Topics
| Mark van der LindenSummaryAffiliation: University Hospital Country: Germany Publications
| Collaborators
|
Detail Information
Publications
Epidemiology of serotype 19A isolates from invasive pneumococcal disease in German childrenMark van der Linden
Institute for Medical Microbiology, National Reference Center for Streptococci, Department of Medical Microbiology, University Hospital RWTH, Pauwelsstr, 30, Aachen, 52074, Germany
BMC Infect Dis 13:70. 2013..Vaccination formulations used were PCV7, PCV10 (from April 2009) and PCV13 (from Dec. 2009, replacing PCV7)...- Effect of heptavalent pneumococcal conjugate vaccination on invasive pneumococcal disease in preterm born infantsSimon Rückinger
Division of Epidemiology, Ludwig Maximilians University of Munich, Institute of Social Pediatrics and Adolescent Medicine, Germany
BMC Infect Dis 10:12. 2010..Data from randomized trials is based on relatively small numbers of preterm born children... 
Serotype distribution in pneumococcal acute otitis media with ruptured tympanic membrane or sepsis in GermanyM Van der Linden
Department of Medical Microbiology, National Reference Centre for Streptococci, University Hospital RWTH Aachen, Pauwelsstr 30, 52074 Aachen, Germany
Eur J Clin Microbiol Infect Dis 29:749-54. 2010..Although based on a very limited selection of acute otitis media isolates, this analysis provides an estimate of the pneumococcal serotypes responsible for otitis media in Germany and underscores the need for future prospective studies...- Molecular characterization of pneumococcal isolates from pets and laboratory animalsMark van der Linden
Department of Medical Microbiology, National Reference Center for Streptococci, University Hospital RWTH, Aachen, Germany
PLoS ONE 4:e8286. 2009..S. pneumoniae was isolated from nose, lung and respiratory tract, eye, ear and other sites... - Clonal relatedness of erythromycin-resistant Streptococcus pyogenes isolates in GermanyRalf R Reinert
Institute for Medical Microbiology, National Reference Center for Streptococci, University Hospital, D 52057 Aachen, Germany
Antimicrob Agents Chemother 48:1369-73. 2004..6% had the efflux type mef(A), 31.5% had erm(A), and 13.0% had erm(B). A total of 23 different multilocus sequence types were observed... - Serotype distribution of invasive pneumococcal disease during the first 60 days of lifeMatthias Imohl
Institute of Medical Microbiology and National Reference Center for Streptococci, University Hospital RWTH, Aachen, Germany
Vaccine 28:4758-62. 2010..Among the non-meningitis cases no nonsusceptibility to amoxicillin was found. Further resistance rates were 14.9% for macrolides, and 4.6% for clindamycin... - Clonal spread of mef-positive macrolide-resistant Streptococcus pneumoniae isolates causing invasive disease in adults in GermanyMark van der Linden
Institute for Medical Microbiology, National Reference Center for Streptococci, University Hospital, Pauwelsstr 30, Aachen, Germany
Antimicrob Agents Chemother 51:1830-4. 2007..6% were erm(B) positive and 63.5% were mef positive. Over the study period, the frequency of resistance rose significantly from 2.2 to 17.0% (P < 0.001). A serotype 14, sequence type 9 clone was the most widespread... - Mechanisms of macrolide resistance among Streptococcus pneumoniae isolates from RussiaRalf R Reinert
Institute for Medical Microbiology, National Reference Center for Streptococci, University Hospital RWTH, Aachen, Germany
Antimicrob Agents Chemother 52:2260-2. 2008..7%], or both erm(B) and mef(E) (30.3%). Isolates with dual resistance genes [erm(B) and mef(E)] belonged to clonal complex CC81 or CC271... - Ribosomal mutations conferring resistance to macrolides in Streptococcus pneumoniae clinical strains isolated in GermanyRalf Rene Reinert
Institute of Medical Microbiology, National Reference Center for Streptococci, Aachen, Germany
Antimicrob Agents Chemother 47:2319-22. 2003..The isolates were found to have multiple mutations in the 23S rRNA and alterations in the L4 ribosomal protein. One strain had an amino acid alteration in the L22 ribosomal protein... - Macrolide-resistant Streptococcus pneumoniae and Streptococcus pyogenes in the pediatric population in Germany during 2000-2001Ralf Rene Reinert
National Reference Center for Streptococci, Institute for Medical Microbiology, University Hospital, D 52057 Aachen, Germany
Antimicrob Agents Chemother 47:489-93. 2003..016 micro g/ml; range, 0.016 to 0.5 micro g/ml). The overall resistance profile of streptococcal respiratory tract isolates is still favorable, but macrolide resistance is of growing concern in Germany... - mef(A) is the predominant macrolide resistance determinant in Streptococcus pneumoniae and Streptococcus pyogenes in GermanyChristine Bley
National Reference Center for Streptococci and Institute of Medical Microbiology, University Hospital RWTH Aachen, Pauwelsstrasse 30, Aachen, Germany
Int J Antimicrob Agents 37:425-31. 2011..0% carried mef(A), 34.5% erm(B) and 13.8% erm(A). Dissemination of a single clone [mef(A)-positive England(14)-9] has significantly contributed to the emergence of macrolide resistance amongst pneumococci in Germany... - Molecular characterization of the first telithromycin-resistant Streptococcus pneumoniae isolate in GermanyRalf Rene Reinert
Institute for Medical Microbiology, National Reference Center for Streptococci, University Hospital, Pauwelsstrasse 30, D 52057 Aachen, Germany
Antimicrob Agents Chemother 49:3520-2. 2005..9%). Telithromycin exhibited good in vitro activity (MIC at which 90% of the isolates tested were inhibited, 0.125 microg/ml). However, one erm(B)-positive isolate was found to be telithromycin resistant (MIC, 8 microg/ml)... - Telithromycin-nonsusceptible clinical isolates of Streptococcus pneumoniae from EuropeAdnan Al-Lahham
Institute for Medical Microbiology, National Reference Center for Streptococci, University Hospital (RWTH, Pauwelsstr. 30, Aachen, Germany
Antimicrob Agents Chemother 50:3897-900. 2006..All strains showed the erm(B) genotype and showed a wide range of combinations of macrolide resistance mechanisms. The predominant clone (n = 7) was serotype 14, sequence type 143... 
Emergence of macrolide and penicillin resistance among invasive pneumococcal isolates in GermanyRalf Rene Reinert
Institute of Medical Microbiology, National Reference Center for Streptococci, University of Aachen, Pauwelsstrasse 30, D 52074 Aachen, Germany
J Antimicrob Chemother 49:61-8. 2002..An analysis of macrolide consumption data during the study period showed that erythromycin resistance was highly correlated to the consumption of newer bd and od macrolides (r = 0.89, P < 0.01)...- Antimicrobial resistance of Streptococcus pneumoniae isolates of outpatients in Germany, 1999-2000Ralf Rene Reinert
Institute of Medical Microbiology, National Reference Center for Streptococci, University Hospital, Pauwelsstrasse 30, DE 52057 Aachen, Germany
Chemotherapy 50:184-9. 2004..The aim of the study was to determine the prevalence of antimicrobial resistance among clinical isolates of Streptococcus pneumoniae during the winter of 1999-2000 in Germany... - New penicillin susceptibility breakpoints for Streptococcus pneumoniae and their effects on susceptibility categorisation in Germany (1992-2008)Matthias Imohl
Institute of Medical Microbiology, National Reference Center for Streptococci, University Hospital RWTH, Pauwelsstr 30, Aachen, Germany
Int J Antimicrob Agents 34:271-3. 2009..2% resistant isolates. When the new CLSI 2008 guidelines are applied, considerably higher resistance rates are observed in the meningitis group (6.5% resistant) than among the non-meningitis cases (0.0% resistant, 0.3% intermediate)... - Regional differences in serotype distribution, pneumococcal vaccine coverage, and antimicrobial resistance of invasive pneumococcal disease among German federal statesMatthias Imohl
Institute of Medical Microbiology, National Reference Center for Streptococci, University Hospital RWTH Aachen, Pauwelsstr 30, 52074 Aachen, Germany
Int J Med Microbiol 300:237-47. 2010..7%. Penicillin G resistance was observed in 6.4% of meningitis cases. Among these, considerably higher rates of resistance were observed in the North-East region (13.0%) than in the North-West (7.1%) and South (1.8%) regions... - Relationship between the original multiply resistant South African isolates of Streptococcus pneumoniae from 1977 to 1978 and contemporary international resistant clonesRalf Rene Reinert
Institute for Medical Microbiology, National Reference Center for Streptococci, University Hospital, RWTH, Pauwelsstrasse 30, Aachen, Germany
J Clin Microbiol 43:6035-41. 2005..New molecular methods have characterized the original multiply resistant South African pneumococcal isolates from 1977 to 1978 and have shown the relationships of these clones to major pneumococcal clones... - Association of serotypes of Streptococcus pneumoniae with age in invasive pneumococcal diseaseMatthias Imohl
Institute of Medical Microbiology, National Reference Center for Streptococci, University Hospital RWTH Aachen, Pauwelsstr 30, Aachen 52074, Germany
J Clin Microbiol 48:1291-6. 2010..The serotypes predominantly affecting patients younger than the remaining collective of patients were 14, 6B, 19F, and 18C, while patients with IPD caused by serotypes 3, 4, and 9V were older than the collective, on average... - Time-kill kinetics of Streptococcus pneumoniae with reduced susceptibility to telithromycinAdnan Al Lahham
Institute of Medical Microbiology, National Reference Centre for Streptococci, Aachen, Germany
Chemotherapy 53:190-3. 2007..Telithromycin is a new ketolide increasingly used in Europe and the United States. Only very few telithromycin-resistant isolates have been described to date... - Characterization of clinical Streptococcus pneumoniae strains from Germany with decreased susceptibility to fluoroquinolonesRalf Rene Reinert
Institute of Medical Microbiology, National Reference Center for Streptococci, University of Aachen, Pauwelsstrasse 30, D 52074 Aachen, Germany
J Antimicrob Chemother 49:1015-8. 2002..In two of the 14 isolates the classical alteration in GyrA (S81F) was found. In only one isolate did alterations in ParC and GyrA exist in parallel... - Four years of universal pneumococcal conjugate infant vaccination in Germany: impact on incidence of invasive pneumococcal disease and serotype distribution in childrenMark van der Linden
National Reference Centre for Streptococci, Institute of Medical Microbiology, University Hospital RWTH Aachen, Germany
Vaccine 30:5880-5. 2012..Initially PCV7 was exclusively used; PCV10 became available from April 2009 and PCV7 was replaced by PCV13 in December 2009... - Antimicrobial susceptibility of Streptococcus pneumoniae in eight European countries from 2001 to 2003Ralf Rene Reinert
Institute of Medical Microbiology, National Reference Centre for Streptococci, University of Aachen RWTH Aachen, Pauwelsstrasse 30, D 52057 Aachen, Germany
Antimicrob Agents Chemother 49:2903-13. 2005..Seven of the 18 strains belonged to new sequence types not hitherto described in the MLST database. Europe-wide surveillance for monitoring of the further spread of these antibiotic-resistant S. pneumoniae clones is warranted... - Macrolide susceptibility and serotype specific macrolide resistance of invasive isolates of Streptococcus pneumoniae in Germany from 1992 to 2008Matthias Imohl
National Reference Center for Streptococci, Department of Medical Microbiology, University Hospital RWTH Aachen, Pauwelsstrasse 30, D 52074 Aachen, Germany
BMC Microbiol 10:299. 2010.... - Superantigen genes are more important than the emm type for the invasiveness of group A Streptococcus infectionMaria Lintges
Institute of Immunology, RWTH Aachen University, Aachen, Germany
J Infect Dis 202:20-8. 2010..In this study, we examined the role of superantigen genes and emm genotypes of clinical Streptococcus pyogenes isolates collected in Germany between 1997 and 2003... - Epidemiology of invasive Streptococcus pyogenes disease in Germany during 2003-2007Matthias Imohl
National Reference Center for Streptococci, Institute of Medical Microbiology, University Hospital, Aachen, Germany
FEMS Immunol Med Microbiol 58:389-96. 2010..6%, followed by clarithromycin (5.5%) and clindamycin (1.2%). The most prominent trend is the reduction of tetracycline-nonsusceptible isolates from 18.6% in 2003 to 8.9% in 2007... - Time-kill study of the activity of telithromycin against macrolide-resistant Streptococcus pneumoniae Isolates with 23S rRNA mutations and changes in ribosomal proteins L4 and L22Ralf Rene Reinert
Institute of Medical Microbiology, National Reference Centre for Streptococci, University of Aachen, Pauwelsstrasse 30, D 52057 Aachen, Germany
Antimicrob Agents Chemother 49:3011-3. 2005..Telithromycin had MICs ranging between 0.03 and 0.25 microg/ml and was bactericidal against four of seven strains after 24 h at two times the MIC... - Invasive group A streptococcal disease and association with varicella in Germany, 1996-2009Matthias Imohl
National Reference Center for Streptococci, Institute of Medical Microbiology, University Hospital RWTH Aachen, Aachen, Germany
FEMS Immunol Med Microbiol 62:101-9. 2011..Among the varicella-positive group, the rate of ssa-positive isolates was considerably higher than that among the varicella-negative group (28.6% vs. 12.6%), as well as the coexistence of speC and ssa (14.3% vs. 3.6%)... - Genetic diversity of pneumococcal surface protein A of Streptococcus pneumoniae meningitis in German childrenChristiane Heeg
National Reference Centre for Streptococci, Institute of Medical Microbiology, University Hospital RWTH Aachen, Aachen, Germany
Vaccine 25:1030-5. 2007..Pneumococcal serotypes were distributed evenly over all clades and families. Interestingly, the distribution of the PspA gene families in Germany was seen to differ slightly that found in other countries... - Serotype-specific penicillin resistance of Streptococcus pneumoniae in Germany from 1992 to 2008Matthias Imohl
Institute of Medical Microbiology, National Reference Center for Streptococci, University Hospital RWTH, Pauwelsstr 30, 52074 Aachen, Germany
Int J Med Microbiol 300:324-30. 2010..While the nonsusceptibility among serotype 19A isolates increased considerably over the years, the development of nonsusceptibility rates among the other serotypes is less and more ambiguous... - Characterization of German penicillin non-susceptible serotype 23F pneumococci using multilocus sequence typingRalf Rene Reinert
Institute of Medical Microbiology, National Reference Center for Streptococci, University Hospital, D 52057 Aachen, Germany
J Med Microbiol 52:981-7. 2003..4 %) have sequence types that have not been reported to date from other countries (STs 353-362). The major penicillin-resistant clones are present in Germany, a country with relatively low levels of beta-lactam resistance... - Molecular epidemiology of macrolide-resistant Streptococcus pneumoniae isolates in EuropeRalf Rene Reinert
Institute for Medical Microbiology, National Reference Center for Streptococci, University Hospital, Pauwelsstrasse 30, Aachen, Germany
J Clin Microbiol 43:1294-300. 2005..Overall, sequence type 81 (Spain23F-1 clone) was by far the most widespread. The mainly erm(B)-positive serotype 14 clone (sequence type 143), first reported in Poland in the mid-1990s, is now widespread in France... - Molecular characterisation of macrolide resistance mechanisms of Streptococcus pneumoniae and Streptococcus pyogenes isolated in Germany, 2002-2003Ralf Rene Reinert
Institute for Medical Microbiology, National Reference Center for Streptococci, University Hospital, Pauwelsstrasse 30, D 52057 Aachen, Germany
Int J Antimicrob Agents 24:43-7. 2004..This highly sensitive and specific PCR assay to detect macrolide resistance has the potential to provide sufficiently rapid results to improve antibiotic treatment of streptococcal infections... - Susceptibility to tuberculosis is associated with TLR1 polymorphisms resulting in a lack of TLR1 cell surface expressionPeter Uciechowski
Institute of Immunology, Medical Faculty, Rheinisch Westfaelische Technische Hochschule Aachen University, Aachen, Germany
J Leukoc Biol 90:377-88. 2011..Our data gain new insights in the role of TLR1 in M. tuberculosis defense and provide the first evidence that TLR1 variants are associated with susceptibility to TB in a low-incidence country... - Epidemiology of Streptococcus pneumoniae Serogroup 6 Isolates from IPD in Children and Adults in GermanyMark van der Linden
National Reference Center for Streptococci, Department of Medical Microbiology, University Hospital RWTH, Aachen, Germany
PLoS ONE 8:e60848. 2013..The four serotype 6D isolates had ST 948, ST 2185 and two new STs: 8422 and 8442. Two serogroup 6 isolates could not be assigned to a serotype, but had STs common to serogroup 6... - Temporal Variations among Invasive Pneumococcal Disease Serotypes in Children and Adults in Germany (1992-2008)Matthias Imohl
National Reference Center for Streptococci, Institute of Medical Microbiology, University Hospital RWTH, 52074 Aachen, Germany
Int J Microbiol 2010:874189. 2010..3%; 10v, 72.8%; 13v, 83.5%) than among adults (7v, 39.9%; 10v, 55.5%; 13v, 73.5%). The temporal variations in serotype distribution have to be kept in mind when interpreting vaccine coverages reported in epidemiological studies... - Activity of the new quinolones WCK 771, WCK 1152 and WCK 1153 against clinical isolates of Streptococcus pneumoniae and Streptococcus pyogenesAdnan Al-Lahham
Institute of Medical Microbiology, National Reference Centre for Streptococci, University Hospital (RWTH Aachen, D-52057 Aachen, Germany
J Antimicrob Chemother 56:1130-3. 2005..pneumoniae, whereas WCK 1152 and WCK 1153 were more potent and were able to overcome quinolone resistance in both S. pneumoniae and S. pyogenes...