Affiliation: University of Veterinary Medicine
Valentin Weigand P. Intracellular invasion and persistence: survival strategies of Streptococcus suis and Mycobacterium avium ssp. paratuberculosis. Berl Munch Tierarztl Wochenschr. 2004;117:459-63 pubmed
..In S. suis, intracellular life may represent only a transient retreat phase, whereas in MAP it is the predominant in vivo niche of the pathogen. ..
Seele J, Beineke A, Hillermann L, Jaschok Kentner B, von Pawel Rammingen U, Valentin Weigand P, et al
. The immunoglobulin M-degrading enzyme of Streptococcus suis, IdeSsuis, is involved in complement evasion. Vet Res. 2015;46:45 pubmed publisher
..In conclusion, this study demonstrates that Ide(Ssuis) is a novel complement evasion factor, which is important for bacterial survival in porcine blood during the early adaptive (IgM-dominated) immune response. ..
Doran K, Fulde M, Gratz N, Kim B, Nau R, Prasadarao N, et al
. Host-pathogen interactions in bacterial meningitis. Acta Neuropathol. 2016;131:185-209 pubmed publisher
Seele J, Nau R, Prajeeth C, Stangel M, Valentin Weigand P, Seitz M. Astrocytes Enhance Streptococcus suis-Glial Cell Interaction in Primary Astrocyte-Microglial Cell Co-Cultures. Pathogens. 2016;5: pubmed publisher
..suis. Astrocyte-microglial cell co-cultures are suitable to study S. suis infections and bacteria-cell association as well as NO release by microglial cells was enhanced in the presence of astrocytes. ..
Willenborg J, Koczula A, Fulde M, De Greeff A, Beineke A, Eisenreich W, et al
. FlpS, the FNR-Like Protein of Streptococcus suis Is an Essential, Oxygen-Sensing Activator of the Arginine Deiminase System. Pathogens. 2016;5: pubmed publisher
..Based on these results, we propose that the core function of S. suis FlpS is the oxygen-dependent activation of the arginine deiminase system. ..
Warneboldt F, Sander S, Beineke A, Valentin Weigand P, Kamphues J, Baums C. Clearance of Streptococcus suis in Stomach Contents of Differently Fed Growing Pigs. Pathogens. 2016;5: pubmed publisher
..In conclusion, the porcine stomach constitutes a very efficient barrier against oro-gastrointenstinal S. suis infections. Conditions leading to the passage of S. suis through the stomach remain to be identified. ..
Seitz M, Valentin Weigand P, Willenborg J. Use of Antibiotics and Antimicrobial Resistance in Veterinary Medicine as Exemplified by the Swine Pathogen Streptococcus suis. Curr Top Microbiol Immunol. 2016;398:103-121 pubmed publisher
..The latter shows that we hardly understand the complexity of factors affecting the success of antimicrobial treatment of (porcine) infectious diseases and underlines the need for further research in this field. ..
Koczula A, Jarek M, Visscher C, Valentin Weigand P, Goethe R, Willenborg J. Transcriptomic Analysis Reveals Selective Metabolic Adaptation of Streptococcus suis to Porcine Blood and Cerebrospinal Fluid. Pathogens. 2017;6: pubmed publisher
..In conclusion, our data revealed niche-specific metabolic gene activity which emphasizes a selective adaptation of S. suis to host environments. ..
Rungelrath V, Wohlsein J, Siebert U, Stott J, Prenger Berninghoff E, von Pawel Rammingen U, et al
. Identification of a novel host-specific IgG protease in Streptococcus phocae subsp. phocae. Vet Microbiol. 2017;201:42-48 pubmed publisher
..phocae subsp. phocae involved in immune evasion. Furthermore, the fact that IdeP cleaves solely IgG of certain marine mammals reflects functional adaption of S. phocae subsp. phocae to grey and harbor seals as its main hosts. ..