Peter Vajkoczy

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. ncbi request reprint Continuous low-dose chemotherapy plus inhibition of cyclooxygenase-2 as an antiangiogenic therapy of glioblastoma multiforme
    Jochen Tuettenberg
    Department of Neurosurgery, Klinikum Mannheim, Medical Faculty, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    J Cancer Res Clin Oncol 131:31-40. 2005
  2. ncbi request reprint Measuring VEGF-Flk-1 activity and consequences of VEGF-Flk-1 targeting in vivo using intravital microscopy: clinical applications
    P Vajkoczy
    Department of Neurosurgery, Klinikum Mannheim, University of Heidelberg, Mannheim, Germany
    Oncologist 5:16-9. 2000
  3. ncbi request reprint Penetrating craniocerebral injuries in a civilian population in mid-Europe
    P Vajkoczy
    Department of Neurosurgery, Klinikum Mannheim, University of Heidelberg, Germany
    Clin Neurol Neurosurg 101:175-81. 1999
  4. ncbi request reprint Effect of intra-arterial papaverine on regional cerebral blood flow in hemodynamically relevant cerebral vasospasm
    P Vajkoczy
    Department of Neurosurgery, Klinikum Mannheim, University of Heidelberg, Mannheim, Germany
    Stroke 32:498-505. 2001
  5. ncbi request reprint Clazosentan (AXV-034343), a selective endothelin A receptor antagonist, in the prevention of cerebral vasospasm following severe aneurysmal subarachnoid hemorrhage: results of a randomized, double-blind, placebo-controlled, multicenter phase IIa study
    Peter Vajkoczy
    Department of Neurosurgery, University Hospital Mannheim, and Faculty for Clinical Medicine, Karl Ruprecht University of Heidelberg, Mannheim, Switzerland
    J Neurosurg 103:9-17. 2005
  6. pmc Inhibition of tumor growth, angiogenesis, and microcirculation by the novel Flk-1 inhibitor SU5416 as assessed by intravital multi-fluorescence videomicroscopy
    P Vajkoczy
    Department of Neurosurgery, Klinikum Mannheim, University of Heidelberg, Germany
    Neoplasia 1:31-41. 1999
  7. pmc Microtumor growth initiates angiogenic sprouting with simultaneous expression of VEGF, VEGF receptor-2, and angiopoietin-2
    Peter Vajkoczy
    Department of Neurosurgery, Klinikum Mannheim, University of Heidelberg, Theodor Kutzer Ufer 103, D 68167 Mannheim, Germany
    J Clin Invest 109:777-85. 2002
  8. ncbi request reprint Continuous monitoring of regional cerebral blood flow: experimental and clinical validation of a novel thermal diffusion microprobe
    P Vajkoczy
    Department of Neurosurgery and Anesthesiology, Klinikum Mannheim, University of Heidelberg, Germany
    J Neurosurg 93:265-74. 2000
  9. ncbi request reprint Targeting angiogenesis inhibits tumor infiltration and expression of the pro-invasive protein SPARC
    P Vajkoczy
    Department of Neurosurgery, Klinikum Mannheim, University of Heidelberg, Mannheim, Germany
    Int J Cancer 87:261-8. 2000
  10. ncbi request reprint Regional cerebral blood flow monitoring in the diagnosis of delayed ischemia following aneurysmal subarachnoid hemorrhage
    Peter Vajkoczy
    Department of Neurosurgery, Klinikum Mannheim, University of Heidelberg, Mannheim, Germany
    J Neurosurg 98:1227-34. 2003

Detail Information

Publications114 found, 100 shown here

  1. ncbi request reprint Continuous low-dose chemotherapy plus inhibition of cyclooxygenase-2 as an antiangiogenic therapy of glioblastoma multiforme
    Jochen Tuettenberg
    Department of Neurosurgery, Klinikum Mannheim, Medical Faculty, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    J Cancer Res Clin Oncol 131:31-40. 2005
    ..The aim of this study was to evaluate the safety and activity of continuous low-dose temozolomide (TMZ) plus the COX-2 inhibitor rofecoxib in patients with newly diagnosed GBM...
  2. ncbi request reprint Measuring VEGF-Flk-1 activity and consequences of VEGF-Flk-1 targeting in vivo using intravital microscopy: clinical applications
    P Vajkoczy
    Department of Neurosurgery, Klinikum Mannheim, University of Heidelberg, Mannheim, Germany
    Oncologist 5:16-9. 2000
    ..This finding should be considered in upcoming clinical trials targeting individual signal transduction systems in cancer patients...
  3. ncbi request reprint Penetrating craniocerebral injuries in a civilian population in mid-Europe
    P Vajkoczy
    Department of Neurosurgery, Klinikum Mannheim, University of Heidelberg, Germany
    Clin Neurol Neurosurg 101:175-81. 1999
    ..Predictive variables identified in this study and a novel CT-grading algorithm may help in decision making...
  4. ncbi request reprint Effect of intra-arterial papaverine on regional cerebral blood flow in hemodynamically relevant cerebral vasospasm
    P Vajkoczy
    Department of Neurosurgery, Klinikum Mannheim, University of Heidelberg, Mannheim, Germany
    Stroke 32:498-505. 2001
    ..The aim of the present study was to continuously assess regional cerebral blood flow (rCBF) during and after IAP with the use of quantitative, bedside thermal diffusion flowmetry...
  5. ncbi request reprint Clazosentan (AXV-034343), a selective endothelin A receptor antagonist, in the prevention of cerebral vasospasm following severe aneurysmal subarachnoid hemorrhage: results of a randomized, double-blind, placebo-controlled, multicenter phase IIa study
    Peter Vajkoczy
    Department of Neurosurgery, University Hospital Mannheim, and Faculty for Clinical Medicine, Karl Ruprecht University of Heidelberg, Mannheim, Switzerland
    J Neurosurg 103:9-17. 2005
    ....
  6. pmc Inhibition of tumor growth, angiogenesis, and microcirculation by the novel Flk-1 inhibitor SU5416 as assessed by intravital multi-fluorescence videomicroscopy
    P Vajkoczy
    Department of Neurosurgery, Klinikum Mannheim, University of Heidelberg, Germany
    Neoplasia 1:31-41. 1999
    ..This study provides insight into microvascular consequences of Flk-1/KDR targeting in vivo and may have important implications for the future treatment of angiogenesis-dependent neoplasms...
  7. pmc Microtumor growth initiates angiogenic sprouting with simultaneous expression of VEGF, VEGF receptor-2, and angiopoietin-2
    Peter Vajkoczy
    Department of Neurosurgery, Klinikum Mannheim, University of Heidelberg, Theodor Kutzer Ufer 103, D 68167 Mannheim, Germany
    J Clin Invest 109:777-85. 2002
    ..The results of this study suggest a new concept of vascular tumor initiation that may have important implications for the clinical application of antiangiogenic strategies...
  8. ncbi request reprint Continuous monitoring of regional cerebral blood flow: experimental and clinical validation of a novel thermal diffusion microprobe
    P Vajkoczy
    Department of Neurosurgery and Anesthesiology, Klinikum Mannheim, University of Heidelberg, Germany
    J Neurosurg 93:265-74. 2000
    ..In this article, a novel thermal diffusion (TD) microprobe is evaluated for the continuous and quantitative assessment of intraparenchymal regional cerebral blood flow (rCBF)...
  9. ncbi request reprint Targeting angiogenesis inhibits tumor infiltration and expression of the pro-invasive protein SPARC
    P Vajkoczy
    Department of Neurosurgery, Klinikum Mannheim, University of Heidelberg, Mannheim, Germany
    Int J Cancer 87:261-8. 2000
    ....
  10. ncbi request reprint Regional cerebral blood flow monitoring in the diagnosis of delayed ischemia following aneurysmal subarachnoid hemorrhage
    Peter Vajkoczy
    Department of Neurosurgery, Klinikum Mannheim, University of Heidelberg, Mannheim, Germany
    J Neurosurg 98:1227-34. 2003
    ..The goal of this study was to evaluate regional cerebral blood flow (rCBF) monitoring, performed using thermal-diffusion (TD) flowmetry, as a novel means for the bedside diagnosis of symptomatic vasospasm...
  11. ncbi request reprint Glioma cell migration is associated with glioma-induced angiogenesis in vivo
    P Vajkoczy
    Department of Neurosurgery, Klinikum Mannheim, University of Heidelberg, Mannheim, Germany
    Int J Dev Neurosci 17:557-63. 1999
    ..Intravital fluorescence microscopy represents a versatile technique to assess the complex relationship between glioma-driven angiogenesis and glioma cell invasion...
  12. pmc Dominant-negative inhibition of the Axl receptor tyrosine kinase suppresses brain tumor cell growth and invasion and prolongs survival
    Peter Vajkoczy
    Department of Neurosurgery, Medical Faculty of the University of Heidelberg, D 68167 Mannheim, Germany
    Proc Natl Acad Sci U S A 103:5799-804. 2006
    ..Our findings implicate Axl in gliomagenesis and validate it as a promising target for the development of approaches toward a therapy of these highly aggressive but, as yet, therapy-refractory, tumors...
  13. ncbi request reprint Combined inhibition of vascular endothelial growth factor and platelet-derived growth factor signaling: effects on the angiogenesis, microcirculation, and growth of orthotopic malignant gliomas
    Mohammad Reza Farhadi
    Department of Neurosurgery, University Hospital, Faculty of Clinical Medicine, University of Heidelberg, Mannheim, Germany
    J Neurosurg 102:363-70. 2005
    ....
  14. ncbi request reprint Clinical implications of cortical microvasculature in adult Moyamoya disease
    Marcus Czabanka
    Department of Neurosurgery, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Augustenburgerplatz 1, Berlin 13353, Germany
    J Cereb Blood Flow Metab 29:1383-7. 2009
    ..We show that patients with a higher arteriogenic potential to alter cortical microvasculature are characterized by a more favorable hemodynamic situation and reduced clinical symptoms...
  15. pmc EphB4 controls blood vascular morphogenesis during postnatal angiogenesis
    Ralf Erber
    Department of Neurosurgery, Faculty for Clinical Medicine of the University of Heidelberg, University Hospital Mannheim, Mannheim, Germany
    EMBO J 25:628-41. 2006
    ..This implies that both neoplastic and non-neoplastic vascularization is driven not only by a vascular initiation program but also by a vascular patterning program mediated by guidance molecules...
  16. doi request reprint Ischemia independent lesion evolution during focal stroke in rats
    Johannes Woitzik
    Department of Neurosurgery, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Exp Neurol 218:41-6. 2009
    ..Relevant flow restrictions are detectable only during early stages of infarct maturation, whereas the propagation of secondary factors may be the predominant mechanism for delayed infarct evolution...
  17. doi request reprint Clinical evaluation of the safety and efficacy of lumbar cerebrospinal fluid drainage for the treatment of refractory increased intracranial pressure
    Jochen Tuettenberg
    Departments of Neurosurgery, University Hospital Mannheim, Faculty of Medicine Mannheim, University of Heidelberg, Germany
    J Neurosurg 110:1200-8. 2009
    ....
  18. doi request reprint Characterization of cortical microvascularization in adult moyamoya disease
    Marcus Czabanka
    Department of Neurosurgery, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Am Augustenburgerplatz 1, 13353 Berlin, Germany
    Stroke 39:1703-9. 2008
    ..It was the aim of our study to characterize the anatomic pattern and microhemodynamics of cortical microvascularization in MMD...
  19. pmc Imaging of hypoxic-ischemic penumbra with (18)F-fluoromisonidazole PET/CT and measurement of related cerebral metabolism in aneurysmal subarachnoid hemorrhage
    Asita S Sarrafzadeh
    Department of Neurosurgery, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Cereb Blood Flow Metab 30:36-45. 2010
    ..This technique has the potential to improve our understanding of the role of cellular hypoxia in aneurysmal SAH...
  20. doi request reprint Effects of sunitinib on tumor hemodynamics and delivery of chemotherapy
    Marcus Czabanka
    Department of Neurosurgery, Universitätsmedizin Charité, Berlin, Germany
    Int J Cancer 124:1293-300. 2009
    ..These results provide the basis for a potential chemosensitizing effect of sunitinib...
  21. doi request reprint The oxygen reactivity index and its relation to sensor technology in patients with severe brain lesions
    Julius Dengler
    Department of Neurosurgery, Charite, Universitaetsmedizin Berlin, CVK, Augustenburger Platz 1, 13553, Berlin, Germany
    Neurocrit Care 19:74-8. 2013
    ..SB, Integra Neuroscience, France) and Neurovent-PTO (Raumedic, Germany) probes in patients after aneurysmal SAH or severe TBI...
  22. doi request reprint Intraoperative neurophysiological monitoring of extracranial-intracranial bypass procedures
    Julius Dengler
    Department of Neurosurgery, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Neurosurg 119:207-14. 2013
    ..Intraoperative neurophysiological monitoring results were compared with those of intraoperative blood flow monitoring to assess bypass graft perfusion...
  23. doi request reprint Continuous low-dose temozolomide and celecoxib in recurrent glioblastoma
    Florian Stockhammer
    Department of Neurosurgery, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Neurooncol 100:407-15. 2010
    ..041, t-test). Low-dose continuous temozolomide in combination with celecoxib seems to have activity in recurrent glioblastoma without relevant toxicity. High FET uptake correlated with a better outcome under metronomic therapy...
  24. ncbi request reprint Far-distant metastases along the CSF pathway of glioblastoma multiforme during continuous low-dose chemotherapy with temozolomide and celecoxib
    Marcel Seiz
    Department of Neurosurgery, Medical Faculty of the University of Heidelberg, Mannheim, Germany
    Neurosurg Rev 33:375-81; discussion 381. 2010
    ..Here, we describe extreme far-distant metastases along the neural axis of glioblastoma multiforme in four patients receiving metronomic antiangiogenic chemotherapy and review the literature to discuss possible mechanisms...
  25. doi request reprint Correlation of clinical outcome with pressure-, oxygen-, and flow-related indices of cerebrovascular reactivity in patients following aneurysmal SAH
    Martin Barth
    Department of Neurosurgery, Medical Faculty Mannheim of the Karl Ruprecht University of Heidelberg, University Hospital Mannheim, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Neurocrit Care 12:234-43. 2010
    ..However, CR may be determined using different paradigms and it is unclear, which measurement method most suitable reflects the clinical course or is able to predict clinical deterioration...
  26. ncbi request reprint Effects of hypervolemia and hypertension on regional cerebral blood flow, intracranial pressure, and brain tissue oxygenation after subarachnoid hemorrhage
    Elke Muench
    Department of Anesthesiology, University Hospital Mannheim, Mannheim, Germany
    Crit Care Med 35:1844-51; quiz 1852. 2007
    ..The aim of the study was to investigate the influence of the three arms of triple-H therapy on regional cerebral blood flow and brain tissue oxygenation...
  27. doi request reprint Circulating endothelial progenitor cells in malignant gliomas
    Neysan Rafat
    Department of Anaesthesiology and Critical Care Medicine, Medical Faculty Mannheim, University of Heidelberg, Germany
    J Neurosurg 112:43-9. 2010
    ..The authors were also interested in whether a correlation could be observed between the level of cEPCs and the extent of glioma angiogenesis determined by conventional methods...
  28. doi request reprint Vertebral artery-posterior inferior cerebellar artery bypass using a radial artery graft for hemorrhagic dissecting vertebral artery aneurysms: surgical technique and report of 2 cases
    Marcus Czabanka
    Department of Neurosurgery, Charite Universitatsmedizin Berlin, Germany
    J Neurosurg 114:1074-9. 2011
    ....
  29. ncbi request reprint Extra-intracranial standard bypass in the elderly: perioperative risk, bypass patency and outcome
    Nora Sandow
    Department of Neurosurgery, Charite Universitatsmedizin Berlin, Berlin, Germany
    Cerebrovasc Dis 36:228-35. 2013
    ..We therefore designed a retrospective study to address the question whether EC-IC bypass is a safe and efficient treatment in a patient cohort ≥70 years...
  30. doi request reprint Intraoperative monitoring of cerebral blood flow by laser speckle contrast analysis
    Nils Hecht
    Department of Neurosurgery, Charite Universitatsmedizin Berlin, Berlin, Germany
    Neurosurg Focus 27:E11. 2009
    ..The purpose of this preliminary study was to address the general feasibility of LASCA in terms of handling and image quality and to provide an example of its clinical implications...
  31. doi request reprint Relevance of cerebral interleukin-6 after aneurysmal subarachnoid hemorrhage
    Asita Sarrafzadeh
    Department of Neurosurgery, Campus Virchow Medical Center, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany
    Neurocrit Care 13:339-46. 2010
    ....
  32. doi request reprint Increased levels of circulating endothelial progenitor cells in patients with Moyamoya disease
    Neysan Rafat
    Department of Anaesthesiology, Medical Faculty Mannheim, University Hospital Mannheim, University of Heidelberg, Mannheim, Germany
    Stroke 40:432-8. 2009
    ..The mechanisms involved in the upregulation of the arteriogenesis and angiogenesis in MMD still remain unknown. In the present study we investigated if circulating endothelial progenitor cells are increasingly mobilized during MMD...
  33. doi request reprint Aspirin resistance in patients with hemodynamic cerebral ischemia undergoing extracranial-intracranial bypass surgery
    Daniel Jussen
    Department of Neurosurgery, Charite University Medicine Berlin, Berlin, Germany
    Cerebrovasc Dis 35:355-62. 2013
    ....
  34. doi request reprint High ICP as trigger of proinflammatory IL-6 cytokine activation in aneurysmal subarachnoid hemorrhage
    Daniela Graetz
    Department of Neurosurgery, Charite Universitatsmedizin Berlin, Berlin, Germany
    Neurol Res 32:728-35. 2010
    ..This study aimed to analyse the origin of interleukin-6 (IL-6) in respect to ICP and cerebral metabolism in SAH patients...
  35. doi request reprint Navigated transcranial magnetic stimulation for preoperative functional diagnostics in brain tumor surgery
    Thomas Picht
    Department of Neurosurgery, Charite Universitaetsmedizin, Berlin, Germany
    Neurosurgery 65:93-8; discussion 98-9. 2009
    ..The aim of this study was to evaluate the usefulness of TMS for operation planning when combined with a sensor-based electromagnetic navigation system (nTMS)...
  36. doi request reprint Decompressive craniectomy in aneurysmal subarachnoid hemorrhage: relation to cerebral perfusion pressure and metabolism
    Alexandra Nagel
    Department of Neurosurgery, Charite Universitatsmedizin Berlin, Berlin, Germany
    Neurocrit Care 11:384-94. 2009
    ..As one treatment option for increased intracranial pressure (ICP), decompressive craniectomy (DC) is discussed. Its impact on cerebral metabolism and outcome in SAH patients is evaluated in this pilot study...
  37. ncbi request reprint Granulocyte-macrophage colony-stimulating factor-induced vessel growth restores cerebral blood supply after bilateral carotid artery occlusion
    Ulf C Schneider
    Department of Neurosurgery, University Hospital Mannheim, University of Heidelberg, Mannheim, Germany
    Stroke 38:1320-8. 2007
    ..The purpose of this study was to investigate the effects of GM-CSF on cerebral hemodynamics and vessel growth in a rat model of chronically impaired cerebral blood flow (CBF)...
  38. doi request reprint Characterization of functional outcome and quality of life following subarachnoid hemorrhage in patients treated with and without nicardipine prolonged-release implants
    Martin Barth
    Department of Neurosurgery, University Hospital, Mannheim Faculty for Clinical Medicine, Karl Ruprecht University of Heidelberg, Theodor Kutzer Ufer 1 3, D 68167 Mannheim, Germany
    J Neurosurg 110:955-60. 2009
    ..Because quality of life (QOL) measurements more reliably seem to describe the patient's true condition, the present study was conducted to assess FO and QOL 1 year after aneurysm rupture in patients with and without NPRIs...
  39. doi request reprint Age-dependent revascularization patterns in the treatment of moyamoya disease in a European patient population
    Marcus Czabanka
    Department of Neurosurgery, Charite Universitatsmedizin Berlin, Berlin, Germany
    Neurosurg Focus 26:E9. 2009
    ..The aim of this study was to investigate the relative contribution of direct and indirect revascularization procedures to the restoration of collateral blood supply in adult and pediatric patients with MMD...
  40. doi request reprint The reliability of topographic measurements from navigated transcranial magnetic stimulation in healthy volunteers and tumor patients
    Anna Zdunczyk
    Department of Neurosurgery, Charite University Hospital, Augustenburger Platz 1, 13353, Berlin, Germany
    Acta Neurochir (Wien) 155:1309-17. 2013
    ..The aim of this experimental study was to assess the intraexaminer and interexaminer reliability of topographic mapping with nTMS...
  41. doi request reprint The preoperative use of navigated transcranial magnetic stimulation facilitates early resection of suspected low-grade gliomas in the motor cortex
    Thomas Picht
    Department of Neurosurgery, Charite University Hospital, Berlin, Germany
    Acta Neurochir (Wien) 155:1813-21. 2013
    ..The study aim is to assess what influence preoperative navigated transcranial magnetic stimulation (nTMS) has on the treatment strategy and clinical outcome for suspected low-grade gliomas in presumed motor eloquent location...
  42. ncbi request reprint D-dimer elevation and paresis predict thromboembolic events during bevacizumab therapy for recurrent malignant glioma
    Martin Misch
    Department of Neurosurgery, University Medicine Gottingen, Robert Koch Str 40, 37075 Gottingen, Germany
    Anticancer Res 33:2093-8. 2013
    ..The major side-effects of bevacizumab in glioma treatment are venous thromboembolic events (VTE). We retrospectively evaluated factors potentially predictive of thromboembolic events...
  43. doi request reprint Clusters of spreading depolarizations are associated with disturbed cerebral metabolism in patients with aneurysmal subarachnoid hemorrhage
    Oliver W Sakowitz
    University of Heidelberg, Department of Neurosurgery, Im Neuenheimer Feld 400, D 69120 Heidelberg, Germany
    Stroke 44:220-3. 2013
    ..We studied the dynamics of extracellular brain tissue concentrations of glucose, lactate, pyruvate, and glutamate during the occurrence of spreading depolarizations (SDs) in patients with aneurysmal subarachnoid hemorrhage...
  44. pmc Functional analysis of Pro-inflammatory properties within the cerebrospinal fluid after subarachnoid hemorrhage in vivo and in vitro
    Ulf C Schneider
    Department of Neurosurgery, Charite Universitaetsmedizin, Augustenburger Platz 1, 13353 Berlin, Germany
    J Neuroinflammation 9:28. 2012
    ..To functionally characterize pro-inflammatory and vasoconstrictive properties of cerebrospinal fluid after aneurysmal subarachnoid hemorrhage (SAH) in vivo and in vitro...
  45. doi request reprint The use of nicardipine prolonged release implants (NPRI) in microsurgical clipping after aneurysmal subarachnoid haemorrhage: comparison with endovascular treatment
    Ulf C Schneider
    Department of Neurosurgery, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Germany
    Acta Neurochir (Wien) 153:2119-25. 2011
    ..Yet, the comparison with results after endovascular coiling is lacking. This study was conducted to determine the differences in the incidence of cerebral vasospasm and infarctions between those two treatment modalities..
  46. ncbi request reprint The use of the excimer laser-assisted anastomosis technique alleviates neuroanesthesia during cerebral high-flow revascularization
    Elke Muench
    Department of Anesthesiology, Klinikum Mannheim, University of Heidelberg, Mannheim, Germany
    J Neurosurg Anesthesiol 19:273-9. 2007
    ....
  47. ncbi request reprint Effects of fentanyl and S(+)-ketamine on cerebral hemodynamics, gastrointestinal motility, and need of vasopressors in patients with intracranial pathologies: a pilot study
    Marc D Schmittner
    Department of Anesthesiology and Critical Care Medicine, University Hospital Mannheim, University of Heidelberg, Mannheim, Germany
    J Neurosurg Anesthesiol 19:257-62. 2007
    ..Our results indicate that S(+)-ketamine does not increase ICP and that its use in neurosurgical patients should not be discouraged on the basis of ICP-related concerns...
  48. ncbi request reprint Recurrence pattern in glioblastoma multiforme patients treated with anti-angiogenic chemotherapy
    Jochen Tuettenberg
    Department of Neurosurgery, Universitatsmedizin Mannheim, University of Heidelberg, 68167 Mannheim, Germany
    J Cancer Res Clin Oncol 135:1239-44. 2009
    ..Under experimental conditions, anti-angiogenic therapy strategies lead to an increased invasion. Here we report on the pattern of tumour recurrence in glioblastoma patients treated with an anti-angiogenic chemotherapy...
  49. ncbi request reprint Preoperative functional mapping for rolandic brain tumor surgery: comparison of navigated transcranial magnetic stimulation to direct cortical stimulation
    Thomas Picht
    Department of Neurosurgery, Charite Universitaetsmedizin, Berlin, Germany
    Neurosurgery 69:581-8; discussion 588. 2011
    ..Transcranial magnetic stimulation (TMS) is the only noninvasive method for presurgical stimulation mapping of cortical function. Recent technical advancements have significantly increased the focality and usability of the method...
  50. ncbi request reprint Effect of nicardipine prolonged-release implants on cerebral vasospasm and clinical outcome after severe aneurysmal subarachnoid hemorrhage: a prospective, randomized, double-blind phase IIa study
    Martin Barth
    Department of Neurosurgery, University Hospital Mannheim, Faculty for Clinical Medicine of the Karl Ruprecht University of Heidelberg, Mannheim, Germany
    Stroke 38:330-6. 2007
    ..The purpose of this study was to investigate the effect of nicardipine prolonged-release implants (NPRIs) on cerebral vasospasm and clinical outcome after severe subarachnoid hemorrhage...
  51. ncbi request reprint First experiences with low-dose anti-angiogenic treatment in gliomatosis cerebri with signs of angiogenic activity
    Marcel Seiz
    Department of Neurosurgery, Ruprecht Karls University Heidelberg, Medical Faculty Mannheim, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Anticancer Res 29:3261-7. 2009
    ..The prognosis is dismal and therapeutical options are still controversial. In contrast to other high-grade gliomas, angiogenesis is thought to be absent in gliomatosis cerebri...
  52. ncbi request reprint Increased vessel diameter of leptomeningeal anastomoses after hypoxic preconditioning
    Johannes Woitzik
    Department of Neurosurgery, University Hospital Mannheim, Faculty of Medicine Mannheim, Ruprecht Karls University Heidelberg, Mannheim, Germany
    Brain Res 1115:209-12. 2006
    ..This finding may display the anatomical correlate to previously described perfusion changes after preconditioning...
  53. doi request reprint Subarachnoid haemorrhage WFNS grade V: is maximal treatment worthwhile?
    Maria Wostrack
    Department of Neurosurgery, Klinikum rechts der Isar, Technical University of Munich, 81675, Munich, Germany
    Acta Neurochir (Wien) 155:579-86. 2013
    ..The aim of the study was to verify possible predictive factors and the probability of a favourable outcome in maximally treated patients...
  54. doi request reprint Plastic relocation of motor cortex in a patient with LGG (low grade glioma) confirmed by NBS (navigated brain stimulation)
    Satoshi Takahashi
    Department of Neurosurgery, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Acta Neurochir (Wien) 154:2003-8; discussion 2008. 2012
    ..Plastic changes in M1 localization permitted complete tumour removal without neurological sequela. To our knowledge, this is the first report on a LGG patient where induced brain plasticity has been confirmed by NBS mapping...
  55. doi request reprint Assessing the functional status of the motor system in brain tumor patients using transcranial magnetic stimulation
    Thomas Picht
    Department of Neurosurgery, Charite University Hospital Berlin, Berlin, Germany
    Acta Neurochir (Wien) 154:2075-81. 2012
    ..The aim of this paper is to provide reference values for these neurophysiological measurements from a large and varied clinical sample...
  56. doi request reprint The Y-shaped double-barrel bypass in the treatment of large and giant anterior communicating artery aneurysms
    Julius Dengler
    Department of Neurosurgery, Charite Universitatsmedizin Berlin, Germany
    J Neurosurg 118:444-50. 2013
    ..The Y-shaped double-barrel bypass using a radial artery graft allows for safe and effective occlusion of large and giant ACoA aneurysms that cannot be treated by direct clip application...
  57. doi request reprint Cerebral glucose and spreading depolarization in patients with aneurysmal subarachnoid hemorrhage
    Asita Sarrafzadeh
    Department of Neurosurgery, Charite University Medicine, Berlin, Germany
    Acta Neurochir Suppl 115:143-7. 2013
    ..Rapid-sampling MD techniques and analyses of SD clusters may elucidate more detail of the relationship between SD and brain energy metabolism...
  58. doi request reprint Assessment of the influence of navigated transcranial magnetic stimulation on surgical planning for tumors in or near the motor cortex
    Thomas Picht
    Department of Neurosurgery, Charite University Hospital, Berlin, Germany
    Neurosurgery 70:1248-56; discussion 1256-7. 2012
    ..Navigated transcranial magnetic stimulation (nTMS) can be used to map functionally essential motor areas preoperatively...
  59. doi request reprint Myoblast-mediated gene therapy via encephalomyosynangiosis--a novel strategy for local delivery of gene products to the brain surface
    Nils Hecht
    Department of Neurosurgery, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany
    J Neurosci Methods 201:61-6. 2011
    ..This method could be used in the future to deliver angiogenic growth factors to the muscle/brain interface in order to improve revascularization after an EMS...
  60. doi request reprint Modified flow- and oxygen-related autoregulation indices for continuous monitoring of cerebral autoregulation
    Nils Hecht
    Department of Neurosurgery, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany
    J Neurosci Methods 201:399-403. 2011
    ..Temporal synchronization for the calculation of both ORx and FRx may permit continuous monitoring of these indices with higher sensitivity...
  61. doi request reprint Cerebral tissue oxygenation measured by two different probes: challenges and interpretation
    Julius Dengler
    Department of Neurosurgery, Charite, Universitaetsmedizin Berlin, CVK, Augustenburger Platz 1, 13553, Berlin, Germany
    Intensive Care Med 37:1809-15. 2011
    ..We therefore compared both probes in comatose patients suffering from traumatic brain injury (TBI) or subarachnoid haemorrhage (SAH) during dynamic changes of inspirational oxygen fraction (FiO(2)) and mean arterial pressure (MAP)...
  62. pmc Delayed cerebral ischemia and spreading depolarization in absence of angiographic vasospasm after subarachnoid hemorrhage
    Johannes Woitzik
    Department of Neurosurgery, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Cereb Blood Flow Metab 32:203-12. 2012
    ..The number of SDs correlated significantly with the development of DCI. This may explain why reduction of angiographic vasospasm alone has not been sufficient to improve outcome in some clinical studies...
  63. doi request reprint Identification of the optimal cortical target point for extracranial-intracranial bypass surgery in patients with hemodynamic cerebrovascular insufficiency
    Pablo Gerardo Peña-Tapia
    Department of Neurosurgery, University Hospital Mannheim, University of Heidelberg, Mannheim, Germany
    J Neurosurg 108:655-61. 2008
    ..The objective of this report is to describe a new approach to identify the optimal cortical target point for extracranial-intracranial (EC-IC) bypass surgery, to reliably find suitable recipient vessels for the anastomosis...
  64. ncbi request reprint Current advances in the diagnosis of vasospasm
    Elke Munch
    Department of Anesthesiology, Klinikum Mannheim, University of Heidelberg, Mannheim, Germany
    Neurol Res 28:703-12. 2006
    ..On the basis of the currently available monitoring technologies, an algorithm for the diagnosis of vasospasm is presented...
  65. ncbi request reprint Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanisms
    Ralf Erber
    Department of Neurosurgery, Medical Faculty of the University of Heidelberg, Mannheim, Germany
    FASEB J 18:338-40. 2004
    ....
  66. doi request reprint Revival of extra-intracranial bypass surgery
    Peter Vajkoczy
    Department of Neurosurgery, Universitätsmedizin Charité, Berlin, Germany
    Curr Opin Neurol 22:90-5. 2009
    ..Extra-intracranial bypass surgery has regained significant relevance over the past years. The aim of this review is to highlight the current indications and recent developments in this field...
  67. ncbi request reprint Moyamoya-like vasculopathy (moyamoya syndrome) in children
    Peter Horn
    Department of Neurosurgery, Universitatsklinikum Mannheim, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Childs Nerv Syst 20:382-91. 2004
    ..Adequate cerebral vascular imaging should be considered in all pediatric patients with inherited or acquired systemic disorders and symptoms attributable to cerebral ischemia...
  68. doi request reprint Watertight dural closure: is it necessary? A prospective randomized trial in patients with supratentorial craniotomies
    Martin Barth
    Department of Neurosurgery, University Hospital Mannheim, Ruprecht Karls University of Heidelberg, Mannheim, Germany
    Neurosurgery 63:352-8; discussion 358. 2008
    ..The aim of the current study was to prospectively analyze complication rates and costs associated with dural closure in patients undergoing supratentorial craniotomies, randomized for watertight and adaptive dural closures...
  69. ncbi request reprint Influence of TBK-1 on tumor angiogenesis and microvascular inflammation
    Marcus Czabanka
    Department of Neurosurgery, Charite Universitaetsmedizin, Berlin, Germany
    Front Biosci 13:7243-9. 2008
    ..The TBK-1 pathway might be an important cross-link between angiogenesis and inflammation representing a possible target for anti-tumor therapy...
  70. ncbi request reprint Vascular microenvironment in gliomas
    Peter Vajkoczy
    Department of Neurosurgery, Klinikum Mannheim, University of Heidelberg, D 68167 Mannheim, Germany
    Cancer Treat Res 117:249-62. 2004
    ..An improved understanding of the vascular microenvironment in gliomas will help in the future to optimize glioma imaging and to improve delivery of vectors for gene therapy or encapsulated drug carriers for pharmacotherapy in patients...
  71. ncbi request reprint Cortical perfusion measurement by indocyanine-green videoangiography in patients undergoing hemicraniectomy for malignant stroke
    Johannes Woitzik
    Department of Neurosurgery, University Hospital Mannheim, Faculty of Clinical Medicine, Mannheim of the Ruprecht Karls University of Heidelberg, Mannheim, Germany
    Stroke 37:1549-51. 2006
    ..Therefore, we have adapted near-infrared indocyanine-green (ICG) videoangiography to assess cortical perfusion intraoperatively...
  72. ncbi request reprint Hemodynamic reserve and high-intensity transient signals in moyamoya disease
    Peter Horn
    Department of Neurosurgery, University of Heidelberg, Universitatsklinikum Mannheim, Mannheim, Germany
    Cerebrovasc Dis 19:141-6. 2005
    ..The incidence of high-intensity transient signals (HITS) and the degree of hemodynamic compromise were studied in symptomatic patients with MMD...
  73. doi request reprint Microvascular biodistribution of L19-SIP in angiogenesis targeting strategies
    Marcus Czabanka
    Department of Neurosurgery, Universitätsmedizin Charité, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany
    Eur J Cancer 47:1276-84. 2011
    ..The aim of our study was to characterise the microvascular biodistribution and binding process during tumour angiogenesis and after anti-angiogenic therapy...
  74. ncbi request reprint Relevance of intracranial hypertension for cerebral metabolism in aneurysmal subarachnoid hemorrhage. Clinical article
    Alexandra Nagel
    Department of Neurosurgery, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Neurosurg 111:94-101. 2009
    ..Its impact on cerebral metabolism, ICP therapy, and outcome has rarely been studied in patients with aneurysmal subarachnoid hemorrhage (aSAH); such an assessment is the authors' goal in the present study...
  75. doi request reprint Risk of intraoperative ischemia due to temporary vessel occlusion during standard extracranial-intracranial arterial bypass surgery
    Peter Horn
    Department of Neurosurgery, University Hospital Mannheim, Germany
    J Neurosurg 108:464-9. 2008
    ..In this prospective study, the incidence of intraoperative ischemia was investigated in symptomatic patients with steno-occlusive cerebrovascular disease and existing hemodynamic insufficiency...
  76. pmc Cerebral microdialysis for detection of bacterial meningitis in aneurysmal subarachnoid hemorrhage patients: a cohort study
    Florian Schlenk
    Department of Neurosurgery, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany
    Crit Care 13:R2. 2009
    ..Microdialysis (MD) is a technique for monitoring cerebral metabolism in patients with SAH. A cohort study was performed to investigate the value of MD for the diagnosis of BM...
  77. ncbi request reprint Effects of positive end-expiratory pressure on regional cerebral blood flow, intracranial pressure, and brain tissue oxygenation
    Elke Muench
    Departments of Anesthesiology, Klinikum Mannheim, University of Heidelberg, Mannheim, Germany
    Crit Care Med 33:2367-72. 2005
    ..The goal of this study was, to examine the influence of various PEEP levels on intracranial pressure, brain tissue oxygen tension, regional cerebral blood flow, and systemic hemodynamic variables...
  78. ncbi request reprint Power Doppler imaging in detection of surgically induced indirect neoangiogenesis in adult moyamoya disease
    Fabienne Perren
    Departments of Neurology and Neurosurgery, University of Heidelberg, Universitatsklinikum, Mannheim, Germany
    J Neurosurg 103:869-72. 2005
    ....
  79. doi request reprint Prevention of secondary ischemic events by superficial temporal artery-middle cerebral artery bypass surgery after tuberculosis-induced vasculopathy in a 5-year-old child
    Martin Misch
    Department of Neurosurgery, Charite Campus Virchow, Medical University of Berlin, Berlin, Germany
    J Neurosurg Pediatr 6:69-72. 2010
    ..Bypass surgery seems to be a reliable tool to augment cerebral blood flow in tuberculosis-related stenoocclusive changes of cerebral vasculature after the failure of endovascular procedures...
  80. ncbi request reprint Treatment of hemodynamic insufficiency in chronic CCA occlusion using a short saphenous vein interposition graft: diagnostic and technical considerations. An illustrative case report
    Gerrit Alexander Schubert
    Department of Neurosurgery, University Hospital Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Neurosurg Rev 31:123-6, discussion 126. 2008
    ..Successful treatment of hemodynamic insufficiency because of chronic CCA occlusion necessitates a thorough preoperative workup and application of alternative revascularization strategies...
  81. pmc Intravital fluorescence videomicroscopy to study tumor angiogenesis and microcirculation
    P Vajkoczy
    Department of Neurosurgery, Klinikum Mannheim, University of Heidelberg, Mannheim, Germany
    Neoplasia 2:53-61. 2000
    ....
  82. ncbi request reprint Effects of the selective endothelin A (ET(A)) receptor antagonist Clazosentan on cerebral perfusion and cerebral oxygenation following severe subarachnoid hemorrhage - preliminary results from a randomized clinical series
    M Barth
    Department of Neurosurgery, Faculty for Clinical Medicine of the Karl Ruprecht University of Heidelberg, University Hospital Mannheim, Mannheim, Germany
    Acta Neurochir (Wien) 149:911-8; discussion 918. 2007
    ..To study the effects of clazosentan, a new selective endothelin receptor subtype A antagonist, on cerebral perfusion and cerebral oxygenation following severe aneurysmal subarachnoid haemorrhage (aSAH)...
  83. doi request reprint Neurophysiological intraoperative monitoring in neurosurgery: aid or handicap? An international survey
    Mario Cabraja
    Department of Neurosurgery, Charite Universitatsmedizin Berlin, 13353 Berlin, Germany
    Neurosurg Focus 27:E2. 2009
    ..There is an ongoing discussion about the effectiveness of neurophysiological IOM. This questionnaire study was performed to evaluate the attitude of neurosurgeons toward neurophysiological IOM and the availability of this tool...
  84. pmc Multistep nature of microvascular recruitment of ex vivo-expanded embryonic endothelial progenitor cells during tumor angiogenesis
    Peter Vajkoczy
    Department of Neurosurgery, Klinikum Mannheim, University of Heidelberg, Mannheim, Germany
    J Exp Med 197:1755-65. 2003
    ..This paper provides the first in vivo insights into the mechanisms of endothelial progenitor cell recruitment and, thus, indicates novel ways to interfere with pathological neovascularization...
  85. pmc Vestibulo-ocular monitoring as a predictor of outcome after severe traumatic brain injury
    Hans Georg Schlosser
    Department of Neurosurgery, Universitatsmedizin Berlin, Charite Campus Virchow Klinikum, Berlin 13353, Germany
    Crit Care 13:R192. 2009
    ....
  86. doi request reprint Inpatient hyperglycemia following aneurysmal subarachnoid hemorrhage: relation to cerebral metabolism and outcome
    Florian Schlenk
    Department of Neurosurgery, Charite Campus Virchow Medical Center, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Neurocrit Care 11:56-63. 2009
    ..This study aimed to identify a threshold for blood glucose predicting unfavorable outcome, and to evaluate differences in cerebral metabolism in normo and hyperglycemic SAH patients...
  87. ncbi request reprint Liver regeneration in FGF-2-deficient mice: VEGF acts as potential functional substitute for FGF-2
    Jörg Sturm
    Chirurgische Klinik, Universitatsklinikum Mannheim, Germany
    Liver Int 24:161-8. 2004
    ..The aim of the study was to evaluate this role in a FGF-2 knockout mouse model...
  88. ncbi request reprint Quantitative regional cerebral blood flow measurement techniques improve noninvasive detection of cerebrovascular vasospasm after aneurysmal subarachnoid hemorrhage
    P Horn
    Department of Neurosurgery, University Hospital Mannheim, Mannheim, Germany
    Cerebrovasc Dis 12:197-202. 2001
    ....
  89. ncbi request reprint Continuous monitoring of regional cerebral blood flow during temporary arterial occlusion in aneurysm surgery
    C Thome
    Department of Neurosurgery, University Hospital Mannheim, University of Heidelberg, Mannheim, Germany
    J Neurosurg 95:402-11. 2001
    ..Because monitoring of regional cerebral blood flow (rCBF) may limit neurological damage, the authors evaluated a novel thermal diffusion (TD) microprobe for use in the continuous and quantitative assessment of rCBF during TAO...
  90. ncbi request reprint Xenon-induced flow activation in patients with cerebral insult who undergo xenon-enhanced CT blood flow studies
    P Horn
    Department of Neurosurgery, University Hospital Mannheim, Faculty of Clinical Medicine, University Heidelberg, Mannheim, Germany
    AJNR Am J Neuroradiol 22:1543-9. 2001
    ....
  91. ncbi request reprint Source of endothelin-1 in subarachnoid hemorrhage
    T Bertsch
    Department of Clinical Chemistry, Clinic Mannheim, University of Heidelberg, Germany
    Clin Chem Lab Med 39:341-5. 2001
    ..This finding may have important therapeutic implications as anti-leukocyte strategies could prevent cerebrovascular complications in SAH patients...
  92. pmc Inflammatory cytokines in subarachnoid haemorrhage: association with abnormal blood flow velocities in basal cerebral arteries
    K Fassbender
    Department of Neurology, University Clinic Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer, 68135 Mannheim, Germany
    J Neurol Neurosurg Psychiatry 70:534-7. 2001
    ..Together, these findings suggest a role of excessive compartmentalised inflammatory host response in pathogenesis of cerebrovascular complications after SAH...
  93. ncbi request reprint Endothelin-1 in subarachnoid hemorrhage: An acute-phase reactant produced by cerebrospinal fluid leukocytes
    K Fassbender
    Department of Neurology, Clinic Mannheim, University of Heidelberg, Germany
    Stroke 31:2971-5. 2000
    ..In our study, we performed clinical and in vitro experiments to investigate the origin and the mechanisms of the secretion of endothelin-1 in SAH...
  94. ncbi request reprint [Spontaneous occlusion of the circle of Willis (moyamoya disease). Diagnosis and therapy]
    P Horn
    Neurochirurgische Klinik, Universitatsklinikum Mannheim, Fakultät für Klinische Medizin der Universität Heidelberg
    Nervenarzt 72:406-15. 2001
    ..Additionally, indications and techniques of current neurosurgical revascularization procedures are illustrated...
  95. ncbi request reprint Endothelial survival factors and spatial completion, but not pericyte coverage of retinal capillaries determine vessel plasticity
    J Hoffmann
    Medical Clinic and Policlinic 3, Justus Liebig University Giessen, Giessen, Germany
    FASEB J 19:2035-6. 2005
    ....
  96. pmc Alpha4-integrin-VCAM-1 binding mediates G protein-independent capture of encephalitogenic T cell blasts to CNS white matter microvessels
    P Vajkoczy
    Department of Neurosurgery, Klinikum Mannheim, Universitat Heidelberg, Mannheim, Germany
    J Clin Invest 108:557-65. 2001
    ....
  97. ncbi request reprint Extracranial-intracranial arterial bypass surgery improves total brain blood supply in selected symptomatic patients with unilateral internal carotid artery occlusion and insufficient collateralization
    K W Neff
    Department of Clinical Radiology, University of Heidelberg, Universitatsklinikum Mannheim, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Neuroradiology 46:730-7. 2004
    ..EC-IC arterial bypass surgery increases total brain blood supply, allowing restoration of local perfusion in hemodynamically compromised brain tissue in patients with symptomatic ICA occlusion...
  98. ncbi request reprint Angiogenesis in malignant glioma--a target for antitumor therapy?
    J Tuettenberg
    Department of Neurosurgery, University of Heidelberg, Klinikum Mannheim, D 68167 Mannheim, Germany
    Crit Rev Oncol Hematol 59:181-93. 2006
    ..Additionally the problem of monitoring the treatment success of an anti-angiogenic therapy is addressed...
  99. ncbi request reprint Evaluation of extracranial-intracranial arterial bypass function with magnetic resonance angiography
    P Horn
    Department of Neurosurgery, Universitatsklinikum Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Neuroradiology 46:723-9. 2004
    ..The assessment of EC/IC bypass patency with quantitative BVF measurements provides exact, investigator-independent information under physiological conditions. MRA is well correlated with the angiographic bypass grading system...
  100. doi request reprint Experience in using the excimer laser-assisted nonocclusive anastomosis nonocclusive bypass technique for high-flow revascularization: Mannheim-Helsinki series of 64 patients
    Peter Vajkoczy
    Department of Neurosurgery, Charite Universitatsmedizin Berlin, Berlin, Germany
    Neurosurgery 70:49-54; discussion 54-5. 2012
    ..The excimer laser-assisted nonocclusive anastomosis (ELANA) technique enables large-caliber bypass revascularization without temporary occlusion of the parent artery...
  101. ncbi request reprint Vascular microenvironment in gliomas
    P Vajkoczy
    Department of Neurosurgery, Klinikum Mannheim, University of Heidelberg, Germany
    J Neurooncol 50:99-108. 2000
    ..An improved understanding of the vascular microenvironment in gliomas will help in the future to optimize glioma imaging and delivery of vectors for gene therapy or encapsulated drug carriers in patients...