Werner Vach

Summary

Affiliation: University of Freiburg
Country: Germany

Publications

  1. doi request reprint The Move from Accuracy Studies to Randomized Trials in PET: Current Status and Future Directions
    Bettina Siepe
    Department of Anesthesiology, Freiburg University Medical Center, Freiburg, Germany
    J Nucl Med 55:1228-34. 2014
  2. doi request reprint [Benefit assessment of diagnostic procedures: quo vadimus?]
    Werner Vach
    Department für Medizinische Biometrie und Medizinische Informatik, Universitat Freiburg, Stefan Meier Str 26, 79104, Freiburg, Deutschland
    Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 58:256-62. 2015
  3. pmc Impact of availability of guidelines and active surveillance in reducing the incidence of ventilator-associated pneumonia in Europe and worldwide
    Klaus Kaier
    Institute of Medical Biometry and Medical Informatics, University Medical Center, Freiburg, Germany
    BMC Infect Dis 14:199. 2014
  4. pmc Feasibility and impact of an intensified antibiotic stewardship programme targeting cephalosporin and fluoroquinolone use in a tertiary care university medical center
    Johannes P Borde
    Department of Medicine, Abteilung Infektiologie, Universitatsklinikum Freiburg, Hugstetter Straße 55, D 79106 Freiburg i, BR, Germany
    BMC Infect Dis 14:201. 2014
  5. pmc Shared decision-making in antihypertensive therapy: a cluster randomised controlled trial
    Iris Tinsel
    Department of Medicine, Division of General Practice, University Medical Centre Freiburg, Elsässerstr 2m, Freiburg 79110, Germany
    BMC Fam Pract 14:135. 2013
  6. doi request reprint Calibration of clinical prediction rules does not just assess bias
    Werner Vach
    Clinical Epidemiology, Institute of Medical Biometry and Medical Informatics, Freiburg University Medical Center, Freiburg, Germany Electronic address
    J Clin Epidemiol 66:1296-301. 2013
  7. pmc Reproducibility of range of motion and muscle strength measurements in patients with hip osteoarthritis - an inter-rater study
    Erik Poulsen
    Institute of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark
    BMC Musculoskelet Disord 13:242. 2012
  8. pmc Non-surgical treatment of hip osteoarthritis. Hip school, with or without the addition of manual therapy, in comparison to a minimal control intervention: protocol for a three-armed randomized clinical trial
    Erik Poulsen
    Institute of Sports Science and Clinical Biomechanics, University of Southern Denmark, Denmark
    BMC Musculoskelet Disord 12:88. 2011
  9. doi request reprint Construction of a Danish CDI short form for language screening at the age of 36 months: methodological considerations and results
    Werner Vach
    Clinical Epidemiology, Institute of Medical Biometry and Medical Informatics, University Medical Center Freiburg, Germany
    Clin Linguist Phon 24:602-21. 2010
  10. doi request reprint Generating evidence for clinical benefit of PET/CT in diagnosing cancer patients
    Werner Vach
    Clinical Epidemiology, Institute of Medical Biometry and Medical Informatics, Freiburg University Medical Center, Freiburg, Germany
    J Nucl Med 52:77S-85S. 2011

Collaborators

  • Wolfgang A Weber
  • Sabine Hellwig
  • Iris Tinsel
  • Andreas Loh
  • Oke Gerke
  • Henrik Petersen
  • Dorthe Bleses
  • Edith Motschall
  • Anika Buchholz
  • Kirsten Bouchelouche
  • Martin Boeker
  • Erik Poulsen
  • Klaus Kaier
  • H Christian Rischke
  • Bettina Siepe
  • Johannes P Borde
  • Mads H Poulsen
  • Søren Overgaard
  • Jan Hartvigsen
  • Martin Hug
  • Marie Laurence Lambert
  • Teresa Beck
  • Wolfgang Schultze-Seemann
  • Evelina Tacconelli
  • Hartmut Bertz
  • Ursula Theuretzbacher
  • Michaela Steib-Bauert
  • Cordula A Jilg
  • Winfried V Kern
  • Anca L Grosu
  • Annette Geibel-Zehender
  • Jordi Rello
  • Uwe K Frank
  • Martin Wolkewitz
  • Poul Flemming Hoilund-Carlsen
  • Hansjörg Busch
  • Katja de With
  • Philipp T Meyer
  • Gesche Wieser
  • Maria Martin
  • Alexander Frankenschmidt
  • Peter Andel
  • Niels Marcussen
  • Steen Walter
  • Ulla Geertsen
  • Henrik Wulff Christensen
  • Poul F Høilund-Carlsen
  • Niels Svolgaard
  • Signe Inglev Steffansen
  • Jeannette Østergaard Penny
  • Henrik W Christensen
  • Ewa M Roos

Detail Information

Publications19

  1. doi request reprint The Move from Accuracy Studies to Randomized Trials in PET: Current Status and Future Directions
    Bettina Siepe
    Department of Anesthesiology, Freiburg University Medical Center, Freiburg, Germany
    J Nucl Med 55:1228-34. 2014
    ..Our aim was to investigate how far the nuclear medicine community has come on its way from accuracy studies to RCTs and which issues we have to take into account in planning future studies...
  2. doi request reprint [Benefit assessment of diagnostic procedures: quo vadimus?]
    Werner Vach
    Department für Medizinische Biometrie und Medizinische Informatik, Universitat Freiburg, Stefan Meier Str 26, 79104, Freiburg, Deutschland
    Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 58:256-62. 2015
    ..Furthermore, we indicate some of the developments related to the paradigm of individualized care that may influence the use of benefit assessments for diagnostic studies in the future. ..
  3. pmc Impact of availability of guidelines and active surveillance in reducing the incidence of ventilator-associated pneumonia in Europe and worldwide
    Klaus Kaier
    Institute of Medical Biometry and Medical Informatics, University Medical Center, Freiburg, Germany
    BMC Infect Dis 14:199. 2014
    ....
  4. pmc Feasibility and impact of an intensified antibiotic stewardship programme targeting cephalosporin and fluoroquinolone use in a tertiary care university medical center
    Johannes P Borde
    Department of Medicine, Abteilung Infektiologie, Universitatsklinikum Freiburg, Hugstetter Straße 55, D 79106 Freiburg i, BR, Germany
    BMC Infect Dis 14:201. 2014
    ..We implemented an intensified antibiotic stewardship (ABS) programme in the medical service of a university hospital center aiming at a reduction by at least 30% in the use of these two drug classes...
  5. pmc Shared decision-making in antihypertensive therapy: a cluster randomised controlled trial
    Iris Tinsel
    Department of Medicine, Division of General Practice, University Medical Centre Freiburg, Elsässerstr 2m, Freiburg 79110, Germany
    BMC Fam Pract 14:135. 2013
    ..Our hypotheses are that this SDM training (1) enhances the participation of patients and (2) leads to an enhanced decrease in blood pressure (BP) values, compared to patients receiving usual care without prior SDM training for GPs...
  6. doi request reprint Calibration of clinical prediction rules does not just assess bias
    Werner Vach
    Clinical Epidemiology, Institute of Medical Biometry and Medical Informatics, Freiburg University Medical Center, Freiburg, Germany Electronic address
    J Clin Epidemiol 66:1296-301. 2013
    ..In particular, if the rule is based on a linear logistic model, it is often assumed that an overestimation of all coefficients results in a calibration slope less than 1 and an underestimation in a slope larger than 1...
  7. pmc Reproducibility of range of motion and muscle strength measurements in patients with hip osteoarthritis - an inter-rater study
    Erik Poulsen
    Institute of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark
    BMC Musculoskelet Disord 13:242. 2012
    ..Furthermore, the reliability of the overall assessment of clinical hip OA was evaluated. Reporting is in accordance with proposed guidelines for the reporting of reliability and agreement studies (GRRAS)...
  8. pmc Non-surgical treatment of hip osteoarthritis. Hip school, with or without the addition of manual therapy, in comparison to a minimal control intervention: protocol for a three-armed randomized clinical trial
    Erik Poulsen
    Institute of Sports Science and Clinical Biomechanics, University of Southern Denmark, Denmark
    BMC Musculoskelet Disord 12:88. 2011
    ..There is evidence from several trials that exercise therapy is effective. In addition, single trials suggest that patient education in the form of a hip school is a promising intervention and that manual therapy is superior to exercise...
  9. doi request reprint Construction of a Danish CDI short form for language screening at the age of 36 months: methodological considerations and results
    Werner Vach
    Clinical Epidemiology, Institute of Medical Biometry and Medical Informatics, University Medical Center Freiburg, Germany
    Clin Linguist Phon 24:602-21. 2010
    ..Finally we discuss the choice of the most appropriate age for language screening based on a vocabulary score...
  10. doi request reprint Generating evidence for clinical benefit of PET/CT in diagnosing cancer patients
    Werner Vach
    Clinical Epidemiology, Institute of Medical Biometry and Medical Informatics, Freiburg University Medical Center, Freiburg, Germany
    J Nucl Med 52:77S-85S. 2011
    ..Only if decision modeling does not allow definitive conclusions should randomized controlled trials be planned...
  11. pmc Google Scholar as replacement for systematic literature searches: good relative recall and precision are not enough
    Martin Boeker
    Department of Medical Biometry and Medical Informatics, University Medical Center Freiburg, Stefan Meier Str, 26, Freiburg i, BR, 79104, Germany
    BMC Med Res Methodol 13:131. 2013
    ....
  12. pmc How to study optimal timing of PET/CT for monitoring of cancer treatment
    Werner Vach
    Clinical Epidemiology, Institute of Medical Biometry and Medical Informatics, University Medical Center Freiburg Stefan Meier Str 26, D 79104 Freiburg, Germany
    Am J Nucl Med Mol Imaging 1:54-62. 2011
    ..However, the timing of the PET/CT-based evaluation of reduction in viable tumor tissue is a crucial question. We investigated how to plan and analyze studies to optimize this timing...
  13. pmc Game-based e-learning is more effective than a conventional instructional method: a randomized controlled trial with third-year medical students
    Martin Boeker
    Department of Medical Biometry and Medical Informatics, University Medical Center Freiburg, Freiburg i Br, Baden Wurttemberg, Germany
    PLoS ONE 8:e82328. 2013
    ..Most recent systematic reviews and meta-analysis of studies on Game-based learning and GbEl in the medical professions have shown limited effects of these instructional methods...
  14. ncbi request reprint Time-dependent migration of citations through PubMed and OvidSP subsets: a study on a series of simultaneous PubMed and OvidSP searches
    Martin Boeker
    Institute of Medical Biometry and Medical Informatics, University Medical Center Freiburg, Germany
    Stud Health Technol Inform 192:1196. 2013
    ....
  15. doi request reprint Furosemide diminishes ¹⁸F-fluoroethylcholine uptake in prostate cancer in vivo
    H Christian Rischke
    Department of Radiation Oncology, University of Freiburg, Hugstetterstr 55, 79106, Freiburg, Germany
    Eur J Nucl Med Mol Imaging 41:2074-82. 2014
    ..Currently it is unknown if there is any effect of furosemide on (18)F-FECh uptake in organs, tissues and tumour lesions and the extent to which image quality along the urinary tract may be improved by furosemide...
  16. doi request reprint 123I-iodobenzamide SPECT is not an independent predictor of dopaminergic responsiveness in patients with suspected atypical parkinsonian syndromes
    Sabine Hellwig
    Department of Neurology, University Hospital Freiburg, Freiburg, Germany
    J Nucl Med 54:2081-6. 2013
    ..We investigated whether striatal dopamine D2/D3 receptor (D2R) binding assessed by (123)I-iodobenzamide SPECT is an independent predictor of dopaminergic responsiveness in patients with parkinsonism...
  17. pmc Implementation of shared decision making by physician training to optimise hypertension treatment. Study protocol of a cluster-RCT
    Iris Tinsel
    Department of Medicine, Division of General Practice, University Medical Centre Freiburg, Elsässerstr, 2 m, Freiburg, 79110, Germany
    BMC Cardiovasc Disord 12:73. 2012
    ..Until now there exists little information on the effects of shared decision making trainings for general practitioners on patient participation and on lowering blood pressure in hypertensive patients...
  18. doi request reprint [18F]fluoromethylcholine (FCH) positron emission tomography/computed tomography (PET/CT) for lymph node staging of prostate cancer: a prospective study of 210 patients
    Mads H Poulsen
    Department of Urology, Odense University Hospital Institute of Clinical Research, University of Southern Denmark, Odense, Denmark
    BJU Int 110:1666-71. 2012
    ..However, we did detect several bone metastases with [(18) F]FCH PET/CT that the normal bone scans had missed, and this might be worth pursuing...
  19. doi request reprint Three principles to define the success of a diagnostic study could be identified
    Werner Vach
    Clinical Epidemiology, Institute of Medical Biometry and Medical Informatics, Freiburg University Medical Center, Freiburg, Germany
    J Clin Epidemiol 65:293-300. 2012
    ..Diagnostic studies are typically studies with two endpoints, sensitivity and specificity. To define the success of a diagnostic study, results for these two endpoints have to be combined in an appropriate manner...