Gudrun Ulrich-Merzenich

Summary

Affiliation: University of Bonn
Country: Germany

Publications

  1. ncbi request reprint Drug development from natural products: exploiting synergistic effects
    Gudrun Ulrich-Merzenich
    Medical Policlinic of the Rheinische Friedrich Wilhelms University of Bonn, Wilhelmstr 35 37, D 53111 Bonn, Germany
    Indian J Exp Biol 48:208-19. 2010
  2. ncbi request reprint Vitamin C and vitamin E antagonistically modulate human vascular endothelial and smooth muscle cell DNA synthesis and proliferation
    Gudrun Ulrich-Merzenich
    Medizinische Poliklinik, University of Bonn, Germany
    Eur J Nutr 41:27-34. 2002
  3. doi request reprint The lectin-like oxidized low-density lipoprotein receptor-1 as therapeutic target for atherosclerosis, inflammatory conditions and longevity
    Gudrun Ulrich-Merzenich
    University of Bonn, UKB Medical Clinic III, Sigmund Freud Str 25, Bonn, 53127, Germany
    Expert Opin Ther Targets 17:905-19. 2013
  4. doi request reprint Novel neurological and immunological targets for salicylate-based phytopharmaceuticals and for the anti-depressant imipramine
    G Ulrich-Merzenich
    Medizinische Poliklinik, Universitatsklinikum, Rheinische Friedrich Wilhelms Universitat Bonn, Germany
    Phytomedicine 19:930-9. 2012
  5. doi request reprint Prediction of adverse events by in vivo gene expression profiling exemplified for phytopharmaceuticals containing salicylates and the antidepressant imipramine
    G Ulrich-Merzenich
    Medical Clinic III, Universitatsklinikum, Rheinische Friedrich Wilhelms University Bonn, D 53111 Bonn, Germany
    Phytomedicine 19:322-9. 2012
  6. doi request reprint New perspectives for synergy research with the "omic"-technologies
    G Ulrich-Merzenich
    Medical Policlinic of the Rheinische Friedrich Wilhelms University of Bonn, Wilhelmstr 35 37, D 53111 Bonn, Germany
    Phytomedicine 16:495-508. 2009
  7. doi request reprint Synergy research: vitamins and secondary plant components in the maintenance of the redox-homeostasis and in cell signaling
    Gudrun Ulrich-Merzenich
    Medizinische Poliklinik der Rheinischen Friedrich Wilhelms Universität Bonn, Bonn, Germany
    Phytomedicine 16:2-16. 2009
  8. ncbi request reprint Protective effects of taurine on endothelial cells impaired by high glucose and oxidized low density lipoproteins
    Gudrun Ulrich-Merzenich
    Medical Policlinic of the Friedrich Wilhelm University of Bonn, Wilhelmstrasse 35 37, 53111 Bonn, Germany
    Eur J Nutr 46:431-8. 2007
  9. ncbi request reprint Vitamin C promotes human endothelial cell growth via the ERK-signaling pathway
    Gudrun Ulrich-Merzenich
    Medical Policlinic of the Rheinische, Friedrich Wilhelms University of Bonn, Wilhelmstr 35 37 53111 Bonn, Germany
    Eur J Nutr 46:87-94. 2007
  10. ncbi request reprint Application of the "-Omic-" technologies in phytomedicine
    G Ulrich-Merzenich
    Medical Policlinic of Rheinische Friedrich Wilhelms University of Bonn, Wilhelmstr 35 37, D 53111 Bonn, Germany
    Phytomedicine 14:70-82. 2007

Detail Information

Publications20

  1. ncbi request reprint Drug development from natural products: exploiting synergistic effects
    Gudrun Ulrich-Merzenich
    Medical Policlinic of the Rheinische Friedrich Wilhelms University of Bonn, Wilhelmstr 35 37, D 53111 Bonn, Germany
    Indian J Exp Biol 48:208-19. 2010
    ....
  2. ncbi request reprint Vitamin C and vitamin E antagonistically modulate human vascular endothelial and smooth muscle cell DNA synthesis and proliferation
    Gudrun Ulrich-Merzenich
    Medizinische Poliklinik, University of Bonn, Germany
    Eur J Nutr 41:27-34. 2002
    ..They reduce oxidation of low density lipoproteins (oxLDL), thereby protecting human vascular arterial endothelial and smooth muscle cells from oxLDL induced damages...
  3. doi request reprint The lectin-like oxidized low-density lipoprotein receptor-1 as therapeutic target for atherosclerosis, inflammatory conditions and longevity
    Gudrun Ulrich-Merzenich
    University of Bonn, UKB Medical Clinic III, Sigmund Freud Str 25, Bonn, 53127, Germany
    Expert Opin Ther Targets 17:905-19. 2013
    ..Increasing numbers of studies suggest that therapeutic strategies to modulate LOX-1 will have a broad spectrum of applications ranging from cardiovascular diseases to longevity...
  4. doi request reprint Novel neurological and immunological targets for salicylate-based phytopharmaceuticals and for the anti-depressant imipramine
    G Ulrich-Merzenich
    Medizinische Poliklinik, Universitatsklinikum, Rheinische Friedrich Wilhelms Universitat Bonn, Germany
    Phytomedicine 19:930-9. 2012
    ....
  5. doi request reprint Prediction of adverse events by in vivo gene expression profiling exemplified for phytopharmaceuticals containing salicylates and the antidepressant imipramine
    G Ulrich-Merzenich
    Medical Clinic III, Universitatsklinikum, Rheinische Friedrich Wilhelms University Bonn, D 53111 Bonn, Germany
    Phytomedicine 19:322-9. 2012
    ..Treatments had shown antidepressant-like effects...
  6. doi request reprint New perspectives for synergy research with the "omic"-technologies
    G Ulrich-Merzenich
    Medical Policlinic of the Rheinische Friedrich Wilhelms University of Bonn, Wilhelmstr 35 37, D 53111 Bonn, Germany
    Phytomedicine 16:495-508. 2009
    ....
  7. doi request reprint Synergy research: vitamins and secondary plant components in the maintenance of the redox-homeostasis and in cell signaling
    Gudrun Ulrich-Merzenich
    Medizinische Poliklinik der Rheinischen Friedrich Wilhelms Universität Bonn, Bonn, Germany
    Phytomedicine 16:2-16. 2009
    ..Their relevance in the treatment of various diseases is discussed in the context of a multitarget therapy with nutraceuticals and phytotherapeutic drugs...
  8. ncbi request reprint Protective effects of taurine on endothelial cells impaired by high glucose and oxidized low density lipoproteins
    Gudrun Ulrich-Merzenich
    Medical Policlinic of the Friedrich Wilhelm University of Bonn, Wilhelmstrasse 35 37, 53111 Bonn, Germany
    Eur J Nutr 46:431-8. 2007
    ..Endothelial dysfunction, common to diabetes and cardiovascular diseases, is an early step in the development of atherosclerosis and diabetic angiopathies. Deficiencies of taurine have been related to diabetes and cardiovascular diseases...
  9. ncbi request reprint Vitamin C promotes human endothelial cell growth via the ERK-signaling pathway
    Gudrun Ulrich-Merzenich
    Medical Policlinic of the Rheinische, Friedrich Wilhelms University of Bonn, Wilhelmstr 35 37 53111 Bonn, Germany
    Eur J Nutr 46:87-94. 2007
    ..Large primary prevention trials failed to confirm this. Mechanistic studies may contribute to resolve this discrepancy...
  10. ncbi request reprint Application of the "-Omic-" technologies in phytomedicine
    G Ulrich-Merzenich
    Medical Policlinic of Rheinische Friedrich Wilhelms University of Bonn, Wilhelmstr 35 37, D 53111 Bonn, Germany
    Phytomedicine 14:70-82. 2007
    ..The application of the "-omic-" technologies may lead to a change of paradigms towards the application of complex mixtures in medicine and open the new field of phytogenomics, -proteomics and -metabolomics...
  11. ncbi request reprint Simultaneous isolation of endothelial and smooth muscle cells from human umbilical artery or vein and their growth response to low-density lipoproteins
    Gudrun Ulrich-Merzenich
    Medizinische Poliklinik der Universitat Bonn, Wilhelmstrasse 35 37, Germany
    In Vitro Cell Dev Biol Anim 38:265-72. 2002
    ..Further differences of venous and arterial ECs in tolerance toward minimal oxLDLs could be of clinical relevance for coronary artery bypass grafts...
  12. doi request reprint Bolus ingestion of white and green tea increases the concentration of several flavan-3-ols in plasma, but does not affect markers of oxidative stress in healthy non-smokers
    Nadine Müller
    Department of Nutrition and Food Science Nutritional Physiology, University of Bonn, Bonn, Germany
    Mol Nutr Food Res 54:1636-45. 2010
    ..A short-term increase of catechins does not change plasma antioxidant capacity in healthy subjects. Conclusions with respect to health protective effects of WT and GT on the basis of these biomarkers can, thus, not be drawn...
  13. ncbi request reprint Treatment of acquired hemophilia by the Bonn-Malmo Protocol: documentation of an in vivo immunomodulating concept
    Heike Zeitler
    Medical Policlinic, University of Bonn, Wilhelmstrasse 35 37, 53111 Bonn, Germany
    Blood 105:2287-93. 2005
    ..Long-term follow-up (7 months-7 years) showed an overall response rate of 88% for complete remission (CR). When cancer patients were excluded, the CR rate was 97%...
  14. doi request reprint Immunoadsorption in the treatment of acquired haemophilia
    Heike Zeitler
    Internal Medical Clinic I of the University of Bonn, Centre of Extracorporeal Therapy and Autoimmunity, Germany
    Atheroscler Suppl 10:122-5. 2009
    ..However, the severity of bleeding, and therefore the cost-effectiveness of the approach, needs to be considered when initiating this treatment protocol...
  15. doi request reprint The relevance of the bleeding severity in the treatment of acquired haemophilia - an update of a single-centre experience with 67 patients
    H Zeitler
    Internal Medical Clinic I of the University of Bonn, Centre of Extracorporeal Therapy and Autoimmunity CETA, Bonn, Germany
    Haemophilia 16:95-101. 2010
    ..Treatment procedures should be adapted to bleeding severity and inhibitor titres. Under these conditions, AH is a potentially curable autoimmune disorder with an excellent prognosis...
  16. ncbi request reprint [The modified Bonn Malmö protocol (MBMP) in the treatment of acquired haemophilia A]
    H Zeitler
    Medizinische Poliklinik der Universitat Bonn
    Dtsch Med Wochenschr 131:141-7. 2006
    ..Aim of an optimal treatment strategy should be to control bleedings by a rapid and safe elimination of the inhibitor and reinducing long-term immune tolerance...
  17. ncbi request reprint Long-term effects of a multimodal approach including immunoadsorption for the treatment of myasthenic crisis
    Heike Zeitler
    Medical Policlinic, University of Bonn, Bonn, Germany
    Artif Organs 30:597-605. 2006
    ..4 years. No fatalities due to MC occurred. The results demonstrate that our protocol is a potent therapeutic approach in the treatment of MC...
  18. doi request reprint Serotonin mediates PGE2 overexpression through 5-HT2A and 5-HT3 receptor subtypes in serum-free tissue culture of macrophage-like synovial cells
    Matthias F Seidel
    Rheumatology, Medizinische Universitäts Poliklink, Bonn, Germany
    Rheumatol Int 28:1017-22. 2008
    ..The serotonin-induced PGE(2) overexpression appeared thus to be mediated by 5-HT(2A) and 5-HT(3) receptors. This activation might involve COX-2. The findings may explain the potent benefit of 5-HT(3) antagonists...
  19. doi request reprint Immunoadsorption for pregnancy-associated severe acquired hemophilia
    Heike Zeitler
    Medical Clinic I, Centre of Extracorporeal Therapy and Autoimmunity CETA, University Clinic Centre Bonn, Bonn, Germany
    Ther Apher Dial 18:103-10. 2014
    ..In cases of postpartum bleeding the diagnosis of AH should be routinely considered. ..
  20. doi request reprint Multiple benign symmetric lipomatosis--a differential diagnosis of obesity. Is there a rationale for fibrate treatment?
    Heike Zeitler
    Centre of Extracorporeal Treatment and Lipid Disorders, Bonn, Germany
    Obes Surg 18:1354-6. 2008
    ....