Herbert Tschochner

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. ncbi request reprint Pre-ribosomes on the road from the nucleolus to the cytoplasm
    Herbert Tschochner
    Biochemie Zentrum Heidelberg BZH, Im Neuenheimer Feld 328, D 69120 Heidelberg, Germany
    Trends Cell Biol 13:255-63. 2003
  2. ncbi request reprint The composition of the RNA polymerase I transcription machinery switches from initiation to elongation mode
    Mirko Bier
    Biochemie Zentrum Heidelberg, Im Neuenheimer Feld 328, D 69120 Heidelberg, Germany
    FEBS Lett 564:41-6. 2004
  3. ncbi request reprint Dephosphorylation of RNA polymerase I by Fcp1p is required for efficient rRNA synthesis
    Stephan Fath
    Biochemie Zentrum Heidelberg, Im Neuenheimer Feld 328, D 69120 Heidelberg, Germany
    J Biol Chem 279:25251-9. 2004
  4. ncbi request reprint A Noc complex specifically involved in the formation and nuclear export of ribosomal 40 S subunits
    Philipp Milkereit
    Biochemie Zentrum Heidelberg, Im Neuenheimer Feld 328, Germany
    J Biol Chem 278:4072-81. 2003
  5. ncbi request reprint 90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors
    Paola Grandi
    Cellzome AG, Meyerhofstrasse 1, 69117, Heidelberg, Germany
    Mol Cell 10:105-15. 2002
  6. pmc The pre-ribosomal network
    Philipp Milkereit
    Laboratoire de Biologie Moleculaire Eucaryote, F 32062 Toulouse, France
    Nucleic Acids Res 31:799-804. 2003
  7. ncbi request reprint Analysis of the in vivo assembly pathway of eukaryotic 40S ribosomal proteins
    Sébastien Ferreira-Cerca
    Institut fur Biochemie, Genetik und Mikrobiologie, University of Regensburg, Universitatsstrasse 31, 93053 Regensburg, Germany
    Mol Cell 28:446-57. 2007
  8. ncbi request reprint Roles of eukaryotic ribosomal proteins in maturation and transport of pre-18S rRNA and ribosome function
    Sébastien Ferreira-Cerca
    Institut fur Biochemie, Genetik und Mikrobiologie, Universitat Regensburg, Universitätsstr 31, 93053 Regensburg, Germany
    Mol Cell 20:263-75. 2005
  9. ncbi request reprint TFIIH plays an essential role in RNA polymerase I transcription
    Sebastian Iben
    Division of Molecular Biology of the Cell II, German Cancer Research Center, D 69120, Heidelberg, Germany
    Cell 109:297-306. 2002
  10. ncbi request reprint Functional architecture of RNA polymerase I
    Claus D Kuhn
    Gene Center Munich and Center for Integrated Protein Science CIPSM, Department of Chemistry and Biochemistry, Ludwig Maximilians Universitat Munchen, Feodor Lynen Str 25, 81377 Munich, Germany
    Cell 131:1260-72. 2007

Collaborators

  • Ed Hurt
  • Jochen Bassler
  • Ingrid Grummt
  • D Tollervey
  • Philipp Milkereit
  • Sébastien Ferreira-Cerca
  • Holger Kühn
  • Stephan Fath
  • Mirko Bier
  • Claus D Kuhn
  • Gisela Pöll
  • Nicole Gas
  • Daniela Strauss
  • Paola Grandi
  • Sebastian Iben
  • Andreas Neueder
  • Steffen Jakob
  • Marco Gartmann
  • Roland Beckmann
  • Stefan Jennebach
  • Sonja Baumli
  • Patrick Cramer
  • Sebastian R Geiger
  • Jochen Gerber
  • Thorsten Mielke
  • Pierre Emmanuel Gleizes
  • Anja Philippi
  • Jack Greenblatt
  • Michael S Kobor
  • Olivier Gadal
  • Johannes Lechner
  • Sylvia Schütz
  • Bernhard Kuster
  • Deborah Hoogstraten
  • Pavel Hozak
  • Vladimir Rybin
  • Anne Claude Gavin
  • Martina Marzioch
  • Jean Marc Egly
  • Thorsten Schäfer
  • Elisabeth Petfalski

Detail Information

Publications10

  1. ncbi request reprint Pre-ribosomes on the road from the nucleolus to the cytoplasm
    Herbert Tschochner
    Biochemie Zentrum Heidelberg BZH, Im Neuenheimer Feld 328, D 69120 Heidelberg, Germany
    Trends Cell Biol 13:255-63. 2003
    ..The future challenge will be to assign functions to the more than 150 non-ribosomal factors that transiently associate with the developing pre-ribosomes...
  2. ncbi request reprint The composition of the RNA polymerase I transcription machinery switches from initiation to elongation mode
    Mirko Bier
    Biochemie Zentrum Heidelberg, Im Neuenheimer Feld 328, D 69120 Heidelberg, Germany
    FEBS Lett 564:41-6. 2004
    ..Our data support a model in which the elongating Pol I leaves the initiation factors UAF, CF and Rrn3p close by the promoter...
  3. ncbi request reprint Dephosphorylation of RNA polymerase I by Fcp1p is required for efficient rRNA synthesis
    Stephan Fath
    Biochemie Zentrum Heidelberg, Im Neuenheimer Feld 328, D 69120 Heidelberg, Germany
    J Biol Chem 279:25251-9. 2004
    ..We demonstrate that Fcp1 activity is not involved in the formation of the initiation-active form of Pol I (the Pol I-Rrn3p complex) and propose that dephosphorylation of Pol I by Fcp1p facilitates chain elongation during rRNA synthesis...
  4. ncbi request reprint A Noc complex specifically involved in the formation and nuclear export of ribosomal 40 S subunits
    Philipp Milkereit
    Biochemie Zentrum Heidelberg, Im Neuenheimer Feld 328, Germany
    J Biol Chem 278:4072-81. 2003
    ..Thus, Noc4p and Nop14p form a novel Noc complex with a specific role in nucleolar 40 S subunit formation and subsequent export to the cytoplasm...
  5. ncbi request reprint 90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors
    Paola Grandi
    Cellzome AG, Meyerhofstrasse 1, 69117, Heidelberg, Germany
    Mol Cell 10:105-15. 2002
    ..We conclude that the 40S synthesis machinery predominately associates with the 35S pre-rRNA factors, whereas factors required for 60S subunit synthesis largely bind later, showing an unexpected dichotomy in binding...
  6. pmc The pre-ribosomal network
    Philipp Milkereit
    Laboratoire de Biologie Moleculaire Eucaryote, F 32062 Toulouse, France
    Nucleic Acids Res 31:799-804. 2003
    ..Thus, it helps to gain novel insights into the complex network involved in maturation of ribosomal subunits. The database can be accessed at the URL http://www.pre-ribosome.de...
  7. ncbi request reprint Analysis of the in vivo assembly pathway of eukaryotic 40S ribosomal proteins
    Sébastien Ferreira-Cerca
    Institut fur Biochemie, Genetik und Mikrobiologie, University of Regensburg, Universitatsstrasse 31, 93053 Regensburg, Germany
    Mol Cell 28:446-57. 2007
    ..The formation of assembly intermediates of the head controls efficient nuclear export of the SSU and cytoplasmic pre-rRNA maturation steps...
  8. ncbi request reprint Roles of eukaryotic ribosomal proteins in maturation and transport of pre-18S rRNA and ribosome function
    Sébastien Ferreira-Cerca
    Institut fur Biochemie, Genetik und Mikrobiologie, Universitat Regensburg, Universitätsstr 31, 93053 Regensburg, Germany
    Mol Cell 20:263-75. 2005
    ..In contrast, the presence of other r-proteins is mainly required before nuclear export is initiated. Our studies draw a correlation between the in vitro assembly, structural localization, and in vivo function of r-proteins...
  9. ncbi request reprint TFIIH plays an essential role in RNA polymerase I transcription
    Sebastian Iben
    Division of Molecular Biology of the Cell II, German Cancer Research Center, D 69120, Heidelberg, Germany
    Cell 109:297-306. 2002
    ..The results provide a molecular link between RNA polymerase I transcription and transcription-coupled repair of active ribosomal RNA genes...
  10. ncbi request reprint Functional architecture of RNA polymerase I
    Claus D Kuhn
    Gene Center Munich and Center for Integrated Protein Science CIPSM, Department of Chemistry and Biochemistry, Ludwig Maximilians Universitat Munchen, Feodor Lynen Str 25, 81377 Munich, Germany
    Cell 131:1260-72. 2007
    ..In contrast to Pol II, Pol I has a strong intrinsic 3'-RNA cleavage activity, which requires the C-terminal domain of subunit A12.2 and, apparently, enables ribosomal RNA proofreading and 3'-end trimming...