Oliver Treeck

Summary

Affiliation: University of Regensburg
Country: Germany

Publications

  1. ncbi request reprint Novel estrogen receptor beta transcript variants identified in human breast cancer cells affect cell growth and apoptosis of COS-1 cells
    Oliver Treeck
    Department of Obstetrics and Gynecology, University Regensburg, 93053 Regensburg, Germany
    Mol Cell Endocrinol 264:50-60. 2007
  2. doi request reprint Knockdown of ICB-1 gene enhanced estrogen responsiveness of ovarian and breast cancer cells
    Anna Konwisorz
    Department of Obstetrics and Gynecology, University Medical Center Regensburg, Regensburg, Germany
    Endocr Relat Cancer 17:147-57. 2010
  3. doi request reprint Estrogen receptor beta exerts growth-inhibitory effects on human mammary epithelial cells
    Oliver Treeck
    Department of Obstetrics and Gynecology, University of Regensburg, 93053, Regensburg, Germany
    Breast Cancer Res Treat 120:557-65. 2010
  4. doi request reprint Icb-1 Gene expression is elevated in human endometrial adenocarcinoma and is closely associated with HER2 expression
    Anette Springwald
    Department of Obstetrics and Gynecology, University Medical Center Regensburg, Germany
    Cancer Invest 28:904-9. 2010
  5. doi request reprint icb-1 Gene counteracts growth of ovarian cancer cell lines
    Oliver Treeck
    Department of Obstetrics and Gynecology, University Medical Center Regensburg, Regensburg, Germany
    Cancer Lett 335:441-6. 2013
  6. doi request reprint GPR30 gene polymorphisms are associated with progesterone receptor status and histopathological characteristics of breast cancer patients
    Maria Giess
    Department of Obstetrics and Gynecology, University Medical Center Regensburg, Regensburg, Germany
    J Steroid Biochem Mol Biol 118:7-12. 2010
  7. doi request reprint Silencing of the icb-1 gene inhibits the induction of differentiation-associated genes by vitamin D3 and all-trans retinoic acid in gynecological cancer cells
    Martina Haselberger
    Department of Obstetrics and Gynecology, University Medical Center Regensburg, Regensburg, Germany
    Int J Mol Med 28:121-7. 2011
  8. doi request reprint Estrogen receptor β transcript variants associate with oncogene expression in endometrial cancer
    Julia Häring
    Department of Obstetrics and Gynecology, University Medical Center Regensburg, Regensburg, Germany
    Int J Mol Med 29:1127-36. 2012
  9. ncbi request reprint Effects of exon-deleted estrogen receptor beta transcript variants on growth, apoptosis and gene expression of human breast cancer cell lines
    Oliver Treeck
    Department of Obstetrics and Gynecology, University of Regensburg, Landshuter Str 65, 93053 Regensburg, Germany
    Breast Cancer Res Treat 110:507-20. 2008
  10. doi request reprint Identification of novel transcript variants of estrogen receptor α, β and progesterone receptor gene in human endometrium
    Anette Springwald
    Department of Obstetrics and Gynecology, University Medical Center Regensburg, Regensburg, Germany
    Endocrine 37:415-24. 2010

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Novel estrogen receptor beta transcript variants identified in human breast cancer cells affect cell growth and apoptosis of COS-1 cells
    Oliver Treeck
    Department of Obstetrics and Gynecology, University Regensburg, 93053 Regensburg, Germany
    Mol Cell Endocrinol 264:50-60. 2007
    ..With this report increasing the multitude of existing ERbeta mRNA isoforms, we provide further evidence that their synthesis has to be considered as an important level of estrogen signaling...
  2. doi request reprint Knockdown of ICB-1 gene enhanced estrogen responsiveness of ovarian and breast cancer cells
    Anna Konwisorz
    Department of Obstetrics and Gynecology, University Medical Center Regensburg, Regensburg, Germany
    Endocr Relat Cancer 17:147-57. 2010
    ..The identification of ICB-1 as a new player in endocrine-related cancer encourages further studies on the significance of this gene in cancer development and therapy...
  3. doi request reprint Estrogen receptor beta exerts growth-inhibitory effects on human mammary epithelial cells
    Oliver Treeck
    Department of Obstetrics and Gynecology, University of Regensburg, 93053, Regensburg, Germany
    Breast Cancer Res Treat 120:557-65. 2010
    ..The results of this study support the hypothesis that ERbeta acts as a tumor suppressor in mammary epithelium...
  4. doi request reprint Icb-1 Gene expression is elevated in human endometrial adenocarcinoma and is closely associated with HER2 expression
    Anette Springwald
    Department of Obstetrics and Gynecology, University Medical Center Regensburg, Germany
    Cancer Invest 28:904-9. 2010
    ..Furthermore, we observed a highly significant positive correlation of icb-1 transcript levels with c-erbB2 (HER2) expression (p <.0001). Our data strongly encourage further studies on the function of icb-1 in endometrial cancer...
  5. doi request reprint icb-1 Gene counteracts growth of ovarian cancer cell lines
    Oliver Treeck
    Department of Obstetrics and Gynecology, University Medical Center Regensburg, Regensburg, Germany
    Cancer Lett 335:441-6. 2013
    ..Most of the upregulated genes were part of oncogenic pathways regulated by ERα or TNF. Our data suggest that icb-1 gene inhibits growth and progression of ovarian cancer cells...
  6. doi request reprint GPR30 gene polymorphisms are associated with progesterone receptor status and histopathological characteristics of breast cancer patients
    Maria Giess
    Department of Obstetrics and Gynecology, University Medical Center Regensburg, Regensburg, Germany
    J Steroid Biochem Mol Biol 118:7-12. 2010
    ..In conclusion, the results of this study support the important role of GPR30 in breast cancer and encourage functional studies on the molecular mechanisms underlying the association of GPR30 polymorphisms with PR status and tumor growth...
  7. doi request reprint Silencing of the icb-1 gene inhibits the induction of differentiation-associated genes by vitamin D3 and all-trans retinoic acid in gynecological cancer cells
    Martina Haselberger
    Department of Obstetrics and Gynecology, University Medical Center Regensburg, Regensburg, Germany
    Int J Mol Med 28:121-7. 2011
    ..These findings together with the observed co-expression of icb-1 with E-cadherin in breast cancer samples support an important role of the icb-1 gene in cancer cell differentiation...
  8. doi request reprint Estrogen receptor β transcript variants associate with oncogene expression in endometrial cancer
    Julia Häring
    Department of Obstetrics and Gynecology, University Medical Center Regensburg, Regensburg, Germany
    Int J Mol Med 29:1127-36. 2012
    ....
  9. ncbi request reprint Effects of exon-deleted estrogen receptor beta transcript variants on growth, apoptosis and gene expression of human breast cancer cell lines
    Oliver Treeck
    Department of Obstetrics and Gynecology, University of Regensburg, Landshuter Str 65, 93053 Regensburg, Germany
    Breast Cancer Res Treat 110:507-20. 2008
    ....
  10. doi request reprint Identification of novel transcript variants of estrogen receptor α, β and progesterone receptor gene in human endometrium
    Anette Springwald
    Department of Obstetrics and Gynecology, University Medical Center Regensburg, Regensburg, Germany
    Endocrine 37:415-24. 2010
    ..Our identification of additional transcript variations further increases the complexity of steroid hormone receptor gene expression and signalling...
  11. doi request reprint Expression of differentiation-associated gene icb-1 is estrogen-responsive in ovarian and breast cancer cell lines
    Julia Bollmann
    Department of Obstetrics and Gynecology, University of Regensburg, Landshuter Street 65, 93053 Regensburg, Germany
    J Steroid Biochem Mol Biol 109:16-21. 2008
    ..Whether icb-1 is a mediator of estrogen-triggered cellular differentiation processes has to be determined in further studies...
  12. doi request reprint Correlation of body mass index and menopausal status with the intra-tumoral estrogen system in invasive breast cancer
    Georg Pfeiler
    Department of Obstetrics and Gynecology, University of Regensburg, Regensburg, Germany
    Gynecol Endocrinol 25:183-7. 2009
    ..We tested the hypothesis that obesity and menopausal status influence the intra-tumoral estrogen system of breast cancer tissue...
  13. doi request reprint Estrogen receptor beta gene polymorphisms and susceptibility to uterine fibroids
    Claudia Fischer
    Department of Obstetrics and Gynecology, University of Regensburg, 93053 Regensburg, Germany
    Gynecol Endocrinol 26:4-9. 2010
    ..In conclusion, our data clearly suggest that the tested SNPs in the promotor region of human ESR2 gene are not associated with the development of uterine fibroids...
  14. doi request reprint Additive effects of trastuzumab and genistein on human breast cancer cells
    Claus Lattrich
    Department of Obstetrics and Gynecology, University Medical Center Regensburg, Regensburg, Germany
    Anticancer Drugs 22:253-61. 2011
    ..The relevance of these data particularly for women with HER2-overexpressing and ERα/β-positive breast cancer has to be verified in animal or clinical studies...
  15. doi request reprint Estrogen receptor β agonists affect growth and gene expression of human breast cancer cell lines
    Claus Lattrich
    Department of Obstetrics and Gynecology, University Medical Center Regensburg, Regensburg, Germany
    Steroids 78:195-202. 2013
    ..The observed inhibitory effects of 3β-Adiol on breast cancer cell growth encourage further studies on the potential of this and other ERβ agonists as targeted drugs for breast cancer therapy...
  16. ncbi request reprint Expression of icb-1 gene is interferon-gamma inducible in breast and ovarian cancer cell lines and affects the IFN gamma-response of SK-OV-3 ovarian cancer cells
    Oliver Treeck
    Department of Obstetrics and Gynecology, University of Regensburg, Caritas Krankenhaus St Josef, Landshuter Str 65, 93053 Regensburg, Germany
    Cytokine 32:137-42. 2005
    ..In conclusion, we report identification of the novel interferon-gamma inducible gene icb-1 which is able to affect the response of ovarian cancer cells to this cytokine...
  17. doi request reprint Effects of a combined treatment with GPR30 agonist G-1 and herceptin on growth and gene expression of human breast cancer cell lines
    Julia Lubig
    Department of Obstetrics and Gynecology, University Medical Center Regensburg, Regensburg, Germany
    Cancer Invest 30:372-9. 2012
    ..Combined treatment also resulted in expression changes of c-fos, cyclin D1, or p21/WAF-1. The results of our study encourage further attempts to test the relevance of these in vitro data in the clinical setting...
  18. doi request reprint Network analysis of icb-1 gene function in human breast cancer cells
    Oliver Treeck
    Department of Obstetrics and Gynecology, Laboratory of Molecular Oncology, University Medical Center Regensburg, Regensburg, Germany
    J Cell Biochem 113:2979-88. 2012
    ..The data of this study suggest that icb-1 might exert a tumor-suppressor function in breast cancer and that its loss might confer relative resistance of breast cancer cells to apoptotic drugs...
  19. ncbi request reprint Detection of an elevated HER2 expression in MCF-7 breast cancer cells overexpressing estrogen receptor beta1
    Claus Lattrich
    Department of Obstetrics and Gynecology, University of Regensburg, D 93053 Regensburg, Germany
    Oncol Rep 19:811-7. 2008
    ..This is one of the molecular mechanisms underlying the significant ERbeta/HER2 co-expression observed in recent clinical studies...
  20. ncbi request reprint Estrogen receptor {beta}1 exerts antitumoral effects on SK-OV-3 ovarian cancer cells
    Oliver Treeck
    Department of Obstetrics and Gynecology, Klinik fur Frauenheilkunde und Geburtshilfe, University of Regensburg, Landshuter Strasse 65, 93053 Regensburg, Germany
    J Endocrinol 193:421-33. 2007
    ..Our data demonstrate that ERbeta1, but not the exon-deleted isoforms tested exerts multiple antitumoral effects on SK-OV-3 ovarian cancer cells even in the absence of estradiol or functional ERalpha...
  21. doi request reprint Endometrial expression of estrogen receptor β and its splice variants in patients with and without endometriosis
    Ingolf Juhasz-Böss
    Department of Obstetrics and Gynecology, University of Regensburg, Landshuterstr 53, 93053 Regensburg, Germany
    Arch Gynecol Obstet 284:885-91. 2011
    ..In this study, we have examined the expression of the four main ERβ transcript isoforms in human endometrial tissue in women with or without endometriosis...
  22. doi request reprint Polymorphisms in the promoter region of ESR2 gene and breast cancer susceptibility
    Oliver Treeck
    Department of Obstetrics and Gynecology, University of Regensburg, Landshuter Strasse 65, Regensburg, Germany
    J Steroid Biochem Mol Biol 114:207-11. 2009
    ..Our data suggest that a SNP in the promoter region of ESR2 gene might be able to affect breast cancer risk. These results further support the emerging hypothesis that ERbeta is an important factor in breast cancer development...
  23. doi request reprint Role of estrogen receptor β in gynecological cancer
    Julia Häring
    Department of Obstetrics and Gynecology, University Medical Center Regensburg, Regensburg, Germany
    Gynecol Oncol 127:673-6. 2012
    ..Besides its possible role as a prognostic factor, ERβ might be a potential target for the treatment of ovarian and endometrial cancer...
  24. doi request reprint Single nucleotide polymorphisms in the regulatory region of gonadotropin-releasing hormone receptor gene and breast cancer susceptibility
    Claus Lattrich
    Department of Obstetrics and Gynecology, University Medical Center Regensburg, D 93057 Regensburg, Germany
    Oncol Rep 28:1091-5. 2012
    ..Our data suggest a potential role of GnRHR gene polymorphisms in the development of breast cancer...
  25. ncbi request reprint Antiestrogens modulate MT1 melatonin receptor expression in breast and ovarian cancer cell lines
    Oliver Treeck
    Department of Obstetrics and Gynecology, University Regensburg, Germany
    Oncol Rep 15:231-5. 2006
    ..Our findings support the existence of close interaction between estrogen and melatonin signaling. Moreover, our data suggest that melatonin signaling is modulated by antiestrogens in breast and ovarian cancer cells...
  26. ncbi request reprint Effects of a combined treatment with mTOR inhibitor RAD001 and tamoxifen in vitro on growth and apoptosis of human cancer cells
    Oliver Treeck
    Department of Obstetrics and Gynecology, University Regensburg, Caritas Hospital St Josef, Landshuter Strasse 65, 93053 Regensburg, Germany
    Gynecol Oncol 102:292-9. 2006
    ....
  27. ncbi request reprint Apoptotic effects of signal transduction inhibitors on human tumor cells with different PTEN expression
    Georg Pfeiler
    Department of Obstetrics and Gynecology, University of Regensburg, Caritas Hospital St Josef, Landshuter Strasse 65, 93053 Regensburg, Germany
    Oncol Rep 18:1305-9. 2007
    ..Our data underline the importance of PTEN expression regarding the induction of apoptosis through various targeted therapies...
  28. doi request reprint Single nucleotide polymorphisms in human gene icb-1 and breast cancer susceptibility
    Anette Springwald
    Department of Obstetrics and Gynecology, University of Regensburg, Regensburg, Germany
    Cancer Invest 27:669-72. 2009
    ..Our data suggest that SNP rs1467465 of human gene icb-1 might affect breast cancer susceptibility...
  29. doi request reprint Expression of cysteine protease cathepsin L is increased in endometrial cancer and correlates with expression of growth regulatory genes
    Maciej Skrzypczak
    Department of Obstetrics and Gynecology, University Medical Center Regensburg, Regensburg, Germany
    Cancer Invest 30:398-403. 2012
    ..Our data suggest that CTSL2 might be involved in progression of endometrial cancer...
  30. ncbi request reprint Adiponectin effects on human breast cancer cells are dependent on 17-beta estradiol
    Georg H Pfeiler
    Department of Obstetrics and Gynecology, University of Regensburg, D 93042 Regensburg, Germany
    Oncol Rep 19:787-93. 2008
    ....
  31. doi request reprint Influence of insulin resistance on adiponectin receptor expression in breast cancer
    Georg Pfeiler
    Department of Obstetrics and Gynecology, University of Regensburg, 93042 Regensburg, Germany
    Maturitas 63:253-6. 2009
    ..In this study, we investigated the relationship between intratumoral adiponectin receptor expression and insulin resistance as well as intratumoral insulin/IGF receptor expression in breast cancer specimen...
  32. ncbi request reprint H-ras dependent estrogenic effects of epidermal growth factor in the estrogen-independent breast cancer cell line MDA-MB-231
    Oliver Treeck
    Department of Obstetrics and Gynecology, University of Regensburg, Regensburg, Germany
    Breast Cancer Res Treat 80:155-62. 2003
    ..This mechanism was shown to be dependent on EGFR and H-ras activity, but independent of the presence of functional ERalpha...
  33. ncbi request reprint Tamoxifen long-term treatment in vitro alters the apoptotic response of MCF-7 breast cancer cells
    Oliver Treeck
    Department of Obstetrics and Gynecology, University of Regensburg, Caritas Hospital St Josef, Regensburg, Germany
    Anticancer Drugs 15:787-93. 2004
    ....
  34. ncbi request reprint Detection of increased icb-1 transcript levels in maturing HL-60 cells: a novel marker for granulocytic and monocytic in vitro differentiation
    Oliver Treeck
    Department of Obstetrics and Gynecology, Medical University of Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Leuk Res 26:765-9. 2002
    ..Expression of icb-1 can be used as a novel marker for in vitro differentiation processes of HL-60 cells...
  35. ncbi request reprint Effects of a combination of exemestane and paclitaxel on human tumor cells in vitro
    Danqing Chen
    Clinic for Obstetrics and Gynecology, University of Regensburg, Caritas Hospital St Josef, Regensburg, Germany
    Anticancer Drugs 15:55-61. 2004
    ....
  36. ncbi request reprint Effects of prolonged tamoxifen treatment on receptor expression and apoptosis of ovarian cancer cells
    Rong Zhou
    Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, 610041 Chengdu, PR China
    Gynecol Oncol 96:678-83. 2005
    ..In this study, we investigated the long-term effects of this drug on estrogen-receptor-positive ovarian cancer cells...
  37. ncbi request reprint Estradiol differentially modulates the exocytotic proteins SNAP-25 and munc-18 in pituitary gonadotrophs
    Jürgen M Weiss
    Department of Obstetrics and Gynaecology, University of Luebeck, Luebeck, Germany
    J Mol Endocrinol 38:305-14. 2007
    ..In conclusion, munc-18 and SNAP-25 were oppositionally influenced by estradiol. The results suggest that estradiol modulates the expression of exocytotic proteins in gonadotrophs and thus affects LH secretion...