Anke Tonjes

Summary

Affiliation: University of Leipzig
Country: Germany

Publications

  1. pmc Adipokine pattern in subjects with impaired fasting glucose and impaired glucose tolerance in comparison to normal glucose tolerance and diabetes
    Anke Tonjes
    Department of Medicine, University of Leipzig, Leipzig, Germany
    PLoS ONE 5:e13911. 2010
  2. pmc Effects of SLC10A2 variant rs9514089 on gallstone risk and serum cholesterol levels- meta-analysis of three independent cohorts
    Anke Tonjes
    Department of Medicine, Division of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany
    BMC Med Genet 12:149. 2011
  3. ncbi request reprint Effect of a 4 week physical training program on plasma concentrations of inflammatory markers in patients with abnormal glucose tolerance
    Andreas Oberbach
    Junior Research Group N03, IZKF Leipzig, Faculty of Medicine, University of Leipzig, Germany
    Eur J Endocrinol 154:577-85. 2006
  4. pmc Genetic and evolutionary analyses of the human bone morphogenetic protein receptor 2 (BMPR2) in the pathophysiology of obesity
    Dorit Schleinitz
    Interdisciplinary Center for Clinical Research, University of Leipzig, Leipzig, Germany
    PLoS ONE 6:e16155. 2011
  5. doi request reprint Role of genetic variation in the cannabinoid type 1 receptor gene (CNR1) in the pathophysiology of human obesity
    Dorit Schleinitz
    Interdisciplinary Centre for Clinical Research, Medical Faculty, University of Leipzig, Leipzig, Germany
    Pharmacogenomics 11:693-702. 2010
  6. pmc Gene expression of PPARgamma and PGC-1alpha in human omental and subcutaneous adipose tissues is related to insulin resistance markers and mediates beneficial effects of physical training
    Karen Ruschke
    Department of Medicine, Endocrinology Diabetes, University of Leipzig, Liebigstrasse 20, 04103 Leipzig, Germany
    Eur J Endocrinol 162:515-23. 2010
  7. ncbi request reprint Role of genetic variation in the human sodium-glucose cotransporter 2 gene (SGLT2) in glucose homeostasis
    Uta Enigk
    Interdisciplinary Centre for Clinical Research, University of Leipzig, Leipzig, Germany
    Pharmacogenomics 12:1119-26. 2011
  8. ncbi request reprint Effect of genetic variation in the human fatty acid synthase gene (FASN) on obesity and fat depot-specific mRNA expression
    Dorit Schleinitz
    Interdisciplinary Centre for Clinical Research, Leipzig, Germany
    Obesity (Silver Spring) 18:1218-25. 2010
  9. doi request reprint R1467H variant in the rho guanine nucleotide exchange factor 11 (ARHGEF11) is associated with impaired glucose tolerance and type 2 diabetes in German Caucasians
    Yvonne Bottcher
    Medical Department III, University of Leipzig, Philipp Rosenthal Str 27, 04103 Leipzig, Germany
    J Hum Genet 53:365-7. 2008
  10. ncbi request reprint Analysis of a rare functional truncating mutation rs61757459 in vaspin (SERPINA12) on circulating vaspin levels
    Jana Breitfeld
    Department of Medicine, University of Leipzig, Leipzig, Germany
    J Mol Med (Berl) 91:1285-92. 2013

Detail Information

Publications37

  1. pmc Adipokine pattern in subjects with impaired fasting glucose and impaired glucose tolerance in comparison to normal glucose tolerance and diabetes
    Anke Tonjes
    Department of Medicine, University of Leipzig, Leipzig, Germany
    PLoS ONE 5:e13911. 2010
    ..Therefore, the aim of this study was to assess distinct adipokine profiles in patients with normal glucose tolerance (NGT), impaired fasting glucose (IFG), impaired glucose tolerance (IGT) or T2D...
  2. pmc Effects of SLC10A2 variant rs9514089 on gallstone risk and serum cholesterol levels- meta-analysis of three independent cohorts
    Anke Tonjes
    Department of Medicine, Division of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany
    BMC Med Genet 12:149. 2011
    ..Recently, a single nucleotide polymorphism (SNP) rs9514089 in SLC10A2 (apical sodium-dependent bile acid transporter gene) has been identified as a susceptibility variant for cholelithiasis in humans...
  3. ncbi request reprint Effect of a 4 week physical training program on plasma concentrations of inflammatory markers in patients with abnormal glucose tolerance
    Andreas Oberbach
    Junior Research Group N03, IZKF Leipzig, Faculty of Medicine, University of Leipzig, Germany
    Eur J Endocrinol 154:577-85. 2006
    ..The beneficial effects of physical activity on a reduced risk of coronary heart disease could at least in part be mediated by improved markers of inflammation...
  4. pmc Genetic and evolutionary analyses of the human bone morphogenetic protein receptor 2 (BMPR2) in the pathophysiology of obesity
    Dorit Schleinitz
    Interdisciplinary Center for Clinical Research, University of Leipzig, Leipzig, Germany
    PLoS ONE 6:e16155. 2011
    ..The BMPR2 locus has been suggested as target of recent selection in human populations. We hypothesized that BMPR2 might have a role in the pathophysiology of obesity...
  5. doi request reprint Role of genetic variation in the cannabinoid type 1 receptor gene (CNR1) in the pathophysiology of human obesity
    Dorit Schleinitz
    Interdisciplinary Centre for Clinical Research, Medical Faculty, University of Leipzig, Leipzig, Germany
    Pharmacogenomics 11:693-702. 2010
    ..Here we investigated the effects of genetic variation in the cannabinoid type 1 receptor gene (CNR1) on its mRNA expression in adipose tissue from visceral and subcutaneous depots and on the development of obesity...
  6. pmc Gene expression of PPARgamma and PGC-1alpha in human omental and subcutaneous adipose tissues is related to insulin resistance markers and mediates beneficial effects of physical training
    Karen Ruschke
    Department of Medicine, Endocrinology Diabetes, University of Leipzig, Liebigstrasse 20, 04103 Leipzig, Germany
    Eur J Endocrinol 162:515-23. 2010
    ....
  7. ncbi request reprint Role of genetic variation in the human sodium-glucose cotransporter 2 gene (SGLT2) in glucose homeostasis
    Uta Enigk
    Interdisciplinary Centre for Clinical Research, University of Leipzig, Leipzig, Germany
    Pharmacogenomics 12:1119-26. 2011
    ..We therefore investigated the effects of common genetic variation in SGLT2 on human Type 2 diabetes and related traits...
  8. ncbi request reprint Effect of genetic variation in the human fatty acid synthase gene (FASN) on obesity and fat depot-specific mRNA expression
    Dorit Schleinitz
    Interdisciplinary Centre for Clinical Research, Leipzig, Germany
    Obesity (Silver Spring) 18:1218-25. 2010
    ..04). No effect of genetic variation in FASN on obesity was found in children. In conclusion, our data indicate a role of FASN genetic variation in susceptibility to obesity in adults...
  9. doi request reprint R1467H variant in the rho guanine nucleotide exchange factor 11 (ARHGEF11) is associated with impaired glucose tolerance and type 2 diabetes in German Caucasians
    Yvonne Bottcher
    Medical Department III, University of Leipzig, Philipp Rosenthal Str 27, 04103 Leipzig, Germany
    J Hum Genet 53:365-7. 2008
    ..Our study replicated associations of the R1467H with increased risk of T2D or T2D/IGT, thus, implicating a potential role of ARHGEF11 in the aetiology of T2D and IGT...
  10. ncbi request reprint Analysis of a rare functional truncating mutation rs61757459 in vaspin (SERPINA12) on circulating vaspin levels
    Jana Breitfeld
    Department of Medicine, University of Leipzig, Leipzig, Germany
    J Mol Med (Berl) 91:1285-92. 2013
    ..coli and in lysate, but not in supernatant of HEK293 cells. We conclude that rs61757459 is a functional mutation that results in a truncated protein whose instability likely results in reduced serum vaspin levels...
  11. pmc Adipose tissue expression and genetic variants of the bone morphogenetic protein receptor 1A gene (BMPR1A) are associated with human obesity
    Yvonne Bottcher
    Department of Medicine, University of Leipzig, Leipzig, Germany
    Diabetes 58:2119-28. 2009
    ..Members of the family of bone morphogenetic proteins (BMPs) are important regulators of adipogenesis. We examined the role of the BMP receptor 1A gene (BMPR1A) in the pathophysiology of human obesity...
  12. pmc Genetic variation in GPR133 is associated with height: genome wide association study in the self-contained population of Sorbs
    Anke Tonjes
    Department of Medicine, University of Leipzig, Leipzig, Germany
    Hum Mol Genet 18:4662-8. 2009
    ..7 x 10(-8) (beta = 0.949). In conclusion, our GWAS suggests novel loci influencing height. In view of the robust replication in five different cohorts, we propose GPR133 to be a novel gene associated with adult height...
  13. pmc Role of vaspin in human eating behaviour
    Jana Breitfeld
    Department of Medicine, University of Leipzig, Leipzig, Germany
    PLoS ONE 8:e54140. 2013
    ..We therefore hypothesized that vaspin may play a role in human eating behaviour...
  14. pmc Effects of genetic variants in ADCY5, GIPR, GCKR and VPS13C on early impairment of glucose and insulin metabolism in children
    Jan Windholz
    University Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany
    PLoS ONE 6:e22101. 2011
    ..We investigated the role of four of these loci (ADCY5, GIPR, GCKR and VPS13C) in early impairment of glucose and insulin metabolism in children...
  15. doi request reprint Fibroblast growth factor-21 serum concentrations are associated with metabolic and hepatic markers in humans
    Susan Kralisch
    Medical Department, University of Leipzig, Liebigstrasse 18, 04103 Leipzig, Germany Leipzig University Medical Center, IFB AdiposityDiseases, 04103 Leipzig, Germany
    J Endocrinol 216:135-43. 2013
    ..FGF21 serum concentrations are associated with facets of the metabolic syndrome, hepatocellular function, as well as GH status...
  16. pmc Association of FTO variants with BMI and fat mass in the self-contained population of Sorbs in Germany
    Anke Tonjes
    Department of Medicine, Coordination Centre for Clinical Trials, University of Leipzig, Leipzig, Germany
    Eur J Hum Genet 18:104-10. 2010
    ....
  17. ncbi request reprint Visfatin is a positive regulator of MCP-1 in human adipocytes in vitro and in mice in vivo
    Grit Sommer
    Department of Internal Medicine III, University of Leipzig, Leipzig, Germany
    Obesity (Silver Spring) 18:1486-92. 2010
    ..Taken together, our results demonstrate that visfatin upregulates MCP-1 supporting a possible role of MCP-1 in mediating the proinflammatory effects of visfatin...
  18. doi request reprint Long-term exercise training decreases interleukin-6 (IL-6) serum levels in subjects with impaired glucose tolerance: effect of the -174G/C variant in IL-6 gene
    Andreas Oberbach
    Department of Medicine, Faculty of Medicine, University of Leipzig, Philipp Rosenthal Str 27, D 04103 Leipzig, Germany
    Eur J Endocrinol 159:129-36. 2008
    ..However, there are heterogeneous data on whether circulating IL-6 is altered by exercise training. We therefore hypothesize that genetic factors modify the individual changes in IL-6 levels after long-term training...
  19. pmc THOC5: a novel gene involved in HDL-cholesterol metabolism
    Maria Keller
    IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany
    J Lipid Res 54:3170-6. 2013
    ..The small interfering RNA-mediated mRNA silencing of THOC5 in HepG2 cells resulted in lower mRNA levels of APOA1, SCARB1, and ABCG8 (all P < 0.05). We propose THOC5 to be a novel gene involved in the regulation of serum HDL-C levels...
  20. ncbi request reprint Assay-dependent variability of serum insulin levels during oral glucose tolerance test: influence on reference intervals for insulin and on cut-off values for insulin sensitivity indices
    Maria Werner
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Leipzig, Germany
    Clin Chem Lab Med 46:240-6. 2008
    ..The aim of this study was to investigate the variability of insulin levels for reference intervals and of insulin sensitivity indices during oGTT by three different insulin immunoassays...
  21. pmc Identification of adipokine clusters related to parameters of fat mass, insulin sensitivity and inflammation
    Gesine Flehmig
    Department of Medicine, University of Leipzig, Leipzig, Germany
    PLoS ONE 9:e99785. 2014
    ..Whether adipokine patterns are relevant for the predictive assessment of intervention outcomes needs to be further investigated. ..
  22. pmc TAS2R38 and its influence on smoking behavior and glucose homeostasis in the German Sorbs
    Maria Keller
    IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany
    PLoS ONE 8:e80512. 2013
    ..We tested whether the TAS2R38 variants (rs713598; rs1726866 and rs10246939) may be related to eating behavior, anthropometric parameters, metabolic traits and consumer goods intake in the German Sorbs...
  23. pmc Reduced food intake and body weight in mice deficient for the G protein-coupled receptor GPR82
    Kathrin M Y Engel
    Molecular Biochemistry, Institute of Biochemistry, Medical Faculty, University of Leipzig, Leipzig, Germany
    PLoS ONE 6:e29400. 2011
    ..GPR82 may represent a thrifty gene most probably representing an advantage during human expansion into new environments...
  24. ncbi request reprint The role of the Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma in diabetes risk
    Anke Tonjes
    Department of Medicine, University of Leipzig, Leipzig, Germany
    Curr Opin Clin Nutr Metab Care 10:410-4. 2007
    ..To provide a timely update of the literature regarding the role of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor gamma gene in type 2 diabetes and related phenotypes...
  25. ncbi request reprint The genetics of euthyroid familial goiter
    Yvonne Bottcher
    III Medical Department, University of Leipzig, Ph Rosenthal Str 27, 04103 Leipzig, Germany
    Trends Endocrinol Metab 16:314-9. 2005
    ..Family and twin studies suggest a considerable influence by a strong genetic component in euthyroid familial goiter...
  26. pmc A common variant of PNPLA3 (p.I148M) is not associated with alcoholic chronic pancreatitis
    Jonas Rosendahl
    Division of Gastroenterology and Rheumatology, Department for Internal Medicine, Neurology and Dermatology, University of Leipzig, Leipzig, Germany
    PLoS ONE 7:e29433. 2012
    ..I148M) is associated with the development of alcoholic liver cirrhosis (ALC). Since, alcoholic CP and ALC share the same aetiology PNPLA3 variant (p.I148M) possibly influences the development of alcoholic CP...
  27. pmc Population-genetic comparison of the Sorbian isolate population in Germany with the German KORA population using genome-wide SNP arrays
    Arnd Gross
    Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Haertelstrasse 16 18, 04107 Leipzig, Germany
    BMC Genet 12:67. 2011
    ..We also aim to separate effects of over-sampling of families in the Sorbs sample from effects of genetic isolation and compare the power of genetic association studies between the samples...
  28. ncbi request reprint Tissue inhibitor of metalloproteinase-1 predicts adiposity in humans
    Susan Kralisch
    Department of Internal Medicine III, University of Leipzig, Ph Rosenthal Str 27, 04103 Leipzig, Germany
    Eur J Endocrinol 156:257-61. 2007
    ..However, it is unclear whether TIMP-1 independently predicts adiposity in humans and whether serum levels are increased in s.c. and visceral obesity...
  29. ncbi request reprint Effects of genetic variation in the human retinol binding protein-4 gene (RBP4) on insulin resistance and fat depot-specific mRNA expression
    Peter Kovacs
    Interdisciplinary Centre for Clinical Research, University of Leipzig, Leipzig, Germany
    Diabetes 56:3095-100. 2007
    ..Serum retinol binding protein 4 (RBP4) is a new liver- and adipocyte-derived signal that may contribute to insulin resistance. Therefore, the RBP4 gene represents a plausible candidate gene involved in susceptibility to type 2 diabetes...
  30. doi request reprint SGLT2: a potential target for the pharmacogenetics of Type 2 diabetes?
    Anke Tonjes
    University of Leipzig, Medical Department, Liebigstraße 21, 04103 Leipzig, Germany
    Pharmacogenomics 14:825-33. 2013
    ..SLC5A2 polymorphisms might therefore represent potential candidates for pharmacogenomic studies targeting the impact of these variants on the efficacy of antidiabetic treatment that is based on inhibition of SGLT2 activity...
  31. pmc Common genetic variation near MC4R has a sex-specific impact on human brain structure and eating behavior
    Annette Horstmann
    Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany IFB Adiposity Diseases, University of Leipzig, Germany
    PLoS ONE 8:e74362. 2013
    ..These findings suggest that rs17782313's effect on eating behavior is mediated by central mechanisms and that these effects are sex-specific. ..
  32. ncbi request reprint Sialylation of human thyrotropin receptor improves and prolongs its cell-surface expression
    Romy Frenzel
    Medical Department, University of Leipzig, D 04103 Leipzig, Germany
    Mol Pharmacol 68:1106-13. 2005
    ..Our data demonstrate for the first time that the transfer of sialic acid can improve and prolong cell-surface expression of a transmembrane receptor...
  33. ncbi request reprint Expression of regulators of g protein signaling mRNA is differentially regulated in hot and cold thyroid nodules
    Anke Tonjes
    III Medical Department, University of Leipzig, Leipzig, Germany
    Thyroid 14:896-901. 2004
    ..RGS 10 mRNA was significantly reduced in HTN. We therefore propose that downregulation of several RGS transcripts in thyroid nodules might contribute to tumor growth within the thyroid gland...
  34. pmc Serum levels of acylcarnitines are altered in prediabetic conditions
    Manuel Mai
    Division of Endocrinology, Department for Internal Medicine, Neurology and Dermatology, University of Leipzig, Leipzig, Germany
    PLoS ONE 8:e82459. 2013
    ..Therefore, the aim of this study was to investigate serum concentrations of short-, medium- and long-chain acylcarnitines as markers of mitochondrial function in volunteers with normal, impaired or diabetic glucose control...
  35. ncbi request reprint Impaired enteral levothyroxine absorption in hypothyroidism refractory to oral therapy after thyroid ablation for papillary thyroid cancer: case report and kinetic studies
    Anke Tonjes
    Medizinische Klinik III, Universitat Leipzig, Leipzig, Germany
    Thyroid 16:1047-51. 2006
    ..However, we would like to suggest the possibility of a specific intestinal uptake deficit, which will only become apparent in the case of previous thyroid ablation...
  36. ncbi request reprint Association of Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma with Pre-diabetic phenotypes: meta-analysis of 57 studies on nondiabetic individuals
    Anke Tonjes
    University of Leipzig, IIIrd Medical Department, Philipp Rosenthal Str 27, 04103 Leipzig, Germany
    Diabetes Care 29:2489-97. 2006
    ..The purpose of the present study was to reveal a significant association with pre-diabetic phenotypes in nondiabetic individuals based on a systematic meta-analysis of all available published evidence...
  37. pmc Involvement of the chemokine-like receptor GPR33 in innate immunity
    Jens Bohnekamp
    Institute of Biochemistry, Medical Faculty, University of Leipzig, 04103 Leipzig, Germany
    Biochem Biophys Res Commun 396:272-7. 2010
    ..Our data indicate an important role of GPR33 function in innate immunity which became dispensable during human evolution most likely due to past or balancing selection...