Burkhard Tönshoff

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. ncbi request reprint Treatment strategies in pediatric solid organ transplant recipients with calcineurin inhibitor-induced nephrotoxicity
    Burkhard Tönshoff
    Department of Pediatrics I, University Children s Hospital, Heidelberg, Germany
    Pediatr Transplant 10:721-9. 2006
  2. ncbi request reprint Steroid withdrawal in pediatric and adult renal transplant recipients
    Burkhard Tönshoff
    University Children s Hospital, Im Neuenheimer Feld 153, 69120 Heidelberg, Germany
    Pediatr Nephrol 20:409-17. 2005
  3. doi request reprint Pediatric aspects of therapeutic drug monitoring of mycophenolic acid in renal transplantation
    Burkhard Tönshoff
    University Children s Hospital Heidelberg, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany
    Transplant Rev (Orlando) 25:78-89. 2011
  4. ncbi request reprint Comparison of the Emit immunoassay with HPLC for therapeutic drug monitoring of mycophenolic acid in pediatric renal-transplant recipients on mycophenolate mofetil therapy
    Lutz T Weber
    Division of Pediatric Nephrology, University Children s Hospital, Im Neuenheimer Feld 150, 69120 Heidelberg, Germany
    Clin Chem 48:517-25. 2002
  5. ncbi request reprint Successful withdrawal of steroids in pediatric renal transplant recipients receiving cyclosporine A and mycophenolate mofetil treatment: results after four years
    Britta Höcker
    University Children s Hospital, Im Neuenheimer Feld 150, 69120 Heidelberg, Germany
    Transplantation 78:228-34. 2004
  6. ncbi request reprint SRL-based immunosuppression vs. CNI minimization in pediatric renal transplant recipients with chronic CNI nephrotoxicity
    Britta Höcker
    Division of Pediatric Nephrology, University Children s Hospital Heidelberg, Im Neuenheimer Feld, Heidelberg, Germany
    Pediatr Transplant 10:593-601. 2006
  7. doi request reprint Epidemiology and morbidity of Epstein-Barr virus infection in pediatric renal transplant recipients: a multicenter, prospective study
    Britta Höcker
    University Children s Hospital, Im Neuenheimer Feld 430, D 69120 Heidelberg, Germany
    Clin Infect Dis 56:84-92. 2013
  8. doi request reprint Improved growth and cardiovascular risk after late steroid withdrawal: 2-year results of a prospective, randomised trial in paediatric renal transplantation
    Britta Höcker
    Department of Pediatrics I, University Children s Hospital Heidelberg, 69120 Heidelberg, Germany
    Nephrol Dial Transplant 25:617-24. 2010
  9. ncbi request reprint Cyclosporin A absorption profiles in pediatric renal transplant recipients predict the risk of acute rejection
    Lutz T Weber
    Division of Pediatric Nephrology, University Children s Hospital, Heidelber, Germany
    Ther Drug Monit 26:415-24. 2004
  10. ncbi request reprint Differential effects of insulin-like growth factor binding proteins-1, -2, -3, and -6 on cultured growth plate chondrocytes
    Daniela Kiepe
    Division of Pediatric Nephrology, University Children s Hospital, Heidelberg, Germany
    Kidney Int 62:1591-600. 2002

Detail Information

Publications46

  1. ncbi request reprint Treatment strategies in pediatric solid organ transplant recipients with calcineurin inhibitor-induced nephrotoxicity
    Burkhard Tönshoff
    Department of Pediatrics I, University Children s Hospital, Heidelberg, Germany
    Pediatr Transplant 10:721-9. 2006
    ..Substitution of CNIs by mTOR inhibitors is therefore promising, but requires validation in long-term studies in large cohorts...
  2. ncbi request reprint Steroid withdrawal in pediatric and adult renal transplant recipients
    Burkhard Tönshoff
    University Children s Hospital, Im Neuenheimer Feld 153, 69120 Heidelberg, Germany
    Pediatr Nephrol 20:409-17. 2005
    ..The Mid-European Study Group on Pediatric Renal Transplantation and the Arbeitsgemeinschaft fur Padiatrische Nephrologie are currently performing a prospective randomized trial to validate these observations...
  3. doi request reprint Pediatric aspects of therapeutic drug monitoring of mycophenolic acid in renal transplantation
    Burkhard Tönshoff
    University Children s Hospital Heidelberg, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany
    Transplant Rev (Orlando) 25:78-89. 2011
    ..Clearly, more research is required to determine whether pediatric patients will benefit from therapeutic drug monitoring of MPA for long-term maintenance immunosuppression with MMF...
  4. ncbi request reprint Comparison of the Emit immunoassay with HPLC for therapeutic drug monitoring of mycophenolic acid in pediatric renal-transplant recipients on mycophenolate mofetil therapy
    Lutz T Weber
    Division of Pediatric Nephrology, University Children s Hospital, Im Neuenheimer Feld 150, 69120 Heidelberg, Germany
    Clin Chem 48:517-25. 2002
    ..HPLC is currently the preferred method for accurate measurement of mycophenolic acid (MPA). This study was designed to validate the Emit compared with HPLC in relation to clinical outcome measurements...
  5. ncbi request reprint Successful withdrawal of steroids in pediatric renal transplant recipients receiving cyclosporine A and mycophenolate mofetil treatment: results after four years
    Britta Höcker
    University Children s Hospital, Im Neuenheimer Feld 150, 69120 Heidelberg, Germany
    Transplantation 78:228-34. 2004
    ..The addition of mycophenolate mofetil (MMF) to a cyclosporine A (CsA)-based immunosuppressive regimen after renal transplantation may allow steroid withdrawal and amelioration or avoidance of steroid-specific side effects...
  6. ncbi request reprint SRL-based immunosuppression vs. CNI minimization in pediatric renal transplant recipients with chronic CNI nephrotoxicity
    Britta Höcker
    Division of Pediatric Nephrology, University Children s Hospital Heidelberg, Im Neuenheimer Feld, Heidelberg, Germany
    Pediatr Transplant 10:593-601. 2006
    ....
  7. doi request reprint Epidemiology and morbidity of Epstein-Barr virus infection in pediatric renal transplant recipients: a multicenter, prospective study
    Britta Höcker
    University Children s Hospital, Im Neuenheimer Feld 430, D 69120 Heidelberg, Germany
    Clin Infect Dis 56:84-92. 2013
    ..The epidemiology and morbidity of Epstein-Barr virus (EBV) infection in pediatric renal transplant recipients have been characterized insufficiently...
  8. doi request reprint Improved growth and cardiovascular risk after late steroid withdrawal: 2-year results of a prospective, randomised trial in paediatric renal transplantation
    Britta Höcker
    Department of Pediatrics I, University Children s Hospital Heidelberg, 69120 Heidelberg, Germany
    Nephrol Dial Transplant 25:617-24. 2010
    ..Long-term corticosteroid treatment impairs growth and increases cardiovascular risk factors. Hence, steroid withdrawal constitutes a major topic in paediatric renal transplantation and maintenance immunosuppression...
  9. ncbi request reprint Cyclosporin A absorption profiles in pediatric renal transplant recipients predict the risk of acute rejection
    Lutz T Weber
    Division of Pediatric Nephrology, University Children s Hospital, Heidelber, Germany
    Ther Drug Monit 26:415-24. 2004
    ..89) and the lowest percentage prediction error. These data indicate that absorption profiling in pediatric renal transplant recipients has the potential to optimize immunosuppressive therapy with CsA...
  10. ncbi request reprint Differential effects of insulin-like growth factor binding proteins-1, -2, -3, and -6 on cultured growth plate chondrocytes
    Daniela Kiepe
    Division of Pediatric Nephrology, University Children s Hospital, Heidelberg, Germany
    Kidney Int 62:1591-600. 2002
    ....
  11. ncbi request reprint Mycophenolate mofetil suspension in pediatric renal transplantation: three-year data from the tricontinental trial
    Britta Höcker
    Division of Pediatric Nephrology, University Children s Hospital Heidelberg, Heidelberg, Germany
    Pediatr Transplant 9:504-11. 2005
    ..The present study shows that MMF therapy in pediatric renal transplant recipients leads to an excellent patient and graft survival 3 yr post-transplant with an acceptable safety profile...
  12. doi request reprint Bleeding complications in pediatric ABO-incompatible kidney transplantation
    Betti Schaefer
    Division of Pediatric Nephrology, Center for Pediatric and Adolescent Medicine, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany
    Pediatr Nephrol 28:327-32. 2013
    ..ABO-incompatible renal transplantation (ABOi-RTx) following preconditioning with immunoadsorption (IA) and rituximab is a promising approach to facilitate living-related RTx. However, clinical experience is limited in pediatric patients...
  13. ncbi request reprint The pharmacokinetic-pharmacodynamic relationship for total and free mycophenolic Acid in pediatric renal transplant recipients: a report of the german study group on mycophenolate mofetil therapy
    Lutz T Weber
    Division of Pediatric Nephrology, University Children s Hospital, Heidelberg, Germany
    J Am Soc Nephrol 13:759-68. 2002
    ..For the assessment of the toxic risk of MMF regarding leukopenia and/or infections, measurement of free MPA appears to be more appropriate...
  14. ncbi request reprint Soluble CD30 and ELISA-detected human leukocyte antigen antibodies for the prediction of acute rejection in pediatric renal transplant recipients
    Heiko Billing
    Department of Pediatrics I, University Children s Hospital, D 69120 Heidelberg, Germany
    Transpl Int 26:331-8. 2013
    ..TWIST, Clinical Trial No: FG-506-02-43)...
  15. ncbi request reprint Recurrence of proteinuria 10 years post-transplant in NPHS2-associated focal segmental glomerulosclerosis after conversion from cyclosporin A to sirolimus
    Britta Höcker
    Division of Pediatric Nephrology, University Children s Hospital, Im Neuenheimer Feld 153, 69120 Heidelberg, Germany
    Pediatr Nephrol 21:1476-9. 2006
    ..The close temporal relationship of FSGS recurrence with CsA withdrawal and conversion to SRL suggests that caution should be exercised in the use of CsA-free immunosuppression also in patients with NPHS2-associated FSGS...
  16. doi request reprint IVIG and rituximab for treatment of chronic antibody-mediated rejection: a prospective study in paediatric renal transplantation with a 2-year follow-up
    Heiko Billing
    Department of Pediatrics I, University Children s Hospital, Heidelberg, Germany
    Transpl Int 25:1165-73. 2012
    ....
  17. doi request reprint Longitudinal growth on an everolimus- versus an MMF-based steroid-free immunosuppressive regimen in paediatric renal transplant recipients
    Heiko Billing
    Department of Paediatrics I, University Children s Hospital, Heidelberg, Germany
    Transpl Int 26:903-9. 2013
    ..Hence, low-dose EVR does not appear to negatively impact short-term growth in pediatric renal transplant recipients...
  18. ncbi request reprint Analysis of the functional muscle-bone unit of the forearm in pediatric renal transplant recipients
    Eva Maria Rüth
    Division of Pediatric Nephrology, and Department of Pediatric Radiology, University Children s Hospital, Heidelberg, Germany
    Kidney Int 66:1694-706. 2004
    ..In addition, we investigated the muscle-bone relationship in these patients because under physiologic conditions bone strength continually adapts to increasing mechanical loads, that is, muscle force...
  19. ncbi request reprint Validation of an abbreviated pharmacokinetic profile for the estimation of mycophenolic acid exposure in pediatric renal transplant recipients
    Lutz T Weber
    University Children s Hospital Heidelberg, Germany
    Ther Drug Monit 28:623-31. 2006
    ....
  20. doi request reprint Increased cyclosporin a sensitivity in vivo in pediatric renal transplant recipients compared with adults
    Heiko Billing
    Department of Pediatrics I, University Children s Hospital, Heidelberg, Germany
    Ther Drug Monit 34:554-60. 2012
    ..However, these results have not yet been reproduced in the complexity of an in vivo immune system, because reliable biomarkers of CsA effects have not been available...
  21. doi request reprint Comparison of MMF efficacy and safety in paediatric vs. adult renal transplantation: subgroup analysis of the randomised, multicentre FDCC trial
    Britta Höcker
    University Children s Hospital Heidelberg, Germany
    Nephrol Dial Transplant 26:1073-9. 2011
    ..Mycophenolate mofetil (MMF) is widely used for immunosuppressive therapy in renal transplantation, but comparative data regarding efficacy and safety in paediatric vs. adult kidney allograft recipients in one and the same study are lacking...
  22. doi request reprint Pharmacodynamic monitoring by residual NFAT-regulated gene expression in stable pediatric liver transplant recipients
    Heiko Billing
    Department of Pediatrics I, University Children s Hospital Surgery, University of Heidelberg, Heidelberg, Germany
    Pediatr Transplant 16:187-94. 2012
    ....
  23. doi request reprint Long-term pharmacokinetics of mycophenolic acid in pediatric renal transplant recipients over 3 years posttransplant
    Lutz T Weber
    University Children s Hospital, Division of Pediatric Nephrology, Im Neuenheimer Feld 153, Heidelberg, Germany
    Ther Drug Monit 30:570-5. 2008
    ..Dose-normalized MPA exposure increases in the first 9 months posttransplant, consistent with a reduced MPA metabolism and increased enterohepatic recycling of MPA...
  24. doi request reprint Calcineurin inhibitor-free immunosuppression in pediatric renal transplantation: a viable option?
    Britta Höcker
    Division of Pediatric Nephrology, University Children s Hospital Heidelberg, Heidelberg, Germany
    Paediatr Drugs 13:49-69. 2011
    ....
  25. doi request reprint Pharmacokinetics and immunodynamics of basiliximab in pediatric renal transplant recipients on mycophenolate mofetil comedication
    Britta Höcker
    Department of Pediatrics I, University Children s Hospital Heidelberg, Heidelberg, Germany
    Transplantation 86:1234-40. 2008
    ....
  26. doi request reprint Successful treatment of chronic antibody-mediated rejection with IVIG and rituximab in pediatric renal transplant recipients
    Heiko Billing
    Department of Pediatrics I, University Children s Hospital, Heidelberg, Germany
    Transplantation 86:1214-21. 2008
    ..We therefore initiated a pilot study on treatment of CAMR with an antihumoral regimen consisting of high-dose intravenous immunoglobulin (IVIG) and the chimeric anti-CD20 antibody rituximab...
  27. ncbi request reprint Signaling mechanisms leading to regulation of proliferation and differentiation of the mesenchymal chondrogenic cell line RCJ3.1C5.18 in response to IGF-I
    Sonia Ciarmatori
    University Children s Hospital, Im Neuenheimer Feld 153, Heidelberg, Germany
    J Mol Endocrinol 38:493-508. 2007
    ..This mechanism might be essential for the complex and cell stage-specific anabolic action of IGF-I in the growth plate...
  28. doi request reprint Prospective, randomized trial on late steroid withdrawal in pediatric renal transplant recipients under cyclosporine microemulsion and mycophenolate mofetil
    Britta Höcker
    Department of Pediatrics I, University Children s Hospital Heidelberg, Heidelberg, Germany
    Transplantation 87:934-41. 2009
    ..Many transplant centers practice late steroid withdrawal after pediatric renal transplantation, but evidence-based data on the overall risk-to-benefit ratio in this patient population are lacking...
  29. ncbi request reprint Differential expression of IGF system components in proliferating vs. differentiating growth plate chondrocytes: the functional role of IGFBP-5
    Daniela Kiepe
    University Children s Hospital, Im Neuenheimer Feld 153, 69120 Heidelberg, Germany
    Am J Physiol Endocrinol Metab 290:E363-71. 2006
    ..These data suggest that the developmental stage of the chondrocyte is an important determinant of IGF and IGFBP expression and imply a functional role for IGFBP-5 for upregulating IGF action during chondrocyte differentiation in vivo...
  30. doi request reprint Defined carboxy-terminal fragments of insulin-like growth factor (IGF) binding protein-2 exert similar mitogenic activity on cultured rat growth plate chondrocytes as IGF-I
    Daniela Kiepe
    University Children s Hospital, Im Neuenheimer Feld 153, 69120 Heidelberg, Germany
    Endocrinology 149:4901-11. 2008
    ..These data imply a novel role of naturally occurring IGFBP-2 fragments for the endocrine and paracrine/autocrine regulation of longitudinal growth...
  31. doi request reprint (Val-)Ganciclovir prophylaxis reduces Epstein-Barr virus primary infection in pediatric renal transplantation
    Britta Höcker
    University Children s Hospital, Heidelberg, Germany
    Transpl Int 25:723-31. 2012
    ..Chemoprophylaxis with VGCV/GCV is associated with a reduced incidence of EBV viremia in high-risk pediatric kidney allograft recipients in the first year post-transplant. (ClinicalTrials.gov number: NCT00963248)...
  32. doi request reprint Pharmacodynamic monitoring of cyclosporine A by NFAT-regulated gene expression and the relationship with infectious complications in pediatric renal transplant recipients
    Heiko Billing
    University Children s Hospital Heidelberg, Im Neuenheimer Feld 430, Heidelberg, Germany
    Pediatr Transplant 14:844-51. 2010
    ....
  33. doi request reprint The IGF/IGFBP system in relation to macroscopic bone architecture in pediatric renal transplant patients
    Daniela Kiepe
    University Children s Hospital, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany
    Pediatr Nephrol 25:659-67. 2010
    ..The positive correlation of IGF-I with cortical thickness underlines the importance of this hormonal system in the modeling of bone, particularly periosteal growth...
  34. doi request reprint Insulin-like growth factors in normal and diseased kidney
    Daniela Kiepe
    Department of Pediatrics I, University Children s Hospital Heidelberg, INF 430, D 69120 Heidelberg, Germany
    Endocrinol Metab Clin North Am 41:351-74, vii. 2012
    ..The potential therapeutic uses of recombinant human IGF-I for the treatment of acute and chronic kidney failure are briefly discussed...
  35. ncbi request reprint Immunosuppressive drug monitoring of sirolimus and cyclosporine in pediatric patients
    Michael Oellerich
    Department of Clinical Chemistry, George August University Göttingen, and University Children s Hospital, Heidelberg, Germany
    Clin Biochem 37:424-8. 2004
    ..Abbreviated AUC strategies may be preferable for optimization of CsA exposure in pediatric patients...
  36. ncbi request reprint Insulin-like growth factor (IGF)-I stimulates cell proliferation and induces IGF binding protein (IGFBP)-3 and IGFBP-5 gene expression in cultured growth plate chondrocytes via distinct signaling pathways
    Daniela Kiepe
    University Children s Hospital, Im Neuenheimer Feld 153, 69120 Heidelberg, Germany
    Endocrinology 146:3096-104. 2005
    ....
  37. doi request reprint Treatment strategies to minimize or prevent chronic allograft dysfunction in pediatric renal transplant recipients: an overview
    Britta Höcker
    University Children s Hospital, Im Neuenheimer Feld 430, D 69120 Heidelberg, Germany
    Paediatr Drugs 11:381-96. 2009
    ....
  38. ncbi request reprint [Training requirements, expertise and basic conditions of committed medical educators in Germany]
    Sören Huwendiek
    Zentrum für Kinder und Jugendmedizin, Universitatsklinikum Heidelberg, Klinik Kinderheilkunde 1, Heidelberg
    Z Evid Fortbild Qual Gesundhwes 102:613-7. 2008
    ..Against this backdrop, we initiated a web-based survey amongst members of the "Gesellschaft für Medizinische Ausbildung" (German Section of the Association for Medical Education in Europe) e.V. (GMA)...
  39. ncbi request reprint [When should you suspect meningitis?]
    Sören Huwendiek
    Universitätsklinik für, Kinder und Jugendmedizin Heidelberg
    MMW Fortschr Med 149:15-8. 2007
    ..The important task of the primary physician is to recognize the life-threatening condition in time and to refer the patient immediately to the next hospital...
  40. ncbi request reprint Functional and morphologic evaluation of congenital urinary tract dilatation by using combined static-dynamic MR urography: findings in kidneys with a single collecting system
    Wiltrud K Rohrschneider
    Dept of Pediatric Radiology, Radiological Clinic, Univ of Heidelberg, Im Neuenheimer Feld 153, Germany
    Radiology 224:683-94. 2002
    ..To assess combined static-dynamic magnetic resonance (MR) urography in the evaluation of congenital urinary tract dilatation in infants and children...
  41. pmc Mobilization of circulating endothelial progenitor cells correlates with the clinical course of hantavirus disease
    Ellen Krautkrämer
    Department of Nephrology, University of Heidelberg, Heidelberg, Germany
    J Virol 88:483-9. 2014
    ..Our data indicate that cEPCs may play a role in the repair of hantavirus-induced endothelial damage, thereby influencing the clinical course and the severity of symptoms. ..
  42. ncbi request reprint Longitudinal analysis of T-helper cell phenotypes in renal-transplant recipients undergoing growth hormone therapy
    Anette Melk
    Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
    Transplantation 78:1792-801. 2004
    ..We therefore evaluated the immune phenotypes of pediatric renal-transplant recipients and controls in response to rhGH with regard to a possible shift toward a T-helper (TH)1-type response...
  43. ncbi request reprint Recurrence of focal-segmental glomerulosclerosis in children after renal transplantation: clinical and genetic aspects
    Stefanie Weber
    University Children s Hospital Heidelberg, Heidelberg, Germany
    Transplantation 80:S128-34. 2005
    ..Prospective studies will be necessary to better evaluate different therapeutic approaches...
  44. pmc Molecular evidence of Pneumocystis transmission in pediatric transplant unit
    Britta Höcker
    University Children s Hospital, Im Neuenheimer Feld 150, 69120 Heidelberg, Germany
    Emerg Infect Dis 11:330-2. 2005
    ..An infant with mitochondriopathy was the probable index patient...
  45. ncbi request reprint Growth hormone/insulin-like growth factor system in children with chronic renal failure
    Burkhard Tönshoff
    University Children s Hospital, Im Neuenheimer Feld 153, 69120 Heidelberg, Germany
    Pediatr Nephrol 20:279-89. 2005
    ..These data indicate that growth failure in CRF is mainly due to functional IGF deficiency. Combined therapy with rhGH and rhIGF-I is therefore a logical approach...
  46. doi request reprint Expertise, needs and challenges of medical educators: Results of an international web survey
    Sören Huwendiek
    University Children s Hospital Heidelberg, Germany
    Med Teach 32:912-8. 2010
    ..Little is known about how medical educators perceive their own expertise, needs and challenges in relation to medical education...