Burkhard Tönshoff

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. ncbi Pediatric aspects of therapeutic drug monitoring of mycophenolic acid in renal transplantation
    Burkhard Tönshoff
    University Children s Hospital Heidelberg, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany
    Transplant Rev (Orlando) 25:78-89. 2011
  2. ncbi Treatment strategies in pediatric solid organ transplant recipients with calcineurin inhibitor-induced nephrotoxicity
    Burkhard Tönshoff
    Department of Pediatrics I, University Children s Hospital, Heidelberg, Germany
    Pediatr Transplant 10:721-9. 2006
  3. ncbi Steroid withdrawal in pediatric and adult renal transplant recipients
    Burkhard Tönshoff
    University Children s Hospital, Im Neuenheimer Feld 153, 69120 Heidelberg, Germany
    Pediatr Nephrol 20:409-17. 2005
  4. ncbi Successful withdrawal of steroids in pediatric renal transplant recipients receiving cyclosporine A and mycophenolate mofetil treatment: results after four years
    Britta Höcker
    University Children s Hospital, Im Neuenheimer Feld 150, 69120 Heidelberg, Germany
    Transplantation 78:228-34. 2004
  5. ncbi Mycophenolate mofetil suspension in pediatric renal transplantation: three-year data from the tricontinental trial
    Britta Höcker
    Division of Pediatric Nephrology, University Children s Hospital Heidelberg, Heidelberg, Germany
    Pediatr Transplant 9:504-11. 2005
  6. ncbi Improved growth and cardiovascular risk after late steroid withdrawal: 2-year results of a prospective, randomised trial in paediatric renal transplantation
    Britta Höcker
    Department of Pediatrics I, University Children s Hospital Heidelberg, 69120 Heidelberg, Germany
    Nephrol Dial Transplant 25:617-24. 2010
  7. ncbi SRL-based immunosuppression vs. CNI minimization in pediatric renal transplant recipients with chronic CNI nephrotoxicity
    Britta Höcker
    Division of Pediatric Nephrology, University Children s Hospital Heidelberg, Im Neuenheimer Feld, Heidelberg, Germany
    Pediatr Transplant 10:593-601. 2006
  8. ncbi Recurrence of proteinuria 10 years post-transplant in NPHS2-associated focal segmental glomerulosclerosis after conversion from cyclosporin A to sirolimus
    Britta Höcker
    Division of Pediatric Nephrology, University Children s Hospital, Im Neuenheimer Feld 153, 69120 Heidelberg, Germany
    Pediatr Nephrol 21:1476-9. 2006
  9. ncbi Analysis of the functional muscle-bone unit of the forearm in pediatric renal transplant recipients
    Eva Maria Rüth
    Division of Pediatric Nephrology, and Department of Pediatric Radiology, University Children s Hospital, Heidelberg, Germany
    Kidney Int 66:1694-706. 2004
  10. ncbi Comparison of MMF efficacy and safety in paediatric vs. adult renal transplantation: subgroup analysis of the randomised, multicentre FDCC trial
    Britta Höcker
    University Children s Hospital Heidelberg, Germany
    Nephrol Dial Transplant 26:1073-9. 2011

Detail Information

Publications42

  1. ncbi Pediatric aspects of therapeutic drug monitoring of mycophenolic acid in renal transplantation
    Burkhard Tönshoff
    University Children s Hospital Heidelberg, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany
    Transplant Rev (Orlando) 25:78-89. 2011
    ..Clearly, more research is required to determine whether pediatric patients will benefit from therapeutic drug monitoring of MPA for long-term maintenance immunosuppression with MMF...
  2. ncbi Treatment strategies in pediatric solid organ transplant recipients with calcineurin inhibitor-induced nephrotoxicity
    Burkhard Tönshoff
    Department of Pediatrics I, University Children s Hospital, Heidelberg, Germany
    Pediatr Transplant 10:721-9. 2006
    ..Substitution of CNIs by mTOR inhibitors is therefore promising, but requires validation in long-term studies in large cohorts...
  3. ncbi Steroid withdrawal in pediatric and adult renal transplant recipients
    Burkhard Tönshoff
    University Children s Hospital, Im Neuenheimer Feld 153, 69120 Heidelberg, Germany
    Pediatr Nephrol 20:409-17. 2005
    ..The Mid-European Study Group on Pediatric Renal Transplantation and the Arbeitsgemeinschaft fur Padiatrische Nephrologie are currently performing a prospective randomized trial to validate these observations...
  4. ncbi Successful withdrawal of steroids in pediatric renal transplant recipients receiving cyclosporine A and mycophenolate mofetil treatment: results after four years
    Britta Höcker
    University Children s Hospital, Im Neuenheimer Feld 150, 69120 Heidelberg, Germany
    Transplantation 78:228-34. 2004
    ..The addition of mycophenolate mofetil (MMF) to a cyclosporine A (CsA)-based immunosuppressive regimen after renal transplantation may allow steroid withdrawal and amelioration or avoidance of steroid-specific side effects...
  5. ncbi Mycophenolate mofetil suspension in pediatric renal transplantation: three-year data from the tricontinental trial
    Britta Höcker
    Division of Pediatric Nephrology, University Children s Hospital Heidelberg, Heidelberg, Germany
    Pediatr Transplant 9:504-11. 2005
    ..The present study shows that MMF therapy in pediatric renal transplant recipients leads to an excellent patient and graft survival 3 yr post-transplant with an acceptable safety profile...
  6. ncbi Improved growth and cardiovascular risk after late steroid withdrawal: 2-year results of a prospective, randomised trial in paediatric renal transplantation
    Britta Höcker
    Department of Pediatrics I, University Children s Hospital Heidelberg, 69120 Heidelberg, Germany
    Nephrol Dial Transplant 25:617-24. 2010
    ..Long-term corticosteroid treatment impairs growth and increases cardiovascular risk factors. Hence, steroid withdrawal constitutes a major topic in paediatric renal transplantation and maintenance immunosuppression...
  7. ncbi SRL-based immunosuppression vs. CNI minimization in pediatric renal transplant recipients with chronic CNI nephrotoxicity
    Britta Höcker
    Division of Pediatric Nephrology, University Children s Hospital Heidelberg, Im Neuenheimer Feld, Heidelberg, Germany
    Pediatr Transplant 10:593-601. 2006
    ....
  8. ncbi Recurrence of proteinuria 10 years post-transplant in NPHS2-associated focal segmental glomerulosclerosis after conversion from cyclosporin A to sirolimus
    Britta Höcker
    Division of Pediatric Nephrology, University Children s Hospital, Im Neuenheimer Feld 153, 69120 Heidelberg, Germany
    Pediatr Nephrol 21:1476-9. 2006
    ..The close temporal relationship of FSGS recurrence with CsA withdrawal and conversion to SRL suggests that caution should be exercised in the use of CsA-free immunosuppression also in patients with NPHS2-associated FSGS...
  9. ncbi Analysis of the functional muscle-bone unit of the forearm in pediatric renal transplant recipients
    Eva Maria Rüth
    Division of Pediatric Nephrology, and Department of Pediatric Radiology, University Children s Hospital, Heidelberg, Germany
    Kidney Int 66:1694-706. 2004
    ..In addition, we investigated the muscle-bone relationship in these patients because under physiologic conditions bone strength continually adapts to increasing mechanical loads, that is, muscle force...
  10. ncbi Comparison of MMF efficacy and safety in paediatric vs. adult renal transplantation: subgroup analysis of the randomised, multicentre FDCC trial
    Britta Höcker
    University Children s Hospital Heidelberg, Germany
    Nephrol Dial Transplant 26:1073-9. 2011
    ..Mycophenolate mofetil (MMF) is widely used for immunosuppressive therapy in renal transplantation, but comparative data regarding efficacy and safety in paediatric vs. adult kidney allograft recipients in one and the same study are lacking...
  11. ncbi Epidemiology and morbidity of epstein-barr virus infection in pediatric renal transplant recipients: a multicenter, prospective study
    Britta Höcker
    University Children s Hospital, Im Neuenheimer Feld 430, D 69120 Heidelberg, Germany
    Clin Infect Dis 56:84-92. 2013
    ..The epidemiology and morbidity of Epstein-Barr virus (EBV) infection in pediatric renal transplant recipients have been characterized insufficiently...
  12. ncbi Pharmacodynamic monitoring by residual NFAT-regulated gene expression in stable pediatric liver transplant recipients
    Heiko Billing
    Department of Pediatrics I, University Children s Hospital Surgery, University of Heidelberg, Heidelberg, Germany
    Pediatr Transplant 16:187-94. 2012
    ....
  13. ncbi Pharmacokinetics and immunodynamics of basiliximab in pediatric renal transplant recipients on mycophenolate mofetil comedication
    Britta Höcker
    Department of Pediatrics I, University Children s Hospital Heidelberg, Heidelberg, Germany
    Transplantation 86:1234-40. 2008
    ....
  14. ncbi Successful treatment of chronic antibody-mediated rejection with IVIG and rituximab in pediatric renal transplant recipients
    Heiko Billing
    Department of Pediatrics I, University Children s Hospital, Heidelberg, Germany
    Transplantation 86:1214-21. 2008
    ..We therefore initiated a pilot study on treatment of CAMR with an antihumoral regimen consisting of high-dose intravenous immunoglobulin (IVIG) and the chimeric anti-CD20 antibody rituximab...
  15. ncbi Calcineurin inhibitor-free immunosuppression in pediatric renal transplantation: a viable option?
    Britta Höcker
    Division of Pediatric Nephrology, University Children s Hospital Heidelberg, Heidelberg, Germany
    Paediatr Drugs 13:49-69. 2011
    ....
  16. ncbi Signaling mechanisms leading to regulation of proliferation and differentiation of the mesenchymal chondrogenic cell line RCJ3.1C5.18 in response to IGF-I
    Sonia Ciarmatori
    University Children s Hospital, Im Neuenheimer Feld 153, Heidelberg, Germany
    J Mol Endocrinol 38:493-508. 2007
    ..This mechanism might be essential for the complex and cell stage-specific anabolic action of IGF-I in the growth plate...
  17. ncbi Long-term pharmacokinetics of mycophenolic acid in pediatric renal transplant recipients over 3 years posttransplant
    Lutz T Weber
    University Children s Hospital, Division of Pediatric Nephrology, Im Neuenheimer Feld 153, Heidelberg, Germany
    Ther Drug Monit 30:570-5. 2008
    ..Dose-normalized MPA exposure increases in the first 9 months posttransplant, consistent with a reduced MPA metabolism and increased enterohepatic recycling of MPA...
  18. ncbi Differential effects of insulin-like growth factor binding proteins-1, -2, -3, and -6 on cultured growth plate chondrocytes
    Daniela Kiepe
    Division of Pediatric Nephrology, University Children's Hospital, Heidelberg, Germany
    Kidney Int 62:1591-600. 2002
    ..IGFBP-3, however, can either inhibit IGF-independent and IGF-dependent cell proliferation, or enhance IGF responsiveness of chondrocytes dependent on the temporal relationship to the IGF exposure...
  19. ncbi Defined carboxy-terminal fragments of insulin-like growth factor (IGF) binding protein-2 exert similar mitogenic activity on cultured rat growth plate chondrocytes as IGF-I
    Daniela Kiepe
    University Children s Hospital, Im Neuenheimer Feld 153, 69120 Heidelberg, Germany
    Endocrinology 149:4901-11. 2008
    ..These data imply a novel role of naturally occurring IGFBP-2 fragments for the endocrine and paracrine/autocrine regulation of longitudinal growth...
  20. ncbi Differential expression of IGF system components in proliferating vs. differentiating growth plate chondrocytes: the functional role of IGFBP-5
    Daniela Kiepe
    University Children s Hospital, Im Neuenheimer Feld 153, 69120 Heidelberg, Germany
    Am J Physiol Endocrinol Metab 290:E363-71. 2006
    ..These data suggest that the developmental stage of the chondrocyte is an important determinant of IGF and IGFBP expression and imply a functional role for IGFBP-5 for upregulating IGF action during chondrocyte differentiation in vivo...
  21. ncbi Prospective, randomized trial on late steroid withdrawal in pediatric renal transplant recipients under cyclosporine microemulsion and mycophenolate mofetil
    Britta Höcker
    Department of Pediatrics I, University Children s Hospital Heidelberg, Heidelberg, Germany
    Transplantation 87:934-41. 2009
    ..Many transplant centers practice late steroid withdrawal after pediatric renal transplantation, but evidence-based data on the overall risk-to-benefit ratio in this patient population are lacking...
  22. ncbi IVIG and rituximab for treatment of chronic antibody-mediated rejection: a prospective study in paediatric renal transplantation with a 2-year follow-up
    Heiko Billing
    Department of Pediatrics I, University Children s Hospital, Heidelberg, Germany
    Transpl Int 25:1165-73. 2012
    ....
  23. ncbi Increased cyclosporin a sensitivity in vivo in pediatric renal transplant recipients compared with adults
    Heiko Billing
    Department of Pediatrics I, University Children s Hospital, Heidelberg, Germany
    Ther Drug Monit 34:554-60. 2012
    ..However, these results have not yet been reproduced in the complexity of an in vivo immune system, because reliable biomarkers of CsA effects have not been available...
  24. ncbi (Val-)Ganciclovir prophylaxis reduces Epstein-Barr virus primary infection in pediatric renal transplantation
    Britta Höcker
    University Children s Hospital, Heidelberg, Germany
    Transpl Int 25:723-31. 2012
    ..Chemoprophylaxis with VGCV/GCV is associated with a reduced incidence of EBV viremia in high-risk pediatric kidney allograft recipients in the first year post-transplant. (ClinicalTrials.gov number: NCT00963248)...
  25. ncbi Pharmacodynamic monitoring of cyclosporine A by NFAT-regulated gene expression and the relationship with infectious complications in pediatric renal transplant recipients
    Heiko Billing
    University Children s Hospital Heidelberg, Im Neuenheimer Feld 430, Heidelberg, Germany
    Pediatr Transplant 14:844-51. 2010
    ....
  26. ncbi The IGF/IGFBP system in relation to macroscopic bone architecture in pediatric renal transplant patients
    Daniela Kiepe
    University Children s Hospital, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany
    Pediatr Nephrol 25:659-67. 2010
    ..The positive correlation of IGF-I with cortical thickness underlines the importance of this hormonal system in the modeling of bone, particularly periosteal growth...
  27. ncbi Comparison of the Emit immunoassay with HPLC for therapeutic drug monitoring of mycophenolic acid in pediatric renal-transplant recipients on mycophenolate mofetil therapy
    Lutz T Weber
    Division of Pediatric Nephrology, University Children's Hospital, Im Neuenheimer Feld 150, 69120 Heidelberg, Germany
    Clin Chem 48:517-25. 2002
    ..However, because of the cross-reactivity of the antibody used in the Emit assay with the active MPA acyl glucuronide metabolite, the decision thresholds for the Emit were higher than those calculated from HPLC measurements...
  28. ncbi Soluble CD30 and ELISA-detected human leukocyte antigen antibodies for the prediction of acute rejection in pediatric renal transplant recipients
    Heiko Billing
    Department of Pediatrics I, University Children s Hospital, D 69120 Heidelberg, Germany
    Transpl Int 26:331-8. 2013
    ..TWIST, Clinical Trial No: FG-506-02-43)...
  29. ncbi Bleeding complications in pediatric ABO-incompatible kidney transplantation
    Betti Schaefer
    Division of Pediatric Nephrology, Center for Pediatric and Adolescent Medicine, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany
    Pediatr Nephrol 28:327-32. 2013
    ..ABO-incompatible renal transplantation (ABOi-RTx) following preconditioning with immunoadsorption (IA) and rituximab is a promising approach to facilitate living-related RTx. However, clinical experience is limited in pediatric patients...
  30. ncbi Insulin-like growth factors in normal and diseased kidney
    Daniela Kiepe
    Department of Pediatrics I, University Children s Hospital Heidelberg, INF 430, D 69120 Heidelberg, Germany
    Endocrinol Metab Clin North Am 41:351-74, vii. 2012
    ..The potential therapeutic uses of recombinant human IGF-I for the treatment of acute and chronic kidney failure are briefly discussed...
  31. ncbi Treatment strategies to minimize or prevent chronic allograft dysfunction in pediatric renal transplant recipients: an overview
    Britta Höcker
    University Children s Hospital, Im Neuenheimer Feld 430, D 69120 Heidelberg, Germany
    Paediatr Drugs 11:381-96. 2009
    ....
  32. ncbi Insulin-like growth factor (IGF)-I stimulates cell proliferation and induces IGF binding protein (IGFBP)-3 and IGFBP-5 gene expression in cultured growth plate chondrocytes via distinct signaling pathways
    Daniela Kiepe
    University Children s Hospital, Im Neuenheimer Feld 153, 69120 Heidelberg, Germany
    Endocrinology 146:3096-104. 2005
    ....
  33. ncbi Immunosuppressive drug monitoring of sirolimus and cyclosporine in pediatric patients
    Michael Oellerich
    Department of Clinical Chemistry, George August University Göttingen, and University Children s Hospital, Heidelberg, Germany
    Clin Biochem 37:424-8. 2004
    ..Abbreviated AUC strategies may be preferable for optimization of CsA exposure in pediatric patients...
  34. ncbi [Training requirements, expertise and basic conditions of committed medical educators in Germany]
    Sören Huwendiek
    Zentrum für Kinder und Jugendmedizin, Universitatsklinikum Heidelberg, Klinik Kinderheilkunde 1, Heidelberg
    Z Evid Fortbild Qual Gesundhwes 102:613-7. 2008
    ..Against this backdrop, we initiated a web-based survey amongst members of the "Gesellschaft für Medizinische Ausbildung" (German Section of the Association for Medical Education in Europe) e.V. (GMA)...
  35. ncbi [When should you suspect meningitis?]
    Sören Huwendiek
    Universitätsklinik für, Kinder und Jugendmedizin Heidelberg
    MMW Fortschr Med 149:15-8. 2007
    ..The important task of the primary physician is to recognize the life-threatening condition in time and to refer the patient immediately to the next hospital...
  36. ncbi Functional and morphologic evaluation of congenital urinary tract dilatation by using combined static-dynamic MR urography: findings in kidneys with a single collecting system
    Wiltrud K Rohrschneider
    Dept of Pediatric Radiology, Radiological Clinic, Univ of Heidelberg, Im Neuenheimer Feld 153, Germany
    Radiology 224:683-94. 2002
    ..To assess combined static-dynamic magnetic resonance (MR) urography in the evaluation of congenital urinary tract dilatation in infants and children...
  37. ncbi The pharmacokinetic-pharmacodynamic relationship for total and free mycophenolic Acid in pediatric renal transplant recipients: a report of the german study group on mycophenolate mofetil therapy
    Lutz T Weber
    Division of Pediatric Nephrology, University Children's Hospital, Heidelberg, Germany
    J Am Soc Nephrol 13:759-68. 2002
    ..For the assessment of the toxic risk of MMF regarding leukopenia and/or infections, measurement of free MPA appears to be more appropriate...
  38. ncbi Longitudinal analysis of T-helper cell phenotypes in renal-transplant recipients undergoing growth hormone therapy
    Anette Melk
    Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
    Transplantation 78:1792-801. 2004
    ..We therefore evaluated the immune phenotypes of pediatric renal-transplant recipients and controls in response to rhGH with regard to a possible shift toward a T-helper (TH)1-type response...
  39. ncbi Molecular evidence of Pneumocystis transmission in pediatric transplant unit
    Britta Höcker
    University Children s Hospital, Im Neuenheimer Feld 150, 69120 Heidelberg, Germany
    Emerg Infect Dis 11:330-2. 2005
    ..An infant with mitochondriopathy was the probable index patient...
  40. ncbi Recurrence of focal-segmental glomerulosclerosis in children after renal transplantation: clinical and genetic aspects
    Stefanie Weber
    University Children s Hospital Heidelberg, Heidelberg, Germany
    Transplantation 80:S128-34. 2005
    ..Prospective studies will be necessary to better evaluate different therapeutic approaches...
  41. ncbi Growth hormone/insulin-like growth factor system in children with chronic renal failure
    Burkhard Tönshoff
    University Children s Hospital, Im Neuenheimer Feld 153, 69120 Heidelberg, Germany
    Pediatr Nephrol 20:279-89. 2005
    ..These data indicate that growth failure in CRF is mainly due to functional IGF deficiency. Combined therapy with rhGH and rhIGF-I is therefore a logical approach...
  42. ncbi Expertise, needs and challenges of medical educators: Results of an international web survey
    Sören Huwendiek
    University Children s Hospital Heidelberg, Germany
    Med Teach 32:912-8. 2010
    ..Little is known about how medical educators perceive their own expertise, needs and challenges in relation to medical education...