Lars Timmermann

Summary

Affiliation: University of Cologne
Country: Germany

Publications

  1. ncbi request reprint Pathological cerebral oscillatory activity in Parkinson's disease: a critical review on methods, data and hypotheses
    Lars Timmermann
    University Hospital Cologne, Department of Neurology, Joseph Stelzmann Str 9, 50924 Köln, Germany
    Expert Rev Med Devices 4:651-61. 2007
  2. pmc Parkinson subtypes progress differently in clinical course and imaging pattern
    Carsten Eggers
    Department of Neurology, University of Cologne, Cologne, Germany
    PLoS ONE 7:e46813. 2012
  3. doi request reprint A new rechargeable device for deep brain stimulation: a prospective patient satisfaction survey
    Lars Timmermann
    Department of Neurology, University Hospital Cologne, Cologne, Germany
    Eur Neurol 69:193-9. 2013
  4. doi request reprint [Parkinson's disease: current standards in diagnostics and therapy]
    L Timmermann
    Klinik und Poliklinik fur Neurologie, Universitätsklinikum Köln
    Fortschr Neurol Psychiatr 80:560-9. 2012
  5. doi request reprint Parkinson's disease and pathological oscillatory activity: is the beta band the bad guy? - New lessons learned from low-frequency deep brain stimulation
    Lars Timmermann
    Department of Neurology, University Hospital Cologne, Germany
    Exp Neurol 233:123-5. 2012
  6. ncbi request reprint Differential effects of levodopa and subthalamic nucleus deep brain stimulation on bradykinesia in Parkinson's disease
    Lars Timmermann
    Department of Neurology, University of Cologne, Cologne, Germany
    Mov Disord 23:218-27. 2008
  7. ncbi request reprint Impaired cerebral oscillatory processing in hepatic encephalopathy
    L Timmermann
    Department of Neurology, University Hospital Cologne, Germany
    Clin Neurophysiol 119:265-72. 2008
  8. ncbi request reprint [Deep brain stimulation for treatment of dystonia and tremor]
    L Timmermann
    Klinik und Poliklinik fur Neurologie, Universitätsklinikum Köln, Joseph Stelzmann Strasse 9, Koln, Germany
    Nervenarzt 81:680-7. 2010
  9. doi request reprint Modulating pathological oscillatory activity in Parkinson's disease: What's the rhythm?
    Lars Timmermann
    Department of Neurology, University Hospital Cologne, Germany
    Exp Neurol 215:209-11. 2009
  10. ncbi request reprint [Deep brain stimulation for tremor in multiple sclerosis : consensus recommendations of the German Deep Brain Stimulation Association]
    L Timmermann
    Klinik und Poliklinik fur Neurologie, Klinikum der Universität zu Köln, Kerpener Strasse 62, 50924, Koln, Deutschland
    Nervenarzt 80:673-7. 2009

Collaborators

Detail Information

Publications76

  1. ncbi request reprint Pathological cerebral oscillatory activity in Parkinson's disease: a critical review on methods, data and hypotheses
    Lars Timmermann
    University Hospital Cologne, Department of Neurology, Joseph Stelzmann Str 9, 50924 Köln, Germany
    Expert Rev Med Devices 4:651-61. 2007
    ....
  2. pmc Parkinson subtypes progress differently in clinical course and imaging pattern
    Carsten Eggers
    Department of Neurology, University of Cologne, Cologne, Germany
    PLoS ONE 7:e46813. 2012
    ..To elucidate whether Parkinson's disease (PD) subtypes show a differential pattern of FP-CIT-SPECT binding during the disease course...
  3. doi request reprint A new rechargeable device for deep brain stimulation: a prospective patient satisfaction survey
    Lars Timmermann
    Department of Neurology, University Hospital Cologne, Cologne, Germany
    Eur Neurol 69:193-9. 2013
    ..In PD, younger patients, without signs of dementia and good technical understanding, might have highest benefit...
  4. doi request reprint [Parkinson's disease: current standards in diagnostics and therapy]
    L Timmermann
    Klinik und Poliklinik fur Neurologie, Universitätsklinikum Köln
    Fortschr Neurol Psychiatr 80:560-9. 2012
    ..Deep drain stimulation requires, however, a close preoperative work-up and individual consideration of potential effects and side effects...
  5. doi request reprint Parkinson's disease and pathological oscillatory activity: is the beta band the bad guy? - New lessons learned from low-frequency deep brain stimulation
    Lars Timmermann
    Department of Neurology, University Hospital Cologne, Germany
    Exp Neurol 233:123-5. 2012
    ..Taken together, the study adds a further piece to the puzzle of understanding the pathophysiology of Parkinson's disease and the mechanisms of deep brain stimulation...
  6. ncbi request reprint Differential effects of levodopa and subthalamic nucleus deep brain stimulation on bradykinesia in Parkinson's disease
    Lars Timmermann
    Department of Neurology, University of Cologne, Cologne, Germany
    Mov Disord 23:218-27. 2008
    ..This study demonstrates a better effect of levodopa on distal finger movements and STN-DBS on proximal diadochokinesia. Furthermore, a complementary effect of both therapies on brain areas involved in bradykinesia can be assumed...
  7. ncbi request reprint Impaired cerebral oscillatory processing in hepatic encephalopathy
    L Timmermann
    Department of Neurology, University Hospital Cologne, Germany
    Clin Neurophysiol 119:265-72. 2008
    ..The present study tested the hypothesis that worsening of motor and sensory symptoms of HE results from a common basic deficit in the cerebral oscillatory processing within the human motor and visual system...
  8. ncbi request reprint [Deep brain stimulation for treatment of dystonia and tremor]
    L Timmermann
    Klinik und Poliklinik fur Neurologie, Universitätsklinikum Köln, Joseph Stelzmann Strasse 9, Koln, Germany
    Nervenarzt 81:680-7. 2010
    ....
  9. doi request reprint Modulating pathological oscillatory activity in Parkinson's disease: What's the rhythm?
    Lars Timmermann
    Department of Neurology, University Hospital Cologne, Germany
    Exp Neurol 215:209-11. 2009
    ..The present commentary summarizes the current pathophysiological concepts of pathological oscillatory activity in Parkinson's disease and highlights the new ideas of modulatory intervention...
  10. ncbi request reprint [Deep brain stimulation for tremor in multiple sclerosis : consensus recommendations of the German Deep Brain Stimulation Association]
    L Timmermann
    Klinik und Poliklinik fur Neurologie, Klinikum der Universität zu Köln, Kerpener Strasse 62, 50924, Koln, Deutschland
    Nervenarzt 80:673-7. 2009
    ....
  11. doi request reprint [Dementia in morbus Parkinson: reasonable diagnostics and rational therapy]
    L Timmermann
    Klinik und Poliklinik fur Neurologie, Universitätsklinik Köln
    Fortschr Neurol Psychiatr 78:513-8. 2010
    ..g., acetylcholine esterase inhibitors or, perspectively, neuropsychological training methods...
  12. pmc Dystonia in neurodegeneration with brain iron accumulation: outcome of bilateral pallidal stimulation
    L Timmermann
    Klinik und Poliklinik fur Neurologie, Uniklinik Köln, Kerpener Str 62, 50924 Köln, Germany
    Brain 133:701-12. 2010
    ..The patients with more severe dystonia seem to benefit more. A well-controlled, multi-centre prospective study is necessary to enable evidence-based therapeutic decisions and better predict therapeutic outcomes...
  13. doi request reprint Characterisation of tremor-associated local field potentials in the subthalamic nucleus in Parkinson's disease
    Christiane Reck
    Department of Neurology, Heinrich Heine University, Dusseldorf, Germany
    Eur J Neurosci 29:599-612. 2009
    ..These findings suggest the existence of distribution- and muscle-specific tremor-associated LFP activity at different tremor frequencies and an organisation of tremor-related subloops within the STN...
  14. doi request reprint Coherence analysis of local field potentials in the subthalamic nucleus: differences in parkinsonian rest and postural tremor
    Christiane Reck
    Department of Neurology, University Hospital Cologne, Cologne, Germany
    Eur J Neurosci 32:1202-14. 2010
    ..The data suggest a specific topography of 'tremor clusters' for rest and postural tremor. Furthermore, we presume that the same tremor mechanisms exist in patients with tremor-dominant and akinetic-rigid PD, but to different degrees...
  15. ncbi request reprint Synchronized brain network underlying postural tremor in Wilson's disease
    Martin Südmeyer
    Department of Neurology, Heinrich Heine University, Dusseldorf, Germany
    Mov Disord 21:1935-40. 2006
    ..Taken together, our results indicate that WD postural tremor is generated within a synchronized cerebello-thalamo-cortical network, comprising S1/M1, higher cortical motor areas (SMA, PM), and PPC...
  16. doi request reprint Levodopa affects functional brain networks in Parkinsonian resting tremor
    Bettina Pollok
    Department of Neurology, Heinrich Heine University, Dusseldorf, Germany
    Mov Disord 24:91-8. 2009
    ....
  17. doi request reprint Differential distribution of coherence between beta-band subthalamic oscillations and forearm muscles in Parkinson's disease during isometric contraction
    Christiane Reck
    Department of Neurology, University Hospital Cologne, Cologne, Germany
    Clin Neurophysiol 120:1601-9. 2009
    ..However, the beta-band coupling between STN and muscle activity, its distribution and relation to motor symptoms remains unclear...
  18. doi request reprint Causality between local field potentials of the subthalamic nucleus and electromyograms of forearm muscles in Parkinson's disease
    Esther Florin
    Department of Neurology, University Hospital Cologne, Koln, Germany
    Eur J Neurosci 31:491-8. 2010
    ..Therefore, the effect of deep brain stimulation in the subthalamic nucleus could, at least in part, result from a blockade of pathological afferent input...
  19. doi request reprint Essential tremor and tremor in Parkinson's disease are associated with distinct 'tremor clusters' in the ventral thalamus
    David J Pedrosa
    Department of Neurology, University Hospital Cologne, Cologne, Germany
    Exp Neurol 237:435-43. 2012
    ..The data strongly suggest that within VLp individual tremor-related electrophysiological signatures exist in ET and PD tremor...
  20. doi request reprint Patients' expectations of deep brain stimulation, and subjective perceived outcome related to clinical measures in Parkinson's disease: a mixed-method approach
    Franziska Maier
    Department of Neurology, University of Cologne, Cologne, Germany
    J Neurol Neurosurg Psychiatry 84:1273-81. 2013
    ..To study patients' expectations of subthalamic deep brain stimulation (STN-DBS) and their subjective perceived outcome, by using qualitative and quantitative methods in Parkinson's disease (PD)...
  21. doi request reprint Deep brain stimulation of the ventral intermediate nucleus in patients with essential tremor: stimulation below intercommissural line is more efficient but equally effective as stimulation above
    Michael T Barbe
    Department of Neurology, University Hospital Cologne, Cologne, Germany
    Exp Neurol 230:131-7. 2011
    ..In this study the clinical benefit of VIM and PSA DBS on postural tremor suppression was systematically evaluated in a two step approach with a 3D ultrasound kinematic analysis tool...
  22. doi request reprint Ten Hertz thalamus stimulation increases tremor activity in the subthalamic nucleus in a patient with Parkinson's disease
    Esther Florin
    Department of Neurology, University Hospital Cologne, Kerpener Str 62, 50937 Koln, Cologne, Germany
    Clin Neurophysiol 119:2098-103. 2008
    ..By recording local field potentials (LFPs) in the subthalamic nucleus (STN) while stimulating the nucleus ventralis intermedius thalami (VIM), information of the stimulation effects should be gained...
  23. pmc The cerebral oscillatory network of voluntary tremor
    Bettina Pollok
    Department of Neurology, Heinrich Heine University, Moorenstrasse 5, 40225 Duesseldorf, Germany
    J Physiol 554:871-8. 2004
    ..Thus, our data are consistent with the hypothesis that parkinsonian resting tremor involves oscillatory cerebro-cerebral coupling in a physiologically pre-existing network...
  24. ncbi request reprint Decision-making under risk is improved by both dopaminergic medication and subthalamic stimulation in Parkinson's disease
    Jana K Boller
    Department of Neurology, University of Cologne, Kerpener Strasse 62, 50937 Cologne, Germany Electronic address
    Exp Neurol 254:70-7. 2014
    ..The data suggest a positive influence of both MED and STN-DBS on making decisions under risk in PD patients, an effect which seems to be mediated by mechanisms other than the use of negative feedback. ..
  25. doi request reprint Impaired self-awareness of motor deficits in Parkinson's disease: association with motor asymmetry and motor phenotypes
    Franziska Maier
    Department of Neurology, University Hospital Cologne, Cologne, Germany
    Mov Disord 27:1443-7. 2012
    ..This study investigated impaired self-awareness of motor deficits in nondemented, nondepressed Parkinson's disease (PD) patients during a defined clinical on state...
  26. ncbi request reprint Frequency-dependent reciprocal modulation of verbal fluency and motor functions in subthalamic deep brain stimulation
    Lars Wojtecki
    Department of Neurology, Heinrich Heine University, Moorenstrasse 5, 40225 Dusseldorf, Germany
    Arch Neurol 63:1273-6. 2006
    ..In contrast, low-frequency DBS leads to deterioration of motor functions. It is not known whether low-frequency STN DBS also has an effect on frontal functions...
  27. ncbi request reprint Oscillatory coupling in writing and writer's cramp
    Markus Butz
    Department of Neurology, MEG Laboratory, Heinrich Heine University, Moorenstr 5, D 40225 Dusseldorf, Germany
    J Physiol Paris 99:14-20. 2006
    ..These results are consistent with the often described bilateral pathophysiology and impaired sensorimotor integration in writer's cramp patients...
  28. doi request reprint Clinical outcome of subthalamic stimulation in Parkinson's disease is improved by intraoperative multiple trajectories microelectrode recording
    Christiane Reck
    Department of Neurology, University Hospital Cologne, Cologne, Germany
    J Neurol Surg A Cent Eur Neurosurg 73:377-86. 2012
    ..The aim of the study is to investigate whether MER combined with intraoperative evaluation of stimulation effects improve clinical outcome in PD patients undergoing STN DBS surgery...
  29. ncbi request reprint Postural tremor in Wilson's disease: a magnetoencephalographic study
    Martin Südmeyer
    Department of Neurology, Heinrich Heine University, Dusseldorf, Germany
    Mov Disord 19:1476-82. 2004
    ..Taken together, our results indicate that postural tremor in WD is mediated through a pathological oscillatory drive from the primary motor cortex...
  30. ncbi request reprint Oscillatory activity reflects the excitability of the human somatosensory system
    Markus Ploner
    Department of Neurology, Heinrich Heine University, Moorenstrasse 5, 40225 Dusseldorf, Germany
    Neuroimage 32:1231-6. 2006
    ....
  31. ncbi request reprint Ten-Hertz stimulation of subthalamic nucleus deteriorates motor symptoms in Parkinson's disease
    Lars Timmermann
    Department of Neurology, Heinrich Heine University, Dusseldorf, Germany
    Mov Disord 19:1328-33. 2004
    ..This finding indicates the clinical relevance of pathological 10 Hz synchronization in PD...
  32. doi request reprint Reliability of multivariate causality measures for neural data
    Esther Florin
    Department of Neurology, University Hospital Cologne, Cologne, Germany
    J Neurosci Methods 198:344-58. 2011
    ..This showed the usefulness of our simulation results for practical applications in order to draw correct inferences and distinguish between conflicting evidence obtained with different causality measures...
  33. ncbi request reprint Wilson's disease tremor is associated with magnetic resonance imaging lesions in basal ganglia structures
    Martin Südmeyer
    Department of Neurology, Heinrich Heine University, Dusseldorf, Germany
    Mov Disord 21:2134-9. 2006
    ..Our results demonstrate for the first time that Wilson's disease tremor is associated with lesions of the globus pallidus, the head of the caudate nucleus, and the substantia nigra...
  34. doi request reprint Task-specific modulation of effective connectivity during two simple unimanual motor tasks: a 122-channel EEG study
    Damian M Herz
    Department of Neurology, University Hospital Cologne, Cologne, Germany
    Neuroimage 59:3187-93. 2012
    ..The results highlight the potential of DCM to characterize context-specific changes in coupling within functional brain networks...
  35. ncbi request reprint The cerebral oscillatory network of parkinsonian resting tremor
    Lars Timmermann
    Department of Neurology, Heinrich Heine University, Duesseldorf, Germany
    Brain 126:199-212. 2003
    ..The main frequency of cerebro-cerebral coupling corresponds to double the tremor frequency...
  36. ncbi request reprint Pain suppresses spontaneous brain rhythms
    Markus Ploner
    Department of Neurology, Heinrich Heine University, 40225 Dusseldorf, Germany
    Cereb Cortex 16:537-40. 2006
    ..This global change in excitability may reflect the alerting function of pain which opens the gates for processing of and reacting to stimuli of existential relevance...
  37. ncbi request reprint Parkinson's disease patients with subthalamic stimulation and carers judge quality of life differently
    Catharine J Lewis
    Department of Neurology, University of Cologne, Cologne, Germany
    Parkinsonism Relat Disord 20:514-9. 2014
    ..This disruption could negatively influence the family dynamic, leading to different perceptions of the STN-DBS outcome by patients and caregivers...
  38. doi request reprint Akinetic-rigid and tremor-dominant Parkinson's disease patients show different patterns of FP-CIT single photon emission computed tomography
    Carsten Eggers
    Department of Neurology, University of Cologne, Cologne, Germany
    Mov Disord 26:416-23. 2011
    ..To elucidate whether Parkinson's disease subtypes show a different pattern of Iodine-123 fluoropropyl-;carbomethoxy-3 β-(FP-CIT) single photon emission computed tomography (SPECT) binding in accordance with neuropathological findings...
  39. doi request reprint Subthalamic stimulation modulates self-estimation of patients with Parkinson's disease and induces risk-seeking behaviour
    Esther Florin
    1 Department of Neurology, University Hospital Cologne, Germany
    Brain 136:3271-81. 2013
    ....
  40. ncbi request reprint Pathological crying induced by deep brain stimulation
    Lars Wojtecki
    Department of Neurology, Heinrich Heine University, Dusseldorf, Germany
    Mov Disord 22:1314-6. 2007
    ..These findings indicate that the STN and possibly also ponto-cerebellar pathways are involved in psychomotor control and in the modulation of PLC...
  41. pmc Gamma oscillations in human primary somatosensory cortex reflect pain perception
    Joachim Gross
    Department of Neurology, Heinrich Heine University, Dusseldorf, Germany
    PLoS Biol 5:e133. 2007
    ..Our findings support the hypothesis that gamma oscillations are related to the internal representation of behaviorally relevant stimuli that should receive preferred processing...
  42. doi request reprint Differential effects of dopaminergic medication on basic motor performance and executive functions in Parkinson's disease
    Jochen Michely
    Max Planck Institute for Neurological Research, Gleueler Strasse 50, 50931, Cologne, Germany
    Neuropsychologia 50:2506-14. 2012
    ..Specifically, we assessed how behavioral changes relate to medication, disease severity, and basic motor or cognitive deficits...
  43. ncbi request reprint Perilesional pathological oscillatory activity in the magnetoencephalogram of patients with cortical brain lesions
    Markus Butz
    Department of Neurology, Heinrich Heine University, Moorenstrasse 5, 40225 Dusseldorf, Germany
    Neurosci Lett 355:93-6. 2004
    ..Our results indicate that perilesional delta activity is common after ischemic cortical stroke. However, the functional significance remains to be elucidated...
  44. ncbi request reprint Verbal fluency in essential tremor patients: the effects of deep brain stimulation
    David J Pedrosa
    Department of Neurology, University Hospital Cologne, Cologne, Germany Electronic address
    Brain Stimul 7:359-64. 2014
    ..To assess the effects of different frequencies of thalamic Deep-Brain-Stimulation (DBS) on cognitive performance of patients suffering from Essential Tremor (ET)...
  45. ncbi request reprint Hypomania and mania related to dopamine replacement therapy in Parkinson's disease
    Franziska Maier
    Department of Neurology, University of Cologne, Cologne, Germany Electronic address
    Parkinsonism Relat Disord 20:421-7. 2014
    ..To investigate hypomania and mania related to dopamine replacement therapy (DRT) in Parkinson's disease (PD)...
  46. doi request reprint Effects of low-frequency thalamic deep brain stimulation in essential tremor patients
    David J Pedrosa
    Department of Neurology, University Hospital Cologne, Cologne, Germany Electronic address
    Exp Neurol 248:205-12. 2013
    ..Therefore, we hypothesized thalamic 10 Hz-stimulation, which is known to worsen motor functions, having more impact on intentional tremor than on postural tremor...
  47. doi request reprint Deep brain stimulation in the nucleus ventralis intermedius in patients with essential tremor: habituation of tremor suppression
    Michael T Barbe
    Department of Neurology, University Hospital Cologne, Kerpener Str 62, 50937 Cologne, Germany
    J Neurol 258:434-9. 2011
    ..Our results provide further evidence for a tolerance effect in chronic VIM stimulation thereby suggesting that frequently alternating stimulation protocols should be tested in future studies of ET patients treated with VIM-DBS...
  48. doi request reprint Visual assessment of dopaminergic degeneration pattern in 123I-FP-CIT SPECT differentiates patients with atypical parkinsonian syndromes and idiopathic Parkinson's disease
    Deniz Kahraman
    Department of Nuclear Medicine, University Hospital of Cologne, Kerpener Str 62, 50924, Cologne, Germany
    J Neurol 259:251-60. 2012
    ..Within the first 5 years of disease, the occurrence of a burst striatum degeneration pattern has a high positive predictive value of APS...
  49. doi request reprint The effect of filtering on Granger causality based multivariate causality measures
    Esther Florin
    Department of Neurology, University Hospital Cologne, Cologne, Germany
    Neuroimage 50:577-88. 2010
    ..In general, the multivariate causality measures are very sensitive to data preprocessing...
  50. ncbi request reprint Coupling between cerebellar hemispheres: behavioural, anatomic, and functional data
    Bettina Pollok
    Department of Neurology, Heinrich Heine University, Duesseldorf, Germany
    Cerebellum 5:212-9. 2006
    ..The present article reviews behavioural, functional, and anatomic data to shed light on possible interactions between both cerebellar hemispheres during the execution of timed motor behaviour...
  51. ncbi request reprint Physiological and pathological oscillatory networks in the human motor system
    Alfons Schnitzler
    Department of Neurology, Heinrich Heine University, Moorenstrasse 5, 40225 Dusseldorf, Germany
    J Physiol Paris 99:3-7. 2006
    ..In conclusion, the analysis of oscillatory cerebral networks provides new insights into physiological mechanisms of motor control and pathophysiological mechanisms of tremor disorders...
  52. doi request reprint Hallucinations in neurodegenerative diseases
    Lothar Burghaus
    Department of Neurology, University of Cologne, Cologne, Germany
    CNS Neurosci Ther 18:149-59. 2012
    ..The risk of increased neuroleptic sensitivity further restricts the treatment options in patients with Lewy Body Dementia. Coping Strategies and improvement of visual acuity and sleep quality may be useful therapeutic complements...
  53. ncbi request reprint Neural synchronization in hepatic encephalopathy
    Lars Timmermann
    Department of Neurology, University Hospital Dusseldorf, Heinrich Heine University, Dusseldorf, Germany
    Metab Brain Dis 20:337-46. 2005
    ..Taken together, pathological synchronization of neuronal activity may turn out to be a promising pathophysiological concept for linking neuronal dysfunction to the diversity of clinical deficits in HE...
  54. ncbi request reprint Pain processing is faster than tactile processing in the human brain
    Markus Ploner
    Department of Neurology, Heinrich Heine University, D 40225 Dusseldorf, Germany
    J Neurosci 26:10879-82. 2006
    ..Our observation shows how the cerebral organization of pain processing enhances motor responses to potentially harmful stimuli and thereby subserves the particular behavioral demands of pain...
  55. ncbi request reprint Cerebellar networks with basal ganglia: feasibility for tracking cerebello-pallidal and subthalamo-cerebellar projections in the human brain
    Esther Annegret Pelzer
    Max Planck Institute for Neurological Research Cologne, Cologne, Germany Department of Neurology, University Hospital Cologne, Kerpener Strasse 62, Cologne, 50937, Germany
    Eur J Neurosci 38:3106-14. 2013
    ..These findings support the role of the cerebellum as a satellite system of established cortico-basal ganglia networks in humans. ..
  56. ncbi request reprint Deep brain stimulation in the ventrolateral thalamus/subthalamic area in dystonia with head tremor
    K Amande M Pauls
    Department of Neurology, University Hospital Cologne, University of Cologne, Cologne, Germany
    Mov Disord 29:953-9. 2014
    ..We assessed the effect of thalamic/subthalamic area DBS (Th-DBS) on dystonic head tremor and dystonia in a single-blind design...
  57. doi request reprint Levodopa reinstates connectivity from prefrontal to premotor cortex during externally paced movement in Parkinson's disease
    Damian M Herz
    Department of Neurology, University Hospital Cologne, Cologne, Germany Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark Electronic address
    Neuroimage 90:15-23. 2014
    ....
  58. ncbi request reprint Are dopa-responsive dystonia and Parkinson's disease related disorders? A case report
    Carsten Eggers
    Department of Neurology, University Hospital of Cologne, Kerpener Str 62, 50924 Cologne, Germany
    Parkinsonism Relat Disord 18:666-8. 2012
    ..DRD patients may also develop Parkinsonism which resembles idiopathic Parkinson's disease. In classical DRD no changes in the dopaminergic uptake have been observed...
  59. doi request reprint Perrault Syndrome with progressive nervous system involvement
    Carsten Kobe
    Department of Nuclear Medicine, University of Cologne, Cologne, Germany
    Clin Nucl Med 33:922-4. 2008
    ..The fluorodeoxyglucose positron emission tomography (PET) of our patient brought results indicating a progressive heredoataxia. PET is helpful in the early detection of the progressive central nervous involvement of PS...
  60. doi request reprint Gait and upper limb variability in Parkinson's disease patients with and without freezing of gait
    Michael T Barbe
    Department of Neurology, University Hospital Cologne, Kerpener Str 62, 50937, Cologne, Germany
    J Neurol 261:330-42. 2014
    ..Upper limb freezing is not correlated to lower limb freezing, implicating a different pathophysiology. ..
  61. doi request reprint Effects of deep brain stimulation in dyskinetic cerebral palsy: a meta-analysis
    Anne Koy
    Department of Neurology, University Hospital Cologne, Germany
    Mov Disord 28:647-54. 2013
    ..2013 Movement Disorder Society...
  62. pmc Cortical representation of first and second pain sensation in humans
    Markus Ploner
    Department of Neurology, Heinrich Heine University, 40225 Dusseldorf, Germany
    Proc Natl Acad Sci U S A 99:12444-8. 2002
    ..First pain signals threat and provides precise sensory information for an immediate withdrawal, whereas second pain attracts longer-lasting attention and motivates behavioral responses to limit further injury and optimize recovery...
  63. ncbi request reprint Cortical origin of mini-asterixis in hepatic encephalopathy
    L Timmermann
    Department of Neurology, Heinrich Heine University, Dusseldorf, Germany
    Neurology 58:295-8. 2002
    ..The corticomuscular coupling demonstrates the involvement of M1 in asterixis and may reflect a pathologically slowed and synchronized motor cortical drive...
  64. doi request reprint Sequential escalation of therapy in "malignant" cerebral venous and sinus thrombosis
    Christian Dohmen
    Department of Neurology, University Hospital of Cologne, Kerpenerstr 62, 50924, Cologne, Germany
    Neurocrit Care 12:98-102. 2010
    ..Local thrombolysis has been successfully performed in several cases. In cases of impending herniation hemicraniectomy has been suggested as ultima ratio. We describe sequential escalation of therapy in "malignant" CVST...
  65. ncbi request reprint Involvement of the motor cortex in pseudochoreoathetosis
    L Timmermann
    Department of Neurology, Heinrich-Heine University, Duesseldorf, Germany
    Mov Disord 16:876-81. 2001
    ..The enhanced MEG-EMG coherence in pseudochoreoathetosis probably reflects a pathologically strong motor cortical drive of spinal motorneurons after deafferentation...
  66. pmc Dynamic imaging of coherent sources: Studying neural interactions in the human brain
    J Gross
    Department of Neurology, Heinrich-Heine-University, Moorenstrasse 5, D-40225 Duesseldorf, Germany
    Proc Natl Acad Sci U S A 98:694-9. 2001
    ....
  67. ncbi request reprint Mini-asterixis in hepatic encephalopathy induced by pathologic thalamo-motor-cortical coupling
    L Timmermann
    Department of Neurology, Heinrich Heine University, Dusseldorf, Germany
    Neurology 61:689-92. 2003
    ..HE patients showed thalamo-motor-cortical coupling at a significantly lower frequency than the coupling in control subjects. The pathologic motor cortical drive in HE probably results from altered thalamocortical oscillatory coupling...
  68. pmc Review: management of Parkinson's disease
    David J Pedrosa
    Department of Neurology, University Hospital Cologne, Cologne, Germany
    Neuropsychiatr Dis Treat 9:321-40. 2013
    ..Additionally, emerging new therapeutic options such as continuous pump therapies, eg, with apomorphine or parenteral levodopa, or the implantation of electrodes for deep brain stimulation were also considered...
  69. ncbi request reprint Properties of MEG tomographic maps obtained with spatial filtering
    J Gross
    Department of Neurology, Heinrich Heine University, Moorenstrasse 5, D 40225 Duesseldorf, Germany
    Neuroimage 19:1329-36. 2003
    ..It is important for assigning local maxima of activation to specific anatomical structures and may be used to test for differences in localization between different experimental conditions...
  70. ncbi request reprint Task-dependent oscillations during unimanual and bimanual movements in the human primary motor cortex and SMA studied with magnetoencephalography
    J Gross
    Department of Neurology, Heinrich Heine University, Duesseldorf, Germany
    Neuroimage 26:91-8. 2005
    ..In summary, our results indicate a differential functional role of oscillatory activity and coupling in the motor system...
  71. pmc The neural basis of intermittent motor control in humans
    J Gross
    Department of Neurology, Heinrich Heine University, D 40225 Duesseldorf, Germany
    Proc Natl Acad Sci U S A 99:2299-302. 2002
    ..Our findings suggest that coupling of 6- to 9-Hz oscillatory activity in the cerebello-thalamo-cortical loop represents the neural mechanism for the intermittent control of continuous movements...
  72. ncbi request reprint Differential coding of pain intensity in the human primary and secondary somatosensory cortex
    L Timmermann
    Department of Neurology, Heinrich-Heine-University, Moorenstrasse 5, 40225 Dusseldorf, Germany
    J Neurophysiol 86:1499-503. 2001
    ..Instead, SII may subserve recognition of the noxious nature and attention toward painful stimuli...
  73. ncbi request reprint Synchronised oscillations of the human sensorimotor cortex
    A Schnitzler
    Department of Neurology, Heinrich Heine University, Dusseldorf, Germany
    Acta Neurobiol Exp (Wars) 60:271-87. 2000
    ..Thus, investigation of oscillatory sensorimotor activity proceeds from phenomenology to function and provides an interesting approach to address questions in human motor physiology and pathophysiology...
  74. ncbi request reprint Critical flicker frequency for quantification of low-grade hepatic encephalopathy
    Gerald Kircheis
    Clinic for Gastroenterology, Hepatology and Infectiology, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
    Hepatology 35:357-66. 2002
    ..In conclusion, CFF is a sensitive, simple, and reliable parameter for quantification of low-grade HE severity in cirrhotic patients and may be useful for the detection and monitoring of SHE...
  75. ncbi request reprint A randomized trial of deep-brain stimulation for Parkinson's disease
    Gunther Deuschl
    Christian Albrechts University, Kiel, Germany
    N Engl J Med 355:896-908. 2006
    ..Neurostimulation of the subthalamic nucleus reduces levodopa-related motor complications in advanced Parkinson's disease. We compared this treatment plus medication with medical management...
  76. ncbi request reprint Pallidal deep brain stimulation improves quality of life in segmental and generalized dystonia: results from a prospective, randomized sham-controlled trial
    Joerg Mueller
    Mov Disord 23:131-4. 2008
    ..The open-label extension phase resulted in a significant improvement in all SF-36 domains following 6 months of neurostimulation. These results demonstrate a favorable impact of DBS on HRQoL in primary dystonia...