Christian Timmann

Summary

Affiliation: University of Hamburg
Country: Germany

Publications

  1. ncbi request reprint Two novel mutations R653H and E230K in the Mediterranean fever gene associated with disease
    C Timmann
    Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 74, D 20359, Hamburg, Germany
    Mutat Res 479:235-9. 2001
  2. doi request reprint Human genetic resistance to Onchocerca volvulus: evidence for linkage to chromosome 2p from an autosome-wide scan
    Christian Timmann
    Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    J Infect Dis 198:427-33. 2008
  3. ncbi request reprint Diagnosis of alpha+-thalassemias by determining the ratio of the two alpha-globin gene copies by oligonucleotide hybridization and melting curve analysis
    Christian Timmann
    Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, and Institute of Medical Biometry and Statistics, University Hospital Schleswig Holstein Campus Lübeck, Lubeck, Germany
    Clin Chem 51:1711-3. 2005
  4. ncbi request reprint Promoter haplotypes of the interleukin-10 gene influence proliferation of peripheral blood cells in response to helminth antigen
    C Timmann
    Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    Genes Immun 5:256-60. 2004
  5. doi request reprint [Molecular diagnostics of hereditary fever syndromes. Familial Mediterranean fever (FMF), hyperimmunoglobulin D syndrome (HIDS), tumor necrosis factor receptor-associated periodic syndrome (TRAPS), cryopyrin-associated periodic syndrome (CAPS: FCAS, MWS,
    C Timmann
    Abteilung für Tropenmedizinische Grundlagenforschung, Bernhard Nocht Institut fur Tropenmedizin, 20359 Hamburg
    Z Rheumatol 68:720-5. 2009
  6. ncbi request reprint Familial Mediterranean fever with amyloidosis associated with novel exon 2 mutation (S1791) of the MEFV gene
    Christian Timmann
    Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 74, 20359 Hamburg, Germany
    Blood Cells Mol Dis 31:320-3. 2003
  7. ncbi request reprint Cutaneous pathology in onchocerciasis associated with pronounced systemic T-helper 2-type responses to Onchocerca volvulus
    C Timmann
    Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 74, 20359 Hamburg, Germany
    Br J Dermatol 149:782-7. 2003
  8. ncbi request reprint Hemoglobin variants and disease manifestations in severe falciparum malaria
    Jurgen May
    Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    JAMA 297:2220-6. 2007
  9. pmc Genome-wide linkage analysis of malaria infection intensity and mild disease
    Christian Timmann
    Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    PLoS Genet 3:e48. 2007
  10. pmc A -436C>A polymorphism in the human FAS gene promoter associated with severe childhood malaria
    Kathrin Schuldt
    Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    PLoS Genet 7:e1002066. 2011

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Two novel mutations R653H and E230K in the Mediterranean fever gene associated with disease
    C Timmann
    Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 74, D 20359, Hamburg, Germany
    Mutat Res 479:235-9. 2001
    ..DNA sequencing and PCR-RFLP typing of the families confirmed the mutations and verified recessive modes of inheritance...
  2. doi request reprint Human genetic resistance to Onchocerca volvulus: evidence for linkage to chromosome 2p from an autosome-wide scan
    Christian Timmann
    Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    J Infect Dis 198:427-33. 2008
    ..Several lines of evidence suggest a relevant influence of human genetics...
  3. ncbi request reprint Diagnosis of alpha+-thalassemias by determining the ratio of the two alpha-globin gene copies by oligonucleotide hybridization and melting curve analysis
    Christian Timmann
    Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, and Institute of Medical Biometry and Statistics, University Hospital Schleswig Holstein Campus Lübeck, Lubeck, Germany
    Clin Chem 51:1711-3. 2005
  4. ncbi request reprint Promoter haplotypes of the interleukin-10 gene influence proliferation of peripheral blood cells in response to helminth antigen
    C Timmann
    Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    Genes Immun 5:256-60. 2004
    ..To our knowledge, this is the first time that an influence of IL-10 promoter variants is shown on the adaptive immune response...
  5. doi request reprint [Molecular diagnostics of hereditary fever syndromes. Familial Mediterranean fever (FMF), hyperimmunoglobulin D syndrome (HIDS), tumor necrosis factor receptor-associated periodic syndrome (TRAPS), cryopyrin-associated periodic syndrome (CAPS: FCAS, MWS,
    C Timmann
    Abteilung für Tropenmedizinische Grundlagenforschung, Bernhard Nocht Institut fur Tropenmedizin, 20359 Hamburg
    Z Rheumatol 68:720-5. 2009
    ....
  6. ncbi request reprint Familial Mediterranean fever with amyloidosis associated with novel exon 2 mutation (S1791) of the MEFV gene
    Christian Timmann
    Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 74, 20359 Hamburg, Germany
    Blood Cells Mol Dis 31:320-3. 2003
    ....
  7. ncbi request reprint Cutaneous pathology in onchocerciasis associated with pronounced systemic T-helper 2-type responses to Onchocerca volvulus
    C Timmann
    Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 74, 20359 Hamburg, Germany
    Br J Dermatol 149:782-7. 2003
    ..Of 18 million people world-wide who are infested with the tissue nematode Onchocerca volvulus, more than 30% are considered to have skin lesions, the pathomechanisms of which are poorly understood...
  8. ncbi request reprint Hemoglobin variants and disease manifestations in severe falciparum malaria
    Jurgen May
    Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    JAMA 297:2220-6. 2007
    ....
  9. pmc Genome-wide linkage analysis of malaria infection intensity and mild disease
    Christian Timmann
    Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    PLoS Genet 3:e48. 2007
    ..7%; 95% confidence interval, 15.7%-59.7%). The identification of genetic variants underlying the linkage signals may reveal as yet unrecognized pathways influencing human resistance to malaria...
  10. pmc A -436C>A polymorphism in the human FAS gene promoter associated with severe childhood malaria
    Kathrin Schuldt
    Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    PLoS Genet 7:e1002066. 2011
    ....
  11. doi request reprint Genome-wide association study indicates two novel resistance loci for severe malaria
    Christian Timmann
    Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany
    Nature 489:443-6. 2012
    ..Our findings underline the potential of the GWA approach to provide candidates for the development of control measures against infectious diseases in humans...
  12. doi request reprint FCGR2A functional genetic variant associated with susceptibility to severe malarial anaemia in Ghanaian children
    Kathrin Schuldt
    Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 74, Hamburg, Germany
    J Med Genet 47:471-5. 2010
    ....
  13. ncbi request reprint Onchocerca volvulus-exposed persons fail to produce interferon-gamma in response to O. volvulus antigen but mount proliferative responses with interleukin-5 and IL-13 production that decrease with increasing microfilarial density
    Norbert W Brattig
    Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 74, 20359 Hamburg, Germany
    J Infect Dis 185:1148-54. 2002
    ....
  14. ncbi request reprint Promoter polymorphism of the anion-exchange protein 1 associated with severe malarial anemia and fatality
    Vera von Kalckreuth
    Research Group for Infection Epidemiology, Bernhard Nocht Institute for Tropical Medicine, D 20359 Hamburg, Germany
    J Infect Dis 194:949-57. 2006
    ..These results demonstrate that the AE1 promoter allele might influence the infection phenotype and the risk of fatal outcome in children with severe malaria. In this regard, a crucial role of the AE1 protein in malaria is emphasized...
  15. pmc Genotyping of Plasmodium falciparum pyrimethamine resistance by matrix-assisted laser desorption-ionization time-of-flight mass spectrometry
    Florian Marks
    Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    Antimicrob Agents Chemother 48:466-72. 2004
    ..As demonstrated by the example of PYR resistance, MALDI-TOF MS allows for rapid and automated high-throughput assessment of drug sensitivity in P. falciparum malaria...
  16. doi request reprint Malaria, mummies, mutations: Tutankhamun's archaeological autopsy
    Christian Timmann
    Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 74, Hamburg, Germany
    Trop Med Int Health 15:1278-80. 2010
    ..We are sceptical towards this elucidation of the cause of death of King Tut and discuss alternative and differential diagnoses, among them, in particular, sickle cell disease and Gauche’s disease...
  17. ncbi request reprint Colchicine use in children and adolescents with familial Mediterranean fever: literature review and consensus statement
    Tilmann Kallinich
    Department of Pediatric Pneumology and Immunology, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany
    Pediatrics 119:e474-83. 2007
    ..On the basis of this analysis, a consensus statement on the application of colchicine in children and adolescents with familial Mediterranean fever was developed by caregivers from Germany, Austria, and Turkey...
  18. ncbi request reprint Hereditary periodic fever with systemic amyloidosis: is hyper-IgD syndrome really a benign disease?
    Rainer Siewert
    Department of Nephrology, Solingen General Hospital, University of Cologne, Solingen, Germany
    Am J Kidney Dis 48:e41-5. 2006
    ..These unusual complications of HIDS seriously challenge the assumption that the disease is associated with a good prognosis...
  19. ncbi request reprint Capillary refill time as an independent prognostic indicator in severe and complicated malaria
    Jennifer A Evans
    Kumasi Centre for Collaborative Research in Tropical Medicine, Kumasi, Ghana
    J Pediatr 149:676-81. 2006
    ..To improve algorithms for the identification of children at risk of dying of malaria in endemic areas...