Enrico Tiacci

Summary

Affiliation: University of Essen
Country: Germany

Publications

  1. ncbi request reprint Evolving concepts in the pathogenesis of hairy-cell leukaemia
    Enrico Tiacci
    Institute of Haematology, University of Perugia, Italy
    Nat Rev Cancer 6:437-48. 2006
  2. pmc BRAF mutations in hairy-cell leukemia
    Enrico Tiacci
    Institute of Hematology, University of Perugia, Perugia, Italy
    N Engl J Med 364:2305-15. 2011
  3. ncbi request reprint Mutated nucleophosmin detects clonal multilineage involvement in acute myeloid leukemia: Impact on WHO classification
    Laura Pasqualucci
    Institute of Hematology, University of Perugia, Perugia, Italy
    Blood 108:4146-55. 2006
  4. ncbi request reprint Both carboxy-terminus NES motif and mutated tryptophan(s) are crucial for aberrant nuclear export of nucleophosmin leukemic mutants in NPMc+ AML
    Brunangelo Falini
    Institute of Hematology, University of Perugia, 06122 Perugia, Italy
    Blood 107:4514-23. 2006
  5. doi request reprint IRTA1 is selectively expressed in nodal and extranodal marginal zone lymphomas
    Brunangelo Falini
    Institute of Haematology, University of Perugia, Ospedale S Maria della Misericordia, Perugia, Italy
    Histopathology 61:930-41. 2012
  6. pmc Constant activation of the RAF-MEK-ERK pathway as a diagnostic and therapeutic target in hairy cell leukemia
    Enrico Tiacci
    Institute of Hematology, Ospedale S Maria della Misericordia, University of Perugia, Perugia, Italy
    Haematologica 98:635-9. 2013
  7. ncbi request reprint Tumor protein D52 (TPD52): a novel B-cell/plasma-cell molecule with unique expression pattern and Ca(2+)-dependent association with annexin VI
    Enrico Tiacci
    Section of Physiopathology, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    Blood 105:2812-20. 2005
  8. ncbi request reprint PAX5 expression in acute leukemias: higher B-lineage specificity than CD79a and selective association with t(8;21)-acute myelogenous leukemia
    Enrico Tiacci
    Institutes of Hematology and Internal Medicine, University of Perugia, Perugia, Italy
    Cancer Res 64:7399-404. 2004
  9. doi request reprint The human NPM1 mutation A perturbs megakaryopoiesis in a conditional mouse model
    Paolo Sportoletti
    Institute of Hematology, University of Perugia, Ospedale S Mariadella Misericordia, Perugia, Italy
    Blood 121:3447-58. 2013
  10. doi request reprint Acute myeloid leukemia with mutated nucleophosmin (NPM1): is it a distinct entity?
    Brunangelo Falini
    Institute of Hematology, University of Perugia, Ospedale S Maria della Misericordia, S Andrea delle Fratte, Perugia, Italy
    Blood 117:1109-20. 2011

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Evolving concepts in the pathogenesis of hairy-cell leukaemia
    Enrico Tiacci
    Institute of Haematology, University of Perugia, Italy
    Nat Rev Cancer 6:437-48. 2006
    ....
  2. pmc BRAF mutations in hairy-cell leukemia
    Enrico Tiacci
    Institute of Hematology, University of Perugia, Perugia, Italy
    N Engl J Med 364:2305-15. 2011
    ..Hairy-cell leukemia (HCL) is a well-defined clinicopathological entity whose underlying genetic lesion is still obscure...
  3. ncbi request reprint Mutated nucleophosmin detects clonal multilineage involvement in acute myeloid leukemia: Impact on WHO classification
    Laura Pasqualucci
    Institute of Hematology, University of Perugia, Perugia, Italy
    Blood 108:4146-55. 2006
    ....
  4. ncbi request reprint Both carboxy-terminus NES motif and mutated tryptophan(s) are crucial for aberrant nuclear export of nucleophosmin leukemic mutants in NPMc+ AML
    Brunangelo Falini
    Institute of Hematology, University of Perugia, 06122 Perugia, Italy
    Blood 107:4514-23. 2006
    ..These findings indicate that potential therapeutic strategies aimed to retarget NPM to its physiological sites will have to overcome 2 obstacles, the new NES motif and the mutated tryptophan(s) at the NPM mutant C-terminus...
  5. doi request reprint IRTA1 is selectively expressed in nodal and extranodal marginal zone lymphomas
    Brunangelo Falini
    Institute of Haematology, University of Perugia, Ospedale S Maria della Misericordia, Perugia, Italy
    Histopathology 61:930-41. 2012
    ..The aim of this study was to search for a molecule selectively expressed by marginal zone (MZ) lymphomas (MZLs), whose diagnosis is currently based on morphological criteria and negativity for markers detectable in other B-cell lymphomas...
  6. pmc Constant activation of the RAF-MEK-ERK pathway as a diagnostic and therapeutic target in hairy cell leukemia
    Enrico Tiacci
    Institute of Hematology, Ospedale S Maria della Misericordia, University of Perugia, Perugia, Italy
    Haematologica 98:635-9. 2013
    ....
  7. ncbi request reprint Tumor protein D52 (TPD52): a novel B-cell/plasma-cell molecule with unique expression pattern and Ca(2+)-dependent association with annexin VI
    Enrico Tiacci
    Section of Physiopathology, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    Blood 105:2812-20. 2005
    ..Finally, the anti-TPD52 monoclonal antibody served as a valuable tool for the diagnosis of B-cell malignancies...
  8. ncbi request reprint PAX5 expression in acute leukemias: higher B-lineage specificity than CD79a and selective association with t(8;21)-acute myelogenous leukemia
    Enrico Tiacci
    Institutes of Hematology and Internal Medicine, University of Perugia, Perugia, Italy
    Cancer Res 64:7399-404. 2004
    ..e. the aberrant expression of B-cell genes...
  9. doi request reprint The human NPM1 mutation A perturbs megakaryopoiesis in a conditional mouse model
    Paolo Sportoletti
    Institute of Hematology, University of Perugia, Ospedale S Mariadella Misericordia, Perugia, Italy
    Blood 121:3447-58. 2013
    ..Our mouse model provides evidence that the NPM1 mutant affects megakaryocytic development, further expanding our knowledge of the role of NPM1 mutant in leukemogenesis...
  10. doi request reprint Acute myeloid leukemia with mutated nucleophosmin (NPM1): is it a distinct entity?
    Brunangelo Falini
    Institute of Hematology, University of Perugia, Ospedale S Maria della Misericordia, S Andrea delle Fratte, Perugia, Italy
    Blood 117:1109-20. 2011
    ..Altogether, these pieces of evidence point to NPM1-mutated AML as a founder genetic event that defines a distinct leukemia entity accounting for approximately one-third of all AML...
  11. ncbi request reprint New classification of acute myeloid leukemia and precursor-related neoplasms: changes and unsolved issues
    Brunangelo Falini
    Institute of Hematology, University of Perugia, Perugia, Italy
    Discov Med 10:281-92. 2010
    ..Finally, we describe the unique characteristics of myeloid proliferations associated with Down syndrome and blastic plasmacytoid dendritic cell neoplasm...
  12. ncbi request reprint Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype
    Brunangelo Falini
    Institute of Hematology, University of Perugia, Perugia, Italy
    N Engl J Med 352:254-66. 2005
    ..Nucleophosmin (NPM), a nucleocytoplasmic shuttling protein with prominent nucleolar localization, regulates the ARF-p53 tumor-suppressor pathway. Translocations involving the NPM gene cause cytoplasmic dislocation of the NPM protein...
  13. doi request reprint Mutational landscape of AML with normal cytogenetics: biological and clinical implications
    Maria Paola Martelli
    Institute of Hematology, University of Perugia, Perugia, Italy
    Blood Rev 27:13-22. 2013
    ..In addition, we outline the prognostic value of mutations for risk stratification of CN-AML patients and discuss the potential of mutations discovery process for developing new molecular targeted therapies...
  14. ncbi request reprint Aberrant somatic hypermutation in tumor cells of nodular-lymphocyte-predominant and classic Hodgkin lymphoma
    Arcangelo Liso
    Institute of Hematology, University of Perugia, Policlinico, Monteluce, 06122 Perugia, Italy
    Blood 108:1013-20. 2006
    ..Our finding that NLPHL and cHL are targeted by aberrant SHM, as is DLBCL, suggests that these lymphomas may share common molecular pathogenetic events...
  15. doi request reprint Simple genetic diagnosis of hairy cell leukemia by sensitive detection of the BRAF-V600E mutation
    Enrico Tiacci
    Institute of Hematology, University of Perugia, Perugia, Italy
    Blood 119:192-5. 2012
    ..Conversely, 115 non-HCL chronic B-cell neoplasms, including 79 HCL-like disorders, were invariably negative for BRAF-V600E. This molecular assay is a powerful tool for improving the diagnostic accuracy in HCL...
  16. ncbi request reprint Simple diagnostic assay for hairy cell leukaemia by immunocytochemical detection of annexin A1 (ANXA1)
    Brunangelo Falini
    Institute of Haematology, University of Perugia, Perugia, Italy
    Lancet 363:1869-70. 2004
    ....
  17. doi request reprint Immunohistochemical surrogates for genetic alterations of CCDN1, PML, ALK, and NPM1 genes in lymphomas and acute myeloid leukemia
    Brunangelo Falini
    Institute of Hematology, University of Perugia, Perugia, Italy
    Best Pract Res Clin Haematol 23:417-31. 2010
    ..Genome wide based discovery of new tumor-associated genetic lesions that are suitable for antibody targeting promises to further expand the application of immunohistochemistry for the molecular classification of hematological neoplasms...
  18. ncbi request reprint Expression of the IRTA1 receptor identifies intraepithelial and subepithelial marginal zone B cells of the mucosa-associated lymphoid tissue (MALT)
    Brunangelo Falini
    Institute of Hematology, University of Perugia, 06122 Perugia, Italy
    Blood 102:3684-92. 2003
    ..Collectively, these results suggest a role of IRTA1 in the immune function of B cells within epithelia...
  19. pmc Origin and pathogenesis of nodular lymphocyte-predominant Hodgkin lymphoma as revealed by global gene expression analysis
    Verena Brune
    Institute for Cell Biology Tumor Research, University of Duisburg Essen Medical School, 45122 Essen, Germany
    J Exp Med 205:2251-68. 2008
    ..Thus, these findings shed new light on the nature of L&H cells, reveal several novel pathogenetic mechanisms in NLPHL, and may help in differential diagnosis and lead to novel therapeutic strategies...
  20. ncbi request reprint [Global gene expression analysis and novel signalling pathways in Hodgkin lymphoma]
    Andreas Bräuninger
    Senckenbergisches Institut für Pathologie, Klinikum der J W Goethe Universitat, Frankfurt
    Verh Dtsch Ges Pathol 90:136-41. 2006
    ....
  21. ncbi request reprint Acute myeloid leukemia bearing cytoplasmic nucleophosmin (NPMc+ AML) shows a distinct gene expression profile characterized by up-regulation of genes involved in stem-cell maintenance
    Myriam Alcalay
    IFOM IEO Campus, Via Adamello 16, 20139, Milan, Italy
    Blood 106:899-902. 2005
    ..The molecular signature of NPMc+ AML includes up-regulation of several genes putatively involved in the maintenance of a stem-cell phenotype, suggesting that NPMc+ AML may derive from a multipotent hematopoietic progenitor...
  22. pmc Gene expression profiling of hairy cell leukemia reveals a phenotype related to memory B cells with altered expression of chemokine and adhesion receptors
    Katia Basso
    Institute of Hematology, Policlinico Monteluce, Perugia 06100, Italy
    J Exp Med 199:59-68. 2004
    ..These results have biological implications relevant to the pathogenesis of this malignancy as well as clinical implications for its diagnosis and therapy...
  23. ncbi request reprint T-bet-positive and IRTA1-positive monocytoid B cells differ from marginal zone B cells and epithelial-associated B cells in their antigen profile and topographical distribution
    Korinna Johrens
    Institute for Pathology, Charite, Campus Benjamin Franklin, Medical University Berlin, Germany
    Haematologica 90:1070-7. 2005
    ..To clarify this issue we studied the antigen profile and topographical distribution of these cell types...